Discovery of AMG 925, a FLT3 and CDK4 Dual Kinase Inhibitor with Preferential Affinity for the Activated State of FLT3
Li, Zhihong, Wang, Xianghong, Eksterowicz, John, Gribble, Michael W, Alba, Grace Q, Ayres, Merrill, Carlson, Timothy J, Chen, Ada, Chen, Xiaoqi, Cho, Robert, Connors, Richard V, DeGraffenreid, Michael, Deignan, Jeffrey T, Duquette, Jason, Fan, Pingchen, Fisher, Benjamin, Fu, Jiasheng, Huard, Justin N, Kaizerman, Jacob, Keegan, Kathleen S, Li, Cong, Li, Kexue, Li, Yunxiao, Liang, Lingming, Liu, Wen, Lively, Sarah E, Lo, Mei-Chu, Ma, Ji, McMinn, Dustin L, Mihalic, Jeffrey T, Modi, Kriti, Ngo, Rachel, Pattabiraman, Kanaka, Piper, Derek E, Queva, Christophe, Ragains, Mark L, Suchomel, Julia, Thibault, Steve, Walker, Nigel, Wang, Xiaodong, Wang, Zhulun, Wanska, Malgorzata, Wehn, Paul M, Weidner, Margaret F, Zhang, Alex J, Zhao, Xiaoning, Kamb, Alexander, Wickramasinghe, Dineli, Dai, Kang, McGee, Lawrence R, Medina, Julio C
Published in Journal of medicinal chemistry (24.04.2014)
Published in Journal of medicinal chemistry (24.04.2014)
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Discovery of a novel series of melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity
Mihalic, Jeffrey T., Chen, Xiaoqi, Fan, Pingchen, Chen, Xi, Fu, Ying, Liang, Lingming, Reed, Michael, Tang, Liang, Chen, Jin-Long, Jaen, Juan, Li, Leping, Dai, Kang
Published in Bioorganic & medicinal chemistry letters (01.12.2011)
Published in Bioorganic & medicinal chemistry letters (01.12.2011)
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Discovery of a novel melanin concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition
Mihalic, Jeffrey T., Fan, Pingchen, Chen, Xiaoqi, Chen, Xi, Fu, Ying, Motani, Alykhan, Liang, Lingming, Lindstrom, Michelle, Tang, Liang, Chen, Jin-Long, Jaen, Juan, Dai, Kang, Li, Leping
Published in Bioorganic & medicinal chemistry letters (01.06.2012)
Published in Bioorganic & medicinal chemistry letters (01.06.2012)
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Discovery of a new class of ghrelin receptor antagonists
Mihalic, Jeffrey T., Kim, Yong-Jae, Lizarzaburu, Mike, Chen, Xiaoqi, Deignan, Jeff, Wanska, Malgorzata, Yu, Ming, Fu, Jiasheng, Chen, Xi, Zhang, Alex, Connors, Richard, Liang, Lingming, Lindstrom, Michelle, Ma, Ji, Tang, Liang, Dai, Kang, Li, Leping
Published in Bioorganic & medicinal chemistry letters (01.03.2012)
Published in Bioorganic & medicinal chemistry letters (01.03.2012)
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Optimization of the heterocyclic core of the quinazolinone-derived CXCR3 antagonists
Li, An-Rong, Johnson, Michael G., Liu, Jiwen, Chen, Xiaoqi, Du, Xiaohui, Mihalic, Jeffrey T., Deignan, Jeffrey, Gustin, Darin J., Duquette, Jason, Fu, Zice, Zhu, Liusheng, Marcus, Andrew P., Bergeron, Phillipe, McGee, Lawrence R., Danao, Jay, Lemon, Bryan, Carabeo, Teresa, Sullivan, Timothy, Ma, Ji, Tang, Liang, Tonn, George, Collins, Tassie L., Medina, Julio C.
