Soluble Guanylate Cyclase Stimulators and Activators
Sandner, Peter, Zimmer, Daniel P., Milne, G. Todd, Follmann, Markus, Hobbs, Adrian, Stasch, Johannes-Peter
Published in Handbook of experimental pharmacology (2021)
Published in Handbook of experimental pharmacology (2021)
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Journal Article
An exploratory, randomised, placebo-controlled, 14 day trial of the soluble guanylate cyclase stimulator praliciguat in participants with type 2 diabetes and hypertension
Hanrahan, John P., Seferovic, Jelena P., Wakefield, James D., Wilson, Phebe J., Chickering, Jennifer G., Jung, Joon, Carlson, Kenneth E., Zimmer, Daniel P., Frelinger, Andrew L., Michelson, Alan D., Morrow, Linda, Hall, Michael, Currie, Mark G., Milne, G. Todd, Profy, Albert T.
Published in Diabetologia (01.04.2020)
Published in Diabetologia (01.04.2020)
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Journal Article
Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease
Zimmer, Daniel P, Shea, Courtney M, Tobin, Jenny V, Tchernychev, Boris, Germano, Peter, Sykes, Kristie, Banijamali, Ali R, Jacobson, Sarah, Bernier, Sylvie G, Sarno, Renee, Carvalho, Andrew, Chien, Yueh-Tyng, Graul, Regina, Buys, Emmanuel S, Jones, Juli E, Wakefield, James D, Price, Gavrielle M, Chickering, Jennifer G, Milne, G Todd, Currie, Mark G, Masferrer, Jaime L
Published in Frontiers in pharmacology (08.04.2020)
Published in Frontiers in pharmacology (08.04.2020)
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Journal Article
Identification of the Proteins Required for Biosynthesis of Diphthamide, the Target of Bacterial ADP-Ribosylating Toxins on Translation Elongation Factor 2
Liu, Shihui, Milne, G. Todd, Kuremsky, Jeffrey G., Fink, Gerald R., Leppla, Stephen H.
Published in Molecular and Cellular Biology (01.11.2004)
Published in Molecular and Cellular Biology (01.11.2004)
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Journal Article
Inhibition of Filamentation Can Be Used To Treat Disseminated Candidiasis
SAVILLE, Stephen P, LAZZELL, Anna L, BRYANT, Alexander P, FRETZEN, Angelika, MONREAL, Alex, SOLBERG, Erik O, MONTEAGUDO, Carlos, LOPEZ-RIBOT, Jose L, MILNE, G. Todd
Published in Antimicrobial Agents and Chemotherapy (01.10.2006)
Published in Antimicrobial Agents and Chemotherapy (01.10.2006)
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Journal Article
Fatty acid amide hydrolase (FAAH) inhibitors exert pharmacological effects, but lack antinociceptive efficacy in rats with neuropathic spinal cord injury pain
Hama, Aldric T, Germano, Peter, Varghese, Matthew S, Cravatt, Benjamin F, Milne, G Todd, Pearson, James P, Sagen, Jacqueline
Published in PloS one (02.05.2014)
Published in PloS one (02.05.2014)
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Journal Article
Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical‐stage soluble guanylate cyclase stimulator in rats
Banijamali, Ali R., Carvalho, Andrew E., Wakefield, James D., Germano, Peter, Barden, Timothy C., Tobin, Jenny V., Zimmer, Daniel P., Masferrer, Jaime L., Profy, Albert T., Currie, Mark G., Todd Milne, G.
