Amivantamab (JNJ-61186372), an Fc Enhanced EGFR/cMet Bispecific Antibody, Induces Receptor Downmodulation and Antitumor Activity by Monocyte/Macrophage Trogocytosis
Vijayaraghavan, Smruthi, Lipfert, Lorraine, Chevalier, Kristen, Bushey, Barbara S., Henley, Benjamin, Lenhart, Ryan, Sendecki, Jocelyn, Beqiri, Marilda, Millar, Hillary J., Packman, Kathryn, Lorenzi, Matthew V., Laquerre, Sylvie, Moores, Sheri L.
Published in Molecular cancer therapeutics (01.10.2020)
Published in Molecular cancer therapeutics (01.10.2020)
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Journal Article
Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity
Brehmer, Dirk, Beke, Lijs, Wu, Tongfei, Millar, Hillary J, Moy, Christopher, Sun, Weimei, Mannens, Geert, Pande, Vineet, Boeckx, An, van Heerde, Erika, Nys, Thomas, Gustin, Emmanuel M, Verbist, Bie, Zhou, Longen, Fan, Yue, Bhargava, Vipul, Safabakhsh, Pegah, Vinken, Petra, Verhulst, Tinne, Gilbert, Angelique, Rai, Sumit, Graubert, Timothy A, Pastore, Friederike, Fiore, Danilo, Gu, Junchen, Johnson, Amy, Philippar, Ulrike, Morschhäuser, Barbara, Walker, David, De Lange, Desiree, Keersmaekers, Vikki, Viellevoye, Marcel, Diels, Gaston, Schepens, Wim, Thuring, Jan Willem, Meerpoel, Lieven, Packman, Kathryn, Lorenzi, Matthew V, Laquerre, Sylvie
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
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Journal Article
Extracellular matrix metalloproteinase inducer stimulates tumor angiogenesis by elevating vascular endothelial cell growth factor and matrix metalloproteinases
YI TANG, NAKADA, Marian T, KESAVAN, Prabakaran, MCCABE, Francis, MILLAR, Hillary, RAFFERTY, Patricia, BUGELSKI, Peter, LI YAN
Published in Cancer research (Chicago, Ill.) (15.04.2005)
Published in Cancer research (Chicago, Ill.) (15.04.2005)
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Journal Article
Regulation of Vascular Endothelial Growth Factor Expression by EMMPRIN via the PI3K-Akt Signaling Pathway
Tang, Yi, Nakada, Marian T, Rafferty, Patricia, Laraio, Jenny, McCabe, Francis L, Millar, Hillary, Cunningham, Mark, Snyder, Linda A, Bugelski, Peter, Yan, Li
Published in Molecular cancer research (01.06.2006)
Published in Molecular cancer research (01.06.2006)
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Journal Article
CNTO 859, a humanized anti‐tissue factor monoclonal antibody, is a potent inhibitor of breast cancer metastasis and tumor growth in xenograft models
Ngo, Cam V., Picha, Kristen, McCabe, Francis, Millar, Hillary, Tawadros, Richard, Tam, Susan H., Nakada, Marian T., Anderson, G. Mark
Published in International journal of cancer (15.03.2007)
Published in International journal of cancer (15.03.2007)
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Journal Article
Circulating Human Interleukin-8 as an Indicator of Cancer Progression in a Nude Rat Orthotopic Human Non–Small Cell Lung Carcinoma Model
MILLAR, Hillary J, NEMETH, Jeffrey A, MCCABE, Francis L, PIKOUNIS, Bill, WICKSTROM, Eric
Published in Cancer epidemiology, biomarkers & prevention (01.08.2008)
Published in Cancer epidemiology, biomarkers & prevention (01.08.2008)
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Journal Article
αv Integrin-Targeted Immunoconjugates Regress Established Human Tumors in Xenograft Models
QIMING CHEN, MILLAR, Hillary J, ANDERSON, G. Mark, MCCABE, Francis L, MANNING, Carol D, STEEVES, Rita, LAI, Kate, KELLOGG, Brenda, LUTZ, Robert J, TRIKHA, Mohit, NAKADA, Marian T
Published in Clinical cancer research (15.06.2007)
Published in Clinical cancer research (15.06.2007)
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Journal Article
Abstract 5651: JNJ-61186372, an Fc enhanced EGFR/cMet bispecific antibody, mediates EGFR and cMet downmodulation and therapeutic efficacy preclinically through monocyte / macrophage mediated trogocytosis
Vijayaraghavan, Smruthi, Lipfert, Lorraine, Bushey, Barbara, Chevalier, Kristen, Henley, Benjamin, Lenhart, Ryan, Beqiri, Marilda, Millar, Hillary J., Packman, Kathryn, Lorenzi, Matthew V., Laquerre, Sylvie, Moores, Sheri
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Abstract 950: In vivo efficacy and pharmacodynamic modulation of JNJ-64619178, a selective PRMT5 inhibitor, in human lung and hematologic preclinical models
Millar, Hillary J., Brehmer, Dirk, Verhulst, Tinne, Haddish-Berhane, Nahor, Greway, Tony, Gaffney, Dana, Boeckx, An, Heerde, Erika Van, Nys, Thomas, Portale, Joseph, Philippar, Ulrike, Wu, Tongfei, Laquerre, Sylvie, Packman, Kathryn
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Abstract 3905: Translational efficacy and safety modeling and simulation to support the clinical development of JNJ-64619178, a PRMT5 inhibitor
Guo, Yue, Haddish-Berhane, Nahor, Millar, Hillary J., Verhulst, Tinne, Greway, Tony, Zhou, Junguo, DeZwart, Loeckie, Gaffney, Dana, Portale, Joseph, Brehmer, Dirk, Boeckx, An, Heerde, Erika Van, Ouellet, Daniele
