Genome mining- and synthetic biology-enabled production of hypermodified peptides
Bhushan, Agneya, Egli, Peter J., Peters, Eike E., Freeman, Michael F., Piel, Jörn
Published in Nature chemistry (01.10.2019)
Published in Nature chemistry (01.10.2019)
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Journal Article
Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides
Freeman, Michael F., Gurgui, Cristian, Helf, Maximilian J., Morinaka, Brandon I., Uria, Agustinus R., Oldham, Neil J., Sahl, Hans-Georg, Matsunaga, Shigeki, Piel, Jörn
Published in Science (American Association for the Advancement of Science) (19.10.2012)
Published in Science (American Association for the Advancement of Science) (19.10.2012)
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Journal Article
Conformational rearrangements enable iterative backbone N-methylation in RiPP biosynthesis
Miller, Fredarla S., Crone, Kathryn K., Jensen, Matthew R., Shaw, Sudipta, Harcombe, William R., Elias, Mikael H., Freeman, Michael F.
Published in Nature communications (09.09.2021)
Published in Nature communications (09.09.2021)
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Journal Article
Seven enzymes create extraordinary molecular complexity in an uncultivated bacterium
Freeman, Michael F., Helf, Maximilian J., Bhushan, Agneya, Morinaka, Brandon I., Piel, Jörn
Published in Nature chemistry (28.11.2016)
Published in Nature chemistry (28.11.2016)
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Journal Article
A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds
Song, Haigang, van der Velden, Niels S, Shiran, Sally L, Bleiziffer, Patrick, Zach, Christina, Sieber, Ramon, Imani, Aman S, Krausbeck, Florian, Aebi, Markus, Freeman, Michael F, Riniker, Sereina, Künzler, Markus, Naismith, James H
Published in Science advances (01.08.2018)
Published in Science advances (01.08.2018)
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TaxiBGC: a Taxonomy-Guided Approach for Profiling Experimentally Characterized Microbial Biosynthetic Gene Clusters and Secondary Metabolite Production Potential in Metagenomes
Gupta, Vinod K, Bakshi, Utpal, Chang, Daniel, Lee, Aileen R, Davis, 3rd, John M, Chandrasekaran, Sriram, Jin, Yong-Su, Freeman, Michael F, Sung, Jaeyun
Published in mSystems (20.12.2022)
Published in mSystems (20.12.2022)
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Journal Article
Insights into cis-autoproteolysis reveal a reactive state formed through conformational rearrangement
Buller, Andrew R., Freeman, Michael F., Wright, Nathan T., Schildbach, Joel F., Townsend, Craig A.
Published in Proceedings of the National Academy of Sciences - PNAS (14.02.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (14.02.2012)
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Journal Article
Autoproteolytic Activation of ThnT Results in Structural Reorganization Necessary for Substrate Binding and Catalysis
Buller, Andrew R., Labonte, Jason W., Freeman, Michael F., Wright, Nathan T., Schildbach, Joel F., Townsend, Craig A.
Published in Journal of molecular biology (28.09.2012)
Published in Journal of molecular biology (28.09.2012)
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Journal Article
Seven enzymes create extraordinary molecular complexity in an uncultivated bacterium
Freeman, Michael F., Helf, Maximilian J., Bhushan, Agneya, Morinaka, Brandon I., Piel, Jörn
Published in Nature chemistry (01.04.2017)
Published in Nature chemistry (01.04.2017)
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Journal Article
A multiproducer microbiome generates chemical diversity in the marine sponge Mycale hentscheli
Rust, Michael, Helfrich, Eric J. N., Freeman, Michael F., Nanudorn, Pakjira, Field, Christopher M., Rückert, Christian, Kündig, Tomas, Page, Michael J., Webb, Victoria L., Kalinowski, Jörn, Sunagawa, Shinichi, Piel, Jörn
Published in Proceedings of the National Academy of Sciences - PNAS (28.04.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (28.04.2020)
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Journal Article
Distinct Autocatalytic α-N-Methylating Precursors Expand the Borosin RiPP Family of Peptide Natural Products
Quijano, Marissa R, Zach, Christina, Miller, Fredarla S, Lee, Aileen R, Imani, Aman S, Künzler, Markus, Freeman, Michael F
Published in Journal of the American Chemical Society (19.06.2019)
Published in Journal of the American Chemical Society (19.06.2019)
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Journal Article
An Orthogonal D2O‐Based Induction System that Provides Insights into d‐Amino Acid Pattern Formation by Radical S‐Adenosylmethionine Peptide Epimerases
Morinaka, Brandon I., Verest, Marjan, Freeman, Michael F., Gugger, Muriel, Piel, Jörn
Published in Angewandte Chemie International Edition (16.01.2017)
Published in Angewandte Chemie International Edition (16.01.2017)
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Journal Article
Radical S-Adenosyl Methionine Epimerases: Regioselective Introduction of Diverse D-Amino Acid Patterns into Peptide Natural Products
Morinaka, Brandon I., Vagstad, Anna L., Helf, Maximilian J., Gugger, Muriel, Kegler, Carsten, Freeman, Michael F., Bode, Helge B., Piel, Jörn
Published in Angewandte Chemie International Edition (04.08.2014)
Published in Angewandte Chemie International Edition (04.08.2014)
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Journal Article
Investigations into PoyH, a promiscuous protease from polytheonamide biosynthesis
Helf, Maximilian J., Freeman, Michael F., Piel, Jörn
Published in Journal of industrial microbiology & biotechnology (01.03.2019)
Published in Journal of industrial microbiology & biotechnology (01.03.2019)
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