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Published in The Journal of biological chemistry (20.02.2015)
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JAK2V617F drives Mcl-1 expression and sensitizes hematologic cell lines to dual inhibition of JAK2 and Bcl-xL
Guo, Jun, Roberts, Lisa, Chen, Zhui, Merta, Philip J, Glaser, Keith B, Shah, O Jameel
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Published in PloS one (17.03.2015)
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Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195
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Published in ACS medicinal chemistry letters (14.02.2013)
Published in ACS medicinal chemistry letters (14.02.2013)
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Hajduk, Philip J, Metz, James T, Johnson, Eric F, Soni, Niru B, Merta, Philip J, Kifle, Lemma
Published in Nature chemical biology (01.04.2011)
Published in Nature chemical biology (01.04.2011)
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A-432411, a novel indolinone compound that disrupts spindle pole formation and inhibits human cancer cell growth
Chen, Zehan, Merta, Philip J, Lin, Nan-Hong, Tahir, Stephen K, Kovar, Peter, Sham, Hing L, Zhang, Haiying
Published in Molecular cancer therapeutics (01.04.2005)
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Synthesis and SAR evaluation of oxadiazolopyrazines as selective Haemophilus influenzae antibacterial agents
Beebe, Xenia, Nilius, Angela M., Merta, Philip J., Soni, Niru B., Bui, Mai H., Wagner, Rolf, Beutel, Bruce A.
Published in Bioorganic & medicinal chemistry letters (06.10.2003)
Published in Bioorganic & medicinal chemistry letters (06.10.2003)
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Novel Approach to Mapping of Resistance Mutations in Whole Genomes by Using Restriction Enzyme Modulation of Transformation Efficiency
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Published in Antimicrobial Agents and Chemotherapy (01.07.2005)
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Potent and Selective Inhibitors of CDPK1 from T. gondii and C. parvum Based on a 5‑Aminopyrazole-4-carboxamide Scaffold
Zhang, Zhongsheng, Ojo, Kayode K, Vidadala, RamaSubbaRao, Huang, Wenlin, Geiger, Jennifer A, Scheele, Suzanne, Choi, Ryan, Reid, Molly C, Keyloun, Katelyn R, Rivas, Kasey, Kallur Siddaramaiah, Latha, Comess, Kenneth M, Robinson, Kenneth P, Merta, Philip J, Kifle, Lemma, Hol, Wim G. J, Parsons, Marilyn, Merritt, Ethan A, Maly, Dustin J, Verlinde, Christophe L. M. J, Van Voorhis, Wesley C, Fan, Erkang
Published in ACS medicinal chemistry letters (09.01.2014)
Published in ACS medicinal chemistry letters (09.01.2014)
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Pyrimidine-Based Tricyclic Molecules as Potent and Orally Efficacious Inhibitors of Wee1 Kinase
Tong, Yunsong, Torrent, Maricel, Florjancic, Alan S, Bromberg, Kenneth D, Buchanan, Fritz G, Ferguson, Debra C, Johnson, Eric F, Lasko, Loren M, Maag, David, Merta, Philip J, Olson, Amanda M, Osterling, Donald J, Soni, Nirupama, Shoemaker, Alexander R, Penning, Thomas D
Published in ACS medicinal chemistry letters (08.01.2015)
Published in ACS medicinal chemistry letters (08.01.2015)
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Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[ b, e][1,4]diazepin-11-ones as potent Chk1 inhibitors
Hasvold, Lisa A., Wang, Le, Przytulinska, Magdalena, Xiao, Zhan, Chen, Zehan, Gu, Wen-Zhen, Merta, Philip J., Xue, John, Kovar, Peter, Zhang, Haiying, Park, Chang, Sowin, Thomas J., Rosenberg, Saul H., Lin, Nan-Horng
Published in Bioorganic & medicinal chemistry (01.04.2008)
