Reduced efficacy of a Src kinase inhibitor in crowded protein solution
Kasahara, Kento, Re, Suyong, Nawrocki, Grzegorz, Oshima, Hiraku, Mishima-Tsumagari, Chiemi, Miyata-Yabuki, Yukako, Kukimoto-Niino, Mutsuko, Yu, Isseki, Shirouzu, Mikako, Feig, Michael, Sugita, Yuji
Published in Nature communications (02.07.2021)
Published in Nature communications (02.07.2021)
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Journal Article
Bis-Heteroaryl Pyrazoles: Identification of Orally Bioavailable Inhibitors of Activin Receptor-Like Kinase-2 (R206H)
Sekimata, Katsuhiko, Sato, Tomohiro, Sakai, Naoki, Watanabe, Hisami, Mishima-Tsumagari, Chiemi, Taguri, Tomonori, Matsumoto, Takehisa, Fujii, Yoshifumi, Handa, Noriko, Honma, Teruki, Tanaka, Akiko, Shirouzu, Mikako, Yokoyama, Shigeyuki, Miyazono, Kohei, Hashizume, Yoshinobu, Koyama, Hiroo
Published in Chemical & pharmaceutical bulletin (01.03.2019)
Published in Chemical & pharmaceutical bulletin (01.03.2019)
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Journal Article
Structural basis for the dual GTPase specificity of the DOCK10 guanine nucleotide exchange factor
Kukimoto-Niino, Mutsuko, Ihara, Kentaro, Mishima-Tsumagari, Chiemi, Inoue, Mio, Fukui, Yoshinori, Yokoyama, Shigeyuki, Shirouzu, Mikako
Published in Biochemical and biophysical research communications (23.04.2023)
Published in Biochemical and biophysical research communications (23.04.2023)
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Journal Article
Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye
Sakurai, Tetsuya, Uruno, Takehito, Sugiura, Yuki, Tatsuguchi, Takaaki, Yamamura, Kazuhiko, Ushijima, Miho, Hattori, Yuko, Kukimoto-Niino, Mutsuko, Mishima-Tsumagari, Chiemi, Watanabe, Mayuki, Suematsu, Makoto, Fukui, Yoshinori
Published in Science signaling (31.07.2018)
Published in Science signaling (31.07.2018)
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Journal Article
Unique structure of ozoralizumab, a trivalent anti-TNFα NANOBODY ® compound, offers the potential advantage of mitigating the risk of immune complex-induced inflammation
Kyuuma, Masanao, Kaku, Ayaka, Mishima-Tsumagari, Chiemi, Ogawa, Bunichiro, Endo, Mayumi, Tamura, Yunoshin, Ishikura, Kei-Ichiro, Mima, Masashi, Nakanishi, Yutaka, Fujii, Yasuyuki
Published in Frontiers in immunology (14.04.2023)
Published in Frontiers in immunology (14.04.2023)
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Journal Article
Granzyme A Stimulates pDCs to Promote Adaptive Immunity via Induction of Type I IFN
Shimizu, Kanako, Yamasaki, Satoru, Sakurai, Maki, Yumoto, Noriko, Ikeda, Mariko, Mishima-Tsumagari, Chiemi, Kukimoto-Niino, Mutsuko, Watanabe, Takashi, Kawamura, Masami, Shirouzu, Mikako, Fujii, Shin-Ichiro
Published in Frontiers in immunology (26.06.2019)
Published in Frontiers in immunology (26.06.2019)
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Journal Article
Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms
Hanawa-Suetsugu, Kyoko, Kukimoto-Niino, Mutsuko, Mishima-Tsumagari, Chiemi, Akasaka, Ryogo, Ohsawa, Noboru, Sekine, Shun-ichi, Ito, Takuhiro, Tochio, Naoya, Koshiba, Seizo, Kigawa, Takanori, Terada, Takaho, Shirouzu, Mikako, Nishikimi, Akihiko, Uruno, Takehito, Katakai, Tomoya, Kinashi, Tatsuo, Kohda, Daisuke, Fukui, Yoshinori, Yokoyama, Shigeyuki
Published in Proceedings of the National Academy of Sciences - PNAS (28.02.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (28.02.2012)
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Journal Article
Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex
Kukimoto-Niino, Mutsuko, Katsura, Kazushige, Kaushik, Rahul, Ehara, Haruhiko, Yokoyama, Takeshi, Uchikubo-Kamo, Tomomi, Nakagawa, Reiko, Mishima-Tsumagari, Chiemi, Yonemochi, Mayumi, Ikeda, Mariko, Hanada, Kazuharu, Zhang, Kam Y. J., Shirouzu, Mikako
Published in Science advances (01.07.2021)
Published in Science advances (01.07.2021)
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Journal Article
Targeting Ras-binding domain of ELMO1 by computational nanobody design
Tam, Chunlai, Kukimoto-Niino, Mutsuko, Miyata-Yabuki, Yukako, Tsuda, Kengo, Mishima-Tsumagari, Chiemi, Ihara, Kentaro, Inoue, Mio, Yonemochi, Mayumi, Hanada, Kazuharu, Matsumoto, Takehisa, Shirouzu, Mikako, Zhang, Kam Y. J.
