Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index
Shen, Wen, De Hoyos, Cheryl L, Migawa, Michael T, Vickers, Timothy A, Sun, Hong, Low, Audrey, Bell, 3rd, Thomas A, Rahdar, Meghdad, Mukhopadhyay, Swagatam, Hart, Christopher E, Bell, Melanie, Riney, Stan, Murray, Susan F, Greenlee, Sarah, Crooke, Rosanne M, Liang, Xue-Hai, Seth, Punit P, Crooke, Stanley T
Published in Nature biotechnology (01.06.2019)
Published in Nature biotechnology (01.06.2019)
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Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides
Anderson, Brooke A, Freestone, Graeme C, Low, Audrey, De-Hoyos, Cheryl L, III, William J Drury, Østergaard, Michael E, Migawa, Michael T, Fazio, Michael, Wan, W Brad, Berdeja, Andres, Scandalis, Eli, Burel, Sebastien A, Vickers, Timothy A, Crooke, Stanley T, Swayze, Eric E, Liang, Xuehai, Seth, Punit P
Published in Nucleic acids research (20.09.2021)
Published in Nucleic acids research (20.09.2021)
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Site-specific incorporation of 5′-methyl DNA enhances the therapeutic profile of gapmer ASOs
Vasquez, Guillermo, Freestone, Graeme C, Wan, W Brad, Low, Audrey, De Hoyos, Cheryl Li, Yu, Jinghua, Prakash, Thazha P, Ǿstergaard, Michael E, Liang, Xue-hai, Crooke, Stanley T, Swayze, Eric E, Migawa, Michael T, Seth, Punit P
Published in Nucleic acids research (26.02.2021)
Published in Nucleic acids research (26.02.2021)
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Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides
Østergaard, Michael E, De Hoyos, Cheryl L, Wan, W Brad, Shen, Wen, Low, Audrey, Berdeja, Andres, Vasquez, Guillermo, Murray, Susan, Migawa, Michael T, Liang, Xue-Hai, Swayze, Eric E, Crooke, Stanley T, Seth, Punit P
Published in Nucleic acids research (28.02.2020)
Published in Nucleic acids research (28.02.2020)
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Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages
Wan, W Brad, Migawa, Michael T, Vasquez, Guillermo, Murray, Heather M, Nichols, Josh G, Gaus, Hans, Berdeja, Andres, Lee, Sam, Hart, Christopher E, Lima, Walt F, Swayze, Eric E, Seth, Punit P
Published in Nucleic acids research (16.12.2014)
Published in Nucleic acids research (16.12.2014)
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Comprehensive Structure–Activity Relationship of Triantennary N‑Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes
Prakash, Thazha P, Yu, Jinghua, Migawa, Michael T, Kinberger, Garth A, Wan, W. Brad, Østergaard, Michael E, Carty, Recaldo L, Vasquez, Guillermo, Low, Audrey, Chappell, Alfred, Schmidt, Karsten, Aghajan, Mariam, Crosby, Jeff, Murray, Heather M, Booten, Sheri L, Hsiao, Jill, Soriano, Armand, Machemer, Todd, Cauntay, Patrick, Burel, Sebastien A, Murray, Susan F, Gaus, Hans, Graham, Mark J, Swayze, Eric E, Seth, Punit P
Published in Journal of medicinal chemistry (24.03.2016)
Published in Journal of medicinal chemistry (24.03.2016)
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Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals
Swayze, Eric E, Siwkowski, Andrew M, Wancewicz, Edward V, Migawa, Michael T, Wyrzykiewicz, Tadeusz K, Hung, Gene, Monia, Brett P, Bennett, and C. Frank
Published in Nucleic acids research (01.01.2007)
Published in Nucleic acids research (01.01.2007)
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Efficient Synthesis and Biological Evaluation of 5′-GalNAc Conjugated Antisense Oligonucleotides
Østergaard, Michael E, Yu, Jinghua, Kinberger, Garth A, Wan, W. Brad, Migawa, Michael T, Vasquez, Guillermo, Schmidt, Karsten, Gaus, Hans J, Murray, Heather M, Low, Audrey, Swayze, Eric E, Prakash, Thazha P, Seth, Punit P
Published in Bioconjugate chemistry (19.08.2015)
Published in Bioconjugate chemistry (19.08.2015)
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Journal Article
Solid-phase synthesis of 5′-triantennary N-acetylgalactosamine conjugated antisense oligonucleotides using phosphoramidite chemistry
Prakash, Thazha P., Brad Wan, W., Low, Audrey, Yu, Jinghua, Chappell, Alfred E., Gaus, Hans, Kinberger, Garth A., Østergaard, Michael E., Migawa, Michael T., Swayze, Eric E., Seth, Punit P.
