Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome
Zhang, Hongbing, Pao, Lily I., Zhou, Aileen, Brace, Arthur D., Halenbeck, Robert, Hsu, Amy W., Bray, Thomas L., Hestir, Kevin, Bosch, Elizabeth, Lee, Ernestine, Wang, Gang, Liu, Haixia, Wong, Brian R., Kavanaugh, W. Michael, Williams, Lewis T.
Published in Proceedings of the National Academy of Sciences - PNAS (04.11.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (04.11.2014)
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A Probody T Cell-Engaging Bispecific Antibody Targeting EGFR and CD3 Inhibits Colon Cancer Growth with Limited Toxicity
Boustany, Leila M, LaPorte, Sherry L, Wong, Laurie, White, Clayton, Vinod, Veena, Shen, Joel, Yu, Wendy, Koditek, David, Winter, Michael B, Moore, Stephen J, Mei, Li, Diep, Linnea, Huang, Yuanhui, Liu, Shouchun, Vasiljeva, Olga, West, Jim, Richardson, Jennifer, Irving, Bryan, Belvin, Marcia, Kavanaugh, W Michael
Published in Cancer research (Chicago, Ill.) (15.11.2022)
Published in Cancer research (Chicago, Ill.) (15.11.2022)
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Nonclinical Efficacy and Safety of CX-2029, an Anti-CD71 Probody-Drug Conjugate
Singh, Shweta, Serwer, Laura, DuPage, Amy, Elkins, Kristi, Chauhan, Niharika, Ravn, Matthew, Buchanan, Fritz, Wang, Leyu, Krimm, Michael, Wong, Ken, Sagert, Jason, Tipton, Kimberly, Moore, Stephen J, Huang, Yuanhui, Jang, Andrew, Ureno, Eric, Miller, Adam, Patrick, Sarah, Duvur, Shanti, Liu, Shouchun, Vasiljeva, Olga, Li, Yingchun, Henriques, Tracy, Badagnani, Ilaria, Jeffries, Shawn, Schleyer, Siew, Leanna, Rob, Krebber, Claus, Viswanathan, Sridhar, Desnoyers, Luc, Terrett, Jonathan, Belvin, Marcia, Morgan-Lappe, Susan, Kavanaugh, W Michael, Richardson, Jennifer
Published in Molecular cancer therapeutics (02.08.2022)
Published in Molecular cancer therapeutics (02.08.2022)
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Model-Informed Drug Development of the Masked Anti-PD-L1 Antibody CX-072
Stroh, Mark, Green, Michelle, Millard, Bjorn L, Apgar, Joshua F, Burke, John M, Garner, Will, Lu, Hong, Lyman, Susan K, Desnoyers, Luc R, Richardson, Jennifer, Hannah, Alison, Kavanaugh, W Michael
Published in Clinical pharmacology and therapeutics (01.02.2021)
Published in Clinical pharmacology and therapeutics (01.02.2021)
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Blockade of nonhormonal fibroblast growth factors by FP-1039 inhibits growth of multiple types of cancer
Harding, Thomas C, Long, Li, Palencia, Servando, Zhang, Hongbing, Sadra, Ali, Hestir, Kevin, Patil, Namrata, Levin, Anita, Hsu, Amy W, Charych, Deborah, Brennan, Thomas, Zanghi, James, Halenbeck, Robert, Marshall, Shannon A, Qin, Minmin, Doberstein, Stephen K, Hollenbaugh, Diane, Kavanaugh, W Michael, Williams, Lewis T, Baker, Kevin P
Published in Science translational medicine (27.03.2013)
Published in Science translational medicine (27.03.2013)
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In vivo imaging of protease activity by Probody therapeutic activation
Wong, Kenneth R., Menendez, Elizabeth, Craik, Charles S., Kavanaugh, W. Michael, Vasiljeva, Olga
Published in Biochimie (01.03.2016)
Published in Biochimie (01.03.2016)
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Conditional PD-1/PD-L1 Probody Therapeutics Induce Comparable Antitumor Immunity but Reduced Systemic Toxicity Compared with Traditional Anti-PD-1/PD-L1 Agents
Assi, Hikmat H, Wong, Chihunt, Tipton, Kimberly A, Mei, Li, Wong, Ken, Razo, Jennifer, Chan, Chanty, Howng, Bruce, Sagert, Jason, Krimm, Michael, Diep, Linnea, Jang, Andrew, Nguyen, Margaret T, Lapuyade, Nicole, Singson, Victoria, Villanueva, Ruth, Paidhungat, Madan, Liu, Shouchun, Rangan, Vangipuram, Vasiljeva, Olga, West, James W, Richardson, Jennifer H, Irving, Bryan, Daniel, Dylan, Belvin, Marcia, Kavanaugh, W Michael
Published in Cancer immunology research (01.12.2021)
Published in Cancer immunology research (01.12.2021)
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A Pilot Screen of a Novel Peptide Hormone Library Identified Candidate GPR83 Ligands
Sallee, Nathan A., Lee, Ernestine, Leffert, Atossa, Ramirez, Silvia, Brace, Arthur D., Halenbeck, Robert, Kavanaugh, W. Michael, Sullivan, Kathleen M. C.
