Potent, Orally Bioavailable Calcitonin Gene-Related Peptide Receptor Antagonists for the Treatment of Migraine: Discovery of N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974)
Paone, Daniel V, Shaw, Anthony W, Nguyen, Diem N, Burgey, Christopher S, Deng, James Z, Kane, Stefanie A, Koblan, Kenneth S, Salvatore, Christopher A, Mosser, Scott D, Johnston, Victor K, Wong, Bradley K, Miller-Stein, Cynthia M, Hershey, James C, Graham, Samuel L, Vacca, Joseph P, Williams, Theresa M
Published in Journal of medicinal chemistry (15.11.2007)
Published in Journal of medicinal chemistry (15.11.2007)
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Hydrophilic interaction chromatography/tandem mass spectrometry for the simultaneous determination of three polar non-structurally related compounds, imipenem, cilastatin and an investigational β-lactamase inhibitor, MK-4698, in biological matrices
Xu, Yang, Xie, Wei, Miller-Stein, Cynthia M., Woolf, Eric J.
Published in Rapid communications in mass spectrometry (30.07.2009)
Published in Rapid communications in mass spectrometry (30.07.2009)
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Elimination of diastereomer interference to determine Telcagepant (MK-0974) in human plasma using on-line turbulent-flow technology and off-line solid-phase extraction coupled with liquid chromatography/tandem mass spectrometry
Xu, Yang, Willson, Kenneth J., Anderson, Melanie D.G., Musson, Donald G., Miller-Stein, Cynthia M., Woolf, Eric J.
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.06.2009)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.06.2009)
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A flexible and high throughput liquid chromatography–tandem mass spectrometric assay for the quantitation of telcagepant in human plasma
Du, Lihong, Miller-Stein, Cynthia M., Valesky, Robert J., Martucci, Ashley N., Woolf, Eric J.
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.05.2009)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.05.2009)
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The Dose Proportionality of Telcagepant after Administration of Single Oral and Intravenous Doses in Healthy Adult Subjects
Han, Tae H., Blanchard, Rebecca L., Palcza, John, Martucci, Ashley, Miller‐Stein, Cynthia M., Gutierrez, Maria, Panebianco, Deborah, Rippley, Ronda K., Lines, Christopher, Murphy, M. Gail
Published in Archives of drug information (01.12.2010)
Published in Archives of drug information (01.12.2010)
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Calcitonin gene-related peptide (CGRP) receptor antagonists: Investigations of a pyridinone template
Nguyen, Diem N., Paone, Daniel V., Shaw, Anthony W., Burgey, Christopher S., Mosser, Scott D., Johnston, Victor, Salvatore, Christopher A., Leonard, Yvonne M., Miller-Stein, Cynthia M., Kane, Stefanie A., Koblan, Kenneth S., Vacca, Joseph P., Graham, Samuel L., Williams, Theresa M.
Published in Bioorganic & medicinal chemistry (15.01.2008)
Published in Bioorganic & medicinal chemistry (15.01.2008)
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Potent 2-[(pyrimidin-4-yl)amine}-1,3-thiazole-5-carbonitrile-based inhibitors of VEGFR-2 (KDR) kinase
Sisko, John T., Tucker, Thomas J., Bilodeau, Mark T., Buser, Carolyn A., Ciecko, Patrice A., Coll, Kathleen E., Fernandes, Christine, Gibbs, Jackson B., Koester, Timothy J., Kohl, Nancy, Lynch, Joseph J., Mao, Xianzhi, McLoughlin, Debra, Miller-Stein, Cynthia M., Rodman, Leonard D., Rickert, Keith W., Sepp-Lorenzino, Laura, Shipman, Jennifer M., Thomas, Kenneth A., Wong, Bradley K., Hartman, George D.
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
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The identification of potent, orally bioavailable tricyclic CGRP receptor antagonists
Bell, Ian M., Bednar, Rodney A., Corcoran, Halea A., Fay, John F., Gallicchio, Steven N., Johnston, Victor K., Hershey, James C., Miller-Stein, Cynthia M., Moore, Eric L., Mosser, Scott D., Roller, Shane A., Salvatore, Christopher A., Theberge, Cory R., Wong, Bradley K., Blair Zartman, C., Kane, Stefanie A., Williams, Theresa M., Graham, Samuel L., Vacca, Joseph P.
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
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Synthesis and Evaluation of Imidazole Acetic Acid Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor as Novel Antithrombotics
Barrow, James C, Nantermet, Philippe G, Stauffer, Shaun R, Ngo, Phung L, Steinbeiser, Melissa A, Mao, Shi-Shan, Carroll, Steven S, Bailey, Carolyn, Colussi, Dennis, Bosserman, Michelle, Burlein, Christine, Cook, Jacquelynn J, Sitko, Gary, Tiller, Philip R, Miller-Stein, Cynthia M, Rose, Mark, McMasters, Daniel R, Vacca, Joseph P, Selnick, Harold G
Published in Journal of medicinal chemistry (04.12.2003)
Published in Journal of medicinal chemistry (04.12.2003)
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