Neutrophil elastase in bronchiectasis
Gramegna, Andrea, Amati, Francesco, Terranova, Leonardo, Sotgiu, Giovanni, Tarsia, Paolo, Miglietta, Daniela, Calderazzo, Maria Adelaide, Aliberti, Stefano, Blasi, Francesco
Published in Respiratory research (19.12.2017)
Published in Respiratory research (19.12.2017)
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Harnessing the translational power of bleomycin model: new insights to guide drug discovery for idiopathic pulmonary fibrosis
Murgo, Annalisa, Bignami, Fabio, Federico, Giuseppina, Villetti, Gino, Civelli, Maurizio, Sala, Angelo, Miglietta, Daniela
Published in Frontiers in pharmacology (30.11.2023)
Published in Frontiers in pharmacology (30.11.2023)
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Nitric oxide enhances the anti-inflammatory and anti-atherogenic activity of atorvastatin in a mouse model of accelerated atherosclerosis
MOMI, Stefania, MONOPOLI, Angela, ALBERTI, Paolo Francesco, FALCINELLI, Emanuela, CORAZZI, Teresa, CONTI, Valentina, MIGLIETTA, Daniela, ONGINI, Ennio, MINUZ, Pietro, GRESELE, Paolo
Published in Cardiovascular research (01.06.2012)
Published in Cardiovascular research (01.06.2012)
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A dual acting compound releasing nitric oxide (NO) and ibuprofen, NCX 320, shows significant therapeutic effects in a mouse model of muscular dystrophy
Sciorati, Clara, Miglietta, Daniela, Buono, Roberta, Pisa, Viviana, Cattaneo, Dario, Azzoni, Emanuele, Brunelli, Silvia, Clementi, Emilio
Published in Pharmacological research (01.09.2011)
Published in Pharmacological research (01.09.2011)
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Discovery, Multiparametric Optimization, and Solid-State Driven Identification of CHF-6550, a Novel Soft Dual Pharmacology Muscarinic Antagonist and β2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases
Carzaniga, Laura, Linney, Ian D., Rizzi, Andrea, Schmidt, Wolfgang, Knight, Christopher K., Mileo, Valentina, Amadei, Francesco, Pastore, Fiorella, Miglietta, Daniela, Cesari, Nicola, Riccardi, Benedetta, Mazzucato, Roberta, Ghidini, Eleonora, Blackaby, Wesley P., Patacchini, Riccardo, Battipaglia, Loredana, Villetti, Gino, Puccini, Paola, Catinella, Silvia, Civelli, Maurizio, Rancati, Fabio
Published in Journal of medicinal chemistry (27.06.2024)
Published in Journal of medicinal chemistry (27.06.2024)
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Journal Article
Discovery, Multiparametric Optimization, and Solid-State Driven Identification of CHF-6550, a Novel Soft Dual Pharmacology Muscarinic Antagonist and β 2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases
Carzaniga, Laura, Linney, Ian D., Rizzi, Andrea, Schmidt, Wolfgang, Knight, Christopher K., Mileo, Valentina, Amadei, Francesco, Pastore, Fiorella, Miglietta, Daniela, Cesari, Nicola, Riccardi, Benedetta, Mazzucato, Roberta, Ghidini, Eleonora, Blackaby, Wesley P., Patacchini, Riccardo, Battipaglia, Loredana, Villetti, Gino, Puccini, Paola, Catinella, Silvia, Civelli, Maurizio, Rancati, Fabio
Published in Journal of medicinal chemistry (27.06.2024)
Published in Journal of medicinal chemistry (27.06.2024)
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NO donors exhibit anti‐inflammatory properties by modulating inflammatory signatures and by regulating the life cycle of dendritic cells
Ripamonti, Chiara, Papagna, Angela, Storini, Claudio, Miglietta, Daniela, Foti, Maria
Published in Journal of leukocyte biology (01.12.2017)
Published in Journal of leukocyte biology (01.12.2017)
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Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and beta(2) Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases
Carzaniga, Laura, Linney, Ian D., Rizzi, Andrea, Delcanale, Maurizio, Schmidt, Wolfgang, Knight, Christopher K., Pastore, Fiorella, Miglietta, Daniela, Carnini, Chiara, Cesari, Nicola, Riccardi, Benedetta, Mileo, Valentina, Venturi, Luca, Moretti, Elisa, Blackaby, Wesley P., Patacchini, Riccardo, Accetta, Alessandro, Biagetti, Matteo, Bassani, Franco, Tondelli, Marina, Murgo, Annalisa, Battipaglia, Loredana, Villetti, Gino, Puccini, Paola, Catinella, Silvia, Civelli, Maurizio, Rancati, Fabio
Published in Journal of medicinal chemistry (11.08.2022)
Published in Journal of medicinal chemistry (11.08.2022)
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Journal Article
Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and β2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases
Carzaniga, Laura, Linney, Ian D., Rizzi, Andrea, Delcanale, Maurizio, Schmidt, Wolfgang, Knight, Christopher K., Pastore, Fiorella, Miglietta, Daniela, Carnini, Chiara, Cesari, Nicola, Riccardi, Benedetta, Mileo, Valentina, Venturi, Luca, Moretti, Elisa, Blackaby, Wesley P., Patacchini, Riccardo, Accetta, Alessandro, Biagetti, Matteo, Bassani, Franco, Tondelli, Marina, Murgo, Annalisa, Battipaglia, Loredana, Villetti, Gino, Puccini, Paola, Catinella, Silvia, Civelli, Maurizio, Rancati, Fabio
