Search Results - "Methot, Nathalie" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Reversible Cysteine Protease Inhibitors Show Promise for a Chagas Disease Cure

Reversible Cysteine Protease Inhibitors Show Promise for a Chagas Disease Cure

by NDAO, Momar, BEAULIEU, Christian, BLACK, W. Cameron, ISABEL, Elise, VASQUEZ-CAMARGO, Fabio, NATH-CHOWDHURY, Milli, MASSE, Frédéric, MELLON, Christophe, METHOT, Nathalie, NICOLL-GRIFFITH, Deborah A
Published in Antimicrobial Agents and Chemotherapy (01.02.2014)

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Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease

Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease

by Beaulieu, Christian, Isabel, Elise, Fortier, Angélique, Massé, Frédéric, Mellon, Christophe, Méthot, Nathalie, Ndao, Momar, Nicoll-Griffith, Deborah, Lee, Doris, Park, Hyeram, Black, W. Cameron
Published in Bioorganic & medicinal chemistry letters (15.12.2010)

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Inhibition of the Activation of Multiple Serine Proteases with a Cathepsin C Inhibitor Requires Sustained Exposure to Prevent Pro-enzyme Processing

Inhibition of the Activation of Multiple Serine Proteases with a Cathepsin C Inhibitor Requires Sustained Exposure to Prevent Pro-enzyme Processing

by Méthot, Nathalie, Rubin, Joel, Guay, Daniel, Beaulieu, Christian, Ethier, Diane, Reddy, T. Jagadeeswar, Riendeau, Denis, Percival, M. David
Published in The Journal of biological chemistry (20.07.2007)

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MF63 [2-(6-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a Selective Microsomal Prostaglandin E Synthase-1 Inhibitor, Relieves Pyresis and Pain in Preclinical Models of Inflammation

MF63 [2-(6-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a Selective Microsomal Prostaglandin E Synthase-1 Inhibitor, Relieves Pyresis and Pain in Preclinical Models of Inflammation

by Xu, Daigen, Rowland, Steven E, Clark, Patsy, Giroux, André, Côté, Bernard, Guiral, Sébastien, Salem, Myriam, Ducharme, Yves, Friesen, Richard W, Méthot, Nathalie, Mancini, Joseph, Audoly, Laurent, Riendeau, Denis
Published in The Journal of pharmacology and experimental therapeutics (01.09.2008)

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Hedgehog Controls Limb Development by Regulating the Activities of Distinct Transcriptional Activator and Repressor Forms of Cubitus interruptus

Hedgehog Controls Limb Development by Regulating the Activities of Distinct Transcriptional Activator and Repressor Forms of Cubitus interruptus

by Méthot, Nathalie, Basler, Konrad
Published in Cell (19.03.1999)

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Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors

Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors

by Côté, Bernard, Boulet, Louise, Brideau, Christine, Claveau, David, Ethier, Diane, Frenette, Richard, Gagnon, Marc, Giroux, André, Guay, Jocelyne, Guiral, Sébastien, Mancini, Joseph, Martins, Evelyn, Massé, Frédéric, Méthot, Nathalie, Riendeau, Denis, Rubin, Joel, Xu, Daigen, Yu, Hongping, Ducharme, Yves, Friesen, Richard W.
Published in Bioorganic & medicinal chemistry letters (15.12.2007)

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Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886

Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886

by RIENDEAU, Denis, ASPIOTIS, Renee, RUBIN, Joel, FRIESEN, Richard W, ETHIER, Diane, GAREAU, Yves, GRIMM, Erich L, GUAY, Jocelyne, GUIRAL, Sébastien, JUTEAU, Hélène, MANCINI, Joseph A, METHOT, Nathalie
Published in Bioorganic & medicinal chemistry letters (15.07.2005)

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Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors

Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors

by Giroux, André, Boulet, Louise, Brideau, Christine, Chau, Anh, Claveau, David, Côté, Bernard, Ethier, Diane, Frenette, Richard, Gagnon, Marc, Guay, Jocelyne, Guiral, Sébastien, Mancini, Joseph, Martins, Evelyn, Massé, Frédéric, Méthot, Nathalie, Riendeau, Denis, Rubin, Joel, Xu, Daigen, Yu, Hongping, Ducharme, Yves, Friesen, Richard W.
Published in Bioorganic & medicinal chemistry letters (15.10.2009)

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Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus

Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus

by Méthot, N, Basler, K
Published in Development (Cambridge) (15.09.2000)

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An absolute requirement for Cubitus interruptus in Hedgehog signaling

An absolute requirement for Cubitus interruptus in Hedgehog signaling

by Méthot, N, Basler, K
Published in Development (Cambridge) (01.03.2001)

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Structure of both the ligand- and lipid-dependent channel-inactive states of the nicotinic acetylcholine receptor probed by FTIR spectroscopy and hydrogen exchange

Structure of both the ligand- and lipid-dependent channel-inactive states of the nicotinic acetylcholine receptor probed by FTIR spectroscopy and hydrogen exchange

by Methot, Nathalie, Demers, Caroline N, Baenziger, John E
Published in Biochemistry (Easton) (01.11.1995)

