Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer
Liu, Xiaoguang, Olszewski, Kellen, Zhang, Yilei, Lim, Esther W., Shi, Jiejun, Zhang, Xiaoshan, Zhang, Jie, Lee, Hyemin, Koppula, Pranavi, Lei, Guang, Zhuang, Li, You, M. James, Fang, Bingliang, Li, Wei, Metallo, Christian M., Poyurovsky, Masha V., Gan, Boyi
Published in Nature cell biology (01.04.2020)
Published in Nature cell biology (01.04.2020)
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Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells
Lewis, Caroline A., Parker, Seth J., Fiske, Brian P., McCloskey, Douglas, Gui, Dan Y., Green, Courtney R., Vokes, Natalie I., Feist, Adam M., Vander Heiden, Matthew G., Metallo, Christian M.
Published in Molecular cell (17.07.2014)
Published in Molecular cell (17.07.2014)
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Metabolic Reprogramming of Stromal Fibroblasts through p62-mTORC1 Signaling Promotes Inflammation and Tumorigenesis
Valencia, Tania, Kim, Ji Young, Abu-Baker, Shadi, Moscat-Pardos, Jorge, Ahn, Christopher S., Reina-Campos, Miguel, Duran, Angeles, Castilla, Elias A., Metallo, Christian M., Diaz-Meco, Maria T., Moscat, Jorge
Published in Cancer cell (14.07.2014)
Published in Cancer cell (14.07.2014)
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Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier
Vacanti, Nathaniel M., Divakaruni, Ajit S., Green, Courtney R., Parker, Seth J., Henry, Robert R., Ciaraldi, Theodore P., Murphy, Anne N., Metallo, Christian M.
Published in Molecular cell (06.11.2014)
Published in Molecular cell (06.11.2014)
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Reductive carboxylation supports redox homeostasis during anchorage-independent growth
Jiang, Lei, Shestov, Alexander A., Swain, Pamela, Yang, Chendong, Parker, Seth J., Wang, Qiong A., Terada, Lance S., Adams, Nicholas D., McCabe, Michael T., Pietrak, Beth, Schmidt, Stan, Metallo, Christian M., Dranka, Brian P., Schwartz, Benjamin, DeBerardinis, Ralph J.
Published in Nature (London) (14.04.2016)
Published in Nature (London) (14.04.2016)
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Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
Commisso, Cosimo, Davidson, Shawn M., Soydaner-Azeloglu, Rengin G., Parker, Seth J., Kamphorst, Jurre J., Hackett, Sean, Grabocka, Elda, Nofal, Michel, Drebin, Jeffrey A., Thompson, Craig B., Rabinowitz, Joshua D., Metallo, Christian M., Vander Heiden, Matthew G., Bar-Sagi, Dafna
Published in Nature (London) (30.05.2013)
Published in Nature (London) (30.05.2013)
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Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models
Svensson, Robert U, Parker, Seth J, Eichner, Lillian J, Kolar, Matthew J, Wallace, Martina, Brun, Sonja N, Lombardo, Portia S, Van Nostrand, Jeanine L, Hutchins, Amanda, Vera, Lilliana, Gerken, Laurie, Greenwood, Jeremy, Bhat, Sathesh, Harriman, Geraldine, Westlin, William F, Harwood, H James, Saghatelian, Alan, Kapeller, Rosana, Metallo, Christian M, Shaw, Reuben J
Published in Nature medicine (01.10.2016)
Published in Nature medicine (01.10.2016)
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ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch
Zhao, Steven, Torres, AnnMarie, Henry, Ryan A., Trefely, Sophie, Wallace, Martina, Lee, Joyce V., Carrer, Alessandro, Sengupta, Arjun, Campbell, Sydney L., Kuo, Yin-Ming, Frey, Alexander J., Meurs, Noah, Viola, John M., Blair, Ian A., Weljie, Aalim M., Metallo, Christian M., Snyder, Nathaniel W., Andrews, Andrew J., Wellen, Kathryn E.
