Targeting MYC dependence in cancer by inhibiting BET bromodomains
Mertz, Jennifer A, Conery, Andrew R, Bryant, Barbara M, Sandy, Peter, Balasubramanian, Srividya, Mele, Deanna A, Bergeron, Louise, Sims, Robert J., III
Published in Proceedings of the National Academy of Sciences - PNAS (04.10.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (04.10.2011)
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Journal Article
Identification of a Benzoisoxazoloazepine Inhibitor (CPI-0610) of the Bromodomain and Extra-Terminal (BET) Family as a Candidate for Human Clinical Trials
Albrecht, Brian K, Gehling, Victor S, Hewitt, Michael C, Vaswani, Rishi G, Côté, Alexandre, Leblanc, Yves, Nasveschuk, Christopher G, Bellon, Steve, Bergeron, Louise, Campbell, Robert, Cantone, Nico, Cooper, Michael R, Cummings, Richard T, Jayaram, Hariharan, Joshi, Shivangi, Mertz, Jennifer A, Neiss, Adrianne, Normant, Emmanuel, O’Meara, Michael, Pardo, Eneida, Poy, Florence, Sandy, Peter, Supko, Jeffrey, Sims, Robert J, Harmange, Jean-Christophe, Taylor, Alexander M, Audia, James E
Published in Journal of medicinal chemistry (25.02.2016)
Published in Journal of medicinal chemistry (25.02.2016)
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Journal Article
Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma
Conery, Andrew R, Centore, Richard C, Neiss, Adrianne, Keller, Patricia J, Joshi, Shivangi, Spillane, Kerry L, Sandy, Peter, Hatton, Charlie, Pardo, Eneida, Zawadzke, Laura, Bommi-Reddy, Archana, Gascoigne, Karen E, Bryant, Barbara M, Mertz, Jennifer A, Sims, Robert J
Published in eLife (05.01.2016)
Published in eLife (05.01.2016)
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Journal Article
Regulation of GLI Underlies a Role for BET Bromodomains in Pancreatic Cancer Growth and the Tumor Microenvironment
Huang, Yinshi, Nahar, Sabikun, Nakagawa, Akifumi, Fernandez-Barrena, Maite G, Mertz, Jennifer A, Bryant, Barbara M, Adams, Curtis E, Mino-Kenudson, Mari, Von Alt, Kate N, Chang, Kevin, Conery, Andrew R, Hatton, Charlie, Sims, 3rd, Robert J, Fernandez-Zapico, Martin E, Wang, Xingpeng, Lillemoe, Keith D, Fernández-Del Castillo, Carlos, Warshaw, Andrew L, Thayer, Sarah P, Liss, Andrew S
Published in Clinical cancer research (15.08.2016)
Published in Clinical cancer research (15.08.2016)
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Journal Article
Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors
Gehling, Victor S, Hewitt, Michael C, Vaswani, Rishi G, Leblanc, Yves, Côté, Alexandre, Nasveschuk, Christopher G, Taylor, Alexander M, Harmange, Jean-Christophe, Audia, James E, Pardo, Eneida, Joshi, Shivangi, Sandy, Peter, Mertz, Jennifer A, Sims, Robert J, Bergeron, Louise, Bryant, Barbara M, Bellon, Steve, Poy, Florence, Jayaram, Hariharan, Sankaranarayanan, Ravichandran, Yellapantula, Sreegouri, Bangalore Srinivasamurthy, Nandana, Birudukota, Swarnakumari, Albrecht, Brian K
Published in ACS medicinal chemistry letters (12.09.2013)
Published in ACS medicinal chemistry letters (12.09.2013)
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Journal Article
Retroviral Rem protein requires processing by signal peptidase and retrotranslocation for nuclear function
Byun, Hyewon, Halani, Nimita, Mertz, Jennifer A., Ali, Almas F., Lozano, Mary M., Dudley, Jaquelin P., Estes, Mary K.
