IL-6/IL-6 receptor system and its role in physiological and pathological conditions
MIHARA, Masahiko, HASHIZUME, Misato, YOSHIDA, Hiroto, SUZUKI, Miho, SHIINA, Masashi
Published in Clinical science (1979) (01.02.2012)
Published in Clinical science (1979) (01.02.2012)
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IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis
Serada, Satoshi, Fujimoto, Minoru, Mihara, Masahiko, Koike, Nobuo, Ohsugi, Yoshiyuki, Nomura, Shintaro, Yoshida, Hiroto, Nishikawa, Teppei, Terabe, Fumitaka, Ohkawara, Tomoharu, Takahashi, Tsuyoshi, Ripley, Barry, Kimura, Akihiro, Kishimoto, Tadamitsu, Naka, Tetsuji
Published in Proceedings of the National Academy of Sciences - PNAS (01.07.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (01.07.2008)
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Blockade of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea
Wakabayashi, Kenichiro, Fujioka, Masato, Kanzaki, Sho, Okano, Hirotaka James, Shibata, Shinsuke, Yamashita, Daisuke, Masuda, Masatsugu, Mihara, Masahiko, Ohsugi, Yoshiyuki, Ogawa, Kaoru, Okano, Hideyuki
Published in Neuroscience research (01.04.2010)
Published in Neuroscience research (01.04.2010)
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Anti‐interleukin‐6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen‐induced arthritis model
Tanaka, Keisuke, Hashizume, Misato, Mihara, Masahiko, Yoshida, Hiroto, Suzuki, Miho, Matsumoto, Yoshihiro
Published in Clinical and experimental immunology (01.02.2014)
Published in Clinical and experimental immunology (01.02.2014)
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Clinical efficacy of risk-stratified prophylaxis with low-dose aspirin for the management of symptomatic venous thromboembolism after total hip arthroplasty
Mihara, Masahiko, Tamaki, Yasunobu, Nakura, Nariaki, Takayanagi, Satoshi, Saito, Akira, Ochiai, Shunsuke, Hirakawa, Kazuo
Published in Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association (01.01.2020)
Published in Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association (01.01.2020)
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Tocilizumab, A Humanized Anti-IL-6R Antibody, as an Emerging Therapeutic Option for Rheumatoid Arthritis: Molecular and Cellular Mechanistic Insights
Hashizume, Misato, Tan, Seng-Lai, Takano, Junichi, Ohsawa, Kazunori, Hasada, Ikuo, Hanasaki, Akira, Ito, Ichiro, Mihara, Masahiko, Nishida, Keiichiro
Published in International Reviews of Immunology (04.05.2015)
Published in International Reviews of Immunology (04.05.2015)
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Tocilizumab, a Humanized Anti-interleukin-6 Receptor Antibody, Ameliorates Joint Swelling in Established Monkey Collagen-Induced Arthritis
Uchiyama, Yasushi, Yorozu, Keigo, Hashizume, Misato, Moriya, Yoichiro, Mihara, Masahiko
Published in Biological & Pharmaceutical Bulletin (01.06.2008)
Published in Biological & Pharmaceutical Bulletin (01.06.2008)
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A Resorcylic Acid Lactone, 5Z-7-Oxozeaenol, Prevents Inflammation by Inhibiting the Catalytic Activity of TAK1 MAPK Kinase Kinase
Ninomiya-Tsuji, Jun, Kajino, Taisuke, Ono, Koichiro, Ohtomo, Toshihiko, Matsumoto, Masahiko, Shiina, Masashi, Mihara, Masahiko, Tsuchiya, Masayuki, Matsumoto, Kunihiro
Published in The Journal of biological chemistry (16.05.2003)
Published in The Journal of biological chemistry (16.05.2003)
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Comparison of effects of alfacalcidol and alendronate on mechanical properties and bone collagen cross-links of callus in the fracture repair rat model
Saito, Mitsuru, Shiraishi, Ayako, Ito, Masako, Sakai, Sadaoki, Hayakawa, Naohiko, Mihara, Masahiko, Marumo, Keishi
Published in Bone (New York, N.Y.) (01.04.2010)
Published in Bone (New York, N.Y.) (01.04.2010)
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High molecular weight hyaluronic acid relieved joint pain and prevented the progression of cartilage degeneration in a rabbit osteoarthritis model after onset of arthritis
Hashizume, Misato, Koike, Nobuo, Yoshida, Hiroto, Suzuki, Miho, Mihara, Masahiko
Published in Modern rheumatology (01.10.2010)
Published in Modern rheumatology (01.10.2010)
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Interleukin-6 Receptor-Mediated Activation of Signal Transducer and Activator of Transcription-3 (STAT3) Promotes Choroidal Neovascularization
Izumi-Nagai, Kanako, Nagai, Norihiro, Ozawa, Yoko, Mihara, Masahiko, Ohsugi, Yoshiyuki, Kurihara, Toshihide, Koto, Takashi, Satofuka, Shingo, Inoue, Makoto, Tsubota, Kazuo, Okano, Hideyuki, Oike, Yuichi, Ishida, Susumu
Published in The American journal of pathology (01.06.2007)
Published in The American journal of pathology (01.06.2007)
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Blockade of interleukin‐6 signaling aggravates ischemic cerebral damage in mice: possible involvement of Stat3 activation in the protection of neurons
Yamashita, Toru, Sawamoto, Kazunobu, Suzuki, Shigeaki, Suzuki, Norihiro, Adachi, Kazuhide, Kawase, Takeshi, Mihara, Masahiko, Ohsugi, Yoshiyuki, Abe, Koji, Okano, Hideyuki
Published in Journal of neurochemistry (01.07.2005)
Published in Journal of neurochemistry (01.07.2005)
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Induction of high-dose tolerance to the rat anti-mouse IL-6 receptor antibody in NZB/NZW F1 mice
Yoshida, Hiroto, Hashizume, Misato, Suzuki, Miho, Mihara, Masahiko
Published in Rheumatology international (01.11.2011)
Published in Rheumatology international (01.11.2011)
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Single and local blockade of interleukin-6 signaling promotes neuronal differentiation from transplanted embryonic stem cell-derived neural precursor cells
Gomi, Masanori, Aoki, Tomohiro, Takagi, Yasushi, Nishimura, Masaki, Ohsugi, Yoshiyuki, Mihara, Masahiko, Nozaki, Kazuhiko, Hashimoto, Nobuo, Miyamoto, Susumu, Takahashi, Jun
Published in Journal of neuroscience research (01.09.2011)
Published in Journal of neuroscience research (01.09.2011)
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The combination therapy with alfacalcidol and risedronate improves the mechanical property in lumbar spine by affecting the material properties in an ovariectomized rat model of osteoporosis
Shiraishi, Ayako, Miyabe, Sayaka, Nakano, Takayoshi, Umakoshi, Yukichi, Ito, Masako, Mihara, Masahiko
Published in BMC musculoskeletal disorders (15.06.2009)
Published in BMC musculoskeletal disorders (15.06.2009)
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The therapy of autoimmune diseases by anti-interleukin-6 receptor antibody
Mihara, Masahiko, Nishimoto, Norihiro, Ohsugi, Yoshiyuki
Published in Expert opinion on biological therapy (01.05.2005)
Published in Expert opinion on biological therapy (01.05.2005)
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