Circulating uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel
LaFavers, Kaice A, Macedo, Etienne, Garimella, Pranav S, Lima, Camila, Khan, Shehnaz, Myslinski, Jered, McClintick, Jeanette, Witzmann, Frank A, Winfree, Seth, Phillips, Carrie L, Hato, Takashi, Dagher, Pierre C, Wu, Xue-Ru, El-Achkar, Tarek M, Micanovic, Radmila
Published in Science translational medicine (02.10.2019)
Published in Science translational medicine (02.10.2019)
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Journal Article
Tamm-Horsfall Protein Regulates Mononuclear Phagocytes in the Kidney
Micanovic, Radmila, Khan, Shehnaz, Janosevic, Danielle, Lee, Maya E, Hato, Takashi, Srour, Edward F, Winfree, Seth, Ghosh, Joydeep, Tong, Yan, Rice, Susan E, Dagher, Pierre C, Wu, Xue-Ru, El-Achkar, Tarek M
Published in Journal of the American Society of Nephrology (01.03.2018)
Published in Journal of the American Society of Nephrology (01.03.2018)
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Journal Article
The kidney protects against sepsis by producing systemic uromodulin
LaFavers, Kaice A, Hage, Chadi A, Gaur, Varun, Micanovic, Radmila, Hato, Takashi, Khan, Shehnaz, Winfree, Seth, Doshi, Simit, Moorthi, Ranjani N, Twigg, Homer, Wu, Xue-Ru, Dagher, Pierre C, Srour, Edward F, El-Achkar, Tarek M
Published in American journal of physiology. Renal physiology (01.08.2022)
Published in American journal of physiology. Renal physiology (01.08.2022)
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Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319
Kharitonenkov, Alexei, Beals, John M, Micanovic, Radmila, Strifler, Beth A, Rathnachalam, Radhakrishnan, Wroblewski, Victor J, Li, Shun, Koester, Anja, Ford, Amy M, Coskun, Tamer, Dunbar, James D, Cheng, Christine C, Frye, Christopher C, Bumol, Thomas F, Moller, David E
Published in PloS one (11.03.2013)
Published in PloS one (11.03.2013)
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Journal Article
Fundamentals of FGF19 & FGF21 action in vitro and in vivo
Adams, Andrew C, Coskun, Tamer, Rovira, Armando R Irizarry, Schneider, Michael A, Raches, David W, Micanovic, Radmila, Bina, Holly A, Dunbar, James D, Kharitonenkov, Alexei
Published in PloS one (31.05.2012)
Published in PloS one (31.05.2012)
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Healthy Women Have Higher Systemic Uromodulin Levels: Identification of Uromodulin as an Estrogen Responsive Gene: FR-PO841
Nanamatsu, Azuma, Micanovic, Radmila, Khan, Shehnaz, El-Achkar, Tarek M., LaFavers, Kaice A.
Published in Journal of the American Society of Nephrology (01.11.2023)
Published in Journal of the American Society of Nephrology (01.11.2023)
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Journal Article
Uromodulin Deficiency Shapes AKI Severity by Enhanced Oxidative Injury and Stress Response in Proximal Tubules With Early Activation of the Inflammasome: FR-PO150
LaFavers, Kaice A., Micanovic, Radmila, Sabo, Angela R., Khan, Shehnaz, Winfree, Seth, El-Achkar, Tarek M.
Published in Journal of the American Society of Nephrology (01.11.2022)
Published in Journal of the American Society of Nephrology (01.11.2022)
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The Kidney Produces a Non-Polymerizing Form of Uromodulin That Associates with Reduced Risk of AKI: PO0419
Micanovic, Radmila, LaFavers, Kaice A., Patidar, Kavish R., Khan, Shehnaz, El-Achkar, Tarek M.
Published in Journal of the American Society of Nephrology (01.10.2021)
Published in Journal of the American Society of Nephrology (01.10.2021)
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Alternative Splicing Generates an Intracellular Uromodulin Isoform that Mediates Mitochondrial Function and Is Up-Regulated in AKI: FR-PO184
Nanamatsu, Azuma, LaFavers, Kaice A., Micanovic, Radmila, Lazar, Virginie, Rhodes, George, Khan, Shehnaz, Bacallao, Robert L., Dagher, Pierre C., Hato, Takashi, El-Achkar, Tarek M.
Published in Journal of the American Society of Nephrology (01.11.2023)
Published in Journal of the American Society of Nephrology (01.11.2023)
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Journal Article
Transcriptomic Profiling of Thick Ascending Limb Cells In Vivo Reveals the Complex Network of Genes Regulated by Uromodulin: PO0629
LaFavers, Kaice A., Khan, Shehnaz, Khan, Nida A., Apple, Laura, Micanovic, Radmila, El-Achkar, Tarek M.
Published in Journal of the American Society of Nephrology (01.10.2020)
Published in Journal of the American Society of Nephrology (01.10.2020)
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Decoy receptor 3 (DcR3) is proteolytically processed to a metabolic fragment having differential activities against Fas ligand and LIGHT
Wroblewski, Victor J, Witcher, Derrick R, Becker, Gerald W, Davis, Kelly A, Dou, Shenshen, Micanovic, Radmila, Newton, Christy M, Noblitt, Timothy W, Richardson, John M, Song, Ho Yeong, Hale, John E
Published in Biochemical pharmacology (15.02.2003)
Published in Biochemical pharmacology (15.02.2003)
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Alternative Splicing of Uromodulin Enhances Mitochondrial Metabolism for Adaptation to Stress in Kidney Epithelial Cells: SA-PO132
Nanamatsu, Azuma, Rhodes, George, LaFavers, Kaice Arminda, Micanovic, Radmila, Lazar, Virginie, Barwinska, Daria, Kamocka, Malgorzata, Phillips, Carrie L., Kelly, Katherine J., Bacallao, Robert L., Dagher, Pierre C., Hato, Takashi, El-Achkar, Tarek M.
Published in Journal of the American Society of Nephrology (01.10.2024)
Published in Journal of the American Society of Nephrology (01.10.2024)
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Uromodulin and Injury Severity Alter Neutrophil Diversity and Signaling in AKI: FR-PO154
Winfree, Seth, LaFavers, Kaice A., Khan, Shehnaz, Micanovic, Radmila, ferreira, Ricardo Melo, Cheng, Ying-Hua, Eadon, Michael T., El-Achkar, Tarek M.
Published in Journal of the American Society of Nephrology (01.11.2022)
Published in Journal of the American Society of Nephrology (01.11.2022)
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Journal Article
Variability in Uromodulin Production and Its Response to Water Loading in Healthy Subjects and Patients With Stone Disease: SA-PO170
LaFavers, Kaice A., Gaddy, Anna R., Micanovic, Radmila, Williams, James C., Coe, Fredric L., El-Achkar, Tarek M., Worcester, Elaine M.
Published in Journal of the American Society of Nephrology (01.11.2022)
Published in Journal of the American Society of Nephrology (01.11.2022)
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Detection of Myeloid Cell Pleiotropy In Situ and the Unique Niches of Immune Cells in Ischemic Kidney Injury Using CODEX Imaging: FR-PO149
Sabo, Angela R., Maghak, Lauren A., Gulbronson, Connor J., Khan, Shehnaz, Micanovic, Radmila, LaFavers, Kaice A., Barwinska, Daria, Williams, James C., El-Achkar, Tarek M., Winfree, Seth
Published in Journal of the American Society of Nephrology (01.11.2022)
Published in Journal of the American Society of Nephrology (01.11.2022)
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