Published in Proceedings of the National Academy of Sciences - PNAS (06.07.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (06.07.2010)
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Journal Article
Discovery of Benzotriazolo[4,3‑d][1,4]diazepines as Orally Active Inhibitors of BET Bromodomains
Taylor, Alexander M, Vaswani, Rishi G, Gehling, Victor S, Hewitt, Michael C, Leblanc, Yves, Audia, James E, Bellon, Steve, Cummings, Richard T, Côté, Alexandre, Harmange, Jean-Christophe, Jayaram, Hari, Joshi, Shivangi, Lora, Jose M, Mertz, Jennifer A, Neiss, Adrianne, Pardo, Eneida, Nasveschuk, Christopher G, Poy, Florence, Sandy, Peter, Setser, Jeremy W, Sims, Robert J, Tang, Yong, Albrecht, Brian K
Published in ACS medicinal chemistry letters (11.02.2016)
Published in ACS medicinal chemistry letters (11.02.2016)
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Journal Article
ALY Is a Common Coactivator of RUNX1 and c-Myb on the Type B Leukemogenic Virus Enhancer
MERTZ, Jennifer A, KOBAYASHI, Ryuji, DUDLEY, Jaquelin P
Published in Journal of Virology (01.04.2007)
Published in Journal of Virology (01.04.2007)
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Journal Article
Comprehensive Target Engagement by the EZH2 Inhibitor Tulmimetostat Allows for Targeting of ARID1A Mutant Cancers
Keller, Patricia J, Adams, Elizabeth J, Wu, Rentian, Côté, Alexandre, Arora, Shilpi, Cantone, Nico, Meyer, Rosana, Mertz, Jennifer A, Gehling, Victor, Cui, Jike, Stuckey, Jacob I, Khanna, Avinash, Zhao, Feng, Chen, Zehua, Yu, Ziyang, Cummings, Richard T, Taimi, Mohammed, Lakhani, Nehal J, Rasco, Drew, Gutierrez, Martin, Duska, Linda, Devitt, Michael, Rippley, Ronda, Levell, Julian, Truong, Jennifer, Wang, Jing, Sun, Kaiming, Trojer, Patrick
Published in Cancer research (Chicago, Ill.) (01.08.2024)
Published in Cancer research (Chicago, Ill.) (01.08.2024)
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Journal Article
Identification and characterization of second-generation EZH2 inhibitors with extended residence times and improved biological activity
Stuckey, Jacob I., Cantone, Nico R., Côté, Alexandre, Arora, Shilpi, Vivat, Valerie, Ramakrishnan, Ashwin, Mertz, Jennifer A., Khanna, Avinash, Brenneman, Jehrod, Gehling, Victor S., Moine, Ludivine, Sims, Robert J., Audia, James E., Trojer, Patrick, Levell, Julian R., Cummings, Richard T.
Published in The Journal of biological chemistry (01.01.2021)
Published in The Journal of biological chemistry (01.01.2021)
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Journal Article
Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition
Ghosh, Srimoyee, Taylor, Alexander, Chin, Melissa, Huang, Hon-Ren, Conery, Andrew R., Mertz, Jennifer A., Salmeron, Andres, Dakle, Pranal J., Mele, Deanna, Cote, Alexandre, Jayaram, Hari, Setser, Jeremy W., Poy, Florence, Hatzivassiliou, Georgia, DeAlmeida-Nagata, Denise, Sandy, Peter, Hatton, Charlie, Romero, F. Anthony, Chiang, Eugene, Reimer, Thornik, Crawford, Terry, Pardo, Eneida, Watson, Venita G., Tsui, Vickie, Cochran, Andrea G., Zawadzke, Laura, Harmange, Jean-Christophe, Audia, James E., Bryant, Barbara M., Cummings, Richard T., Magnuson, Steven R., Grogan, Jane L., Bellon, Steve F., Albrecht, Brian K., Sims, Robert J., Lora, Jose M.
Published in The Journal of biological chemistry (17.06.2016)
Published in The Journal of biological chemistry (17.06.2016)
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Journal Article
Preclinical Anticancer Efficacy of BET Bromodomain Inhibitors Is Determined by the Apoptotic Response
Conery, Andrew R, Centore, Richard C, Spillane, Kerry L, Follmer, Nicole E, Bommi-Reddy, Archana, Hatton, Charlie, Bryant, Barbara M, Greninger, Patricia, Amzallag, Arnaud, Benes, Cyril H, Mertz, Jennifer A, Sims, 3rd, Robert J
Published in Cancer research (Chicago, Ill.) (15.03.2016)
Published in Cancer research (Chicago, Ill.) (15.03.2016)
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Journal Article
Selection for c-myc Integration Sites in Polyclonal T-Cell Lymphomas
Broussard, Dana R, Mertz, Jennifer A, Lozano, M, Dudley, Jaquelin P
Published in Journal of Virology (01.03.2002)
Published in Journal of Virology (01.03.2002)
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Journal Article
Development of methyl isoxazoleazepines as inhibitors of BET
Hewitt, Michael C., Leblanc, Yves, Gehling, Victor S., Vaswani, Rishi G., Cote, Alexandre, Nasveschuk, Christopher G., Taylor, Alexander M., Harmange, Jean-Christophe, Audia, James E., Pardo, Eneida, Cummings, Rich, Joshi, Shivangi, Sandy, Peter, Mertz, Jennifer A., Sims, Robert J., Bergeron, Louise, Bryant, Barbara M., Bellon, Steve, Poy, Florence, Jayaran, Hariharan, Tang, Yong, Albrecht, Brian K.
Published in Bioorganic & medicinal chemistry letters (01.05.2015)
Published in Bioorganic & medicinal chemistry letters (01.05.2015)
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Journal Article
Correction: Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma
Conery, Andrew R, Centore, Richard C, Neiss, Adrianne, Keller, Patricia J, Joshi, Shivangi, Spillane, Kerry L, Sandy, Peter, Hatton, Charlie, Pardo, Eneida, Zawadzke, Laura, Bommi-Reddy, Archana, Gascoigne, Karen E, Bryant, Barbara M, Mertz, Jennifer A, Sims, Robert J
Published in eLife (14.07.2016)
Published in eLife (14.07.2016)
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Journal Article