Search Results - "Michel C. MAILLARD" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Evaluation of 5‑(Trifluoromethyl)-1,2,4-oxadiazole-Based Class IIa HDAC Inhibitors for Huntington’s Disease

Evaluation of 5‑(Trifluoromethyl)-1,2,4-oxadiazole-Based Class IIa HDAC Inhibitors for Huntington’s Disease

by Stott, Andrew J, Maillard, Michel C, Beaumont, Vahri, Allcock, David, Aziz, Omar, Borchers, Alexander H, Blackaby, Wesley, Breccia, Perla, Creighton-Gutteridge, Gillian, Haughan, Alan F, Jarvis, Rebecca E, Luckhurst, Christopher A, Matthews, Kim L, McAllister, George, Pollack, Scott, Saville-Stones, Elizabeth, Van de Poël, Amanda J, Vater, Huw D, Vann, Julie, Williams, Rachel, Yates, Dawn, Muñoz-Sanjuán, Ignacio, Dominguez, Celia
Published in ACS medicinal chemistry letters (11.03.2021)

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Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington’s Disease

Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington’s Disease

by Ladduwahetty, Tammy, Lee, Matthew R., Maillard, Michel C., Cachope, Roger, Todd, Daniel, Barnes, Michael, Beaumont, Vahri, Chauhan, Alka, Gallati, Caroline, Haughan, Alan F., Kempf, Georg, Luckhurst, Christopher A., Matthews, Kim, McAllister, George, Mitchell, Philip, Patel, Hiral, Rose, Mark, Saville-Stones, Elizabeth, Steinbacher, Stefan, Stott, Andrew J., Thatcher, Emma, Tierney, Jason, Urbonas, Liudvikas, Munoz-Sanjuan, Ignacio, Dominguez, Celia
Published in Journal of medicinal chemistry (28.07.2022)

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Exploiting differences in caspase-2 and -3 S₂ subsites for selectivity: Structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors

Exploiting differences in caspase-2 and -3 S₂ subsites for selectivity: Structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors

by Maillard, Michel C, Brookfield, Frederick A, Courtney, Stephen M, Eustache, Florence M, Gemkow, Mark J, Handel, Rebecca K, Johnson, Laura C, Johnson, Peter D, Kerry, Mark A, Krieger, Florian, Meniconi, Mirco, Muñoz-Sanjuán, Ignacio, Palfrey, Jordan J, Park, Hyunsun, Schaertl, Sabine, Taylor, Malcolm G, Weddell, Derek, Dominguez, Celia
Published in Bioorganic & medicinal chemistry (01.10.2011)

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Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor

Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor

by Luckhurst, Christopher A., Aziz, Omar, Beaumont, Vahri, Bürli, Roland W., Breccia, Perla, Maillard, Michel C., Haughan, Alan F., Lamers, Marieke, Leonard, Phil, Matthews, Kim L., Raphy, Gilles, Stott, Andrew J., Munoz-Sanjuan, Ignacio, Thomas, Beth, Wall, Michael, Wishart, Grant, Yates, Dawn, Dominguez, Celia
Published in Bioorganic & medicinal chemistry letters (01.01.2019)

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Design, Synthesis, and Crystal Structure of Hydroxyethyl Secondary Amine-Based Peptidomimetic Inhibitors of Human β-Secretase

Design, Synthesis, and Crystal Structure of Hydroxyethyl Secondary Amine-Based Peptidomimetic Inhibitors of Human β-Secretase

by Maillard, Michel C, Hom, Roy K, Benson, Timothy E, Moon, Joseph B, Mamo, Shumeye, Bienkowski, Michael, Tomasselli, Alfredo G, Woods, Danielle D, Prince, D. Bryan, Paddock, Donna J, Emmons, Thomas L, Tucker, John A, Dappen, Michael S, Brogley, Louis, Thorsett, Eugene D, Jewett, Nancy, Sinha, Sukanto, John, Varghese
Published in Journal of medicinal chemistry (22.02.2007)

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A label-free LC/MS/MS-based enzymatic activity assay for the detection of genuine caspase inhibitors and SAR development

