Beyond the Rule of 5: Lessons Learned from AbbVie's Drugs and Compound Collection
DeGoey, David A, Chen, Hui-Ju, Cox, Philip B, Wendt, Michael D
Published in Journal of medicinal chemistry (12.04.2018)
Published in Journal of medicinal chemistry (12.04.2018)
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Discovery of an Orally Bioavailable Small Molecule Inhibitor of Prosurvival B-Cell Lymphoma 2 Proteins
Park, Cheol-Min, Bruncko, Milan, Adickes, Jessica, Bauch, Joy, Ding, Hong, Kunzer, Aaron, Marsh, Kennan C, Nimmer, Paul, Shoemaker, Alexander R, Song, Xiaohong, Tahir, Stephen K, Tse, Christin, Wang, Xilu, Wendt, Michael D, Yang, Xiufen, Zhang, Haichao, Fesik, Stephen W, Rosenberg, Saul H, Elmore, Steven W
Published in Journal of medicinal chemistry (13.11.2008)
Published in Journal of medicinal chemistry (13.11.2008)
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Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein
Petros, Andrew M., Swann, Steven L., Song, Danying, Swinger, Kerren, Park, Chang, Zhang, Haichao, Wendt, Michael D., Kunzer, Aaron R., Souers, Andrew J., Sun, Chaohong
Published in Bioorganic & medicinal chemistry letters (15.03.2014)
Published in Bioorganic & medicinal chemistry letters (15.03.2014)
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Discovery of a novel small molecule binding site of human survivin
Wendt, Michael D., Sun, Chaohong, Kunzer, Aaron, Sauer, Daryl, Sarris, Kathy, Hoff, Ethan, Yu, Liping, Nettesheim, David G., Chen, Jun, Jin, Sha, Comess, Kenneth M., Fan, Yihong, Anderson, Steven N., Isaac, Binumol, Olejniczak, Edward T., Hajduk, Philip J., Rosenberg, Saul H., Elmore, Steven W.
Published in Bioorganic & medicinal chemistry letters (01.06.2007)
Published in Bioorganic & medicinal chemistry letters (01.06.2007)
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Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy
Leverson, Joel D, Phillips, Darren C, Mitten, Michael J, Boghaert, Erwin R, Diaz, Dolores, Tahir, Stephen K, Belmont, Lisa D, Nimmer, Paul, Xiao, Yu, Ma, Xiaoju Max, Lowes, Kym N, Kovar, Peter, Chen, Jun, Jin, Sha, Smith, Morey, Xue, John, Zhang, Haichao, Oleksijew, Anatol, Magoc, Terrance J, Vaidya, Kedar S, Albert, Daniel H, Tarrant, Jacqueline M, La, Nghi, Wang, Le, Tao, Zhi-Fu, Wendt, Michael D, Sampath, Deepak, Rosenberg, Saul H, Tse, Chris, Huang, David C S, Fairbrother, Wayne J, Elmore, Steven W, Souers, Andrew J
Published in Science translational medicine (18.03.2015)
Published in Science translational medicine (18.03.2015)
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Development of a Convergent Large-Scale Synthesis for Venetoclax, a First-in-Class BCL‑2 Selective Inhibitor
Ku, Yi-Yin, Chan, Vincent S, Christesen, Alan, Grieme, Timothy, Mulhern, Mathew, Pu, Yu-Ming, Wendt, Michael D
Published in Journal of organic chemistry (19.04.2019)
Published in Journal of organic chemistry (19.04.2019)
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Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors
Wang, Le, Pratt, John K, Soltwedel, Todd, Sheppard, George S, Fidanze, Steven D, Liu, Dachun, Hasvold, Lisa A, Mantei, Robert A, Holms, James H, McClellan, William J, Wendt, Michael D, Wada, Carol, Frey, Robin, Hansen, T. Matthew, Hubbard, Robert, Park, Chang H, Li, Leiming, Magoc, Terrance J, Albert, Daniel H, Lin, Xiaoyu, Warder, Scott E, Kovar, Peter, Huang, Xiaoli, Wilcox, Denise, Wang, Rongqi, Rajaraman, Ganesh, Petros, Andrew M, Hutchins, Charles W, Panchal, Sanjay C, Sun, Chaohong, Elmore, Steven W, Shen, Yu, Kati, Warren M, McDaniel, Keith F