Published in SLAS discovery (01.10.2020)
Published in SLAS discovery (01.10.2020)
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Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways
Klippel, Anke, Reinhard, Christoph, Kavanaugh, W. Michael, Apell, Gerald, Escobedo, Maria-Amelia, Williams, Lewis T.
Published in Molecular and Cellular Biology (01.08.1996)
Published in Molecular and Cellular Biology (01.08.1996)
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Activation of Phosphatidylinositol 3-Kinase Is Sufficient for Cell Cycle Entry and Promotes Cellular Changes Characteristic of Oncogenic Transformation
Klippel, Anke, Escobedo, Maria-Amelia, Wachowicz, Matthew S., Apell, Gerald, Brown, Timothy W., Giedlin, Martin A., Kavanaugh, W. Michael, Williams, Lewis T.
Published in Molecular and Cellular Biology (01.10.1998)
Published in Molecular and Cellular Biology (01.10.1998)
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An SH2 Domain-Containing 5′ Inositolphosphatase Inhibits Insulin-Induced GLUT4 Translocation and Growth Factor-Induced Actin Filament Rearrangement
Vollenweider, Peter, Clodi, Martin, Martin, Stuart S., Imamura, Takeshi, Kavanaugh, W. Michael, Olefsky, Jerrold M.
Published in Molecular and Cellular Biology (01.02.1999)
Published in Molecular and Cellular Biology (01.02.1999)
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Semirational design of a potent, artificial agonist of fibroblast growth factor receptors
Kavanaugh, W. Michael, Ballinger, Marcus D, Shyamala, Venkatakrishna, Forrest, Louise D, Deuter-Reinhard, Maja, Doyle, Laura V, Wang, Jian-xin, Panganiban-Lustan, Lootsee, Stratton, Jennifer R, Apell, Gerald, Winter, Jill A, Doyle, Michael V, Rosenberg, Steven
Published in Nature biotechnology (01.12.1999)
Published in Nature biotechnology (01.12.1999)
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Affinity, Specificity, and Kinetics of the Interaction of the SHC Phosphotyrosine Binding Domain with Asparagine-X-X-Phosphotyrosine Motifs of Growth Factor Receptors (∗)
Laminet, Axel A., Apell, Gerald, Conroy, Leah, Kavanaugh, W. Michael
Published in The Journal of biological chemistry (05.01.1996)
Published in The Journal of biological chemistry (05.01.1996)
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Evidence of intratumoral localization, activation, and immunomodulatory effect of CX-072, a probody therapeutic targeting PD-L1, in a phase I/II trial
Lyman, Susan, Naing, Aung, Zein, Ivan Adiputra, Howng, Bruce, Winter, Michael B., Vasiljeva, Olga, Garner, William, Zheng, Beiyao, Stroh, Mark, Kavanaugh, W Michael, Desnoyers, Luc Roland
Published in Journal of clinical oncology (20.05.2020)
Published in Journal of clinical oncology (20.05.2020)
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