Published in Bioorganic & medicinal chemistry (15.01.2008)
Published in Bioorganic & medicinal chemistry (15.01.2008)
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Design and optimization of imidazole derivatives as potent CXCR3 antagonists
Du, Xiaohui, Chen, Xiaoqi, Mihalic, Jeffrey T., Deignan, Jeffrey, Duquette, Jason, Li, An-Rong, Lemon, Bryan, Ma, Ji, Miao, Shichang, Ebsworth, Karen, Sullivan, Timothy J., Tonn, George, Collins, Tassie L., Medina, Julio C.
Published in Bioorganic & medicinal chemistry (15.01.2008)
Published in Bioorganic & medicinal chemistry (15.01.2008)
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Evaluation of AMG 076, a potent and selective MCHR1 antagonist, in rodent and primate obesity models
Motani, Alykhan S., Luo, Jian, Liang, Lingming, Mihalic, Jeffrey T., Chen, Xiaoqi, Tang, Liang, Li, Leping, Jaen, Juan, Chen, Jin‐Long, Dai, Kang
Published in Pharmacology research & perspectives (01.10.2013)
Published in Pharmacology research & perspectives (01.10.2013)
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Evaluation of AMG 076, a potent and selective MCHR 1 antagonist, in rodent and primate obesity models
Motani, Alykhan S., Luo, Jian, Liang, Lingming, Mihalic, Jeffrey T., Chen, Xiaoqi, Tang, Liang, Li, Leping, Jaen, Juan, Chen, Jin‐Long, Dai, Kang
Published in Pharmacology research & perspectives (01.10.2013)
Published in Pharmacology research & perspectives (01.10.2013)
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Incorporation of an Amide into 5-Phosphonoalkyl-6-d-ribitylaminopyrimidinedione Lumazine Synthase Inhibitors Results in an Unexpected Reversal of Selectivity for Riboflavin Synthase vs Lumazine Synthase
Cushman, Mark, Yang, Donglai, Mihalic, Jeffrey T, Chen, Jinhua, Gerhardt, Stefan, Huber, Robert, Fischer, Markus, Kis, Klaus, Bacher, Adelbert
Published in Journal of organic chemistry (04.10.2002)
Published in Journal of organic chemistry (04.10.2002)
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OTHR-02. CHIMERIC AURORA A KINASE (AURKA) DEGRADERS EFFICIENTLY TARGET N-MYC
Valinciute, Gintvile, Eing, Lorenz, Mihalic, Jeffrey, Casey, Colleen E, Tian, Hua, Adhikari, Bikash, Guiducci, Cristiana, Rountree, Ryan, Grohmann, Christoph, Sridharan, Sangita, Lu, Ya-Wen, Vezina-Dawod, Simon, Wegrzyniak, Eric, Chaterjee, Abhinav, Hansen, Gwenn M, Maris, John M, Mossé, Yael P, Eilers, Martin, Wolf, Elmar, Roussel, Martine F
Published in Neuro-oncology (Charlottesville, Va.) (12.06.2023)
Published in Neuro-oncology (Charlottesville, Va.) (12.06.2023)
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Abstract 2850: NX-5948 promotes selective, sub-nanomolar degradation of inhibitor-resistant BTK mutants
