Discovery of 6-chloro-2-trifluoromethyl-7-aryl-7H-imidazo[1,2-a]imidazol-3-ylmethylamines, a novel class of corticotropin-releasing factor receptor type 1 (CRF1R) antagonists
Zuev, Dmitry, Vrudhula, Vivekananda M., Michne, Jodi A., Dasgupta, Bireshwar, Pin, Sokhom S., Huang, Xiaohua Stella, Wu, Dedong, Gao, Qi, Zhang, Jie, Taber, Matthew T., Macor, John E., Dubowchik, Gene M.
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
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Journal Article
An efficient sequence for the preparation of small secondary amine hydrochloride salts for focused library generation without need for distillation or chromatographic purification
Dubowchik, Gene M., Michne, Jodi A., Zuev, Dmitry
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
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Journal Article
Stereoselective Synthesis of New Conformationally Restricted Analogues of a Potent CGRP Receptor Antagonist
Zuev, Dmitry, Michne, Jodi A, Huang, Hong, Beno, Brett R, Wu, Dedong, Gao, Qi, Torrente, John R, Xu, Cen, Conway, Charles M, Macor, John E, Dubowchik, Gene M
Published in Organic letters (09.06.2005)
Published in Organic letters (09.06.2005)
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Journal Article
Synthesis, structure–activity relationships, and anxiolytic activity of 7-aryl-6,7-dihydroimidazoimidazole corticotropin-releasing factor 1 receptor antagonists
Han, Xiaojun, Michne, Jodi A., Pin, Sokhom S., Burris, Kevin D., Balanda, Lynn A., Fung, Lawrence K., Fiedler, Tracey, Browman, Kaitlin E., Taber, Matthew T., Zhang, Jie, Dubowchik, Gene M.
Published in Bioorganic & medicinal chemistry letters (01.09.2005)
Published in Bioorganic & medicinal chemistry letters (01.09.2005)
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Journal Article
Optimization of CRF1R binding affinity of 2-(2,4,6-trichlorophenyl)-4-trifluoromethyl-5-aminomethylthiazoles through rapid and selective parallel synthesis
ZUEV, Dmitry, MICHNE, Jodi A, PIN, Sokhom S, JIE ZHANG, TABER, Matthew T, DUBOWCHIK, Gene M
Published in Bioorganic & medicinal chemistry letters (17.01.2005)
Published in Bioorganic & medicinal chemistry letters (17.01.2005)
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Journal Article
2-Arylaminothiazoles as high-affinity corticotropin-Releasing factor 1 receptor (CRF 1R) antagonists: synthesis, binding studies and behavioral efficacy
Dubowchik, Gene M., Michne, Jodi A., Zuev, Dmitry, Schwartz, Wendy, Scola, Paul M., James, Clint A., Ruediger, Edward H., Pin, Sokhom S., Burris, Kevin D., Balanda, Lynn A., Gao, Qi, Wu, Dedong, Fung, Lawrence, Fiedler, Tracey, Browman, Kaitlin E., Taber, Matthew T., Zhang, Jie
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
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Journal Article
Optimization of CRF 1R binding affinity of 2-(2,4,6-trichlorophenyl)-4-trifluoromethyl-5-aminomethylthiazoles through rapid and selective parallel synthesis
Zuev, Dmitry, Michne, Jodi A., Pin, Sokhom S., Zhang, Jie, Taber, Matthew T., Dubowchik, Gene M.
