Chaste: an open source C++ library for computational physiology and biology
Mirams, Gary R, Arthurs, Christopher J, Bernabeu, Miguel O, Bordas, Rafel, Cooper, Jonathan, Corrias, Alberto, Davit, Yohan, Dunn, Sara-Jane, Fletcher, Alexander G, Harvey, Daniel G, Marsh, Megan E, Osborne, James M, Pathmanathan, Pras, Pitt-Francis, Joe, Southern, James, Zemzemi, Nejib, Gavaghan, David J
Published in PLoS computational biology (14.03.2013)
Published in PLoS computational biology (14.03.2013)
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Journal Article
Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative
Li, Zhihua, Ridder, Bradley J., Han, Xiaomei, Wu, Wendy W., Sheng, Jiansong, Tran, Phu N., Wu, Min, Randolph, Aaron, Johnstone, Ross H., Mirams, Gary R., Kuryshev, Yuri, Kramer, James, Wu, Caiyun, Crumb, William J., Strauss, David G.
Published in Clinical pharmacology and therapeutics (01.02.2019)
Published in Clinical pharmacology and therapeutics (01.02.2019)
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Journal Article
Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If : Novel electrophysiological insights and therapeutic potential
Capel, Rebecca A., DPhil, Herring, Neil, DPhil, MRCP, Kalla, Manish, BSc (Hons), MBBS MRCP, Yavari, Arash, BSc (Hons), MBBS, MRCP, DPhil, Mirams, Gary R., PhD, Douglas, Gillian, PhD, Bub, Gil, PhD, Channon, Keith, MD, FRCP, FMedSci, Paterson, David J., DPhil, DSc, Terrar, Derek A., PhD, Burton, Rebecca-Ann B., MSc, MBA, DPhil
Published in Heart rhythm (01.10.2015)
Published in Heart rhythm (01.10.2015)
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Journal Article
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk
Mirams, Gary R., Cui, Yi, Sher, Anna, Fink, Martin, Cooper, Jonathan, Heath, Bronagh M., McMahon, Nick C., Gavaghan, David J., Noble, Denis
Published in Cardiovascular research (01.07.2011)
Published in Cardiovascular research (01.07.2011)
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Journal Article
Application of cardiac electrophysiology simulations to pro‐arrhythmic safety testing
Mirams, Gary R, Davies, Mark R, Cui, Yi, Kohl, Peter, Noble, Denis
Published in British journal of pharmacology (01.11.2012)
Published in British journal of pharmacology (01.11.2012)
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Journal Article
Uncertainty Quantification Reveals the Importance of Data Variability and Experimental Design Considerations for in Silico Proarrhythmia Risk Assessment
Chang, Kelly C, Dutta, Sara, Mirams, Gary R, Beattie, Kylie A, Sheng, Jiansong, Tran, Phu N, Wu, Min, Wu, Wendy W, Colatsky, Thomas, Strauss, David G, Li, Zhihua
Published in Frontiers in physiology (21.11.2017)
Published in Frontiers in physiology (21.11.2017)
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Journal Article
A web portal for in-silico action potential predictions
Williams, Geoff, Mirams, Gary R.
Published in Journal of pharmacological and toxicological methods (01.09.2015)
Published in Journal of pharmacological and toxicological methods (01.09.2015)
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Journal Article
Computational assessment of drug‐induced effects on the electrocardiogram: from ion channel to body surface potentials
Zemzemi, Nejib, Bernabeu, Miguel O, Saiz, Javier, Cooper, Jonathan, Pathmanathan, Pras, Mirams, Gary R, Pitt‐Francis, Joe, Rodriguez, Blanca
Published in British journal of pharmacology (01.02.2013)
Published in British journal of pharmacology (01.02.2013)
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Journal Article
Cardiac tissue slices: preparation, handling, and successful optical mapping
Wang, Ken, Lee, Peter, Mirams, Gary R, Sarathchandra, Padmini, Borg, Thomas K, Gavaghan, David J, Kohl, Peter, Bollensdorff, Christian
Published in American journal of physiology. Heart and circulatory physiology (01.05.2015)
Published in American journal of physiology. Heart and circulatory physiology (01.05.2015)
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Journal Article
Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG
Jonsson, Malin K.B, Vos, Marc A, Mirams, Gary R, Duker, Göran, Sartipy, Peter, de Boer, Teun P, van Veen, Toon A.B
Published in Journal of molecular and cellular cardiology (01.05.2012)
Published in Journal of molecular and cellular cardiology (01.05.2012)
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Journal Article
Connexin43 contributes to electrotonic conduction across scar tissue in the intact heart
Mahoney, Vanessa M., Mezzano, Valeria, Mirams, Gary R., Maass, Karen, Li, Zhen, Cerrone, Marina, Vasquez, Carolina, Bapat, Aneesh, Delmar, Mario, Morley, Gregory E.
Published in Scientific reports (31.05.2016)
Published in Scientific reports (31.05.2016)
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Journal Article
Neural network emulation of the human ventricular cardiomyocyte action potential for more efficient computations in pharmacological studies
Grandits, Thomas, Augustin, Christoph M, Haase, Gundolf, Jost, Norbert, Mirams, Gary R, Niederer, Steven A, Plank, Gernot, Varró, András, Virág, László, Jung, Alexander
Published in eLife (10.04.2024)
Published in eLife (10.04.2024)
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Journal Article
Prediction of Thorough QT study results using action potential simulations based on ion channel screens
Mirams, Gary R., Davies, Mark R., Brough, Stephen J., Bridgland-Taylor, Matthew H., Cui, Yi, Gavaghan, David J., Abi-Gerges, Najah
Published in Journal of pharmacological and toxicological methods (01.11.2014)
Published in Journal of pharmacological and toxicological methods (01.11.2014)
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Journal Article