Noviski, Mark Andrew, Brathaban, Nivetha, Mukerji, Ratul, Yung, Stephanie, Ye, Jordan, Bousquet, Hugo, Rios, Mateo Sanchez Garcia de los, Bravo, Brandon, Chen, Jiwen, Auger, Paul, Mihalic, Jeffrey, Lu, Hao, Guiducci, Cristiana, Hansen, Gwenn
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Abstract 3423: NX-2127: A first-in-class clinical stage degrader of BTK and IKZF1/3 for the treatment of patients with B cell malignancies
Mihalic, Jeffrey T., Brathaban, Nivetha, Bravo, Brandon, Ingallinera, Timothy, Kato, Daisuke, Lu, Hao, Ma, Jun, McIntosh, Joel, Tenn-McClellan, Austin, Mukerji, Ratul, Noviski, Mark A., Peng, Ge, Perez, Luz, Rountree, Ryan, Tan, May, Wu, Jeffrey, Ye, Jordan, Yung, Stephanie
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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유비퀴틴 프로테오좀 경로를 통해 BTK를 분해시키기 위한 이작용성 화합물
ROBBINS DANIEL W, MIHALIC JEFFREY, WEISS DAHLIA, MCINTOSH JOEL, KATO DAISUKE, SANDS ARTHUR T, WU JEFFREY, PENG GE
Year of Publication 25.06.2021
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Year of Publication 25.06.2021
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PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
EKSTEROWICZ JOHN, HUANG XIN, LIU JIWEN, FISHER BENJAMIN, FOX BRIAN MATTHEW, SUN DAQING, FU JIASHENG, JIAO XIANYUN, MCINTOSH JOEL, FU ZICE, OLSON STEVEN HOWARD, WANG XIAODONG, BECK HILARY PLAKE, GONZALEZ LOPEZ DE TURISO FELIX, LUCAS BRIAN STUART, LI YIHONG, ZHU JIANG, MCMINN DUSTIN, MIHALIC JEFFREY THOMAS, DUQUETTE JASON, MCGEE LAWRENCE, KAYSER FRANK, MA ZHIHUA, REW YOSUP, MEDINA JULIO CESAR, LAI SUJEN, GUSTIN DARIN JAMES, ROVETO PHILIP MARLEY, HEATH JULIE ANNE, CHEN XIAOQI, DEIGNAN JEFFREY, YAN XUELEI, JOHNSON MICHAEL, KOPECKY DAVID JOHN, LI ZHIHONG, GRIBBLE JR. MICHAEL WILLIAM, LOW JONATHAN DANTE, CONNORS RICHARD VICTOR, YU MING, BARTBERGER MICHAEL DAVID, WANG YINGCAI, GONZALEZ BUENROSTRO ANA
Year of Publication 14.11.2023
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Year of Publication 14.11.2023
Patent
PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
EKSTEROWICZ JOHN, HUANG XIN, LIU JIWEN, FISHER BENJAMIN, FOX BRIAN MATTHEW, SUN DAQING, FU JIASHENG, JIAO XIANYUN, MCINTOSH JOEL, FU ZICE, OLSON STEVEN HOWARD, WANG XIAODONG, BECK HILARY PLAKE, GONZALEZ LOPEZ DE TURISO FELIX, LUCAS BRIAN STUART, LI YIHONG, ZHU JIANG, MCMINN DUSTIN, MIHALIC JEFFREY THOMAS, DUQUETTE JASON, MCGEE LAWRENCE, KAYSER FRANK, MA ZHIHUA, REW YOSUP, MEDINA JULIO CESAR, LAI SUJEN, GUSTIN DARIN JAMES, ROVETO PHILIP MARLEY, HEATH JULIE ANNE, CHEN XIAOQI, DEIGNAN JEFFREY, YAN XUELEI, JOHNSON MICHAEL, KOPECKY DAVID JOHN, LI ZHIHONG, GRIBBLE JR. MICHAEL WILLIAM, LOW JONATHAN DANTE, CONNORS RICHARD VICTOR, YU MING, BARTBERGER MICHAEL DAVID, WANG YINGCAI, GONZALEZ BUENROSTRO ANA
Year of Publication 20.06.2022
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Year of Publication 20.06.2022
