Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response
Mulderrig, Lee, Garaycoechea, Juan I, Tuong, Zewen K, Millington, Christopher L, Dingler, Felix A, Ferdinand, John R, Gaul, Liam, Tadross, John A, Arends, Mark J, O'Rahilly, Stephen, Crossan, Gerry P, Clatworthy, Menna R, Patel, Ketan J
Published in Nature (London) (02.12.2021)
Published in Nature (London) (02.12.2021)
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Journal Article
Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans
Dingler, Felix A., Wang, Meng, Mu, Anfeng, Millington, Christopher L., Oberbeck, Nina, Watcham, Sam, Pontel, Lucas B., Kamimae-Lanning, Ashley N., Langevin, Frederic, Nadler, Camille, Cordell, Rebecca L., Monks, Paul S., Yu, Rui, Wilson, Nicola K., Hira, Asuka, Yoshida, Kenichi, Mori, Minako, Okamoto, Yusuke, Okuno, Yusuke, Muramatsu, Hideki, Shiraishi, Yuichi, Kobayashi, Masayuki, Moriguchi, Toshinori, Osumi, Tomoo, Kato, Motohiro, Miyano, Satoru, Ito, Etsuro, Kojima, Seiji, Yabe, Hiromasa, Yabe, Miharu, Matsuo, Keitaro, Ogawa, Seishi, Göttgens, Berthold, Hodskinson, Michael R.G., Takata, Minoru, Patel, Ketan J.
Published in Molecular cell (17.12.2020)
Published in Molecular cell (17.12.2020)
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Journal Article
Formaldehyde regulates S -adenosylmethionine biosynthesis and one-carbon metabolism
Pham, Vanha N, Bruemmer, Kevin J, Toh, Joel D W, Ge, Eva J, Tenney, Logan, Ward, Carl C, Dingler, Felix A, Millington, Christopher L, Garcia-Prieto, Carlos A, Pulos-Holmes, Mia C, Ingolia, Nicholas T, Pontel, Lucas B, Esteller, Manel, Patel, Ketan J, Nomura, Daniel K, Chang, Christopher J
Published in Science (American Association for the Advancement of Science) (03.11.2023)
Published in Science (American Association for the Advancement of Science) (03.11.2023)
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Journal Article
Efficient Synthesis of DNA Duplexes Containing Reduced Acetaldehyde Interstrand Cross-Links
Morton, Sally B., Finger, L. David, van der Sluijs, Roxanne, Mulcrone, William D., Hodskinson, Michael, Millington, Christopher L., Vanhinsbergh, Christina, Patel, Ketan J., Dickman, Mark J., Knipscheer, Puck, Grasby, Jane A., Williams, David M.
Published in Journal of the American Chemical Society (18.01.2023)
Published in Journal of the American Chemical Society (18.01.2023)
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Journal Article
Aldehyde-mediated inhibition of asparagine biosynthesis has implications for diabetes and alcoholism
John, Tobias, Saffoon, Nadia, Walsby-Tickle, John, Hester, Svenja S, Dingler, Felix A, Millington, Christopher L, McCullagh, James S. O, Patel, Ketan J, Hopkinson, Richard J, Schofield, Christopher J
Published in Chemical science (Cambridge) (14.02.2024)
Published in Chemical science (Cambridge) (14.02.2024)
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Journal Article
Spatial Memory and Microglia Activation in a Mouse Model of Chronic Neuroinflammation and the Anti-inflammatory Effects of Apigenin
Chesworth, Rose, Gamage, Rashmi, Ullah, Faheem, Sonego, Sandra, Millington, Christopher, Fernandez, Amanda, Liang, Huazheng, Karl, Tim, Münch, Gerald, Niedermayer, Garry, Gyengesi, Erika
Published in Frontiers in neuroscience (30.07.2021)
Published in Frontiers in neuroscience (30.07.2021)
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Journal Article
Chronic Neuroinflammation in Alzheimer’s Disease : New Perspectives on Animal Models and Promising Candidate Drugs
Münch, Gerald, Campbell, Iain L., Aldrich-Wright, Janice R., Gyengesi, Erika, Rangel, Alejandra, Karunaweera, Niloo, Millington, Christopher, Sonego, Sandra
Published in BioMed research international (01.01.2014)
Published in BioMed research international (01.01.2014)
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Journal Article
Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation–π interactions
Wilkinson, Oliver J, Latypov, Vitaly, Tubbs, Julie L, Millington, Christopher L, Morita, Rihito, Blackburn, Hannah, Marriott, Andrew, McGown, Gail, Thorncroft, Mary, Watson, Amanda J, Connolly, Bernard A, Grasby, Jane A, Masui, Ryoji, Hunter, Christopher A, Tainer, John A, Margison, Geoffrey P, Williams, David M