A label-free LC/MS/MS-based enzymatic activity assay for the detection of genuine caspase inhibitors and SAR development

by Maillard, Michel C, Dominguez, Celia, Gemkow, Mark J, Krieger, Florian, Park, Hyunsun, Schaertl, Sabine, Winkler, Dirk, Muñoz-Sanjuán, Ignacio
Published in Journal of biomolecular screening (01.09.2013)

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Design, Synthesis, and Pharmacological Evaluation of Conformationally Constrained Analogues of N,N‘-Diaryl- and N-Aryl-N-aralkylguanidines as Potent Inhibitors of Neuronal Na+ Channels

Design, Synthesis, and Pharmacological Evaluation of Conformationally Constrained Analogues of N,N‘-Diaryl- and N-Aryl-N-aralkylguanidines as Potent Inhibitors of Neuronal Na+ Channels

by Maillard, Michel C, Perlman, Michael E, Amitay, Oved, Baxter, Deborah, Berlove, David, Connaughton, Sonia, Fischer, James B, Guo, Jun Qing, Hu, Lain-Yen, McBurney, Robert N, Nagy, Peter I, Subbarao, Katragadda, Yost, Elizabeth A, Zhang, Lu, Durant, Graham J
Published in Journal of medicinal chemistry (30.07.1998)

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Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class Ha histone deacetylase inhibitor

Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class Ha histone deacetylase inhibitor

by Luckhurst, Christopher A., Aziz, Omar, Beaumont, Vahri, Burli, Roland W., Breccia, Perla, Maillard, Michel C., Haughan, Alan F., Lamers, Marieke, Leonard, Phil, Matthews, Kim L., Raphy, Gilles, Stott, Andrew J., Munoz-Sanjuan, Ignacio, Thomas, Beth, Wall, Michael, Wishart, Grant, Yates, Dawn, Dominguez, Celia
Published in Bioorganic & medicinal chemistry letters (01.01.2019)

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Evaluation of 5-(Trifluoromethyl)-1,2,4-oxadiazole-Based Class Ila HDAC Inhibitors for Huntington's Disease

Evaluation of 5-(Trifluoromethyl)-1,2,4-oxadiazole-Based Class Ila HDAC Inhibitors for Huntington's Disease

by Stott, Andrew J., Maillard, Michel C., Beaumont, Vahri, Allcock, David, Aziz, Omar, Borchers, Alexander H., Blackaby, Wesley, Breccia, Perla, Creighton-Gutteridge, Gillian, Haughan, Alan F., Jarvis, Rebecca E., Luckhurst, Christopher A., Matthews, Kim L., McAllister, George, Pollack, Scott, Saville-Stones, Elizabeth, Van de Poel, Amanda J., Vater, Huw D., Vann, Julie, Williams, Rachel, Yates, Dawn, Munoz-Sanjuan, Ignacio, Dominguez, Celia
Published in ACS medicinal chemistry letters (11.03.2021)

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Exploiting differences in caspase-2 and -3 S 2 subsites for selectivity: Structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors

Exploiting differences in caspase-2 and -3 S 2 subsites for selectivity: Structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors

by Maillard, Michel C., Brookfield, Frederick A., Courtney, Stephen M., Eustache, Florence M., Gemkow, Mark J., Handel, Rebecca K., Johnson, Laura C., Johnson, Peter D., Kerry, Mark A., Krieger, Florian, Meniconi, Mirco, Muñoz-Sanjuán, Ignacio, Palfrey, Jordan J., Park, Hyunsun, Schaertl, Sabine, Taylor, Malcolm G., Weddell, Derek, Dominguez, Celia
Published in Bioorganic & medicinal chemistry (01.10.2011)

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Journal Article

Exploiting differences in caspase-2 and -3 S sub(2 subsites for selectivity: Structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors)

Exploiting differences in caspase-2 and -3 S sub(2 subsites for selectivity: Structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors)

by Maillard, Michel C, Brookfield, Frederick A, Courtney, Stephen M, Eustache, Florence M, Gemkow, Mark J, Handel, Rebecca K, Johnson, Laura C, Johnson, Peter D, Kerry, Mark A, Krieger, Florian, Meniconi, Mirco, Munoz-Sanjuan, Ignacio, Palfrey, Jordan J, Park, Hyunsun, Schaertl, Sabine, Taylor, Malcolm G, Weddell, Derek, Dominguez, Celia
Published in Bioorganic & medicinal chemistry (01.10.2011)

