Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States
Stepan, Antonia F, Walker, Daniel P, Bauman, Jonathan, Price, David A, Baillie, Thomas A, Kalgutkar, Amit S, Aleo, Michael D
Published in Chemical research in toxicology (19.09.2011)
Published in Chemical research in toxicology (19.09.2011)
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Journal Article
Moving beyond Binary Predictions of Human Drug-Induced Liver Injury (DILI) toward Contrasting Relative Risk Potential
Aleo, Michael D, Shah, Falgun, Allen, Scott, Barton, Hugh A, Costales, Chester, Lazzaro, Sarah, Leung, Louis, Nilson, Andrea, Obach, R. Scott, Rodrigues, A. David, Will, Yvonne
Published in Chemical research in toxicology (21.01.2020)
Published in Chemical research in toxicology (21.01.2020)
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Journal Article
Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals
Aleo, Michael D, Shah, Falgun, He, Kan, Bonin, Paul D, Rodrigues, A. David
Published in Chemical research in toxicology (15.05.2017)
Published in Chemical research in toxicology (15.05.2017)
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Journal Article
Principles of precision medicine and its application in toxicology
Cook, Jon C., Wu, Hong, Aleo, Michael D., Adkins, Karissa
Published in Journal of toxicological sciences (01.01.2018)
Published in Journal of toxicological sciences (01.01.2018)
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Journal Article
Toxicity assessments of nonsteroidal anti-inflammatory drugs in isolated mitochondria, rat hepatocytes, and zebrafish show good concordance across chemical classes
Nadanaciva, Sashi, Aleo, Michael D., Strock, Christopher J., Stedman, Donald B., Wang, Huijun, Will, Yvonne
Published in Toxicology and applied pharmacology (15.10.2013)
Published in Toxicology and applied pharmacology (15.10.2013)
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Journal Article
Human drug‐induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump
Aleo, Michael D., Luo, Yi, Swiss, Rachel, Bonin, Paul D., Potter, David M., Will, Yvonne
Published in Hepatology (Baltimore, Md.) (01.09.2014)
Published in Hepatology (Baltimore, Md.) (01.09.2014)
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Journal Article
Quantitative systems toxicology (QST) reproduces species differences in PF‐04895162 liver safety due to combined mitochondrial and bile acid toxicity
Generaux, Grant, Lakhani, Vinal V., Yang, Yuching, Nadanaciva, Sashi, Qiu, Luping, Riccardi, Keith, Di, Li, Howell, Brett A., Siler, Scott Q., Watkins, Paul B., Barton, Hugh A., Aleo, Michael D., Shoda, Lisl K. M.
Published in Pharmacology research & perspectives (01.12.2019)
Published in Pharmacology research & perspectives (01.12.2019)
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Journal Article
Setting Clinical Exposure Levels of Concern for Drug-Induced Liver Injury (DILI) Using Mechanistic in vitro Assays
Shah, Falgun, Leung, Louis, Barton, Hugh A, Will, Yvonne, Rodrigues, A David, Greene, Nigel, Aleo, Michael D
Published in Toxicological sciences (01.10.2015)
Published in Toxicological sciences (01.10.2015)
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Journal Article
Phase I study of PF‐04895162, a Kv7 channel opener, reveals unexpected hepatotoxicity in healthy subjects, but not rats or monkeys: clinical evidence of disrupted bile acid homeostasis
Aleo, Michael D., Aubrecht, Jiri, D. Bonin, Paul, Burt, Deborah A., Colangelo, Jennifer, Luo, Lina, Schomaker, Shelli, Swiss, Rachel, Kirby, Simon, C. Rigdon, Greg, Dua, Pinky
Published in Pharmacology research & perspectives (01.02.2019)
Published in Pharmacology research & perspectives (01.02.2019)
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Journal Article
A Novel Lipidomics-Based Approach to Evaluating the Risk of Clinical Hepatotoxicity Potential of Drugs in 3D Human Microtissues
Goracci, Laura, Valeri, Aurora, Sciabola, Simone, Aleo, Michael D, Moritz, Wolfgang, Lichtenberg, Jan, Cruciani, Gabriele
Published in Chemical research in toxicology (21.01.2020)
Published in Chemical research in toxicology (21.01.2020)
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Journal Article
AI/ML Models to Predict the Severity of Drug-Induced Liver Injury for Small Molecules
Rao, Mohan, Nassiri, Vahid, Alhambra, Cristóbal, Snoeys, Jan, Van Goethem, Freddy, Irrechukwu, Onyi, Aleo, Michael D., Geys, Helena, Mitra, Kaushik, Will, Yvonne
Published in Chemical research in toxicology (17.07.2023)
Published in Chemical research in toxicology (17.07.2023)
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Journal Article
Comparisons between in vitro whole cell imaging and in vivo zebrafish-based approaches for identifying potential human hepatotoxicants earlier in pharmaceutical development
Hill, Adrian, Mesens, Natalie, Steemans, Margino, Xu, Jinghai James, Aleo, Michael D.
Published in Drug metabolism reviews (01.02.2012)
Published in Drug metabolism reviews (01.02.2012)
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Journal Article
An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury
Oda, Shingo, Uchida, Yuka, Aleo, Michael D., Koza-Taylor, Petra H., Matsui, Yusuke, Hizue, Masanori, Marroquin, Lisa D., Whritenour, Jessica, Uchida, Eri, Yokoi, Tsuyoshi
Published in Archives of toxicology (2021)
Published in Archives of toxicology (2021)
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Journal Article
Liver safety evaluation of endothelin receptor antagonists using HepatoPac®: A single model impact assessment on hepatocellular health, function and bile acid disposition
Aleo, Michael D., Ukairo, Okechukwu, Moore, Amanda, Irrechukwu, Onyi, Potter, David M., Schneider, Richard P.
Published in Journal of applied toxicology (01.08.2019)
Published in Journal of applied toxicology (01.08.2019)
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Journal Article
Improving the Odds of Success in Drug Discovery: Choosing the Best Compounds for in Vivo Toxicology Studies
Wager, Travis T, Kormos, Bethany L, Brady, Joseph T, Will, Yvonne, Aleo, Michael D, Stedman, Donald B, Kuhn, Max, Chandrasekaran, Ramalakshmi Y
Published in Journal of medicinal chemistry (12.12.2013)
Published in Journal of medicinal chemistry (12.12.2013)
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