Published in Bioorganic & medicinal chemistry letters (01.10.2015)
Published in Bioorganic & medicinal chemistry letters (01.10.2015)
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Elucidation of the Biotransformation Pathways of a Galnac3-conjugated Antisense Oligonucleotide in Rats and Monkeys
Shemesh, Colby S, Yu, Rosie Z, Gaus, Hans J, Greenlee, Sarah, Post, Noah, Schmidt, Karsten, Migawa, Michael T, Seth, Punit P, Zanardi, Thomas A, Prakash, Thazha P, Swayze, Eric E, Henry, Scott P, Wang, Yanfeng
Published in Molecular therapy. Nucleic acids (2016)
Published in Molecular therapy. Nucleic acids (2016)
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A convenient synthesis of 5′-triantennary N-acetyl-galactosamine clusters based on nitromethanetrispropionic acid
Migawa, Michael T., Prakash, Thazha P., Vasquez, Guillermo, Wan, W. Brad, Yu, Jinghua, Kinberger, Garth A., Østergaard, Michael E., Swayze, Eric E., Seth, Punit P.
Published in Bioorganic & medicinal chemistry letters (01.05.2016)
Published in Bioorganic & medicinal chemistry letters (01.05.2016)
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Journal Article
Configuration of the 5′-Methyl Group Modulates the Biophysical and Biological Properties of Locked Nucleic Acid (LNA) Oligonucleotides
Seth, Punit P, Allerson, Charles R, Siwkowski, Andrew, Vasquez, Guillermo, Berdeja, Andres, Migawa, Michael T, Gaus, Hans, Prakash, Thazha P, Bhat, Balkrishen, Swayze, Eric E
Published in Journal of medicinal chemistry (09.12.2010)
Published in Journal of medicinal chemistry (09.12.2010)
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Human RNase H1 Discriminates between Subtle Variations in the Structure of the Heteroduplex Substrate
Lima, Walt F, Rose, John B, Nichols, Josh G, Wu, Hongjiang, Migawa, Michael T, Wyrzykiewicz, Tadeusz K, Siwkowski, Andrew M, Crooke, Stanley T
Published in Molecular pharmacology (01.01.2007)
Published in Molecular pharmacology (01.01.2007)
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Antibacterial Aminoglycosides with a Modified Mode of Binding to the Ribosomal-RNA Decoding Site
François, Boris, Szychowski, Janek, Adhikari, Susanta Sekhar, Pachamuthu, Kandasamy, Swayze, Eric E., Griffey, Richard H., Migawa, Michael T., Westhof, Eric, Hanessian, Stephen
Published in Angewandte Chemie (20.04.2007)
Published in Angewandte Chemie (20.04.2007)
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Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins
Migawa, Michael T, Shen, Wen, Wan, W Brad, Vasquez, Guillermo, Oestergaard, Michael E, Low, Audrey, De Hoyos, Cheryl L, Gupta, Ruchi, Murray, Susan, Tanowitz, Michael, Bell, Melanie, Nichols, Joshua G, Gaus, Hans, Liang, Xue-Hai, Swayze, Eric E, Crooke, Stanley T, Seth, Punit P
Published in Nucleic acids research (20.06.2019)
Published in Nucleic acids research (20.06.2019)
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Journal Article
Antisense oligonucleotides targeting translation inhibitory elements in 5' UTRs can selectively increase protein levels
Liang, Xue-Hai, Sun, Hong, Shen, Wen, Wang, Shiyu, Yao, Joyee, Migawa, Michael T, Bui, Huynh-Hoa, Damle, Sagar S, Riney, Stan, Graham, Mark J, Crooke, Rosanne M, Crooke, Stanley T
Published in Nucleic acids research (19.09.2017)
Published in Nucleic acids research (19.09.2017)
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Journal Article
High-resolution visualization and quantification of nucleic acid–based therapeutics in cells and tissues using Nanoscale secondary ion mass spectrometry (NanoSIMS)
He, Cuiwen, Migawa, Michael T, Chen, Kai, Weston, Thomas A, Tanowitz, Michael, Song, Wenxin, Guagliardo, Paul, Iyer, K Swaminathan, Bennett, C Frank, Fong, Loren G, Seth, Punit P, Young, Stephen G, Jiang, Haibo
Published in Nucleic acids research (11.01.2021)
Published in Nucleic acids research (11.01.2021)
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