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PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
EKSTEROWICZ JOHN, HUANG XIN, LIU JIWEN, FISHER BENJAMIN, FOX BRIAN MATTHEW, SUN DAQING, FU JIASHENG, JIAO XIANYUN, MCINTOSH JOEL, FU ZICE, OLSON STEVEN HOWARD, WANG XIAODONG, BECK HILARY PLAKE, GONZALEZ LOPEZ DE TURISO FELIX, LUCAS BRIAN STUART, LI YIHONG, ZHU JIANG, MCMINN DUSTIN, MIHALIC JEFFREY THOMAS, DUQUETTE JASON, MCGEE LAWRENCE, KAYSER FRANK, MA ZHIHUA, REW YOSUP, MEDINA JULIO CESAR, LAI SUJEN, GUSTIN DARIN JAMES, ROVETO PHILIP MARLEY, HEATH JULIE ANNE, CHEN XIAOQI, DEIGNAN JEFFREY, YAN XUELEI, JOHNSON MICHAEL, KOPECKY DAVID JOHN, LI ZHIHONG, GRIBBLE JR. MICHAEL WILLIAM, LOW JONATHAN DANTE, CONNORS RICHARD VICTOR, YU MING, BARTBERGER MICHAEL DAVID, WANG YINGCAI, GONZALEZ BUENROSTRO ANA
Year of Publication 08.06.2021
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Year of Publication 08.06.2021
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PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
EKSTEROWICZ JOHN, HUANG XIN, LIU JIWEN, FISHER BENJAMIN, FOX BRIAN MATTHEW, SUN DAQING, FU JIASHENG, JIAO XIANYUN, MCINTOSH JOEL, FU ZICE, OLSON STEVEN HOWARD, WANG XIAODONG, BECK HILARY PLAKE, GONZALEZ LOPEZ DE TURISO FELIX, LUCAS BRIAN STUART, LI YIHONG, ZHU JIANG, MCMINN DUSTIN, MIHALIC JEFFREY THOMAS, DUQUETTE JASON, MCGEE LAWRENCE, KAYSER FRANK, MA ZHIHUA, REW YOSUP, MEDINA JULIO CESAR, LAI SUJEN, GUSTIN DARIN JAMES, ROVETO PHILIP MARLEY, HEATH JULIE ANNE, CHEN XIAOQI, DEIGNAN JEFFREY, YAN XUELEI, JOHNSON MICHAEL, KOPECKY DAVID JOHN, LI ZHIHONG, GRIBBLE JR. MICHAEL WILLIAM, LOW JONATHAN DANTE, CONNORS RICHARD VICTOR, YU MING, BARTBERGER MICHAEL DAVID, WANG YINGCAI, GONZALEZ BUENROSTRO ANA
Year of Publication 04.06.2020
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Year of Publication 04.06.2020
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PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
EKSTEROWICZ JOHN, HUANG XIN, LIU JIWEN, FISHER BENJAMIN, FOX BRIAN MATTHEW, SUN DAQING, FU JIASHENG, JIAO XIANYUN, MCINTOSH JOEL, FU ZICE, OLSON STEVEN HOWARD, WANG XIAODONG, BECK HILARY PLAKE, GONZALEZ LOPEZ DE TURISO FELIX, LUCAS BRIAN STUART, LI YIHONG, ZHU JIANG, MCMINN DUSTIN, MIHALIC JEFFREY THOMAS, DUQUETTE JASON, MCGEE LAWRENCE, KAYSER FRANK, MA ZHIHUA, REW YOSUP, MEDINA JULIO CESAR, LAI SUJEN, GUSTIN DARIN JAMES, ROVETO PHILIP MARLEY, HEATH JULIE ANNE, CHEN XIAOQI, DEIGNAN JEFFREY, YAN XUELEI, JOHNSON MICHAEL, KOPECKY DAVID JOHN, LI ZHIHONG, GRIBBLE JR. MICHAEL WILLIAM, LOW JONATHAN DANTE, CONNORS RICHARD VICTOR, YU MING, BARTBERGER MICHAEL DAVID, WANG YINGCAI, GONZALEZ BUENROSTRO ANA
Year of Publication 29.05.2019
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Year of Publication 29.05.2019
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