A synthetic antibiotic class overcoming bacterial multidrug resistance
Mitcheltree, Matthew J, Pisipati, Amarnath, Syroegin, Egor A, Silvestre, Katherine J, Klepacki, Dorota, Mason, Jeremy D, Terwilliger, Daniel W, Testolin, Giambattista, Pote, Aditya R, Wu, Kelvin J Y, Ladley, Richard Porter, Chatman, Kelly, Mankin, Alexander S, Polikanov, Yury S, Myers, Andrew G
Published in Nature (London) (18.11.2021)
Published in Nature (London) (18.11.2021)
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Journal Article
A Practical, Component-Based Synthetic Route to Methylthiolincosamine Permitting Facile Northern-Half Diversification of Lincosamide Antibiotics
Mitcheltree, Matthew J, Stevenson, Jack W, Pisipati, Amarnath, Myers, Andrew G
Published in Journal of the American Chemical Society (12.05.2021)
Published in Journal of the American Chemical Society (12.05.2021)
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Journal Article
Bioisostere Effects on the EPSA of Common Permeability-Limiting Groups
Ecker, Andrew K., Levorse, Dorothy A., Victor, Daniel A., Mitcheltree, Matthew J.
Published in ACS medicinal chemistry letters (09.06.2022)
Published in ACS medicinal chemistry letters (09.06.2022)
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Journal Article
An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance
Wu, Kelvin J Y, Tresco, Ben I C, Ramkissoon, Antonio, Aleksandrova, Elena V, Syroegin, Egor A, See, Dominic N Y, Liow, Priscilla, Dittemore, Georgia A, Yu, Meiyi, Testolin, Giambattista, Mitcheltree, Matthew J, Liu, Richard Y, Svetlov, Maxim S, Polikanov, Yury S, Myers, Andrew G
Published in Science (American Association for the Advancement of Science) (16.02.2024)
Published in Science (American Association for the Advancement of Science) (16.02.2024)
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Journal Article
Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy
Mitcheltree, Matthew J, Li, Derun, Achab, Abdelghani, Beard, Adam, Chakravarthy, Kalyan, Cheng, Mangeng, Cho, Hyelim, Eangoor, Padmanabhan, Fan, Peter, Gathiaka, Symon, Kim, Hai-Young, Lesburg, Charles A, Lyons, Thomas W, Martinot, Theodore A, Miller, J. Richard, McMinn, Spencer, O’Neil, Jennifer, Palani, Anandan, Palte, Rachel L, Saurí, Josep, Sloman, David L, Zhang, Hongjun, Cumming, Jared N, Fischer, Christian
Published in ACS medicinal chemistry letters (09.04.2020)
Published in ACS medicinal chemistry letters (09.04.2020)
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Journal Article
Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors
Li, Derun, Zhang, Hongjun, Lyons, Thomas W, Lu, Min, Achab, Abdelghani, Pu, Qinglin, Childers, Matthew, Mitcheltree, Matthew J, Wang, Jialiang, Martinot, Theodore A, McMinn, Spencer E, Sloman, David L, Palani, Anandan, Beard, Adam, Nogle, Lisa, Gathiaka, Symon, Saurí, Josep, Kim, Hai-Young, Adpressa, Donovon, Spacciapoli, Peter, Miller, J. Richard, Palte, Rachel L, Lesburg, Charles A, Cumming, Jared, Fischer, Christian
Published in ACS medicinal chemistry letters (11.11.2021)
Published in ACS medicinal chemistry letters (11.11.2021)
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Journal Article
Bacterial drug resistance overcome by synthetic restructuring of antibiotics
Published in Nature (London)
(27.10.2021)
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Journal Article
Abstract 297: Innovation in delivering synthetically challenging bicyclic arginase inhibitors to enhance immunotherapy
Li, Derun, Zhang, Hongjun, Lyons, Thomas W., Martinot, Theodore A., Achab, Abdelghani, lu, Min, Nogle, Lisa M., McMinn, Spencer, Mitcheltree, Matthew J., Childers, Matthew, Pu, Qinglin, Gathiaka, Symon, Palani, Anand, Chakravarthy, Kalyan, DeCastro, Amy D., O'Neil, Jennifer, Afshar, Roshi, Walsh, Nicole C., Fan, Peter W., Cheng, Mangeng, Miller, Richard, Doty, Amy, Palte, Rachel, Kim, Hai-Young, Saurí, Josep, Beard, Adam, Brynczka, Christopher, Fischer, Christian
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
RIPK1 INHIBITORS AND METHODS OF USE
Fuller, Peter H, Lu, Min, Mitcheltree, Matthew J, Su, Jing, DiMauro, Erin F, Methot, Joey L, Fradera, Xavier, Musacchio, Andrew J, Siliphaivanh, Phieng
