Pharmacological characterization of 1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid (JNJ-42041935), a potent and selective hypoxia-inducible factor prolyl hydroxylase inhibitor
Barrett, Terrance D, Palomino, Heather L, Brondstetter, Theresa I, Kanelakis, Kimon C, Wu, Xiaodong, Haug, Peter V, Yan, Wen, Young, Andrew, Hua, Hong, Hart, Juliet C, Tran, Da-Thao, Venkatesan, Hariharan, Rosen, Mark D, Peltier, Hillary M, Sepassi, Kia, Rizzolio, Michele C, Bembenek, Scott D, Mirzadegan, Tara, Rabinowitz, Michael H, Shankley, Nigel P
Published in Molecular pharmacology (01.06.2011)
Published in Molecular pharmacology (01.06.2011)
Get full text
Journal Article
Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease
Leonard, Kristi A, Madge, Lisa A, Krawczuk, Paul J, Wang, Aihua, Kreutter, Kevin D, Bacani, Genesis M, Chai, Wenying, Smith, Russell C, Tichenor, Mark S, Harris, Michael C, Malaviya, Ravi, Seierstad, Mark, Johnson, Marguerite E, Venable, Jennifer D, Kim, Suzie, Hirst, Gavin C, Mathur, Ashok S, Rao, Tadimeti S, Edwards, James P, Rizzolio, Michele C, Koudriakova, Tatiana
Published in Journal of medicinal chemistry (26.03.2020)
Published in Journal of medicinal chemistry (26.03.2020)
Get full text
Journal Article
Characterization of a Robust Enzymatic Assay for Inhibitors of 2-Oxoglutarate-Dependent Hydroxylases
Kanelakis, Kimon C., Palomino, Heather L., Li, Lina, Wu, Jiejun, Yan, Wen, Rosen, Mark D., Rizzolio, Michele C., Trivedi, Meghana, Morton, Magda F., Yang, Young, Venkatesan, Hariharan, Rabinowitz, Michael H., Shankley, Nigel P., Barrett, Terrance D.
Published in Journal of biomolecular screening (01.07.2009)
Published in Journal of biomolecular screening (01.07.2009)
Get full text
Journal Article
JNJ-26070109 [(R)4-bromo-N-[1-(2,4-difluoro-phenyl)-ethyl]-2-(quinoxaline-5-sulfonylamino)-benzamide]: a novel, potent, and selective cholecystokinin 2 receptor antagonist with good oral bioavailability
Morton, Magda F, Barrett, Terrance D, Freedman, Jamie, Li, Lina, Rizzolio, Michele C, Prendergast, Clodagh E, Wu, Xiaodong, Moreno, Veronica, Pyati, Jayashree, Figueroa, Katherine, Cagnon, Laurence, Lagaud, Guy, Ver Donck, Luc, Ghoos, Etienne, Allison, Brett, Rabinowitz, Michael H, Shankley, Nigel P
Published in The Journal of pharmacology and experimental therapeutics (01.07.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2011)
Get full text
Journal Article
Identification and Optimization of Anthranilic Sulfonamides as Novel, Selective Cholecystokinin-2 Receptor Antagonists
Allison, Brett D, Phuong, Victor K, McAtee, Laura C, Rosen, Mark, Morton, Magda, Prendergast, Clodagh, Barrett, Terry, Lagaud, Guy, Freedman, Jamie, Li, Lina, Wu, Xiaodong, Venkatesan, Hariharan, Pippel, Marna, Woods, Craig, Rizzolio, Michèle C, Hack, Michael, Hoey, Kenway, Deng, Xiaohu, King, Christopher, Shankley, Nigel P, Rabinowitz, Michael H
Published in Journal of medicinal chemistry (19.10.2006)
Published in Journal of medicinal chemistry (19.10.2006)
Get full text
Journal Article
Design of Selective and Soluble Inhibitors of Tumor Necrosis Factor-α Converting Enzyme (TACE)
Rabinowitz, Michael H, Andrews, Robert C, Becherer, J. David, Bickett, D. Mark, Bubacz, Dulce G, Conway, James G, Cowan, David J, Gaul, Micheal, Glennon, Kimberly, Lambert, Millard H, Leesnitzer, M. Anthony, McDougald, Darryl L, Moss, Marcia L, Musso, David L, Rizzolio, Michele C
Published in Journal of medicinal chemistry (22.11.2001)
Published in Journal of medicinal chemistry (22.11.2001)
Get full text
Journal Article
Pharmacological Characterization of 1-(5-Chloro-6-(trifluoromethoxy)-1 H -benzoimidazol-2-yl)-1 H -pyrazole-4-carboxylic Acid (JNJ-42041935), a Potent and Selective Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor
Barrett, Terrance D., Palomino, Heather L., Brondstetter, Theresa I., Kanelakis, Kimon C., Wu, Xiaodong, Haug, Peter V., Yan, Wen, Young, Andrew, Hua, Hong, Hart, Juliet C., Tran, Da-Thao, Venkatesan, Hariharan, Rosen, Mark D., Peltier, Hillary M., Sepassi, Kia, Rizzolio, Michele C., Bembenek, Scott D., Mirzadegan, Tara, Rabinowitz, Michael H., Shankley, Nigel P.
Published in Molecular pharmacology (01.06.2011)
Published in Molecular pharmacology (01.06.2011)
Get full text
Journal Article
Small molecule inhibitors of the JAK family of kinases
WANG, Aihua, TICHENOR, Mark S, KOUDRIAKOVA, Tatiana, RIZZOLIO, Michele C, SMITH, Russell C, KREUTTER, Kevin D, LEONARD, Kristi
Year of Publication 05.10.2023
Get full text
Year of Publication 05.10.2023
Patent