Published in Proceedings of the National Academy of Sciences - PNAS (13.11.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (13.11.2012)
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Journal Article
Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines
Latypov, Vitaly F, Tubbs, Julie L, Watson, Amanda J, Marriott, Andrew S, McGown, Gail, Thorncroft, Mary, Wilkinson, Oliver J, Senthong, Pattama, Butt, Amna, Arvai, Andrew S, Millington, Christopher L, Povey, Andrew C, Williams, David M, Santibanez-Koref, Mauro F, Tainer, John A, Margison, Geoffrey P
Published in Molecular cell (13.07.2012)
Published in Molecular cell (13.07.2012)
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Journal Article
Atl1 Regulates Choice between Global Genome and Transcription-Coupled Repair of O6-Alkylguanines
Latypov, Vitaly F., Tubbs, Julie L., Watson, Amanda J., Marriott, Andrew S., McGown, Gail, Thorncroft, Mary, Wilkinson, Oliver J., Senthong, Pattama, Butt, Amna, Arvai, Andrew S., Millington, Christopher L., Povey, Andrew C., Williams, David M., Santibanez-Koref, Mauro F., Tainer, John A., Margison, Geoffrey P.
Published in Molecular cell (01.07.2012)
Published in Molecular cell (01.07.2012)
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Journal Article
Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing pyrimidine transition mutations
Zhang, Fang, Tsunoda, Masaru, Suzuki, Kaoru, Kikuchi, Yuji, Wilkinson, Oliver, Millington, Christopher L, Margison, Geoffrey P, Williams, David M, Czarina Morishita, Ella, Takénaka, Akio
Published in Nucleic acids research (01.05.2013)
Published in Nucleic acids research (01.05.2013)
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Journal Article
The nitrosated bile acid DNA lesion O6-carboxymethylguanine is a substrate for the human DNA repair protein O6-methylguanine-DNA methyltransferase
Senthong, Pattama, Millington, Christopher L, Wilkinson, Oliver J, Marriott, Andrew S, Watson, Amanda J, Reamtong, Onrapak, Eyers, Claire E, Williams, David M, Margison, Geoffrey P, Povey, Andrew C
Published in Nucleic acids research (01.03.2013)
Published in Nucleic acids research (01.03.2013)
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Journal Article
Insights into the DNA stabilizing contributions of a bicyclic cytosine analogue: crystal structures of DNA duplexes containing 7,8-dihydropyrido [2,3-d]pyrimidin-2-one
Magat Juan, Ella Czarina, Shimizu, Satoru, Ma, Xiao, Kurose, Taizo, Haraguchi, Tsuyoshi, Zhang, Fang, Tsunoda, Masaru, Ohkubo, Akihiro, Sekine, Mitsuo, Shibata, Takayuki, Millington, Christopher L, Williams, David M, Takénaka, Akio
Published in Nucleic acids research (01.10.2010)
Published in Nucleic acids research (01.10.2010)
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Journal Article
Convenient and efficient syntheses of oligodeoxyribonucleotides containing O(6)-(carboxymethyl)guanine and O(6)-(4-oxo-4-(3-pyridyl)butyl)guanine
Millington, Christopher L, Watson, Amanda J, Marriott, Andrew S, Margison, Geoffrey P, Povey, Andrew C, Williams, David M
Published in Nucleosides, nucleotides & nucleic acids (01.04.2012)
Published in Nucleosides, nucleotides & nucleic acids (01.04.2012)
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Journal Article
O 6-Carboxymethylguanine in DNA forms a sequence context-dependent wobble base-pair structure with thymine
Zhang, Fang, Tsunoda, Masaru, Kikuchi, Yuji, Wilkinson, Oliver, Millington, Christopher L., Margison, Geoffrey P., Williams, David M., Takénaka, Akio
Published in Acta crystallographica. Section D, Biological crystallography. (01.06.2014)
Published in Acta crystallographica. Section D, Biological crystallography. (01.06.2014)
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Journal Article
Reducing DNA Damage Associated with Endogenous Genotoxic Stress in Hematopoietic Stem Cells
Singh, Brijendra, Salinas, Carlo Salas, Hossain, Md Akram, Millington, Christopher, Patel, Ketan, Tong, Wei
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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