Year of Publication 11.07.2024
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Year of Publication 11.07.2024
Patent
PHENYL AZEPINES AS RIPK1 INHIBITORS AND METHODS OF USE THEREOF
Fuller, Peter H, Lu, Min, Mitcheltree, Matthew J, Su, Jing, DiMauro, Erin F, Methot, Joey L, Chen, Joanna L, Dykstra, Kevin D, Fradera, Xavier, Lesburg, Charles A
Year of Publication 27.06.2024
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Year of Publication 27.06.2024
Patent
RIPK1 INHIBITORS AND METHODS OF USE
MUSACCHIO, Andrew, J, LU, Min, SU, Jing, FULLER, Peter, H, FRADERA, Xavier, METHOT, Joey, L, DIMAURO, Erin, F, MITCHELTREE, Matthew, J, SILIPHAIVANH, Phieng
Year of Publication 06.03.2024
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Year of Publication 06.03.2024
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SMALL MOLECULE INHIBITORS OF KRAS PROTEINS
SUMIYAMA, Keiichi, AKEMOTO, Kei, UNO, Takao, OSHIMA, Tsuyoshi, KOBAYAKAWA, Yu, FISCHER, Christian, MIURA, Risako, MITCHELTREE, Matthew J, MA, Xiaoshen, SAKAMOTO, Toshihiro, KAWAMURA, Shuhei, SLOMAN, David L, HENDERSON, Timothy, CHESSARI, Gianni
Year of Publication 11.04.2024
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Year of Publication 11.04.2024
Patent
PHENYL AZEPINES AS RIPK1 INHIBITORS AND METHODS OF USE THEREOF
DYKSTRA, Kevin, D, LU, Min, SU, Jing, FULLER, Peter, H, FRADERA, Xavier, METHOT, Joey, L, LESBURG, Charles, A, CHEN, Joanna, L, MITCHELTREE, Matthew, J, DIMARUO, Erin, F
Year of Publication 06.03.2024
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Year of Publication 06.03.2024
Patent
SMALL MOLECULE INHIBITORS OF KRAS PROTEINS
SUMIYAMA, Keiichi, AKEMOTO, Kei, UNO, Takao, OSHIMA, Tsuyoshi, KOBAYAKAWA, Yu, FISCHER, Christian, MIURA, Risako, MITCHELTREE, Matthew J, MA, Xiaoshen, SAKAMOTO, Toshihiro, KAWAMURA, Shuhei, SLOMAN, David L, HENDERSON, Timothy, CHESSARI, Gianni
Year of Publication 29.02.2024
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Year of Publication 29.02.2024
Patent
SMALL MOLECULE INHIBITORS OF KRAS PROTEINS
AKEMOTO, Kei, PALANI, Anandan, YAMAMOTO, Tomohiro, KOYAMA, Junpei, DEL POZO, Juan, KOBAYAKAWA, Yu, BLACKBURN, Melanie A.S, SANDMEIER, Tobias, SWAMINATHAN, Uma, GIAMBASU, George Madalin, LI, Bing, ASAKURA, Hiroki, KOLAJ, Igri, MITCHELTREE, Matthew J, ZHOU, Hua, KITADE, Makoto, KATTAR, Solomon, KAWAMURA, Shuhei, SLOMAN, David L, RUAN, Emily, KONDO, Hitomi, SUMIYAMA, Keiichi, OSHIMA, Tsuyoshi, SCHÖPF, Patrick, MIURA, Risako, IGUCHI, Satoru, HOWARD, Steven, SAKAMOTO, Toshihiro, GATHIAKA, Symon, RYAN, Michael
Year of Publication 16.05.2024
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Year of Publication 16.05.2024
Patent
SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT
Swaminathan, Uma, Nakamura, Masayuki, Kolaj, Igri, Uehling, Mycah, Kawamura, Shuhei, Schöpf, Patrick, Chessari, Gianni, Chau, Ryan, Gathiaka, Symon, Han, Yongxin, Bharathan, Indu, Graham, Thomas H, Uno, Takao, Howard, Steven, Sagara, Takeshi, Kawai, Yuichi, Palani, Anandan, Hennessy, Elisabeth T, Asakura, Hiroki, Bennett, David Jonathan, Lyons, Thomas W, Sather, Aaron, Shibata, Kazuaki, Hoover, Andrew J, Ye, Yingchun, Mitcheltree, Matthew J, Henderson, Timothy J, Sloman, David L, Christian, Alec H, Kobayakawa, Yu, Hussain, Zahid, Mandal, Mihir, Ma, Xiaoshen, Otte, Ryan D
Year of Publication 18.07.2024
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Year of Publication 18.07.2024
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ARGINASE INHIBITORS AND METHODS OF USE
Lu, Min, Mitcheltree, Matthew J, Gathiaka, Symon, Cumming, Jared N, Li, Derun, Palani, Anandan, Zhang, Hongjun, Achab, Abdelghani Abe, Childers, Matthew L, Lesburg, Charles A, Palte, Rachel L
Year of Publication 24.02.2022
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Year of Publication 24.02.2022
Patent
ARGINASE INHIBITORS AND METHODS OF USE
CUMMING, Jared, N, LU, Min, PALANI, Anandan, PALTE, Rachel, L, ACHAB, Abdelghani Abe, CHILDERS, Matthew, L, ZHANG, Hongjun, GATHIAKA, Symon, LESBURG, Charles, A, LI, Derun, MITCHELTREE, Matthew, J
Year of Publication 28.09.2022
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Year of Publication 28.09.2022
Patent