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Published in Nature biotechnology (01.03.2011)
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Published in Journal of medicinal chemistry (25.02.2016)
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Published in Angewandte Chemie International Edition (12.09.2016)
Published in Angewandte Chemie International Edition (12.09.2016)
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GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain
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Published in ACS medicinal chemistry letters (09.06.2016)
Published in ACS medicinal chemistry letters (09.06.2016)
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Biological plasticity rescues target activity in CRISPR knock outs
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Published in Nature methods (01.11.2019)
Published in Nature methods (01.11.2019)
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The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor
Seal, Jonathan T, Atkinson, Stephen J, Aylott, Helen, Bamborough, Paul, Chung, Chun-wa, Copley, Royston C. B, Gordon, Laurie, Grandi, Paola, Gray, James R. J, Harrison, Lee A, Hayhow, Thomas G, Lindon, Matthew, Messenger, Cassie, Michon, Anne-Marie, Mitchell, Darren, Preston, Alex, Prinjha, Rab K, Rioja, Inmaculada, Taylor, Simon, Wall, Ian D, Watson, Robert J, Woolven, James M, Demont, Emmanuel H
Published in Journal of medicinal chemistry (10.09.2020)
Published in Journal of medicinal chemistry (10.09.2020)
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Design and Synthesis of a Highly Selective and In Vivo-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins
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Published in Journal of medicinal chemistry (10.09.2020)
Published in Journal of medicinal chemistry (10.09.2020)
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Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe
Humphreys, Philip G, Bamborough, Paul, Chung, Chun-wa, Craggs, Peter D, Gordon, Laurie, Grandi, Paola, Hayhow, Thomas G, Hussain, Jameed, Jones, Katherine L, Lindon, Matthew, Michon, Anne-Marie, Renaux, Jessica F, Suckling, Colin J, Tough, David F, Prinjha, Rab K
Published in Journal of medicinal chemistry (26.01.2017)
Published in Journal of medicinal chemistry (26.01.2017)
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Application of Atypical Acetyl-lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains
Clegg, Michael A., Bamborough, Paul, Chung, Chun-wa, Craggs, Peter D., Gordon, Laurie, Grandi, Paola, Leveridge, Melanie, Lindon, Matthew, Liwicki, Gemma M., Michon, Anne-Marie, Molnar, Judit, Rioja, Inmaculada, Soden, Peter E., Theodoulou, Natalie H., Werner, Thilo, Tomkinson, Nicholas C. O., Prinjha, Rab K., Humphreys, Philip G.
Published in Journal of medicinal chemistry (11.06.2020)
Published in Journal of medicinal chemistry (11.06.2020)
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Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors
Bamborough, Paul, Chung, Chun-wa, Furze, Rebecca C, Grandi, Paola, Michon, Anne-Marie, Sheppard, Robert J, Barnett, Heather, Diallo, Hawa, Dixon, David P, Douault, Clement, Jones, Emma J, Karamshi, Bhumika, Mitchell, Darren J, Prinjha, Rab K, Rau, Christina, Watson, Robert J, Werner, Thilo, Demont, Emmanuel H
Published in Journal of medicinal chemistry (13.08.2015)
Published in Journal of medicinal chemistry (13.08.2015)
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Identification of a Series of N‑Methylpyridine-2-carboxamides as Potent and Selective Inhibitors of the Second Bromodomain (BD2) of the Bromo and Extra Terminal Domain (BET) Proteins
Harrison, Lee A, Atkinson, Stephen J, Bassil, Anna, Chung, Chun-wa, Grandi, Paola, Gray, James R. J, Levernier, Etienne, Lewis, Antonia, Lugo, David, Messenger, Cassie, Michon, Anne-Marie, Mitchell, Darren J, Preston, Alex, Prinjha, Rab K, Rioja, Inmaculada, Seal, Jonathan T, Taylor, Simon, Wall, Ian D, Watson, Robert J, Woolven, James M, Demont, Emmanuel H
Published in Journal of medicinal chemistry (12.08.2021)
Published in Journal of medicinal chemistry (12.08.2021)
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Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors
