Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade
Wang, Ziming, Aguilar, Ethan G, Luna, Jesus I, Dunai, Cordelia, Khuat, Lam T, Le, Catherine T, Mirsoian, Annie, Minnar, Christine M, Stoffel, Kevin M, Sturgill, Ian R, Grossenbacher, Steven K, Withers, Sita S, Rebhun, Robert B, Hartigan-O'Connor, Dennis J, Méndez-Lagares, Gema, Tarantal, Alice F, Isseroff, R Rivkah, Griffith, Thomas S, Schalper, Kurt A, Merleev, Alexander, Saha, Asim, Maverakis, Emanual, Kelly, Karen, Aljumaily, Raid, Ibrahimi, Sami, Mukherjee, Sarbajit, Machiorlatti, Michael, Vesely, Sara K, Longo, Dan L, Blazar, Bruce R, Canter, Robert J, Murphy, William J, Monjazeb, Arta M
Published in Nature medicine (01.01.2019)
Published in Nature medicine (01.01.2019)
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Journal Article
Tumour-targeted interleukin-12 and entinostat combination therapy improves cancer survival by reprogramming the tumour immune cell landscape
Hicks, Kristin C, Chariou, Paul L, Ozawa, Yohei, Minnar, Christine M, Knudson, Karin M, Meyer, Thomas J, Bian, Jing, Cam, Margaret, Schlom, Jeffrey, Gameiro, Sofia R
Published in Nature communications (26.08.2021)
Published in Nature communications (26.08.2021)
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Journal Article
Generation of murine tumor models refractory to αPD-1/-L1 therapies due to defects in antigen processing/presentation or IFNγ signaling using CRISPR/Cas9
Chariou, Paul L, Minnar, Christine M, Tandon, Mayank, Guest, Mary R, Chari, Raj, Schlom, Jeffrey, Gameiro, Sofia R
Published in PloS one (01.03.2024)
Published in PloS one (01.03.2024)
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Journal Article
Preclinical and clinical studies of a tumor targeting IL-12 immunocytokine
Minnar, Christine M, Lui, Grace, Gulley, James L, Schlom, Jeffrey, Gameiro, Sofia R
Published in Frontiers in oncology (08.01.2024)
Published in Frontiers in oncology (08.01.2024)
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Journal Article
Tumor-targeted interleukin-12 synergizes with entinostat to overcome PD-1/PD-L1 blockade-resistant tumors harboring MHC-I and APM deficiencies
Minnar, Christine M, Chariou, Paul L, Horn, Lucas A, Hicks, Kristin C, Palena, Claudia, Schlom, Jeffrey, Gameiro, Sofia R
Published in Journal for immunotherapy of cancer (01.06.2022)
Published in Journal for immunotherapy of cancer (01.06.2022)
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Journal Article
Analysis of the tumor microenvironment and anti-tumor efficacy of subcutaneous vs systemic delivery of the bifunctional agent bintrafusp alfa
Ozawa, Yohei, Hicks, Kristin C., Minnar, Christine M., Knudson, Karin M., Schlom, Jeffrey, Gameiro, Sofia R.