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In Vivo Inhibition of Serine Protease Processing Requires a High Fractional Inhibition of Cathepsin C

In Vivo Inhibition of Serine Protease Processing Requires a High Fractional Inhibition of Cathepsin C

by Méthot, Nathalie, Guay, Daniel, Rubin, Joel, Ethier, Diane, Ortega, Karen, Wong, Simon, Normandin, Denis, Beaulieu, Christian, Reddy, T Jagadeeswar, Riendeau, Denis, Percival, M David
Published in Molecular pharmacology (01.06.2008)

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Deletion of Microsomal Prostaglandin E2 (PGE2) Synthase-1 Reduces Inducible and Basal PGE2 Production and Alters the Gastric Prostanoid Profile

by Boulet, Louise, Ouellet, Marc, Bateman, Kevin P., Ethier, Diane, Percival, M. David, Riendeau, Denis, Mancini, Joseph A., Méthot, Nathalie
Published in The Journal of biological chemistry (28.05.2004)

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Secondary Structure of the Nicotinic Acetylcholine Receptor:Implications for Structural Models of a Ligand-Gated Ion Channel

Secondary Structure of the Nicotinic Acetylcholine Receptor:Implications for Structural Models of a Ligand-Gated Ion Channel

by Methot, Nathalie, McCarthy, Michael P, Baenziger, John E
Published in Biochemistry (Easton) (21.06.1994)

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Trisubstituted ureas as potent and selective mPGES-1 inhibitors

Trisubstituted ureas as potent and selective mPGES-1 inhibitors

by Chiasson, Jean-François, Boulet, Louise, Brideau, Christine, Chau, Anh, Claveau, David, Côté, Bernard, Ethier, Diane, Giroux, André, Guay, Jocelyne, Guiral, Sébastien, Mancini, Joseph, Massé, Frédéric, Méthot, Nathalie, Riendeau, Denis, Roy, Patrick, Rubin, Joel, Xu, Daigen, Yu, Hongping, Ducharme, Yves, Friesen, Richard W.
Published in Bioorganic & medicinal chemistry letters (01.03.2011)

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$Differential efficacy of caspase inhibitors on apoptosis markers during sepsis in rats and implication for fractional inhibition requirements for therapeutics$

Differential efficacy of caspase inhibitors on apoptosis markers during sepsis in rats and implication for fractional inhibition requirements for therapeutics

by Méthot, Nathalie, Huang, JingQi, Coulombe, Nathalie, Vaillancourt, John P, Rasper, Dita, Tam, John, Han, Yongxin, Colucci, John, Zamboni, Robert, Xanthoudakis, Steven, Toulmond, Sylvie, Nicholson, Donald W, Roy, Sophie
Published in The Journal of experimental medicine (19.01.2004)

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Smoothened titania particles to improve radionuclide separation and their application to the development of a novel [ 68 Ge]/[ 68 Ga] generator

Smoothened titania particles to improve radionuclide separation and their application to the development of a novel [ 68 Ge]/[ 68 Ga] generator

by Cressier, Damien, Oelsner, Steve, Hunter, Gary, Quarin, Linda, Methot, Nathalie, Wester, Dennis, Barré, Louisa
Published in RSC advances (01.01.2015)

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Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C

Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C

by Guay, Daniel, Beaulieu, Christian, Jagadeeswar Reddy, T., Zamboni, Robert, Methot, Nathalie, Rubin, Joel, Ethier, Diane, David Percival, M.
Published in Bioorganic & medicinal chemistry letters (15.09.2009)

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Smoothened titania particles to improve radionuclide separation and their application to the development of a novel [68Ge]/[68Ga] generatorElectronic supplementary information (ESI) available: Gallium-68 half-life determination (Fig. S1), gallium-68 recovery at Δt = 3 h 00 and 5 h 30 in function of generator age (Table S1), gallium-68 elution yield throughout generator life-span (Fig. S2), illustration of Modular-Lab device (Fig. S3), reagents and materials for the device (Table S2), analytical

Smoothened titania particles to improve radionuclide separation and their application to the development of a novel [68Ge]/[68Ga] generatorElectronic supplementary information (ESI) available: Gallium-68 half-life determination (Fig. S1), gallium-68 recovery at Δt = 3 h 00 and 5 h 30 in function of generator age (Table S1), gallium-68 elution yield throughout generator life-span (Fig. S2), illustration of Modular-Lab device (Fig. S3), reagents and materials for the device (Table S2), analytical

by Cressier, Damien, Oelsner, Steve, Hunter, Gary, Quarin, Linda, Methot, Nathalie, Wester, Dennis, Barré, Louisa
Year of Publication 25.03.2015

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Corrigendum to “Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C” [Bioorg. Med. Chem. Lett. 19 (2009) 5392]

Corrigendum to “Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C” [Bioorg. Med. Chem. Lett. 19 (2009) 5392]

by Guay, Daniel, Beaulieu, Christian, Truchon, Jean-Francois, Reddy, T. Jagadeeswar, Bayly, Christopher I., Zamboni, Robert, Methot, Nathalie, Rubin, Joel, Ethier, Diane, Percival, M. David
Published in Bioorganic & medicinal chemistry letters (15.02.2010)

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