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Abstract 36: The discovery of a novel CD19xCD22 dual-targeting CAR for the development of an IPSC-derived cell therapy
Carton, Jill M., Wheeler, John, Dower, Chris, Campion, Liam, Millar, Hillary J., Beqiri, Marilda, Morse, Barry, Gurung, Buddha, Genovese, Rebecca, DeLuca, Steven, Dominick, Charles, Naso, Michael, Levitsky, Hy
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract 4859: JNJ-64619178, a selective and pseudo-irreversible PRMT5 inhibitor with potent in vitro and in vivo activity, demonstrated in several lung cancer models
Wu, Tongfei, Millar, Hillary, Gaffney, Dana, Beke, Lijs, Mannens, Geert, Vinken, Petra, Sommers, Ivan, Thuring, Jan-Willem, Sun, Weimei, Moy, Christopher, Pande, Vineet, Zhou, Junguo, Haddish-Berhane, Nahor, Salvati, Mark, Laquerre, Sylvie, Lorenzi, Matthew V., Brehmer, Dirk
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Abstract 1916: Discovery of a novel Nectin4 IPSC-derived cell therapy for the treatment of solid tumors
Carton, Jill M., Dower, Chris, Miller, Michael, Wheeler, John, Heron, Sean, Millar, Hillary J., Walker, David, Perry, Daniel J., Lebid, Andriana, Cocka, Luis, Kim, Dae Hwan, Morse, Barry, Gurung, Buddha, Harris, Maisha, Jethon, Annalise, Naso, Michael, Levitsky, Hy
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract 6802: CXCR4 transgene improves in vivo migration and efficacy of engineered iPSC-derived natural killer cells
Millar, Hillary J., Walker, David, Campion, Liam R., Budd, Ciara, Kolluri, Aarti, Sharma, Harsh, Gurung, Buddha, Carton, Jill M., Perry, Daniel J., Alexander, Nicholas, Levitsky, Hyam, Naso, Michael, Morse, Barry A.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Abstract 1492: Development of a CD123xCD3 bispecific antibody to treat acute myeloid leukemia (AML)
Gaudet, Francois, Nemeth, Jennifer F., McDaid, Ronan, Li, Yingzhe, Harman, Benjamin, Millar, Hillary, Teplyakov, Alexey, Wheeler, John, Luo, Jinquan, Tam, Susan, Wu, Sheng-Jiun, Chen, Emily, Babich, Alexander, Elsayed, Yusri, Attar, Ricardo
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Abstract 4199: Inhibition of NF-kB inducing kinase (NIK) selectively abrogates NIK and TRAF3 mutant multiple myeloma tumor growth
Versele, Matthias, Janssen, Lut, Geerts, Tamara, Floren, Wim, Janssens, Boudewijn, Millar, Hillary, Jacoby, Edgar, Gross, Gerhard, Ligny, Yannick, Simonnet, Yvan, Amblard, Nathalie, Querolle, Olivier, Csoka, Imre, Poncelet, Virginie, Tronel, Virginie, Nocquet-Thibault, Sophie, Meerpoel, Lieven, Edwards, James, Salvati, Marc, Balasubramanian, Sriram, Lenox, Laurie, Theuer, Charles, Attar, Ricardo, Stansfield, Ian
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Development of a CD123xCD3 Bispecific Antibody (JNJ-63709178) for the Treatment of Acute Myeloid Leukemia (AML)
Gaudet, François, Nemeth, Jennifer F, McDaid, Ronan, Li, Yingzhe, Harman, Benjamin, Millar, Hillary, Teplyakov, Alexey, Wheeler, John, Luo, Jinquan, Tam, Susan, Wu, Sheng-Jiun, Chen, Emily, Rudnick, Stephen, Chu, Gerald, Hughes, Anna, Luistro, Leopoldo, Chin, Diana, Babich, Alexander, Kalota, Anna, Singh, Indrajeet, Salvati, Mark, Elsayed, Yusri, Attar, Ricardo M.
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Abstract DDT02-04: A novel PRMT5 inhibitor with potent in vitro and in vivo activity in preclinical lung cancer models
Brehmer, Dirk, Wu, Tongfei, Mannens, Geert, Beke, Lijs, Vinken, Petra, Gaffney, Dana, Sun, Weimei, Pande, Vineet, Thuring, Jan-Willem, Millar, Hillary, Poggesi, Italo, Somers, Ivan, Boeckx, An, Parade, Marc, Heerde, Erika van, Nys, Thomas, Yanovich, Carol, Herkert, Barbara, Verhulst, Tinne, Jardin, Marc Du, Meerpoel, Lieven, Moy, Christopher, Diels, Gaston, Viellevoye, Marcel, Schepens, Wim, Poncelet, Alain, Linders, Joannes T., Lawson, Edward C., Edwards, James P., Chetty, Dushen, Laquerre, Sylvie, Lorenzi, Matthew V.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
CNTO 95, a fully human anti αv integrin antibody, inhibits cell signaling, migration, invasion, and spontaneous metastasis of human breast cancer cells
Chen, Qiming, Manning, Carol D., Millar, Hillary, McCabe, Francis L., Ferrante, Catherine, Sharp, Celia, Shahied-Arruda, Lillian, Doshi, Parul, Nakada, Marian T., Anderson, G. Mark
Published in Clinical & experimental metastasis (01.04.2008)
Published in Clinical & experimental metastasis (01.04.2008)
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Abstract C189: CD24 plays an important role on NSCLC cell functions relevant to tumor growth
Macedo, Luciana F., Kaiser, Elizabeth, Jiang, Haiyan, Millar, Hillary, Pietsch, E. Christine, Kaplan, Fred, Wiley, Diana, Snyder, Linda A., Marshall, Debbie
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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