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Journal Article

RHO KINASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF

RHO KINASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF

by LEE, Matthew R, BARNES, Michael, DOMINGUEZ, Celia, MAILLARD, Michel C, LADDUWAHETTY, Tammy, LUCKHURST, Christopher A, STOTT, Andrew J, TIERNEY, Jason, HAUGHAN, Alan F
Year of Publication 28.02.2024

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Patent

RHO KINASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF

RHO KINASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF

by LEE, Matthew R, BARNES, Michael, DOMINGUEZ, Celia, MAILLARD, Michel C, LADDUWAHETTY, Tammy, LUCKHURST, Christopher A, STOTT, Andrew J, TIERNEY, Jason, HAUGHAN, Alan F
Year of Publication 28.02.2024

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Patent

HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF

HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF

by HAUGHAN, ALAN F, STOTT, ANDREW J, WISHART, GRANT, VAN DE POEL, AMANDA, DOMINGUEZ, CELIA, WALL, MICHAEL, BRECCIA, PERLA, MAILLARD, MICHEL C, JARVIS, REBECCA E, LUCKHURST, CHRISTOPHER A, SAVILLE-STONES, ELIZABETH A
Year of Publication 09.01.2024

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Patent

RHO KINASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF

RHO KINASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF

by Tierney, Jason, Barnes, Michael, Ladduwahetty, Tammy, Stott, Andrew J, Haughan, Alan F, Maillard, Michel C, Lee, Matthew R, Luckhurst, Christopher A, Dominguez, Celia
Year of Publication 08.12.2022

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Patent

HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF

HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF

by HAUGHAN, ALAN F, STOTT, ANDREW J, WISHART, GRANT, VAN DE POEL, AMANDA, DOMINGUEZ, CELIA, WALL, MICHAEL, BRECCIA, PERLA, MAILLARD, MICHEL C, JARVIS, REBECCA E, LUCKHURST, CHRISTOPHER A, SAVILLE-STONES, ELIZABETH A
Year of Publication 26.09.2023

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Patent

Histone deacetylase inhibitors and compositions and methods of use thereof

Histone deacetylase inhibitors and compositions and methods of use thereof

by Perla BRECCIA, Christopher A. LUCKHURST, Elizabeth A. SAVILLE-STONES, Celia DOMINGUEZ, Michael WALL, Alan F. HAUGHAN, Amanda VAN DE POEL, Grant WISHART, Rebecca E. JARVIS, Andrew J. STOTT, Michel C. MAILLARD
Year of Publication 01.07.2023

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Patent

Histone deacetylase inhibitors and compositions and methods of use thereof

Histone deacetylase inhibitors and compositions and methods of use thereof

by Christopher A. LUCKHURST, Elizabeth A. SAVILLE-STONES, Perla BRECCIA, Celia DOMINGUEZ, Michael WALL, Alan F. HAUGHAN, Amanda VAN DE POEL, Grant WISHART, Andrew J. STOTT, Rebecca E. JARVIS, Michel C. MAILLARD
Year of Publication 01.07.2023

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Patent

RHO KINASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF

RHO KINASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF

by LEE, Matthew R, BARNES, Michael, DOMINGUEZ, Celia, MAILLARD, Michel C, LADDUWAHETTY, Tammy, LUCKHURST, Christopher A, STOTT, Andrew J, TIERNEY, Jason, HAUGHAN, Alan F
Year of Publication 04.05.2022

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Patent

Histone deacetylase inhibitors and compositions and methods of use thereof

Histone deacetylase inhibitors and compositions and methods of use thereof

by Perla BRECCIA, Christopher A. LUCKHURST, Elizabeth A. SAVILLE-STONES, Celia DOMINGUEZ, Michael WALL, Alan F. HAUGHAN, Amanda VAN DE POEL, Grant WISHART, Rebecca E. JARVIS, Andrew J. STOTT, Michel C. MAILLARD
Year of Publication 01.03.2023

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Patent