A Practical Use of Ligand Efficiency Indices Out of the Fragment-Based Approach: Ligand Efficiency-Guided Lead Identification of Soluble Epoxide Hydrolase Inhibitors
Tanaka, Daisuke, Tsuda, Yusuke, Shiyama, Takaaki, Nishimura, Tamiki, Chiyo, Naoki, Tominaga, Yukio, Sawada, Nobuyuki, Mimoto, Tsutomu, Kusunose, Naoto
Published in Journal of medicinal chemistry (10.02.2011)
Published in Journal of medicinal chemistry (10.02.2011)
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Journal Article
Structure–activity relationships of novel HIV-1 protease inhibitors containing the 3-amino-2-chlorobenzoyl-allophenylnorstatine structure
Mimoto, Tsutomu, Nojima, Satoshi, Terashima, Keisuke, Takaku, Haruo, Shintani, Makoto, Hayashi, Hideya
Published in Bioorganic & medicinal chemistry (01.02.2008)
Published in Bioorganic & medicinal chemistry (01.02.2008)
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Journal Article
JE-2147: A Dipeptide Protease Inhibitor (PI) That Potently Inhibits Multi-PI-Resistant HIV-1
Yoshimura, Kazuhisa, Kato, Ryohei, Yusa, Keisuke, Kavlick, Mark F., Maroun, Victor, Nguyen, Aline, Mimoto, Tsutomu, Ueno, Takamasa, Shintani, Makoto, Falloon, Judith, Masur, Henry, Hayashi, Hideya, Erickson, John, Mitsuya, Hiroaki
Published in Proceedings of the National Academy of Sciences - PNAS (20.07.1999)
Published in Proceedings of the National Academy of Sciences - PNAS (20.07.1999)
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Journal Article
Structure−Activity Relationship of Small-Sized HIV Protease Inhibitors Containing Allophenylnorstatine
Mimoto, Tsutomu, Kato, Ryohei, Takaku, Haruo, Nojima, Satoshi, Terashima, Keisuke, Misawa, Satoru, Fukazawa, Tominaga, Ueno, Takamasa, Sato, Hideharu, Shintani, Makoto, Kiso, Yoshiaki, Hayashi, Hideya
Published in Journal of medicinal chemistry (20.05.1999)
Published in Journal of medicinal chemistry (20.05.1999)
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Journal Article
Structure–activity and structure–metabolism relationships of HIV protease inhibitors containing the 3-hydroxy-2-methylbenzoyl-allophenylnorstatine structure
Mimoto, Tsutomu, Terashima, Keisuke, Nojima, Satoshi, Takaku, Haruo, Nakayama, Mitsunobu, Shintani, Makoto, Yamaoka, Takashi, Hayashi, Hideya
Published in Bioorganic & medicinal chemistry (02.01.2004)
Published in Bioorganic & medicinal chemistry (02.01.2004)
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Journal Article
Structure-Activity Relationship of Orally Potent Tripeptide-Based HIV Protease Inhibitors Containing Hydroxymethylcarbonyl Isostere
MIMOTO, Tsutomu, HATTORI, Naoko, TAKAKU, Haruo, KISANUKI, Sumitsugu, FUKAZAWA, Tominaga, TERASHIMA, Keisuke, KATO, Ryohei, NOJIMA, Satoshi, MISAWA, Satoru, UENO, Takamasa, IMAI, Junya, ENOMOTO, Hiroshi, TANAKA, Shigeki, SAKIKAWA, Hiroshi, SHINTANI, Makoto, HAYASHI, Hideya, KISO, Yoshiaki
Published in Chemical & pharmaceutical bulletin (01.09.2000)
Published in Chemical & pharmaceutical bulletin (01.09.2000)
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Journal Article
KNI-577, a Potent Small-Sized HIV Protease Inhibitor Based on the Dipeptide Containing the Hydroxymethylcarbonyl Isostere as an Ideal Transition-State Mimic
Kiso, Yoshiaki, Yamaguchi, Satoshi, Matsumoto, Hikaru, Mimoto, Tsutomu, Kato, Ryohei, Nojima, Satoshi, Takaku, Haruo, Fukazawa, Tominaga, Kimura, Tooru, Akaji, Kenichi
Published in Archiv der Pharmazie (Weinheim) (01.03.1998)
Published in Archiv der Pharmazie (Weinheim) (01.03.1998)
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Journal Article
KNI-102, A NOVEL TRIPEPTIDE HIV PROTEASE INHIBITOR CONTAINING ALLOPHENYLNORSTATINE AS A TRANSITION-STATE MIMIC
MIMOTO, Tsutomu, IMAI, Junya, TANAKA, Shigeki, HATTORI, Naoko, KISANUKI, Sumitsugu, AKAJI, Kenichi, KISO, Yoshiaki
