Structure-based design and modular synthesis of novel PI4K class II inhibitors bearing a 4-aminoquinazoline scaffold
Misehe, Mbilo, Klima, Martin, Matousova, Marika, Chalupska, Dominika, Dejmek, Milan, Sala, Michal, Mertlikova-Kaiserova, Helena, Boura, Evzen, Nencka, Radim
Published in Bioorganic & medicinal chemistry letters (15.11.2022)
Published in Bioorganic & medicinal chemistry letters (15.11.2022)
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Journal Article
Design, synthesis and evaluation of novel thieno[2,3d]pyrimidine derivatives as potent and specific RIPK2 inhibitors
Misehe, Mbilo, Šála, Michal, Matoušová, Marika, Hercík, Kamil, Kocek, Hugo, Chalupská, Dominika, Chaloupecká, Ema, Hájek, Miroslav, Boura, Evzen, Mertlíková-Kaiserová, Helena, Nencka, Radim
Published in Bioorganic & medicinal chemistry letters (01.01.2024)
Published in Bioorganic & medicinal chemistry letters (01.01.2024)
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Journal Article
Exploring positions 6 and 7 of a quinazoline-based scaffold leads to changes in selectivity and potency towards RIPK2/3 kinases
Misehe, Mbilo, Matoušová, Marika, Dvořáková, Alexandra, Hercík, Kamil, Škach, Kryštof, Chalupská, Dominika, Dejmek, Milan, Šála, Michal, Hájek, Miroslav, Boura, Evzen, Mertlíková-Kaiserová, Helena, Nencka, Radim
Published in European journal of medicinal chemistry (15.11.2023)
Published in European journal of medicinal chemistry (15.11.2023)
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Journal Article