Published in Bioorganic & medicinal chemistry letters (17.01.2005)
Published in Bioorganic & medicinal chemistry letters (17.01.2005)
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Journal Article
IMIDAZOLYL DERIVATIVES AS CORTICOTROPIN RELEASING FACTOR INHIBITORS
HAN XIAOJUN, VRUDHULA VIVEKANANDA M, MICHNE JODI A, DASGUPTA BIRESHWAR, ZUEV DMITRY, DUBOWCHIK GENE M
Year of Publication 04.04.2005
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Year of Publication 04.04.2005
Patent
IMIDAZOLYL DERIVATIVES AS CORTICOTROPIN RELEASING FACTOR INHIBITORS
VRUDHULA, VIVEKANANDA M, DUBOWCHIK, GENE M, HAN, XIAOJUN, ZUEV, DMITRY, DASGUPTA, BIRESHWAR, MICHNE, JODI A
Year of Publication 31.08.2004
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Year of Publication 31.08.2004
Patent
Imidazolyl derivatives as corticotropin releasing factor inhibitors
GENE M. DUBOWCHIK, BIRESHWAR DASGUPTA, JODI A. MICHNE, XIAOJUN HAN, DMITRY ZUEV, VIVEKANANDA M. VRUDHULA
Year of Publication 27.07.2004
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Year of Publication 27.07.2004
Patent
Imidazolyl derivatives as corticotropin releasing factor inhibitors
HAN XIAOJUN, VRUDHULA VIVEKANANDA M, MICHNE JODI A, DASGUPTA BIRESHWAR, ZUEV DMITRY, DUBOWCHIK GENE M
Year of Publication 04.05.2004
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Year of Publication 04.05.2004
Patent
IMIDAZOLYL DERIVATIVES AS CORTICOTROPIN RELEASING FACTOR INHIBITORS
VRUDHULA, VIVEKANANDA, M, DUBOWCHIK, GENE, M, HAN, XIAOJUN, ZUEV, DMITRY, DASGUPTA, BIRESHWAR, MICHNE, JODI, A
Year of Publication 07.04.2004
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Year of Publication 07.04.2004
Patent
IMIDAZOLYL DERIVATIVES AS CORTICOTROPIN RELEASING FACTOR INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
VRUDHULA, VIVEKANANDA M, DUBOWCHIK, GENE M, HAN, XIAOJUN, ZUEV, DMITRY, DASGUPTA, BIRESHWAR, MICHNE, JODI A
Year of Publication 01.03.2004
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Year of Publication 01.03.2004
Patent
Imidazolyl derivatives functioning as inhibitors of corticotropin releasing factor
HAN XIAOJUN, VRUDHULA VIVEKANANDA M, MICHNE JODI A, DASGUPTA BIRESHWAR, ZUEV DMITRY, DUBOWCHIK GENE M
Year of Publication 17.12.2003
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Year of Publication 17.12.2003
Patent
IMIDAZOLYL DERIVATIVES AS CORTICOTROPIN RELEASING FACTOR INHIBITORS
VRUDHULA, VIVEKANANDA, M, DUBOWCHIK, GENE, M, HAN, XIAOJUN, ZUEV, DMITRY, DASGUPTA, BIRESHWAR, MICHNE, JODI, A
Year of Publication 12.11.2003
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Year of Publication 12.11.2003
Patent
Imidazolyl-derivater som kortikotropin-frigjörende faktor inhibitorer
DUBOWCHIK, GENE MICHAEL, VRUDHULA, VIVEKANANDA M, HAN, XIAOJUN, ZUEV, DIMITRY, DASGUPTA, BIRESHWAR, MICHNE, JODI A
Year of Publication 22.09.2003
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Year of Publication 22.09.2003
Patent
Ímídazólýl afleiður sem tálmar kortíkótrópíns losunarþátts
GENE M. DUBOWCHIK, BIRESHWAR DASGUPTA, JODI A. MICHNE, XIAOJUN HAN, DMITRY ZUEV, VIVEKANANDA M. VRUDHULA
Year of Publication 24.07.2003
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Year of Publication 24.07.2003
Patent
Imidazolyl derivatives as corticotropin releasing factor inhibitors
HAN XIAOJUN, VRUDHULA VIVEKANANDA M, MICHNE JODI A, DASGUPTA BIRESHWAR, ZUEV DMITRY, DUBOWCHIK GENE M
Year of Publication 05.12.2002
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Year of Publication 05.12.2002
Patent