Published in Communications biology (17.03.2023)
Published in Communications biology (17.03.2023)
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Journal Article
Structural Basis of Activin Receptor-Like Kinase 2 (R206H) Inhibition by Bis-heteroaryl Pyrazole-Based Inhibitors for the Treatment of Fibrodysplasia Ossificans Progressiva Identified by the Integration of Ligand-Based and Structure-Based Drug Design Approaches
Sato, Tomohiro, Sekimata, Katsuhiko, Sakai, Naoki, Watanabe, Hisami, Mishima-Tsumagari, Chiemi, Taguri, Tomonori, Matsumoto, Takehisa, Fujii, Yoshifumi, Handa, Noriko, Tanaka, Akiko, Shirouzu, Mikako, Yokoyama, Shigeyuki, Hashizume, Yoshinobu, Miyazono, Kohei, Koyama, Hiroo, Honma, Teruki
Published in ACS omega (26.05.2020)
Published in ACS omega (26.05.2020)
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Journal Article
Tetrameric Interaction of the Ectoenzyme CD38 on the Cell Surface Enables Its Catalytic and Raft-Association Activities
Hara-Yokoyama, Miki, Kukimoto-Niino, Mutsuko, Terasawa, Kazue, Harumiya, Satoru, Podyma-Inoue, Katarzyna A., Hino, Nobumasa, Sakamoto, Kensaku, Itoh, Satsuki, Hashii, Noritaka, Hiruta, Yoko, Kawasaki, Nana, Mishima-Tsumagari, Chiemi, Kaitsu, Yoko, Matsumoto, Tomoko, Wakiyama, Motoaki, Shirouzu, Mikako, Kasama, Takeshi, Takayanagi, Hiroshi, Utsunomiya-Tate, Naoko, Takatsu, Kiyoshi, Katada, Toshiaki, Hirabayashi, Yoshio, Yokoyama, Shigeyuki, Yanagishita, Masaki
Published in Structure (London) (05.09.2012)
Published in Structure (London) (05.09.2012)
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Preferential recognition of isocitrate dehydrogenase by a rabbit monoclonal antibody (ab124797) against the C-terminal peptide of RANKL
Terasawa, Kazue, Rajapakshe, Anupama R., Podyma-Inoue, Katarzyna A., Mishima-Tsumagari, Chiemi, Yanagishita, Masaki, Hara-Yokoyama, Miki
Published in Journal of immunological methods (01.05.2015)
Published in Journal of immunological methods (01.05.2015)
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Journal Article
Identification of Critical Residues in Gα13 for Stimulation of p115RhoGEF Activity and the Structure of the Gα13-p115RhoGEF Regulator of G Protein Signaling Homology (RH) Domain Complex
Hajicek, Nicole, Kukimoto-Niino, Mutsuko, Mishima-Tsumagari, Chiemi, Chow, Christina R., Shirouzu, Mikako, Terada, Takaho, Patel, Maulik, Yokoyama, Shigeyuki, Kozasa, Tohru
Published in The Journal of biological chemistry (10.06.2011)
Published in The Journal of biological chemistry (10.06.2011)
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Journal Article
Structural design of the anti-TNFα therapeutic NANOBODY® compound, ozoralizumab, to support its potent and sustained clinical efficacy
Mima, Masashi, Mishima-Tsumagari, Chiemi, Nakano, Koichiro, Morimoto, Mai, Ogata, Hitoshi, Sakata, Mayumi, Iwaoka, Ryo, Iwata, Katsuya, Hachiuma, Kenji, Iwamoto, Kunihiko, Fujii, Yasuyuki, Kurokawa, Tomofumi
Published in Biochemical and biophysical research communications (19.11.2024)
Published in Biochemical and biophysical research communications (19.11.2024)
