Indirubin Derivatives Inhibit Stat3 Signaling and Induce Apoptosis in Human Cancer Cells
Nam, Sangkil, Buettner, Ralf, Turkson, James, Kim, Donghwa, Cheng, Jin Q., Muehlbeyer, Stephan, Hippe, Frankie, Vatter, Sandra, Merz, Karl-Heinz, Eisenbrand, Gerhard, Jove, Richard, Vogt, Peter K.
Published in Proceedings of the National Academy of Sciences - PNAS (26.04.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (26.04.2005)
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Journal Article
Methylisoindigo and Its Bromo-Derivatives Are Selective Tyrosine Kinase Inhibitors, Repressing Cellular Stat3 Activity, and Target CD133+ Cancer Stem Cells in PDAC
Tegethoff, Jana, Bischoff, Roland, Saleh, Sawsan, Blagojevic, Biljana, Merz, Karl-Heinz, Cheng, Xinlai
Published in Molecules (Basel, Switzerland) (13.09.2017)
Published in Molecules (Basel, Switzerland) (13.09.2017)
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Journal Article
Synthesis, topoisomerase-targeting activity and growth inhibition of lycobetaine analogs
Baechler, Simone A., Fehr, Markus, Habermeyer, Michael, Hofmann, Andreas, Merz, Karl-Heinz, Fiebig, Heinz-Herbert, Marko, Doris, Eisenbrand, Gerhard
Published in Bioorganic & medicinal chemistry (01.02.2013)
Published in Bioorganic & medicinal chemistry (01.02.2013)
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Journal Article
Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs
Cheng, Xinlai, Kim, Jee Young, Ghafoory, Shahrouz, Duvaci, Tijen, Rafiee, Roya, Theobald, Jannick, Alborzinia, Hamed, Holenya, Pavlo, Fredebohm, Johannes, Merz, Karl-Heinz, Mehrabi, Arianeb, Hafezi, Mohammadreza, Saffari, Arash, Eisenbrand, Gerhard, Hoheisel, Jörg D., Wölfl, Stefan
Published in Molecular oncology (01.06.2016)
Published in Molecular oncology (01.06.2016)
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Journal Article
Metabolism of methyleugenol in liver microsomes and primary hepatocytes: pattern of metabolites, cytotoxicity, and DNA-adduct formation
Cartus, Alexander T, Herrmann, Kristin, Weishaupt, Lucas W, Merz, Karl-Heinz, Engst, Wolfram, Glatt, Hansruedi, Schrenk, Dieter
Published in Toxicological sciences (01.09.2012)
Published in Toxicological sciences (01.09.2012)
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Journal Article
Biological effects of acrylamide after daily ingestion of various foods in comparison to water: A study in rats
Berger, Franz Ingo, Feld, Julia, Bertow, Daniel, Eisenbrand, Gerhard, Fricker, Gert, Gerhardt, Natalie, Merz, Karl-Heinz, Richling, Elke, Baum, Matthias
Published in Molecular nutrition & food research (01.03.2011)
Published in Molecular nutrition & food research (01.03.2011)
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Journal Article
Characterization of the cytotoxicity of selected Chelidonium alkaloids in rat hepatocytes
Gao, Lan, Schmitz, Hans-Joachim, Merz, Karl-Heinz, Schrenk, Dieter
Published in Toxicology letters (01.09.2019)
Published in Toxicology letters (01.09.2019)
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Journal Article
Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule
Cheng, Xinlai, Merz, Karl-Heinz, Vatter, Sandra, Zeller, Jochen, Muehlbeyer, Stephan, Thommet, Andrea, Christ, Jochen, Wölfl, Stefan, Eisenbrand, Gerhard
Published in Journal of medicinal chemistry (22.06.2017)
Published in Journal of medicinal chemistry (22.06.2017)
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Journal Article
Determination of the Alkylpyrazine Composition of Coffee Using Stable Isotope Dilution–Gas Chromatography–Mass Spectrometry (SIDA-GC-MS)
Pickard, Stephanie, Becker, Irina, Merz, Karl-Heinz, Richling, Elke
Published in Journal of agricultural and food chemistry (03.07.2013)
Published in Journal of agricultural and food chemistry (03.07.2013)
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Journal Article
The Role of Indirubins in Inflammation and Associated Tumorigenesis
Cheng, Xinlai, Merz, Karl-Heinz
Published in Advances in experimental medicine and biology (01.01.2016)
Published in Advances in experimental medicine and biology (01.01.2016)
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Journal Article
Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells
Nam, Sangkil, Wen, Wei, Schroeder, Anne, Herrmann, Andreas, Yu, Hua, Cheng, Xinlai, Merz, Karl-Heinz, Eisenbrand, Gerhard, Li, Hongzhi, Yuan, Yate-Ching, Jove, Richard
Published in Molecular oncology (01.06.2013)
Published in Molecular oncology (01.06.2013)
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Journal Article
Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of Stat5 signaling
Nam, Sangkil, Scuto, Anna, Yang, Fan, Chen, WenYong, Park, Sungman, Yoo, Hwa-Seung, Konig, Heiko, Bhatia, Ravi, Cheng, Xinlai, Merz, Karl-Heinz, Eisenbrand, Gerhard, Jove, Richard
Published in Molecular oncology (01.06.2012)
Published in Molecular oncology (01.06.2012)
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Journal Article
Synthesis and cytotoxicity of novel indirubin-5-carboxamides
Cheng, Xinlai, Rasqué, Paul, Vatter, Sandra, Merz, Karl-Heinz, Eisenbrand, Gerhard
Published in Bioorganic & medicinal chemistry (15.06.2010)
Published in Bioorganic & medicinal chemistry (15.06.2010)
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Journal Article
Metabolism of Methylisoeugenol in Liver Microsomes of Human, Rat, and Bovine Origin
CARTUS, Alexander T, MERZ, Karl-Heinz, SCHRENK, Dieter
Published in Drug metabolism and disposition (01.09.2011)
Published in Drug metabolism and disposition (01.09.2011)
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Journal Article
Genotoxic potential of methyleugenol and selected methyleugenol metabolites in cultured Chinese hamster V79 cells
Maria Groh, Isabel Anna, Cartus, Alexander Thomas, Vallicotti, Sabrina, Kajzar, Julia, Merz, Karl-Heinz, Schrenk, Dieter, Esselen, Melanie
Published in Food & function (01.04.2012)
Published in Food & function (01.04.2012)
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Journal Article
An efficient synthesis of a lycobetaine-tortuosine analogue: A potent topoisomerase inhibitor
Merz, Karl-Heinz, Muller, Thierry, Vanderheiden, Sylvia, Eisenbrand, Gerhard, Marko, Doris, Braese, Stefan
Published in Synlett (18.12.2006)
Published in Synlett (18.12.2006)
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Journal Article
Fate of ¹⁴C-acrylamide in roasted and ground coffee during storage
Baum, Matthias, Böhm, Nadine, Görlitz, Jessica, Lantz, Ingo, Merz, Karl Heinz, Ternité, Rüdiger, Eisenbrand, Gerhard
Published in Molecular nutrition & food research (01.05.2008)
Published in Molecular nutrition & food research (01.05.2008)
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