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Published in eLife (22.05.2015)
Published in eLife (22.05.2015)
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Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic
Chin, Emily N, Yu, Chenguang, Vartabedian, Vincent F, Jia, Ying, Kumar, Manoj, Gamo, Ana M, Vernier, William, Ali, Sabrina H, Kissai, Mildred, Lazar, Daniel C, Nguyen, Nhan, Pereira, Laura E, Benish, Brent, Woods, Ashley K, Joseph, Sean B, Chu, Alan, Johnson, Kristen A, Sander, Philipp N, Martínez-Peña, Francisco, Hampton, Eric N, Young, Travis S, Wolan, Dennis W, Chatterjee, Arnab K, Schultz, Peter G, Petrassi, H Michael, Teijaro, John R, Lairson, Luke L
Published in Science (American Association for the Advancement of Science) (21.08.2020)
Published in Science (American Association for the Advancement of Science) (21.08.2020)
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The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis
Janes, Jeff, Young, Megan E., Chen, Emily, Rogers, Nicole H., Burgstaller-Muehlbacher, Sebastian, Hughes, Laura D., Love, Melissa S., Hull, Mitchell V., Kuhen, Kelli L., Woods, Ashley K., Joseph, Sean B., Petrassi, H. Michael, McNamara, Case W., Tremblay, Matthew S., Su, Andrew I., Schultz, Peter G., Chatterjee, Arnab K.
Published in Proceedings of the National Academy of Sciences - PNAS (16.10.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (16.10.2018)
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Suppressors of Superoxide-H2O2 Production at Site IQ of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury
Brand, Martin D., Goncalves, Renata L.S., Orr, Adam L., Vargas, Leonardo, Gerencser, Akos A., Borch Jensen, Martin, Wang, Yves T., Melov, Simon, Turk, Carolina N., Matzen, Jason T., Dardov, Victoria J., Petrassi, H. Michael, Meeusen, Shelly L., Perevoshchikova, Irina V., Jasper, Heinrich, Brookes, Paul S., Ainscow, Edward K.
Published in Cell metabolism (11.10.2016)
Published in Cell metabolism (11.10.2016)
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Pharmacological and genetic activation of cAMP synthesis disrupts cholesterol utilization in Mycobacterium tuberculosis
Wilburn, Kaley M, Montague, Christine R, Qin, Bo, Woods, Ashley K, Love, Melissa S, McNamara, Case W, Schultz, Peter G, Southard, Teresa L, Huang, Lu, Petrassi, H Michael, VanderVen, Brian C
Published in PLoS pathogens (01.02.2022)
Published in PLoS pathogens (01.02.2022)
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The Tuberculosis Drug Accelerator at year 10: what have we learned?
Aldridge, Bree B., Barros-Aguirre, David, Barry, Clifton E., Bates, Robert H., Berthel, Steven J., Boshoff, Helena I., Chibale, Kelly, Chu, Xin-Jie, Cooper, Christopher B., Dartois, Véronique, Duncan, Ken, Fotouhi, Nader, Gusovsky, Fabian, Hipskind, Philip A., Kempf, Dale J., Lelièvre, Joël, Lenaerts, Anne J., McNamara, Case W., Mizrahi, Valerie, Nathan, Carl, Olsen, David B., Parish, Tanya, Petrassi, H. Michael, Pym, Alexander, Rhee, Kyu Y., Robertson, Gregory T., Rock, Jeremy Michael, Rubin, Eric J., Russell, Betsy, Russell, David G., Sacchettini, James C., Schnappinger, Dirk, Schrimpf, Michael, Upton, Anna M., Warner, Peter, Wyatt, Paul Graham, Yuan, Ying
Published in Nature medicine (01.08.2021)
Published in Nature medicine (01.08.2021)
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Iron limitation in M. tuberculosis has broad impact on central carbon metabolism
Theriault, Monique E., Pisu, Davide, Wilburn, Kaley M., Lê-Bury, Gabrielle, MacNamara, Case W., Michael Petrassi, H., Love, Melissa, Rock, Jeremy M., VanderVen, Brian C., Russell, David G.