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Journal Article
RhoG facilitates a conformational transition in the guanine nucleotide exchange factor complex DOCK5/ELMO1 to an open state
Kukimoto-Niino, Mutsuko, Katsura, Kazushige, Ishizuka-Katsura, Yoshiko, Mishima-Tsumagari, Chiemi, Yonemochi, Mayumi, Inoue, Mio, Nakagawa, Reiko, Kaushik, Rahul, Zhang, Kam Y.J., Shirouzu, Mikako
Published in The Journal of biological chemistry (01.07.2024)
Published in The Journal of biological chemistry (01.07.2024)
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Journal Article
Crystal structure of human acetylcholinesterase in complex with tacrine: Implications for drug discovery
Dileep, K.V., Ihara, Kentaro, Mishima-Tsumagari, Chiemi, Kukimoto-Niino, Mutsuko, Yonemochi, Mayumi, Hanada, Kazuharu, Shirouzu, Mikako, Zhang, Kam Y.J.
Published in International journal of biological macromolecules (15.06.2022)
Published in International journal of biological macromolecules (15.06.2022)
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Journal Article
Discovery of novel indole derivatives as potent and selective inhibitors of proMMP-9 activation
Nishikawa-Shimono, Rie, Kuwabara, Motoi, Fujisaki, Sho, Matsuda, Daisuke, Endo, Mayumi, Kamitani, Masafumi, Futamura, Aya, Nomura, Yusaku, Yamaguchi-Sasaki, Toru, Yabuuchi, Tetsuya, Yamaguchi, Chitose, Tanaka-Yamamoto, Nozomi, Satake, Shunya, Abe-Sato, Kumi, Funayama, Kosuke, Sakata, Mayumi, Takahashi, Shinji, Hirano, Koga, Fukunaga, Takuya, Uozumi, Yoriko, Kato, Sayaka, Tamura, Yunoshin, Nakamori, Tomoaki, Mima, Masashi, Mishima-Tsumagari, Chiemi, Nozawa, Dai, Imai, Yudai, Asami, Taiji
Published in Bioorganic & medicinal chemistry letters (01.01.2024)
Published in Bioorganic & medicinal chemistry letters (01.01.2024)
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Journal Article
Novel bicyclic pyrazoles as potent ALK2 (R206H) inhibitors for the treatment of fibrodysplasia ossificans progressiva
Yamamoto, Hirofumi, Sakai, Naoki, Ohte, Satoshi, Sato, Tomohiro, Sekimata, Katsuhiko, Matsumoto, Takehisa, Nakamura, Kana, Watanabe, Hisami, Mishima-Tsumagari, Chiemi, Tanaka, Akiko, Hashizume, Yoshinobu, Honma, Teruki, Katagiri, Takenobu, Miyazono, Kohei, Tomoda, Hiroshi, Shirouzu, Mikako, Koyama, Hiroo
Published in Bioorganic & medicinal chemistry letters (15.04.2021)
Published in Bioorganic & medicinal chemistry letters (15.04.2021)
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Journal Article
Identification of critical residues in G(alpha)13 for stimulation of p115RhoGEF activity and the structure of the G(alpha)13-p115RhoGEF regulator of G protein signaling homology (RH) domain complex
Hajicek, Nicole, Kukimoto-Niino, Mutsuko, Mishima-Tsumagari, Chiemi, Chow, Christina R, Shirouzu, Mikako, Terada, Takaho, Patel, Maulik, Yokoyama, Shigeyuki, Kozasa, Tohru
Published in The Journal of biological chemistry (10.06.2011)
Published in The Journal of biological chemistry (10.06.2011)
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