Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors
Pei, Zhonghua, Li, Xiaofeng, Longenecker, Kenton, von Geldern, Thomas W, Wiedeman, Paul E, Lubben, Thomas H, Zinker, Bradley A, Stewart, Kent, Ballaron, Stephen J, Stashko, Michael A, Mika, Amanda K, Beno, David W. A, Long, Michelle, Wells, Heidi, Kempf-Grote, Anita J, Madar, David J, McDermott, Todd S, Bhagavatula, Lakshmi, Fickes, Michael G, Pireh, Daisy, Solomon, Larry R, Lake, Marc R, Edalji, Rohinton, Fry, Elizabeth H, Sham, Hing L, Trevillyan, James M
Published in Journal of medicinal chemistry (15.06.2006)
Published in Journal of medicinal chemistry (15.06.2006)
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Discovery of ((4R,5S)-5-Amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a Highly Potent, Selective, Orally Efficacious, and Safe Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes
Pei, Zhonghua, Li, Xiaofeng, von Geldern, Thomas W, Madar, David J, Longenecker, Kenton, Yong, Hong, Lubben, Thomas H, Stewart, Kent D, Zinker, Bradley A, Backes, Bradley J, Judd, Andrew S, Mulhern, Mathew, Ballaron, Stephen J, Stashko, Michael A, Mika, Amanda K, Beno, David W. A, Reinhart, Glenn A, Fryer, Ryan M, Preusser, Lee C, Kempf-Grote, Anita J, Sham, Hing L, Trevillyan, James M
Published in Journal of medicinal chemistry (02.11.2006)
Published in Journal of medicinal chemistry (02.11.2006)
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Journal Article
Differential effects of n-3 polyunsaturated fatty acids on metabolic control and vascular reactivity in the type 2 diabetic ob/ob mouse
Mustad, Vikkie A., DeMichele, Stephen, Huang, Yung-Sheng, Mika, Amanda, Lubbers, Nathan, Berthiaume, Nathalie, Polakowski, Jim, Zinker, Brad
Published in Metabolism, clinical and experimental (01.10.2006)
Published in Metabolism, clinical and experimental (01.10.2006)
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Journal Article
Hepatic Glucocorticoid Receptor Antagonism Is Sufficient to Reduce Elevated Hepatic Glucose Output and Improve Glucose Control in Animal Models of Type 2 Diabetes
Jacobson, Peer B, von Geldern, Thomas W, Ohman, Lars, Osterland, Marie, Wang, Jiahong, Zinker, Bradley, Wilcox, Denise, Nguyen, Phong T, Mika, Amanda, Fung, Steven, Fey, Thomas, Goos-Nilsson, Annika, Grynfarb, Marlena, Barkhem, Tomas, Marsh, Kennan, Beno, David W A, Nga-Nguyen, Bach, Kym, Philip R, Link, James T, Tu, Noah, Edgerton, Dale S, Cherrington, Alan, Efendic, Suad, Lane, Benjamin C, Opgenorth, Terry J
Published in The Journal of pharmacology and experimental therapeutics (01.07.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2005)
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Discovery of 2-[4-{{2-(2S,5R)-2-Cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic Acid (ABT-279): A Very Potent, Selective, Effective, and Well-Tolerated Inhibitor of Dipeptidyl Peptidase-IV, Useful for the Treatment of Diabetes
Madar, David J, Kopecka, Hana, Pireh, Daisy, Yong, Hong, Pei, Zhonghua, Li, Xiaofeng, Wiedeman, Paul E, Djuric, Stevan W, Von Geldern, Thomas W, Fickes, Michael G, Bhagavatula, Lakshmi, McDermott, Todd, Wittenberger, Steven, Richards, Steven J, Longenecker, Kenton L, Stewart, Kent D, Lubben, Thomas H, Ballaron, Stephen J, Stashko, Michael A, Long, Michelle A, Wells, Heidi, Zinker, Bradley A, Mika, Amanda K, Beno, David W. A, Kempf-Grote, Anita J, Polakowski, James, Segreti, Jason, Reinhart, Glenn A, Fryer, Ryan M, Sham, Hing L, Trevillyan, James M
Published in Journal of medicinal chemistry (19.10.2006)
Published in Journal of medicinal chemistry (19.10.2006)
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Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit
Backes, Bradley J., Longenecker, Kenton, Hamilton, Gregory L., Stewart, Kent, Lai, Chunqiu, Kopecka, Hana, von Geldern, Thomas W., Madar, David J., Pei, Zhonghua, Lubben, Thomas H., Zinker, Bradley A., Tian, Zhenping, Ballaron, Stephen J., Stashko, Michael A., Mika, Amanda K., Beno, David W.A., Kempf-Grote, Anita J., Black-Schaefer, Candace, Sham, Hing L., Trevillyan, James M.
Published in Bioorganic & medicinal chemistry letters (01.04.2007)
Published in Bioorganic & medicinal chemistry letters (01.04.2007)
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Discovery and Structure−Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B
Liu, Gang, Szczepankiewicz, Bruce G, Pei, Zhonghua, Janowick, David A, Xin, Zhili, Hajduk, Philip J, Abad-Zapatero, Cele, Liang, Heng, Hutchins, Charles W, Fesik, Stephen W, Ballaron, Steve J, Stashko, Mike A, Lubben, Tom, Mika, Amanda K, Zinker, Bradley A, Trevillyan, James M, Jirousek, Michael R
Published in Journal of medicinal chemistry (22.05.2003)
Published in Journal of medicinal chemistry (22.05.2003)
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Development of insulin resistance and endothelin-1 levels in the Zucker fatty rat
Berthiaume, Nathalie, Mika, Amanda K, Zinker, Bradley A
Published in Metabolism, clinical and experimental (01.07.2003)
Published in Metabolism, clinical and experimental (01.07.2003)
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Journal Article
Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors
Pei, Zhonghua, Li, Xiaofeng, Longenecker, Kenton, von Geldern, Thomas W, Wiedeman, Paul E, Lubben, Thomas H, Zinker, Bradley A, Stewart, Kent, Ballaron, Stephen J, Stashko, Michael A, Mika, Amanda K, Beno, David W. A, Long, Michelle, Wells, Heidi, Kempf-Grote, Anita J, Madar, David J, McDermott, Todd S, Bhagavatula, Lakshmi, Fickes, Michael G, Pireh, Daisy, Solomon, Larry R, Lake, Marc R, Edalji, Rohinton, Fry, Elizabeth H, Sham, Hing L, Trevillyan, James M
Published in Journal of medicinal chemistry (24.08.2006)
Published in Journal of medicinal chemistry (24.08.2006)
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Expanding Medical Education for Local Health Promoters Among Remote Communities of the Peruvian Amazon: An Exploratory Study of an Innovative Program Model
Ebbs, Daniel, Hirschbaum, Julian H, Mika, Amanda, Matsushita, Starr C, Lewis, Joy H
Published in Advances in medical education and practice (01.01.2020)
Published in Advances in medical education and practice (01.01.2020)
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Liver-selective glucocorticoid receptor antagonism decreases glucose production and increases glucose disposal, ameliorating insulin resistance
Zinker, Bradley, Mika, Amanda, Nguyen, Phong, Wilcox, Denise, Öhman, Lars, von Geldern, Thomas W, Opgenorth, Terry, Jacobson, Peer
Published in Metabolism, clinical and experimental (01.03.2007)
Published in Metabolism, clinical and experimental (01.03.2007)
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