Published in Communications biology (09.07.2022)
Published in Communications biology (09.07.2022)
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Discovery, Optimization, and Biological Evaluation of 5‑(2-(Trifluoromethyl)phenyl)indazoles as a Novel Class of Transient Receptor Potential A1 (TRPA1) Antagonists
Rooney, Lisa, Vidal, Agnès, D’Souza, Anne-Marie, Devereux, Nick, Masick, Brian, Boissel, Valerie, West, Ryan, Head, Victoria, Stringer, Rowan, Lao, Jianmin, Petrus, Matt J, Patapoutian, Ardem, Nash, Mark, Stoakley, Natalie, Panesar, Moh, Verkuyl, J. Martin, Schumacher, Andrew M, Petrassi, H. Michael, Tully, David C
Published in Journal of medicinal chemistry (26.06.2014)
Published in Journal of medicinal chemistry (26.06.2014)
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Suppressors of superoxide production from mitochondrial complex III
Orr, Adam L, Vargas, Leonardo, Turk, Carolina N, Baaten, Janine E, Matzen, Jason T, Dardov, Victoria J, Attle, Stephen J, Li, Jing, Quackenbush, Douglas C, Goncalves, Renata L S, Perevoshchikova, Irina V, Petrassi, H Michael, Meeusen, Shelly L, Ainscow, Edward K, Brand, Martin D
Published in Nature chemical biology (14.09.2015)
Published in Nature chemical biology (14.09.2015)
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Short-course quinazoline drug treatments are effective in the Litomosoides sigmodontis and Brugia pahangi jird models
Hübner, Marc P., Gunderson, Emma, Vogel, Ian, Bulman, Christina A., Lim, K.C., Koschel, Marianne, Ehrens, Alexandra, Frohberger, Stefan J., Fendler, Martina, Tricoche, Nancy, Voronin, Denis, Steven, Andrew, Chi, Victor, Bakowski, Malina A., Woods, Ashley K., Petrassi, H. Michael, McNamara, Case W., Beerntsen, Brenda, Chappell, Laura, Sullivan, William, Taylor, Mark J., Turner, Joseph D., Hoerauf, Achim, Lustigman, Sara, Sakanari, Judy A.
Published in International journal for parasitology -- drugs and drug resistance (01.04.2020)
Published in International journal for parasitology -- drugs and drug resistance (01.04.2020)
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Suppressors of Superoxide-H 2 O 2 Production at Site I Q of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury
Brand, Martin D, Goncalves, Renata L S, Orr, Adam L, Vargas, Leonardo, Gerencser, Akos A, Borch Jensen, Martin, Wang, Yves T, Melov, Simon, Turk, Carolina N, Matzen, Jason T, Dardov, Victoria J, Petrassi, H Michael, Meeusen, Shelly L, Perevoshchikova, Irina V, Jasper, Heinrich, Brookes, Paul S, Ainscow, Edward K
Published in Cell metabolism (01.10.2016)
Published in Cell metabolism (01.10.2016)
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Bisaryloxime Ethers as Potent Inhibitors of Transthyretin Amyloid Fibril Formation
Johnson, Steven M, Petrassi, H. Michael, Palaninathan, Satheesh K, Mohamedmohaideen, Nilofar N, Purkey, Hans E, Nichols, Christopher, Chiang, Kyle P, Walkup, Traci, Sacchettini, James C, Sharpless, K. Barry, Kelly, Jeffery W
Published in Journal of medicinal chemistry (10.03.2005)
Published in Journal of medicinal chemistry (10.03.2005)
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Discovery and SAR of a series of 4,6-diamino-1,3,5-triazin-2-ol as novel non-nucleoside reverse transcriptase inhibitors of HIV-1
Liu, Bin, Lee, Younghee, Zou, Jinming, Petrassi, H. Michael, Joseph, Rhoda W., Chao, Wenchun, Michelotti, Enrique L., Bukhtiyarova, Marina, Springman, Eric B., Dorsey, Bruce D.