Published in Oncoimmunology (01.01.2021)
Published in Oncoimmunology (01.01.2021)
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Journal Article
Differential phenotypes of memory CD4 and CD8 T cells in the spleen and peripheral tissues following immunostimulatory therapy
Sckisel, Gail D, Mirsoian, Annie, Minnar, Christine M, Crittenden, Marka, Curti, Brendan, Chen, Jane Q, Blazar, Bruce R, Borowsky, Alexander D, Monjazeb, Arta M, Murphy, William J
Published in Journal for immunotherapy of cancer (18.04.2017)
Published in Journal for immunotherapy of cancer (18.04.2017)
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Journal Article
605 NHS-IL12 plus Entinostat combination effectively targets anti-PD-1/PD-L1 checkpoint resistant murine tumors harboring MHC Class I and antigen processing machinery deficiency
Minnar, Christine, Chariou, Paul, Hicks, Kristin, Schlom, Jeffrey, Gameiro, Sofia
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Journal Article
Mouse Preclinical Cancer Immunotherapy Modeling Involving Anti-PD-1 Therapies Reveals the Need to Use Mouse Reagents to Mirror Clinical Paradigms
Monjazeb, Arta M, Wang, Ziming, Vick, Logan V, Dunai, Cordelia, Minnar, Christine, Khuat, Lam T, Murphy, William J
Published in Cancers (10.02.2021)
Published in Cancers (10.02.2021)
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Journal Article
Systemic immunostimulation induces glucocorticoid-mediated thymic involution succeeded by rebound hyperplasia which is impaired in aged recipients
Collins, Craig P., Khuat, Lam T., Sckisel, Gail D., Vick, Logan V., Minnar, Christine M., Dunai, Cordelia, Le, Catherine T., Curti, Brendan D., Crittenden, Marka, Merleev, Alexander, Sheng, Michael, Chao, Nelson J., Maverakis, Emanual, Rosario, Spencer R., Monjazeb, Arta M., Blazar, Bruce R., Longo, Dan L., Canter, Robert J., Murphy, William J.
Published in Frontiers in immunology (09.09.2024)
Published in Frontiers in immunology (09.09.2024)
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Journal Article
Generation of murine tumor models refractory to [alpha]PD-1/-L1 therapies due to defects in antigen processing/presentation or IFN[gamma] signaling using CRISPR/Cas9
Chariou, Paul L, Minnar, Christine M, Tandon, Mayank, Guest, Mary R, Chari, Raj, Schlom, Jeffrey, Gameiro, Sofia R
Published in PloS one (01.03.2024)
Published in PloS one (01.03.2024)
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Journal Article
Systemic Cancer Immunostimulatory Therapies and Acute Viral Infection Induce Corticosteroid-Mediated Thymic Involution and Naïve T cell Output in Mice and Humans
Yoon, Daniel J, Khuat, Lam Tan, Collins, Craig, Vick, Logan, Sckisel, Gail, Minnar, Christine Mall, Dunai, Cordelia, Curti, Brendan, Chao, Nelson J, Blazar, Bruce, Longo, Dan L, Canter, Robert, Monjazeb, Arta, Murphy, William J
Published in The Journal of immunology (1950) (01.05.2023)
Published in The Journal of immunology (1950) (01.05.2023)
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Journal Article
Abstract 4065: Entinostat synergizes with the IL-15 superagonist N-803 and anti-PD-1 to engage cDC1 and stem-like TCF-1+ CD8+ T and NK cells to overcome colorectal tumors refractory to anti-PD-1 therapy
Minnar, Christine M., Miyamoto, Masaya, Khelifa, Asma S., Lui, Grace, Lothstein, Katherine L., Chariou, Paul L., Meyer, Thomas J., Lobanov, Alexei, Cam, Margaret, Schlom, Jeffrey, Gameiro, Sofia R.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Systemic Stimulatory Cancer Immunotherapy Induces Corticosterone-mediated Thymic Involution
Minnar, Christine Mall, Sckisel, Gail D., Beerthuijzen, Johanna M.T., Aguilar, Ethan G., Mirsoian, Annie, Crittenden, Marka, Blazar, Bruce R., Monjazeb, Arta M., Murphy, William J.
Published in The Journal of immunology (1950) (01.05.2017)
Published in The Journal of immunology (1950) (01.05.2017)
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Journal Article
Abstract 1425: Epigenetic modulation synergizes with a novel TCR β chain directed antibody-fusion molecule to suppress checkpoint-refractory tumors irrespective of MHC I status
Lothstein, Katherine E., Khelifa, Asma S., Miyamoto, Masaya, Minnar, Christine M., Poppe, Lisa, Roller, Nicholas, Bayliffe, Andrew, Liu, Ke, Moisan, Jacques, Katragadda, Madan, Su, Zhen, Schlom, Jeffrey, Gameiro, Sofia R.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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