Published in Journal of medicinal chemistry (11.05.2017)
Published in Journal of medicinal chemistry (11.05.2017)
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An inhibitor of Bcl-2 family proteins induces regression of solid tumours
Fesik, Stephen W, Rosenberg, Saul H, Oltersdorf, Tilman, Elmore, Steven W, Shoemaker, Alexander R, Armstrong, Robert C, Augeri, David J, Belli, Barbara A, Bruncko, Milan, Deckwerth, Thomas L, Dinges, Jurgen, Hajduk, Philip J, Joseph, Mary K, Kitada, Shinichi, Korsmeyer, Stanley J, Kunzer, Aaron R, Letai, Anthony, Li, Chi, Mitten, Michael J, Nettesheim, David G, Ng, ShiChung, Nimmer, Paul M, O'Connor, Jacqueline M, Oleksijew, Anatol, Petros, Andrew M, Reed, John C, Shen, Wang, Tahir, Stephen K, Thompson, Craig B, Tomaselli, Kevin J, Wang, Baole, Wendt, Michael D, Zhang, Haichao
Published in Nature (02.06.2005)
Published in Nature (02.06.2005)
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Studies on the Synthesis of Bafilomycin A1: Stereochemical Aspects of the Fragment Assembly Aldol Reaction for Construction of the C(13)−C(25) Segment
Roush, William R, Bannister, Thomas D, Wendt, Michael D, Jablonowski, Jill A, Scheidt, Karl A
Published in Journal of organic chemistry (14.06.2002)
Published in Journal of organic chemistry (14.06.2002)
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Beyond the Rule of 5: Lessons Learned from AbbVie’s Drugs and Compound Collection: Miniperspective
DeGoey, David A, Chen, Hui-Ju, Cox, Philip B, Wendt, Michael D
Published in Journal of medicinal chemistry (12.04.2018)
Published in Journal of medicinal chemistry (12.04.2018)
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Total Synthesis of (−)-Bafilomycin A1: Application of Diastereoselective Crotylboration and Methyl Ketone Aldol Reactions
Scheidt, Karl A., Tasaka, Akihiro, Bannister, Thomas D., Wendt, Michael D., Roush, William R.
Published in Angewandte Chemie International Edition (01.06.1999)
Published in Angewandte Chemie International Edition (01.06.1999)
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Discovery of A‑1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL‑XL Inhibitor
Wang, Le, Doherty, George A, Judd, Andrew S, Tao, Zhi-Fu, Hansen, T. Matthew, Frey, Robin R, Song, Xiaohong, Bruncko, Milan, Kunzer, Aaron R, Wang, Xilu, Wendt, Michael D, Flygare, John A, Catron, Nathaniel D, Judge, Russell A, Park, Chang H, Shekhar, Shashank, Phillips, Darren C, Nimmer, Paul, Smith, Morey L, Tahir, Stephen K, Xiao, Yu, Xue, John, Zhang, Haichao, Le, Phuong N, Mitten, Michael J, Boghaert, Erwin R, Gao, Wenqing, Kovar, Peter, Choo, Edna F, Diaz, Dolores, Fairbrother, Wayne J, Elmore, Steven W, Sampath, Deepak, Leverson, Joel D, Souers, Andrew James
Published in ACS medicinal chemistry letters (08.10.2020)
Published in ACS medicinal chemistry letters (08.10.2020)
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Journal Article
Discovery and Structure−Activity Relationship of Antagonists of B-Cell Lymphoma 2 Family Proteins with Chemopotentiation Activity in Vitro and in Vivo
