Structural basis of HIV inhibition by translocation-defective RT inhibitor 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA)
Li Salie, Zhe, Kirby, Karen A., Michailidis, Eleftherios, Marchand, Bruno, Singh, Kamalendra, Rohan, Lisa C., Kodama, Eiichi N., Mitsuya, Hiroaki, Parniak, Michael A., Sarafianos, Stefan G.
Published in Proceedings of the National Academy of Sciences - PNAS (16.08.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (16.08.2016)
Get full text
Journal Article
Structure and Function of HIV-1 Reverse Transcriptase: Molecular Mechanisms of Polymerization and Inhibition
Sarafianos, Stefan G., Marchand, Bruno, Das, Kalyan, Himmel, Daniel M., Parniak, Michael A., Hughes, Stephen H., Arnold, Eddy
Published in Journal of molecular biology (23.01.2009)
Published in Journal of molecular biology (23.01.2009)
Get full text
Journal Article
Design, Synthesis, and Biological Evaluations of Hydroxypyridonecarboxylic Acids as Inhibitors of HIV Reverse Transcriptase Associated RNase H
Kankanala, Jayakanth, Kirby, Karen A., Liu, Feng, Miller, Lena, Nagy, Eva, Wilson, Daniel J., Parniak, Michael A., Sarafianos, Stefan G., Wang, Zhengqiang
Published in Journal of medicinal chemistry (26.05.2016)
Published in Journal of medicinal chemistry (26.05.2016)
Get full text
Journal Article
The hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and integrase enzymes
Tavis, John E, Cheng, Xiaohong, Hu, Yuan, Totten, Michael, Cao, Feng, Michailidis, Eleftherios, Aurora, Rajeev, Meyers, Marvin J, Jacobsen, E Jon, Parniak, Michael A, Sarafianos, Stefan G
Published in PLoS pathogens (01.01.2013)
Published in PLoS pathogens (01.01.2013)
Get full text
Journal Article
Oral administration of the nucleoside EFdA (4'-ethynyl-2-fluoro-2'-deoxyadenosine) provides rapid suppression of HIV viremia in humanized mice and favorable pharmacokinetic properties in mice and the rhesus macaque
Stoddart, Cheryl A, Galkina, Sofiya A, Joshi, Pheroze, Kosikova, Galina, Moreno, Mary E, Rivera, Jose M, Sloan, Barbara, Reeve, Aaron B, Sarafianos, Stefan G, Murphey-Corb, Michael, Parniak, Michael A
Published in Antimicrobial agents and chemotherapy (01.07.2015)
Published in Antimicrobial agents and chemotherapy (01.07.2015)
Get full text
Journal Article
Mechanism of Inhibition of HIV-1 Reverse Transcriptase by 4′-Ethynyl-2-fluoro-2′-deoxyadenosine Triphosphate, a Translocation-defective Reverse Transcriptase Inhibitor
Michailidis, Eleftherios, Marchand, Bruno, Kodama, Eiichi N., Singh, Kamlendra, Matsuoka, Masao, Kirby, Karen A., Ryan, Emily M., Sawani, Ali M., Nagy, Eva, Ashida, Noriyuki, Mitsuya, Hiroaki, Parniak, Michael A., Sarafianos, Stefan G.