Published in Journal of medicinal chemistry (11.08.2022)
Published in Journal of medicinal chemistry (11.08.2022)
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Journal Article
Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and β 2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases
Carzaniga, Laura, Linney, Ian D., Rizzi, Andrea, Delcanale, Maurizio, Schmidt, Wolfgang, Knight, Christopher K., Pastore, Fiorella, Miglietta, Daniela, Carnini, Chiara, Cesari, Nicola, Riccardi, Benedetta, Mileo, Valentina, Venturi, Luca, Moretti, Elisa, Blackaby, Wesley P., Patacchini, Riccardo, Accetta, Alessandro, Biagetti, Matteo, Bassani, Franco, Tondelli, Marina, Murgo, Annalisa, Battipaglia, Loredana, Villetti, Gino, Puccini, Paola, Catinella, Silvia, Civelli, Maurizio, Rancati, Fabio
Published in Journal of medicinal chemistry (11.08.2022)
Published in Journal of medicinal chemistry (11.08.2022)
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Evaluation of active neutrophil elastase in sputum of bronchiectasis and cystic fibrosis patients: A comparison among different techniques
Oriano, Martina, Terranova, Leonardo, Sotgiu, Giovanni, Saderi, Laura, Bellofiore, Angela, Retucci, Mariangela, Marotta, Cinzia, Gramegna, Andrea, Miglietta, Daniela, Carnini, Chiara, Marchisio, Paola, Chalmers, James D., Aliberti, Stefano, Blasi, Francesco
Published in Pulmonary pharmacology & therapeutics (01.12.2019)
Published in Pulmonary pharmacology & therapeutics (01.12.2019)
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Naproxcinod shows significant advantages over naproxen in the mdx model of Duchenne Muscular Dystrophy
Miglietta, Daniela, De Palma, Clara, Sciorati, Clara, Vergani, Barbara, Pisa, Viviana, Villa, Antonello, Ongini, Ennio, Clementi, Emilio
Published in Orphanet journal of rare diseases (22.08.2015)
Published in Orphanet journal of rare diseases (22.08.2015)
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Long-term treatment with naproxcinod significantly improves skeletal and cardiac disease phenotype in the mdx mouse model of dystrophy
Uaesoontrachoon, Kitipong, Quinn, James L, Tatem, Kathleen S, Van Der Meulen, Jack H, Yu, Qing, Phadke, Aditi, Miller, Brittany K, Gordish-Dressman, Heather, Ongini, Ennio, Miglietta, Daniela, Nagaraju, Kanneboyina
Published in Human molecular genetics (15.06.2014)
Published in Human molecular genetics (15.06.2014)
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Characterization of the anti-inflammatory properties of NCX 429, a dual-acting compound releasing nitric oxide and naproxen
Amoruso, Angela, Fresu, Luigia Grazia, Dalli, Jesmond, Miglietta, Daniela, Bardelli, Claudio, Canova, Donata Federici, Perretti, Mauro, Brunelleschi, Sandra
Published in Life sciences (1973) (01.04.2015)
Published in Life sciences (1973) (01.04.2015)
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Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma
Steele, Rebecca M., Benedini, Francesca, Biondi, Stefano, Borghi, Valentina, Carzaniga, Laura, Impagnatiello, Francesco, Miglietta, Daniela, Chong, Wesley K.M., Rajapakse, Ranjan, Cecchi, Alessandro, Temperini, Claudia, Supuran, Claudiu T.
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
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Nitric Oxide-Donating Atorvastatin Attenuates Neutrophil Recruitment During Vascular Inflammation Independent of Changes in Plasma Cholesterol
Baetta, Roberta, Granata, Agnese, Miglietta, Daniela, Oliva, Francesca, Arnaboldi, Lorenzo, Bonomo, Alessandra, Ferri, Nicola, Ongini, Ennio, Bellosta, Stefano, Corsini, Alberto
Published in Cardiovascular drugs and therapy (01.06.2013)
Published in Cardiovascular drugs and therapy (01.06.2013)
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Enhanced oxygen saturation in optic nerve head of non-human primate eyes following the intravitreal injection of NCX 434, an innovative nitric oxide-donating glucocorticoid
Khoobehi, Bahram, Chiroli, Valerio, Ronchetti, Daniela, Miglietta, Daniela, Thompson, Hillary, Ongini, Ennio, Impagnatiello, Francesco
Published in Journal of ocular pharmacology and therapeutics (01.04.2011)
Published in Journal of ocular pharmacology and therapeutics (01.04.2011)
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NITRIC OXIDE DONATION FROM THE CINOD NAPROXCINOD COUNTERACTS CYCLOOXYGENASE INHIBITION-DEPENDENT CONTRACTION IN HUMAN MAMMARY ARTERIES
Bolla, Manlio, Poggi, Alessandra, Vergani, Barbara, Gelpi, Guido, Padron, Julio, Miglietta, Daniela
Published in Journal of the American College of Cardiology (09.03.2010)
Published in Journal of the American College of Cardiology (09.03.2010)
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