Published in Cell reports (Cambridge) (18.10.2016)
Published in Cell reports (Cambridge) (18.10.2016)
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Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes
Feyen, Dries A.M., McKeithan, Wesley L., Bruyneel, Arne A.N., Spiering, Sean, Hörmann, Larissa, Ulmer, Bärbel, Zhang, Hui, Briganti, Francesca, Schweizer, Michaela, Hegyi, Bence, Liao, Zhandi, Pölönen, Risto-Pekka, Ginsburg, Kenneth S., Lam, Chi Keung, Serrano, Ricardo, Wahlquist, Christine, Kreymerman, Alexander, Vu, Michelle, Amatya, Prashila L., Behrens, Charlotta S., Ranjbarvaziri, Sara, Maas, Renee G.C., Greenhaw, Matthew, Bernstein, Daniel, Wu, Joseph C., Bers, Donald M., Eschenhagen, Thomas, Metallo, Christian M., Mercola, Mark
Published in Cell reports (Cambridge) (21.07.2020)
Published in Cell reports (Cambridge) (21.07.2020)
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Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD
Garcia, Daniel, Hellberg, Kristina, Chaix, Amandine, Wallace, Martina, Herzig, Sébastien, Badur, Mehmet G., Lin, Terry, Shokhirev, Maxim N., Pinto, Antonio F.M., Ross, Debbie S., Saghatelian, Alan, Panda, Satchidananda, Dow, Lukas E., Metallo, Christian M., Shaw, Reuben J.
Published in Cell reports (Cambridge) (02.01.2019)
Published in Cell reports (Cambridge) (02.01.2019)
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Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy
Gantner, Marin L, Eade, Kevin, Wallace, Martina, Handzlik, Michal K, Fallon, Regis, Trombley, Jennifer, Bonelli, Roberto, Giles, Sarah, Harkins-Perry, Sarah, Heeren, Tjebo F.C, Sauer, Lydia, Ideguchi, Yoichiro, Baldini, Michelle, Scheppke, Lea, Dorrell, Michael I, Kitano, Maki, Hart, Barbara J, Cai, Carolyn, Nagasaki, Takayuki, Badur, Mehmet G, Okada, Mali, Woods, Sasha M, Egan, Catherine, Gillies, Mark, Guymer, Robyn, Eichler, Florian, Bahlo, Melanie, Fruttiger, Marcus, Allikmets, Rando, Bernstein, Paul S, Metallo, Christian M, Friedlander, Martin
Published in The New England journal of medicine (10.10.2019)
Published in The New England journal of medicine (10.10.2019)
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Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism
Tang, Yuefeng, Wallace, Martina, Sanchez-Gurmaches, Joan, Hsiao, Wen-Yu, Li, Huawei, Lee, Peter L., Vernia, Santiago, Metallo, Christian M., Guertin, David A.
Published in Nature communications (21.04.2016)
Published in Nature communications (21.04.2016)
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Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues
Wallace, Martina, Green, Courtney R., Roberts, Lindsay S., Lee, Yujung Michelle, McCarville, Justin L., Sanchez-Gurmaches, Joan, Meurs, Noah, Gengatharan, Jivani M., Hover, Justin D., Phillips, Susan A., Ciaraldi, Theodore P., Guertin, David A., Cabrales, Pedro, Ayres, Janelle S., Nomura, Daniel K., Loomba, Rohit, Metallo, Christian M.
Published in Nature chemical biology (01.11.2018)
Published in Nature chemical biology (01.11.2018)
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Distinct Metabolic States Can Support Self-Renewal and Lipogenesis in Human Pluripotent Stem Cells under Different Culture Conditions
Zhang, Hui, Badur, Mehmet G., Divakaruni, Ajit S., Parker, Seth J., Jäger, Christian, Hiller, Karsten, Murphy, Anne N., Metallo, Christian M.
Published in Cell reports (Cambridge) (09.08.2016)
Published in Cell reports (Cambridge) (09.08.2016)
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