Published in The Journal of biological chemistry (18.12.2009)
Published in The Journal of biological chemistry (18.12.2009)
Get full text
Journal Article
A 2-Hydroxyisoquinoline-1,3-Dione Active-Site RNase H Inhibitor Binds in Multiple Modes to HIV-1 Reverse Transcriptase
Kirby, Karen A, Myshakina, Nataliya A, Christen, Martin T, Chen, Yue-Lei, Schmidt, Hilary A, Huber, Andrew D, Xi, Zhaoyong, Kim, Seongmi, Rao, Rohit K, Kramer, Skyler T, Yang, Qiongying, Singh, Kamalendra, Parniak, Michael A, Wang, Zhengqiang, Ishima, Rieko, Sarafianos, Stefan G
Published in Antimicrobial agents and chemotherapy (01.10.2017)
Published in Antimicrobial agents and chemotherapy (01.10.2017)
Get full text
Journal Article
Discovery of Benzisothiazolone Derivatives as Bifunctional Inhibitors of HIV-1 Reverse Transcriptase DNA Polymerase and Ribonuclease H Activities
Vázquez Rivera, Alondra, Donald, Heather, Alaoui-El-Azher, Mounia, Skoko, John J, Lazo, John S, Parniak, Michael A, Johnston, Paul A, Sluis-Cremer, Nicolas
Published in Biomolecules (Basel, Switzerland) (09.07.2024)
Published in Biomolecules (Basel, Switzerland) (09.07.2024)
Get full text
Journal Article
Efficient Inhibition of HIV Replication in the Gastrointestinal and Female Reproductive Tracts of Humanized BLT Mice by EFdA
Shanmugasundaram, Uma, Kovarova, Martina, Ho, Phong T, Schramm, Nathaniel, Wahl, Angela, Parniak, Michael A, Garcia, J Victor
Published in PloS one (20.07.2016)
Published in PloS one (20.07.2016)
Get full text
Journal Article
Synthesis and Properties of 2′-Deoxy-2′,4′-difluoroarabinose-Modified Nucleic Acids
Martínez-Montero, Saúl, Deleavey, Glen F, Dierker-Viik, Arden, Lindovska, Petra, Ilina, Tatiana, Portella, Guillem, Orozco, Modesto, Parniak, Michael A, González, Carlos, Damha, Masad J
Published in Journal of organic chemistry (20.03.2015)
Published in Journal of organic chemistry (20.03.2015)
Get full text
Journal Article
Response of Simian Immunodeficiency Virus to the Novel Nucleoside Reverse Transcriptase Inhibitor 4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine In Vitro and In Vivo
MURPHEY-CORB, Michael, RAJAKUMAR, Premeela, MICHAEL, Heather, NYAUNDI, Julia, DIDIER, Peter J, REEVE, Aaron B, MITSUYA, Hiroaki, SARAFIANOS, Stefan G, PARNIAK, Michael A
Published in Antimicrobial Agents and Chemotherapy (01.09.2012)
Published in Antimicrobial Agents and Chemotherapy (01.09.2012)
Get full text
Journal Article
HIV-1 Resistance to Islatravir/Tenofovir Combination Therapy in Wild-Type or NRTI-Resistant Strains of Diverse HIV-1 Subtypes
Cilento, Maria E, Wen, Xin, Reeve, Aaron B, Ukah, Obiaara B, Snyder, Alexa A, Carrillo, Ciro M, Smith, Cole P, Edwards, Kristin, Wahoski, Claudia C, Kitzler, Deborah R, Kodama, Eiichi N, Mitsuya, Hiroaki, Parniak, Michael A, Tedbury, Philip R, Sarafianos, Stefan G
Published in Viruses (25.09.2023)
Published in Viruses (25.09.2023)
Get full text
Journal Article
First-In-Class Small Molecule Inhibitors of the Single-Strand DNA Cytosine Deaminase APOBEC3G
Li, Ming, Shandilya, Shivender M. D, Carpenter, Michael A, Rathore, Anurag, Brown, William L, Perkins, Angela L, Harki, Daniel A, Solberg, Jonathan, Hook, Derek J, Pandey, Krishan K, Parniak, Michael A, Johnson, Jeffrey R, Krogan, Nevan J, Somasundaran, Mohan, Ali, Akbar, Schiffer, Celia A, Harris, Reuben S
Published in ACS chemical biology (16.03.2012)
Published in ACS chemical biology (16.03.2012)
Get full text
Journal Article
Biochemical Mechanism of HIV-1 Resistance to Rilpivirine
Singh, Kamalendra, Marchand, Bruno, Rai, Devendra K., Sharma, Bechan, Michailidis, Eleftherios, Ryan, Emily M., Matzek, Kayla B., Leslie, Maxwell D., Hagedorn, Ariel N., Li, Zhe, Norden, Pieter R., Hachiya, Atsuko, Parniak, Michael A., Xu, Hong-Tao, Wainberg, Mark A., Sarafianos, Stefan G.