Demont, Emmanuel H., Chung, Chun-wa, Furze, Rebecca C., Grandi, Paola, Michon, Anne-Marie, Wellaway, Chris, Barrett, Nathalie, Bridges, Angela M., Craggs, Peter D., Diallo, Hawa, Dixon, David P., Douault, Clement, Emmons, Amanda J., Jones, Emma J., Karamshi, Bhumika V., Locke, Kelly, Mitchell, Darren J., Mouzon, Bernadette H., Prinjha, Rab K., Roberts, Andy D., Sheppard, Robert J., Watson, Robert J., Bamborough, Paul
Published in Journal of medicinal chemistry (23.07.2015)
Published in Journal of medicinal chemistry (23.07.2015)
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Aiming to Miss a Moving Target: Bromo and Extra Terminal Domain (BET) Selectivity in Constrained ATAD2 Inhibitors
Bamborough, Paul, Chung, Chun-wa, Furze, Rebecca C, Grandi, Paola, Michon, Anne-Marie, Watson, Robert J, Mitchell, Darren J, Barnett, Heather, Prinjha, Rab K, Rau, Christina, Sheppard, Robert J, Werner, Thilo, Demont, Emmanuel H
Published in Journal of medicinal chemistry (27.09.2018)
Published in Journal of medicinal chemistry (27.09.2018)
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A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit Qualification
Bamborough, Paul, Chung, Chun-wa, Demont, Emmanuel H, Bridges, Angela M, Craggs, Peter D, Dixon, David P, Francis, Peter, Furze, Rebecca C, Grandi, Paola, Jones, Emma J, Karamshi, Bhumika, Locke, Kelly, Lucas, Simon C. C, Michon, Anne-Marie, Mitchell, Darren J, Pogány, Peter, Prinjha, Rab K, Rau, Christina, Roa, Ana Maria, Roberts, Andrew D, Sheppard, Robert J, Watson, Robert J
Published in Journal of medicinal chemistry (22.08.2019)
Published in Journal of medicinal chemistry (22.08.2019)
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A physical and functional map of the human TNF-α/NF-κB signal transduction pathway
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Published in Nature cell biology (01.02.2004)
Published in Nature cell biology (01.02.2004)
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GSK973 Is an Inhibitor of the Second Bromodomains (BD2s) of the Bromodomain and Extra-Terminal (BET) Family
Preston, Alex, Atkinson, Stephen J, Bamborough, Paul, Chung, Chun-wa, Gordon, Laurie J, Grandi, Paola, Gray, James R. J, Harrison, Lee A, Lewis, Antonia J, Lugo, David, Messenger, Cassie, Michon, Anne-Marie, Mitchell, Darren J, Prinjha, Rab K, Rioja, Inmaculada, Seal, Jon, Taylor, Simon, Thesmar, Pierre, Wall, Ian D, Watson, Robert J, Woolven, James M, Demont, Emmanuel H
Published in ACS medicinal chemistry letters (13.08.2020)
Published in ACS medicinal chemistry letters (13.08.2020)
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1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain
Demont, Emmanuel H, Bamborough, Paul, Chung, Chun-wa, Craggs, Peter D, Fallon, David, Gordon, Laurie J, Grandi, Paola, Hobbs, Clare I, Hussain, Jameed, Jones, Emma J, Le Gall, Armelle, Michon, Anne-Marie, Mitchell, Darren J, Prinjha, Rab K, Roberts, Andy D, Sheppard, Robert J, Watson, Robert J
Published in ACS medicinal chemistry letters (13.11.2014)
Published in ACS medicinal chemistry letters (13.11.2014)
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Functional organization of the yeast proteome by systematic analysis of protein complexes
Gavin, Anne-Claude, Superti-Furga, Giulio, Bösche, Markus, Krause, Roland, Grandi, Paola, Marzioch, Martina, Bauer, Andreas, Schultz, Jörg, Rick, Jens M, Michon, Anne-Marie, Cruciat, Cristina-Maria, Remor, Marita, Höfert, Christian, Schelder, Malgorzata, Brajenovic, Miro, Ruffner, Heinz, Merino, Alejandro, Klein, Karin, Hudak, Manuela, Dickson, David, Rudi, Tatjana, Gnau, Volker, Bauch, Angela, Bastuck, Sonja, Huhse, Bettina, Leutwein, Christina, Heurtier, Marie-Anne, Copley, Richard R, Edelmann, Angela, Querfurth, Erich, Rybin, Vladimir, Drewes, Gerard, Raida, Manfred, Bouwmeester, Tewis, Bork, Peer, Seraphin, Bertrand, Kuster, Bernhard, Neubauer, Gitte
Published in Nature (London) (10.01.2002)
Published in Nature (London) (10.01.2002)
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Requirement for Drosophila cytoplasmic tropomyosin in oskar mRNA localization
Erdélyi, Miklós, Michon, Anne-Marie, Guichet, Antoine, Glotzer, Jolanta Bogucka, Ephrussi, Anne
Published in Nature (London) (12.10.1995)
Published in Nature (London) (12.10.1995)
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Proteome survey reveals modularity of the yeast cell machinery
Gavin, A.C, Aloy, P, Grandi, P, Krause, R, Boesche, M, Marzioch, M, Rau, C, Jensen, L.J, Bastuck, S, Dümpelfeld, B
Published in Nature (30.03.2006)
Published in Nature (30.03.2006)
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