The updated biology of hypoxia-inducible factor
Greer, Samantha N, Metcalf, Julie L, Wang, Yi, Ohh, Michael
Published in The EMBO journal (30.05.2012)
Published in The EMBO journal (30.05.2012)
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Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis
Bunda, Severa, Burrell, Kelly, Heir, Pardeep, Zeng, Lifan, Alamsahebpour, Amir, Kano, Yoshihito, Raught, Brian, Zhang, Zhong-Yin, Zadeh, Gelareh, Ohh, Michael
Published in Nature communications (30.11.2015)
Published in Nature communications (30.11.2015)
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HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease
Tarade, Daniel, Robinson, Claire M., Lee, Jeffrey E., Ohh, Michael
Published in Nature communications (22.08.2018)
Published in Nature communications (22.08.2018)
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Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation
Kano, Yoshihito, Gebregiworgis, Teklab, Marshall, Christopher B., Radulovich, Nikolina, Poon, Betty P. K., St-Germain, Jonathan, Cook, Jonathan D., Valencia-Sama, Ivette, Grant, Benjamin M. M., Herrera, Silvia Gabriela, Miao, Jinmin, Raught, Brian, Irwin, Meredith S., Lee, Jeffrey E., Yeh, Jen Jen, Zhang, Zhong-Yin, Tsao, Ming-Sound, Ikura, Mitsuhiko, Ohh, Michael
Published in Nature communications (15.01.2019)
Published in Nature communications (15.01.2019)
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PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells
Liotti, Federica, Kumar, Narender, Prevete, Nella, Marotta, Maria, Sorriento, Daniela, Ieranò, Caterina, Ronchi, Andrea, Marino, Federica Zito, Moretti, Sonia, Colella, Renato, Puxeddu, Efiso, Paladino, Simona, Kano, Yoshihito, Ohh, Michael, Scala, Stefania, Melillo, Rosa Marina
Published in Journal of experimental & clinical cancer research (07.01.2021)
Published in Journal of experimental & clinical cancer research (07.01.2021)
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Src promotes GTPase activity of Ras via tyrosine 32 phosphorylation
Bunda, Severa, Heir, Pardeep, Srikumar, Tharan, Cook, Jonathan D, Burrell, Kelly, Kano, Yoshihito, Lee, Jeffrey E, Zadeh, Gelareh, Raught, Brian, Ohh, Michael
Published in Proceedings of the National Academy of Sciences - PNAS (09.09.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (09.09.2014)
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Journal Article
The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors
Gebregiworgis, Teklab, Kano, Yoshihito, St-Germain, Jonathan, Radulovich, Nikolina, Udaskin, Molly L., Mentes, Ahmet, Huang, Richard, Poon, Betty P. K., He, Wenguang, Valencia-Sama, Ivette, Robinson, Claire M., Huestis, Melissa, Miao, Jinmin, Yeh, Jen Jen, Zhang, Zhong-Yin, Irwin, Meredith S., Lee, Jeffrey E., Tsao, Ming-Sound, Raught, Brian, Marshall, Christopher B., Ohh, Michael, Ikura, Mitsuhiko
Published in Nature communications (01.11.2021)
Published in Nature communications (01.11.2021)
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Journal Article
Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor–mediated upregulation of caveolin-1
Wang, Yi, Roche, Olga, Xu, Chaoying, Moriyama, Eduardo H, Heir, Pardeep, Chung, Jacky, Roos, Frederik C, Chen, Yonghong, Finak, Greg, Milosevic, Michael, Wilson, Brian C, Teh, Bin Tean, Park, Morag, Irwin, Meredith S, Ohh, Michael
Published in Proceedings of the National Academy of Sciences - PNAS (27.03.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (27.03.2012)
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Journal Article
Functional Importance of Dicer Protein in the Adaptive Cellular Response to Hypoxia
Ho, J.J.David, Metcalf, Julie L., Yan, Matthew S., Turgeon, Paul J., Wang, Jenny Jing, Chalsev, Maria, Petruzziello-Pellegrini, Tania N., Tsui, Albert K.Y., He, Jeff Z., Dhamko, Helena, Man, H.S.Jeffrey, Robb, G.Brett, Teh, Bin T., Ohh, Michael, Marsden, Philip A.
Published in The Journal of biological chemistry (17.08.2012)
Published in The Journal of biological chemistry (17.08.2012)
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Journal Article
Hypoxia and viral infectious diseases
Huang, Richard, Huestis, Melissa, Gan, Esther Shuyi, Ooi, Eng Eong, Ohh, Michael
Published in JCI insight (08.04.2021)
Published in JCI insight (08.04.2021)
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Journal Article
Consequences of VHL Loss on Global DNA Methylome
Robinson, Claire M., Lefebvre, Francois, Poon, Betty P., Bousard, Aurelie, Fan, Xiaojun, Lathrop, Mark, Tost, Jorg, Kim, William Y., Riazalhosseini, Yasser, Ohh, Michael
Published in Scientific reports (20.02.2018)
Published in Scientific reports (20.02.2018)
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Journal Article
Hypoxia-inducible Expression of a Natural cis-Antisense Transcript Inhibits Endothelial Nitric-oxide Synthase
Fish, Jason E., Matouk, Charles C., Yeboah, Elizabeth, Bevan, Sian C., Khan, Mukarram, Patil, Kedar, Ohh, Michael, Marsden, Philip A.
Published in The Journal of biological chemistry (25.05.2007)
Published in The Journal of biological chemistry (25.05.2007)
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Journal Article
VHL Promotes E2 Box-Dependent E-Cadherin Transcription by HIF-Mediated Regulation of SIP1 and Snail
Evans, Andrew J., Russell, Ryan C., Roche, Olga, Burry, T. Nadine, Fish, Jason E., Chow, Vinca W. K., Kim, William Y., Saravanan, Arthy, Maynard, Mindy A., Gervais, Michelle L., Sufan, Roxana I., Roberts, Andrew M., Wilson, Leigh A., Betten, Mark, Vandewalle, Cindy, Berx, Geert, Marsden, Philip A., Irwin, Meredith S., Teh, Bin T., Jewett, Michael A. S., Ohh, Michael
Published in Molecular and Cellular Biology (01.01.2007)
Published in Molecular and Cellular Biology (01.01.2007)
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Journal Article
Deficiency in PHD2-mediated hydroxylation of HIF2α underlies Pacak-Zhuang syndrome
Ferens, Fraser G., Taber, Cassandra C., Stuart, Sarah, Hubert, Mia, Tarade, Daniel, Lee, Jeffrey E., Ohh, Michael
Published in Communications biology (28.02.2024)
Published in Communications biology (28.02.2024)
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