Published in The Journal of biological chemistry (02.11.2012)
Published in The Journal of biological chemistry (02.11.2012)
Get full text
Journal Article
In vitro transport characteristics of EFdA, a novel nucleoside reverse transcriptase inhibitor using Caco-2 and MDCKII cell monolayers
Zhang, Wei, Parniak, Michael A., Sarafianos, Stefan G., Empey, Philip E., Rohan, Lisa C.
Published in European journal of pharmacology (05.06.2014)
Published in European journal of pharmacology (05.06.2014)
Get full text
Journal Article
Effects of Substitutions at the 4′ and 2 Positions on the Bioactivity of 4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine
KIRBY, Karen A, MICHAILIDIS, Eleftherios, HUGHES, Stephen H, MITSUYA, Hiroaki, PARNIAK, Michael A, SARAFIANOSA, Stefan G, FETTERLY, Tracy L, STEINBACH, Musetta A, SINGH, Kamalendra, MARCHAND, Bruno, LESLIE, Maxwell D, HAGEDOM, Ariel N, KODAMA, Eiichi N, MARQUEZ, Victor E
Published in Antimicrobial Agents and Chemotherapy (01.12.2013)
Published in Antimicrobial Agents and Chemotherapy (01.12.2013)
Get full text
Journal Article
Identification of Alternative Binding Sites for Inhibitors of HIV-1 Ribonuclease H Through Comparative Analysis of Virtual Enrichment Studies
Felts, Anthony K, LaBarge, Krystal, Bauman, Joseph D, Patel, Dishaben V, Himmel, Daniel M, Arnold, Eddy, Parniak, Michael A, Levy, Ronald M
Published in Journal of chemical information and modeling (22.08.2011)
Published in Journal of chemical information and modeling (22.08.2011)
Get full text
Journal Article
Evaluation of Combinations of 4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine with Clinically Used Antiretroviral Drugs
HACHIYA, Atsuko, REEVE, Aaron B, MITSUYA, Hiroaki, PARNIAK, Michael A, SARAFIANOS, Stefan G, MARCHAND, Bruno, MICHAILIDIS, Eleftherios, YEE TSUEY ONG, KIRBY, Karen A, LESLIE, Maxwell D, OKA, Shinichi, KODAMA, Eiichi N, ROHAN, Lisa C
Published in Antimicrobial Agents and Chemotherapy (01.09.2013)
Published in Antimicrobial Agents and Chemotherapy (01.09.2013)
Get full text
Journal Article
Structural and Inhibition Studies of the RNase H Function of Xenotropic Murine Leukemia Virus-Related Virus Reverse Transcriptase
KIRBY, Karen A, MARCHAND, Bruno, SINGH, Kamalendra, ZHENGQIANG WANG, PARNIAK, Michael A, SARAFIANOS, Stefan G, YEE TSUEY ONG, NDONGWE, Tanyaradzwa P, HACHIYA, Atsuko, MICHAILIDIS, Eleftherios, LESLIE, Maxwell D, SIETSEMA, Daniel V, FETTERLY, Tracy L, DORST, Christopher A
Published in Antimicrobial Agents and Chemotherapy (01.04.2012)
Published in Antimicrobial Agents and Chemotherapy (01.04.2012)
Get full text
Journal Article
Structural Basis of the Allosteric Inhibitor Interaction on the HIV-1 Reverse Transcriptase RNase H Domain
Christen, Martin T., Menon, Lakshmi, Myshakina, Nataliya S., Ahn, Jinwoo, Parniak, Michael A., Ishima, Rieko
Published in Chemical biology & drug design (01.11.2012)
Published in Chemical biology & drug design (01.11.2012)
Get full text
Journal Article