Wendt, Michael D, Shen, Wang, Kunzer, Aaron, McClellan, William J, Bruncko, Milan, Oost, Thorsten K, Ding, Hong, Joseph, Mary K, Zhang, Haichao, Nimmer, Paul M, Ng, Shi-Chung, Shoemaker, Alexander R, Petros, Andrew M, Oleksijew, Anatol, Marsh, Kennan, Bauch, Joy, Oltersdorf, Tilman, Belli, Barbara A, Martineau, Darlene, Fesik, Stephen W, Rosenberg, Saul H, Elmore, Steven W
Published in Journal of medicinal chemistry (09.02.2006)
Published in Journal of medicinal chemistry (09.02.2006)
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Total Synthesis of (−)-Bafilomycin A1
Scheidt, Karl A, Bannister, Thomas D, Tasaka, Akihiro, Wendt, Michael D, Savall, Brad M, Fegley, Glenn J, Roush, William R
Published in Journal of the American Chemical Society (19.06.2002)
Published in Journal of the American Chemical Society (19.06.2002)
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Journal Article
Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL
Bruncko, Milan, Oost, Thorsten K, Belli, Barbara A, Ding, Hong, Joseph, Mary K, Kunzer, Aaron, Martineau, Darlene, McClellan, William J, Mitten, Michael, Ng, Shi-Chung, Nimmer, Paul M, Oltersdorf, Tilman, Park, Cheol-Min, Petros, Andrew M, Shoemaker, Alexander R, Song, Xiaohong, Wang, Xilu, Wendt, Michael D, Zhang, Haichao, Fesik, Stephen W, Rosenberg, Saul H, Elmore, Steven W
Published in Journal of medicinal chemistry (22.02.2007)
Published in Journal of medicinal chemistry (22.02.2007)
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Discovery and Design of Novel HSP90 Inhibitors Using Multiple Fragment-based Design Strategies
Huth, Jeffrey R., Park, Chang, Petros, Andrew M., Kunzer, Aaron R., Wendt, Michael D., Wang, Xilu, Lynch, Christopher L., Mack, Jamey C., Swift, Kerry M., Judge, Russell A., Chen, Jun, Richardson, Paul L., Jin, Sha, Tahir, Stephen K., Matayoshi, Edward D., Dorwin, Sarah A., Ladror, Uri S., Severin, Jean M., Walter, Karl A., Bartley, Diane M., Fesik, Stephen W., Elmore, Steven W., Hajduk, Philip J.
Published in Chemical biology & drug design (01.07.2007)
Published in Chemical biology & drug design (01.07.2007)
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Identification of Novel Binding Interactions in the Development of Potent, Selective 2-Naphthamidine Inhibitors of Urokinase. Synthesis, Structural Analysis, and SAR of N-Phenyl Amide 6-Substitution
Wendt, Michael D, Rockway, Todd W, Geyer, Andrew, McClellan, William, Weitzberg, Moshe, Zhao, Xumiao, Mantei, Robert, Nienaber, Vicki L, Stewart, Kent, Klinghofer, Vered, Giranda, Vincent L
Published in Journal of medicinal chemistry (15.01.2004)
Published in Journal of medicinal chemistry (15.01.2004)
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Structure−Activity Studies for a Novel Series of Tricyclic Substituted Hexahydrobenz[e]isoindole α1A Adrenoceptor Antagonists as Potential Agents for the Symptomatic Treatment of Benign Prostatic Hyperplasia (BPH)
Meyer, Michael D, Altenbach, Robert J, Basha, Fatima Z, Carroll, William A, Condon, Stephen, Elmore, Steven W, Kerwin, James F, Sippy, Kevin B, Tietje, Karin, Wendt, Michael D, Hancock, Arthur A, Brune, Michael E, Buckner, Steven A, Drizin, Irene
Published in Journal of medicinal chemistry (20.04.2000)
Published in Journal of medicinal chemistry (20.04.2000)
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