Origin of rebound virus in chronically SIV-infected Rhesus monkeys following treatment discontinuation
Liu, Po-Ting, Keele, Brandon F., Abbink, Peter, Mercado, Noe B., Liu, Jinyan, Bondzie, Esther A., Chandrashekar, Abishek, Borducchi, Erica N., Hesselgesser, Joseph, Mish, Michael, Chin, Gregory, Bekerman, Elena, Geleziunas, Romas, Barouch, Dan H.
Published in Nature communications (27.10.2020)
Published in Nature communications (27.10.2020)
Get full text
Journal Article
Preparation and biological evaluation of 1′-cyano-2′-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors
Mish, Michael R., Cho, Aesop, Kirschberg, Thorsten, Xu, Jie, Sebastian Zonte, C., Fenaux, Martijn, Park, Yeojin, Babusis, Darius, Feng, Joy Y., Ray, Adrian S., Kim, Choung U.
Published in Bioorganic & medicinal chemistry letters (15.07.2014)
Published in Bioorganic & medicinal chemistry letters (15.07.2014)
Get full text
Journal Article
Discovery of a 2′-fluoro-2′-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties
Kirschberg, Thorsten A., Metobo, Sammy, Clarke, Michael O., Aktoudianakis, Vangelis, Babusis, Darius, Barauskas, Ona, Birkus, Gabriel, Butler, Thomas, Byun, Daniel, Chin, Gregory, Doerffler, Edward, Edwards, Thomas E., Fenaux, Martijn, Lee, Rick, Lew, Willard, Mish, Michael R., Murakami, Eisuke, Park, Yeojin, Squires, Neil H., Tirunagari, Neeraj, Wang, Ting, Whitcomb, Mark, Xu, Jie, Yang, Huiling, Ye, Hong, Zhang, Lijun, Appleby, Todd C., Feng, Joy Y., Ray, Adrian S., Cho, Aesop, Kim, Choung U.
Published in Bioorganic & medicinal chemistry letters (15.04.2017)
Published in Bioorganic & medicinal chemistry letters (15.04.2017)
Get full text
Journal Article
Synthesis and characterization of 1′-C-cyano-2′-fluoro-2′-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors
Kirschberg, Thorsten A., Mish, Michael R., Zhang, Lijun, Squires, Neil H., Wang, Ke-Yu, Cho, Aesop, Feng, Joy Y., Fenaux, Martijn, Babusis, Darius, Park, Yeojin, Ray, Adrian S., Kim, Choung U.
Published in Bioorganic & medicinal chemistry letters (01.03.2015)
Published in Bioorganic & medicinal chemistry letters (01.03.2015)
Get full text
Journal Article
Effect of substitution on novel tricyclic HIV-1 integrase inhibitors
Fardis, Maria, Jin, Haolun, Jabri, Salman, Cai, Ruby Z., Mish, Michael, Tsiang, Manuel, Kim, Choung U.
Published in Bioorganic & medicinal chemistry letters (01.08.2006)
Published in Bioorganic & medicinal chemistry letters (01.08.2006)
Get full text
Journal Article
Toll‐Like Receptor 8 Agonist GS‐9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B
Daffis, Stephane, Balsitis, Scott, Chamberlain, Jason, Zheng, Jim, Santos, Rex, Rowe, William, Ramakrishnan, Dhivya, Pattabiraman, Divya, Spurlock, Sandra, Chu, Ruth, Kang, Don, Mish, Michael, Ramirez, Ricardo, Li, Li, Li, Bei, Ma, Sarina, Hung, Magdeleine, Voitenleitner, Christian, Yon, Changsuek, Suresh, Manasa, Menne, Stephan, Cote, Paul, Delaney, William E., Mackman, Richard, Fletcher, Simon P.
Published in Hepatology (Baltimore, Md.) (01.01.2021)
Published in Hepatology (Baltimore, Md.) (01.01.2021)
Get full text
Journal Article
Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B
Mackman, Richard L, Mish, Michael, Chin, Gregory, Perry, Jason K, Appleby, Todd, Aktoudianakis, Vangelis, Metobo, Sammy, Pyun, Peter, Niu, Congrong, Daffis, Stephane, Yu, Helen, Zheng, Jim, Villasenor, Armando G, Zablocki, Jeff, Chamberlain, Jason, Jin, Haolun, Lee, Gary, Suekawa-Pirrone, Kimberley, Santos, Rex, Delaney, William E, Fletcher, Simon P
Published in Journal of medicinal chemistry (24.09.2020)
Published in Journal of medicinal chemistry (24.09.2020)
Get full text
Journal Article
Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle
Mackman, Richard L, Steadman, Victoria A, Dean, David K, Jansa, Petr, Poullennec, Karine G, Appleby, Todd, Austin, Carol, Blakemore, Caroline A, Cai, Ruby, Cannizzaro, Carina, Chin, Gregory, Chiva, Jean-Yves C, Dunbar, Neil A, Fliri, Hans, Highton, Adrian J, Hui, Hon, Ji, Mingzhe, Jin, Haolun, Karki, Kapil, Keats, Andrew J, Lazarides, Linos, Lee, Yu-Jen, Liclican, Albert, Mish, Michael, Murray, Bernard, Pettit, Simon B, Pyun, Peter, Sangi, Michael, Santos, Rex, Sanvoisin, Jonathan, Schmitz, Uli, Schrier, Adam, Siegel, Dustin, Sperandio, David, Stepan, George, Tian, Yang, Watt, Gregory M, Yang, Hai, Schultz, Brian E
Published in Journal of medicinal chemistry (08.11.2018)
Published in Journal of medicinal chemistry (08.11.2018)
Get full text
Journal Article
Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor
Sperandio, David, Aktoudianakis, Vangelis, Babaoglu, Kerim, Chen, Xiaowu, Elbel, Kristyna, Chin, Gregory, Corkey, Britton, Du, Jinfa, Jiang, Bob, Kobayashi, Tetsuya, Mackman, Richard, Martinez, Ruben, Yang, Hai, Zablocki, Jeff, Kusam, Saritha, Jordan, Kim, Webb, Heather, Bates, Jamie G., Lad, Latesh, Mish, Michael, Niedziela-Majka, Anita, Metobo, Sammy, Sapre, Annapurna, Hung, Magdeleine, Jin, Debi, Fung, Wanchi, Kan, Elaine, Eisenberg, Gene, Larson, Nate, Newby, Zachary E.R., Lansdon, Eric, Tay, Chin, Neve, Richard M., Shevick, Sophia L., Breckenridge, David G.
