Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR
Garcia-Maldonado, Efren, Huber, Andrew D, Chai, Sergio C, Nithianantham, Stanley, Li, Yongtao, Wu, Jing, Poudel, Shyaron, Miller, Darcie J, Seetharaman, Jayaraman, Chen, Taosheng
Published in Nature communications (14.05.2024)
Published in Nature communications (14.05.2024)
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Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism
Duda, David M., Olszewski, Jennifer L., Schuermann, Jonathan P., Kurinov, Igor, Miller, Darcie J., Nourse, Amanda, Alpi, Arno F., Schulman, Brenda A.
Published in Structure (London) (04.06.2013)
Published in Structure (London) (04.06.2013)
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Structural Conservation of Distinctive N-terminal Acetylation-Dependent Interactions across a Family of Mammalian NEDD8 Ligation Enzymes
Monda, Julie K., Scott, Daniel C., Miller, Darcie J., Lydeard, John, King, David, Harper, J. Wade, Bennett, Eric J., Schulman, Brenda A.
Published in Structure (London) (08.01.2013)
Published in Structure (London) (08.01.2013)
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Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1
Dove, Katja K., Olszewski, Jennifer L., Martino, Luigi, Duda, David M., Wu, Xiaoli S., Miller, Darcie J., Reiter, Katherine H., Rittinger, Katrin, Schulman, Brenda A., Klevit, Rachel E.
Published in Structure (London) (06.06.2017)
Published in Structure (London) (06.06.2017)
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Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3
Kamadurai, Hari B, Qiu, Yu, Deng, Alan, Harrison, Joseph S, Macdonald, Chris, Actis, Marcelo, Rodrigues, Patrick, Miller, Darcie J, Souphron, Judith, Lewis, Steven M, Kurinov, Igor, Fujii, Naoaki, Hammel, Michal, Piper, Robert, Kuhlman, Brian, Schulman, Brenda A
Published in eLife (08.08.2013)
Published in eLife (08.08.2013)
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Crystal Structures of YkuI and Its Complex with Second Messenger Cyclic Di-GMP Suggest Catalytic Mechanism of Phosphodiester Bond Cleavage by EAL Domains
Minasov, George, Padavattan, Sivaraman, Shuvalova, Ludmilla, Brunzelle, Joseph S., Miller, Darcie J., Baslé, Arnaud, Massa, Claudia, Collart, Frank R., Schirmer, Tilman, Anderson, Wayne F.
Published in The Journal of biological chemistry (08.05.2009)
Published in The Journal of biological chemistry (08.05.2009)
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Crystal structure of UBA2(ufd)-Ubc9: insights into E1-E2 interactions in Sumo pathways
Wang, Jing, Taherbhoy, Asad M, Hunt, Harold W, Seyedin, Steven N, Miller, David W, Miller, Darcie J, Huang, Danny T, Schulman, Brenda A
Published in PloS one (30.12.2010)
Published in PloS one (30.12.2010)
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Journal Article
Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein
Lin, Wenwei, Huber, Andrew D, Poudel, Shyaron, Li, Yongtao, Seetharaman, Jayaraman, Miller, Darcie J, Chen, Taosheng
Published in Proceedings of the National Academy of Sciences - PNAS (07.03.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (07.03.2023)
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Journal Article
Mechanism for the activation of the anaplastic lymphoma kinase receptor
Reshetnyak, Andrey V, Rossi, Paolo, Myasnikov, Alexander G, Sowaileh, Munia, Mohanty, Jyotidarsini, Nourse, Amanda, Miller, Darcie J, Lax, Irit, Schlessinger, Joseph, Kalodimos, Charalampos G
Published in Nature (London) (02.12.2021)
Published in Nature (London) (02.12.2021)
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Journal Article
Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand
Huber, Andrew D, Poudel, Shyaron, Li, Yongtao, Lin, Wenwei, Wu, Jing, Miller, Darcie J, Chen, Taosheng
Published in Structure (London) (07.12.2023)
Published in Structure (London) (07.12.2023)
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Journal Article
Structure−Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli
KIM, Pilho, ZHANG, Yong-Mei, SHENOY, Gautham, NGUYEN, Quynh-Anh, BOSHOFF, Helena I., MANJUNATHA, Ujjini H., GOODWIN, Michael B., LONSDALE, John, PRICE, Allen C., MILLER, Darcie J., DUNCAN, Ken, WHITE, Stephen W., ROCK, Charles O., BARRY, Clifton E., DOWD, Cynthia S.
Published in Journal of medicinal chemistry (12.01.2006)
Published in Journal of medicinal chemistry (12.01.2006)
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Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases
Zhuang, Min, Calabrese, Matthew F., Liu, Jiang, Waddell, M. Brett, Nourse, Amanda, Hammel, Michal, Miller, Darcie J., Walden, Helen, Duda, David M., Seyedin, Steven N., Hoggard, Timothy, Harper, J. Wade, White, Kevin P., Schulman, Brenda A.
Published in Molecular cell (09.10.2009)
Published in Molecular cell (09.10.2009)
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The genome of a Bacteroidetes inhabitant of the human gut encodes a structurally distinct enoyl-acyl carrier protein reductase (FabI)
Radka, Christopher D., Frank, Matthew W., Yao, Jiangwei, Seetharaman, Jayaraman, Miller, Darcie J., Rock, Charles O.
Published in The Journal of biological chemistry (29.05.2020)
Published in The Journal of biological chemistry (29.05.2020)
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Journal Article
Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C
Brown, Nicholas G., VanderLinden, Ryan, Watson, Edmond R., Weissmann, Florian, Ordureau, Alban, Wu, Kuen-Phon, Zhang, Wei, Yu, Shanshan, Mercredi, Peter Y., Harrison, Joseph S., Davidson, Iain F., Qiao, Renping, Lu, Ying, Dube, Prakash, Brunner, Michael R., Grace, Christy R.R., Miller, Darcie J., Haselbach, David, Jarvis, Marc A., Yamaguchi, Masaya, Yanishevski, David, Petzold, Georg, Sidhu, Sachdev S., Kuhlman, Brian, Kirschner, Marc W., Harper, J. Wade, Peters, Jan-Michael, Stark, Holger, Schulman, Brenda A.
Published in Cell (02.06.2016)
Published in Cell (02.06.2016)
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Journal Article
A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR
Huber, Andrew D, Poudel, Shyaron, Wu, Jing, Miller, Darcie J, Lin, Wenwei, Yang, Lei, Bwayi, Monicah N, Rimmer, Mary Ashley, Gee, Rebecca R Florke, Seetharaman, Jayaraman, Chai, Sergio C, Chen, Taosheng
Published in Nucleic acids research (28.02.2024)
Published in Nucleic acids research (28.02.2024)
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