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
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Potent and Selective Structure-Based Dibenzofuran Inhibitors of Transthyretin Amyloidogenesis: Kinetic Stabilization of the Native State
Petrassi, H. Michael, Johnson, Steven M, Purkey, Hans E, Chiang, Kyle P, Walkup, Traci, Jiang, Xin, Powers, Evan T, Kelly, Jeffery W
Published in Journal of the American Chemical Society (11.05.2005)
Published in Journal of the American Chemical Society (11.05.2005)
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Pharmacological stabilization of the native state of full-length immunoglobulin light chains to treat light chain amyloidosis
Yan, Nicholas L., Morgan, Gareth J., Petrassi, H. Michael, Wilson, Ian A., Kelly, Jeffery W.
Published in Current opinion in chemical biology (01.08.2023)
Published in Current opinion in chemical biology (01.08.2023)
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Suppressors of superoxide production from mitochondrial complex III
Orr, Adam L, Vargas, Leonardo, Turk, Carolina N, Baaten, Janine E, Matzen, Jason T, Dardov, Victoria J, Attle, Stephen J, Li, Jing, Quackenbush, Douglas C, Goncalves, Renata L S, Perevoshchikova, Irina V, Petrassi, H Michael, Meeusen, Shelly L, Ainscow, Edward K, Brand, Martin D
Published in Nature chemical biology (01.11.2015)
Published in Nature chemical biology (01.11.2015)
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Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design
Yan, Nicholas L, Santos-Martins, Diogo, Nair, Reji, Chu, Alan, Wilson, Ian A, Johnson, Kristen A, Forli, Stefano, Morgan, Gareth J, Petrassi, H. Michael, Kelly, Jeffery W
Published in Journal of medicinal chemistry (13.05.2021)
Published in Journal of medicinal chemistry (13.05.2021)
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Targeted Disruption of Myc–Max Oncoprotein Complex by a Small Molecule
Choi, Seung H, Mahankali, Madhupriya, Lee, Sang Jun, Hull, Mitchell, Petrassi, H. Michael, Chatterjee, Arnab K, Schultz, Peter G, Jones, Katherine A, Shen, Weijun
Published in ACS chemical biology (17.11.2017)
Published in ACS chemical biology (17.11.2017)
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Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6‑Azaindole Derivative GNF2133
Liu, Yahu A, Jin, Qihui, Zou, Yefen, Ding, Qiang, Yan, Shanshan, Wang, Zhicheng, Hao, Xueshi, Nguyen, Bao, Zhang, Xiaoyue, Pan, Jianfeng, Mo, Tingting, Jacobsen, Kate, Lam, Thanh, Wu, Tom Y.-H, Petrassi, H. Michael, Bursulaya, Badry, DiDonato, Michael, Gordon, W. Perry, Liu, Bo, Baaten, Janine, Hill, Robert, Nguyen-Tran, Vân, Qiu, Minhua, Zhang, You-Qing, Kamireddy, Anwesh, Espinola, Sheryll, Deaton, Lisa, Ha, Sukwon, Harb, George, Jia, Yong, Li, Jing, Shen, Weijun, Schumacher, Andrew M, Colman, Karyn, Glynne, Richard, Pan, Shifeng, McNamara, Peter, Laffitte, Bryan, Meeusen, Shelly, Molteni, Valentina, Loren, Jon
Published in Journal of medicinal chemistry (26.03.2020)
Published in Journal of medicinal chemistry (26.03.2020)
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Synthesis and structure–activity relationships of aryl fluorosulfate-based inhibitors as novel antitubercular agents
Yang, Baiyuan, Sukheja, Paridhi, Qin, Bo, Li, Gencheng, Bare, Grant A.L., Cascioferro, Alessandro, Love, Melissa S., Petrassi, H. Michael, Sharpless, K. Barry, McNamara, Case W., Chatterjee, Arnab K.
Published in Bioorganic & medicinal chemistry letters (15.01.2024)
Published in Bioorganic & medicinal chemistry letters (15.01.2024)
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