Published in Bioorganic & medicinal chemistry (01.02.2019)
Published in Bioorganic & medicinal chemistry (01.02.2019)
Get full text
Journal Article
Highly Potent HCV NS4B Inhibitors with Activity against Multiple Genotypes
Phillips, Barton, Cai, Ruby, Delaney, William, Du, Zhimin, Ji, Mingzhe, Jin, Haolun, Lee, Johnny, Li, Jiayao, Niedziela-Majka, Anita, Mish, Michael, Pyun, Hyung-Jung, Saugier, Joe, Tirunagari, Neeraj, Wang, Jianhong, Yang, Huiling, Wu, Qiaoyin, Sheng, Chris, Zonte, Catalin
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
Get full text
Journal Article
CD73 화합물
CHIN GREGORY F, GOYAL BINDU, MISH MICHAEL R, ENSAN DEEBA, COSMAN ELLIS JENNIFER L, TAMSHEN KYLE C, HO STEPHEN, MACKMAN RICHARD L, SIEGEL DUSTIN S, CLARKE MICHAEL O, YANG HAI, BARTLETT MARK J
Year of Publication 27.06.2024
Get full text
Year of Publication 27.06.2024
Patent
TOLL LIKE RECEPTOR MODULATOR COMPOUNDS
ZABLOCKI JEFF, CHIN GREGORY, PYUN HYUNG JUNG, METOBO SAMUEL E, MISH MICHAEL R, MACKMAN RICHARD L, AKTOUDIANAKIS EVANGELOS
Year of Publication 14.12.2021
Get full text
Year of Publication 14.12.2021
Patent
항바이러스 화합물
CHIN GREGORY F, GOYAL BINDU, MISH MICHAEL R, JANSA PETR, MACKMAN RICHARD L, SIEGEL DUSTIN S, CLARKE MICHAEL O, BYUN DANIEL H
Year of Publication 24.10.2022
Get full text
Year of Publication 24.10.2022
Patent
PROCESSES FOR PREPARING TOLL-LIKE RECEPTOR MODULATOR COMPOUNDS
MERIT JEFFREY E, WANG XIANGHONG, CHIN GREGORY F, LATHROP STEPHEN P, ZHENG ZEHUA, ASSELIN SYLVIE M, WENDERSKI TODD A, VIEIRA TIAGO, LEW WILLARD, AMBROSI ANDREA, PYUN HYUNG JUNG, BACHRACH FLORENCE J, METOBO SAMUEL E, MISH MICHAEL R, WEINSTEIN ADAM B, BADALOV PAVEL R, MACKMAN RICHARD L, REGENS CHRISTOPHER S, PRITCHETT BEAU P, AKTOUDIANAKIS EVANGELOS
Year of Publication 21.06.2024
Get full text
Year of Publication 21.06.2024
Patent
POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE
DESAI MANOJ C, TREJO MARTIN TERESA ALEJANDRA, BACON ELIZABETH M, COTTELL JEROMY J, CAI ZHENHONG R, TAYLOR JAMES G, LAZERWITH SCOTT E, JI MINGZHE, PYUN HYUNG JUNG, JIN HAOLUN, MISH MICHAEL R, CHEN XIAOWU, MORGANELLI PHILIP ANTHONY
Year of Publication 08.05.2023
Get full text
Year of Publication 08.05.2023
Patent
항바이러스 화합물
CHIN GREGORY F, GOYAL BINDU, SIEGEL DUSTIN S, SPERANDIO DAVID, MISH MICHAEL R, ZHANG LIJUN, HUI HON C, JANSA PETR, MACKMAN RICHARD L, CLARKE MICHAEL O, YANG HAI, CHUN BYOUNG KWON, BYUN DANIEL H
Year of Publication 20.10.2022
Get full text
Year of Publication 20.10.2022
Patent
POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE
DESAI MANOJ C, TREJO MARTIN TERESA ALEJANDRA, BACON ELIZABETH M, COTTELL JEROMY J, CAI ZHENHONG R, TAYLOR JAMES G, LAZERWITH SCOTT E, JI MINGZHE, PYUN HYUNG JUNG, JIN HAOLUN, MISH MICHAEL R, CHEN XIAOWU, MORGANELLI PHILIP ANTHONY
Year of Publication 14.06.2022
Get full text
Year of Publication 14.06.2022
Patent
CD73를 억제하는 2,4-다이옥소피리미딘 화합물
CHIN GREGORY F, GOYAL BINDU, TANG DORIS T, ENSAN DEEBA, SCHROEDER SCOTT D, SIEGEL DUSTIN S, COSMAN JENNIFER L, MISH MICHAEL R, HO STEPHEN, HUI HON C, MACKMAN RICHARD L, CLARKE MICHAEL O, YANG HAI, BARTLETT MARK J, SHAPIRO NATHAN D
Year of Publication 11.01.2023
Get full text
Year of Publication 11.01.2023
Patent