Published in Pharmacology research & perspectives (01.04.2020)
Published in Pharmacology research & perspectives (01.04.2020)
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Journal Article
Fatty acid amide hydrolase (FAAH) inhibition reduces L-3,4-dihydroxyphenylalanine-induced hyperactivity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned non-human primate model of Parkinson's disease
Johnston, Tom H, Huot, Philippe, Fox, Susan H, Wakefield, James D, Sykes, Kristine A, Bartolini, Wilmin P, Milne, G Todd, Pearson, James P, Brotchie, Jonathan M
Published in The Journal of pharmacology and experimental therapeutics (01.02.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2011)
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Journal Article
Effects of the Soluble Guanylate Cyclase Stimulator Praliciguat in Diabetic Kidney Disease: A Randomized Placebo-Controlled Clinical Trial
Hanrahan, John P, de Boer, Ian H, Bakris, George L, Wilson, Phebe J, Wakefield, James D, Seferovic, Jelena P, Chickering, Jennifer G, Chien, Yueh-Tyng, Carlson, Kenneth, Cressman, Michael D, Currie, Mark G, Milne, G Todd, Profy, Albert T
Published in Clinical journal of the American Society of Nephrology (2021)
Published in Clinical journal of the American Society of Nephrology (2021)
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Journal Article
Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and Antifibrotic Effects in Preclinical Models of Disease
Tobin, Jenny V, Zimmer, Daniel P, Shea, Courtney, Germano, Peter, Bernier, Sylvie G, Liu, Guang, Long, Kim, Miyashiro, Joy, Ranganath, Sheila, Jacobson, Sarah, Tang, Kim, Im, G-Yoon Jamie, Sheppeck, 2nd, James, Moore, Joel D, Sykes, Kristine, Wakefield, James, Sarno, Renee, Banijamali, Ali R, Profy, Albert T, Milne, G Todd, Currie, Mark G, Masferrer, Jaime L
Published in The Journal of pharmacology and experimental therapeutics (01.06.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2018)
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Journal Article
Stimulation of Erythrocyte Soluble Guanylyl Cyclase Induces cGMP Export and Cardioprotection in Type 2 Diabetes
Jiao, Tong, Collado, Aida, Mahdi, Ali, Tengbom, John, Tratsiakovich, Yahor, Milne, G. Todd, Alvarsson, Michael, Lundberg, Jon O., Zhou, Zhichao, Yang, Jiangning, Pernow, John
Published in JACC. Basic to translational science (01.08.2023)
Published in JACC. Basic to translational science (01.08.2023)
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Journal Article
A Randomized, Placebo‐Controlled, Multiple‐Ascending‐Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Soluble Guanylate Cyclase Stimulator Praliciguat in Healthy Subjects
Hanrahan, John P., Wakefield, James D., Wilson, Phebe J., Mihova, Marina, Chickering, Jennifer G., Ruff, Dennis, Hall, Michael, Milne, G. Todd, Currie, Mark G., Profy, Albert T.
Published in Clinical pharmacology in drug development (01.07.2019)
Published in Clinical pharmacology in drug development (01.07.2019)
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Journal Article
Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae
Milne, G. Todd, Jin, Shengfang, Shannon, Katie B., Weaver, David T.
Published in Molecular and Cellular Biology (01.08.1996)
Published in Molecular and Cellular Biology (01.08.1996)
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Journal Article
1924-P: Praliciguat, a Clinical-Stage sGC Stimulator, Improves Insulin Sensitivity, Lipid Tolerance, and Energy Utilization in a Mouse Diet-Induced Obesity Model Housed at Thermoneutrality
SCHWARTZKOPF, CHAD, HADCOCK, JOHN, ROUX, JULIEN, LIU, GUANG, SHEA, COURTNEY, CURRIE, MARK, MILNE, G. TODD, MASFERRER, JAIME, JONES, JULI E.
Published in Diabetes (New York, N.Y.) (01.06.2019)
Published in Diabetes (New York, N.Y.) (01.06.2019)
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Journal Article
Mo1504 - The Soluble Guanylate Cyclase Stimulator IW-1701 Enhances Nitric Oxide-Mediated Relaxation of Human Lower Esophageal Sphincter ex vivo
Zimmer, Daniel P., Silva, Ines A., Chien, Yueh-tyng, Milne, G. Todd, Currie, Mark
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
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Journal Article
Fourteen-Day Study of Praliciguat, a Soluble Guanylate Cyclase Stimulator, in Patients with Diabetes and Hypertension
HANRAHAN, JOHN P., WAKEFIELD, JAMES D., WILSON, PHEBE J., MILLER, PAUL, CHICKERING, JENNIFER, MORROW, LINDA, HALL, MICHAEL L., CURRIE, MARK, MILNE, G. TODD, PROFY, ALBERT T.
Published in Diabetes (New York, N.Y.) (01.07.2018)
Published in Diabetes (New York, N.Y.) (01.07.2018)
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Journal Article
The Soluble Guanylate Cyclase Stimulator IW-1701 Enhances Nitric Oxide-Mediated Relaxation of Human Lower Esophageal Sphincter ex vivo
Zimmer, Daniel P, Silva, Ines A, Chien, Yueh-tyng, Milne, G. Todd, Currie, Mark
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
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Journal Article
The Clinical-Stage sGC Stimulator IW-1701 Prevents Increase of Plasma Biomarkers of Intravascular Inflammation and Suppresses Leukocyte-Endothelial Interactions in Tnfα-Treated Mice
Tchernychev, Boris, Feil, Susanne, Germano, Peter, Warren, William, Lonie, Elisabeth, Feil, Robert, Milne, Todd G, Hadcock, John, Chien, Yueh-Tyng, Currie, Mark G, Graul, Regina Margaret
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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