Published in Chemical & pharmaceutical bulletin (1991)
Published in Chemical & pharmaceutical bulletin (1991)
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Journal Article
RATIONAL DESIGN AND SYNTHESIS OF A NOVEL CLASS OF ACTIVE SITE-TARGETED HIV PROTEASE INHIBITORS CONTAINING A HYDROXYMETHYLCARBONYL ISOSTERE. USE OF PHENYLNORSTATINE OR ALLOPHENYLNORSTATINE AS A TRANSITION-STATE MIMIC
MIMOTO, Tsutomu, IMAI, Junya, TANAKA, Shigeki, HATTORI, Naoko, TAKAHASHI, Osamu, KISANUKI, Sumitsugu, NAGANO, Yuichi, SHINTANI, Makoto, HAYASHI, Hideya, SAKIKAWA, Hiroshi, AKAJI, Kenichi, KISO, Yoshiaki
Published in Chemical & pharmaceutical bulletin (1991)
Published in Chemical & pharmaceutical bulletin (1991)
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Journal Article
Kynostatin (KNI-227 and -272, highly potent anti-HIV agents: conformationally constrained tripeptide inhibitors of HIV protease containing allophenylnorstatine
MIMOTO, Tsutomu, IMAI, Junya, KISANUKI, Sumitsugu, ENOMOTO, Hiroshi, HATTORI, Naoko, AKAJI, Kenichi, KISO, Yoshiaki
Published in Chemical & pharmaceutical bulletin (1992)
Published in Chemical & pharmaceutical bulletin (1992)
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Journal Article
Synthesis of di- and tripeptide analogues containing α-ketoamide as a new core structure for inhibition of HIV-1 protease
Sheha, Mahmoud M, Mahfouz, Nadia M, Hassan, Hoda Y, Youssef, Adel F, Mimoto, Tsutomu, Kiso, Yoshiaki
Published in European journal of medicinal chemistry (01.10.2000)
Published in European journal of medicinal chemistry (01.10.2000)
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Journal Article
Structure of HIV-1 protease with KNI-272, a tight-binding transition-state analog containing allophenylnorstatine
Baldwin, Eric T, Bhat, T.Narayana, Gulnik, Sergei, Liu, Beishan, Topol, Igor A, Kiso, Yoshiaki, Mimoto, Tsutomu, Mitsuya, Hiroaki, Erickson, John W
Published in Structure (London) (15.06.1995)
Published in Structure (London) (15.06.1995)
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Journal Article
Existence of β-methylnorleucine in recombinant hirudin produced by Escherichia coli
Muramatsu, Ryo, Negishi, Toru, Mimoto, Tsutomu, Miura, Akira, Misawa, Satoru, Hayashi, Hideya
Published in Journal of biotechnology (14.02.2002)
Published in Journal of biotechnology (14.02.2002)
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Journal Article
NOVEL CYCLIC TETRAPEPTIDE DERIVATIVES AND MEDICINAL USE THEREOF
HORINOUCHI, SUEHARU, MIMOTO, TSUTOMU, YOSHIDA, MINORU, KOMATSU, YASUHIKO, NISHINO, NORIKAZU
Year of Publication 11.03.1999
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Year of Publication 11.03.1999
Patent
NOVEL TRIPEPTIDE COMPOUNDS AND ANTI-AIDS DRUGS
TERASHIMA, KEISUKE, TAKAKU, HARUO, MIMOTO, TSUTOMU, NOJIMA, SATOSHI, KISO, YOSHIAKI
Year of Publication 09.07.1998
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Year of Publication 09.07.1998
Patent
KYNOSTATIN (KNI)-227 AND -272, HIGHLY POTENT ANTI-HIV AGENTS : CONFORMATIONALLY CONSTRAINED TRIPEPTIDE INHIBITORS OF HIV PROTEASE CONTAINING ALLOPHENYLNORSTATINE
MIMOTO, Tsutomu, IMAI, Junya, KISANUKI, Sumitsugu, ENOMOTO, Hiroshi, HATTORI, Naoko, AKAJI, Kenichi, KISO, Yoshiaki
Published in Chemical & pharmaceutical bulletin (01.08.1992)
Published in Chemical & pharmaceutical bulletin (01.08.1992)
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Journal Article
NOVEL DIPEPTIDE COMPOUND AND MEDICINAL USE THEREOF
NOJIMA, SHUN, TERASHIMA, KEISUKE, SHINTANI, MAKOTO, TAKAKU, HARUO, MATSUMOTO, SHINJI, MIMOTO, TSUTOMU
Year of Publication 05.07.2001
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Year of Publication 05.07.2001
Patent