Published in Bioorganic & medicinal chemistry (01.04.2008)
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Novel Antibacterial Class: A Series of Tetracyclic Derivatives
Hinman, Mira M, Rosenberg, Teresa A, Balli, Darlene, Black-Schaefer, Candace, Chovan, Linda E, Kalvin, Douglas, Merta, Philip J, Nilius, Angela M, Pratt, Steve D, Soni, Niru B, Wagenaar, Frank L, Weitzberg, Moshe, Wagner, Rolf, Beutel, Bruce A
Published in Journal of medicinal chemistry (10.08.2006)
Published in Journal of medicinal chemistry (10.08.2006)
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1,4-Dihydroindeno[1,2- c]pyrazoles as potent checkpoint kinase 1 inhibitors: Extended exploration on phenyl ring substitutions and preliminary ADME/PK studies
Tong, Yunsong, Claiborne, Akiyo, Pyzytulinska, Magdalena, Tao, Zhi-Fu, Stewart, Kent D., Kovar, Peter, Chen, Zehan, Credo, Robert B., Guan, Ran, Merta, Philip J., Zhang, Haiying, Bouska, Jennifer, Everitt, Elizabeth A., Murry, Bernard P., Hickman, Dean, Stratton, Tim J., Wu, Jian, Rosenberg, Saul H., Sham, Hing L., Sowin, Thomas J., Lin, Nan-horng
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
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Cyanopyridyl containing 1,4-dihydroindeno[1,2- c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability
Tong, Yunsong, Przytulinska, Magdalena, Tao, Zhi-Fu, Bouska, Jennifer, Stewart, Kent D., Park, Chang, Li, Gaoquan, Claiborne, Akiyo, Kovar, Peter, Chen, Zehan, Merta, Philip J., Bui, Mai-Ha, Olson, Amanda, Osterling, Donald, Zhang, Haiying, Sham, Hing L., Rosenberg, Saul H., Sowin, Thomas J., Lin, Nan-horng
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
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Novel Antibacterial Class
DANDLIKER, Peter J, PRATT, Steve D, CHOVAN, Linda E, HICKMAN, Robert K, DALY, Melissa M, KAKAVAS, Stephan, PING ZHONG, ZHENSHENG CAO, DAVID, Caroline A, XIAOLING XUEI, LERNER, Claude G, SONI, Niru B, NILIUS, Angela M, MAI BUI, SHEN, Linus L, YINGNA CAI, MERTA, Philip J, SAIKI, Anne Y. C, BEUTEL, Bruce A, BLACK-SCHAEFER, Candace, XIAOAN RUAN, TOWNE, Danli L, CLARK, Richard F, ENGLUND, Erika E, WAGNER, Rolf, WEITZBERG, Moshe
Published in Antimicrobial Agents and Chemotherapy (01.12.2003)
Published in Antimicrobial Agents and Chemotherapy (01.12.2003)
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From Bacterial Genomes to Novel Antibacterial Agents: Discovery, Characterization, and Antibacterial Activity of Compounds that Bind to HI0065 (YjeE) from Haemophilus influenzae
Lerner, Claude G., Hajduk, Philip J., Wagner, Rolf, Wagenaar, Frank L., Woodall, Charlotte, Gu, Yu‐Gui, Searle, Xenia B., Florjancic, Alan S., Zhang, Tianyuan, Clark, Richard F., Cooper, Curt S., Mack, Jamey C., Yu, Liping, Cai, Mengli, Betz, Steven F., Chovan, Linda E., McCall, J. Owen, Black‐Schaefer, Candace L., Kakavas, Stephan J., Schurdak, Mark E., Comess, Kenneth M., Walter, Karl A., Edalji, Rohinton, Dorwin, Sarah A., Smith, Richard A., Hebert, Eric J., Harlan, John E., Metzger, Randy E., Merta, Philip J., Baranowski, John L., Coen, Michael L., Thornewell, Susan J., Shivakumar, Annapur G., Saiki, Anne Y., Soni, Niru, Bui, Mai, Balli, Darlene J., Sanders, William J., Nilius, Angela M., Holzman, Thomas F., Fesik, Stephen W., Beutel, Bruce A.
Published in Chemical biology & drug design (01.06.2007)
Published in Chemical biology & drug design (01.06.2007)
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A strategy for discovery of novel broad-spectrum antibacterials using a high-throughput Streptococcus pneumoniae transcription/translation screen
Pratt, Steven D, David, Caroline A, Black-Schaefer, Candace, Dandliker, Peter J, Xuei, Xiaoling, Warrior, Usha, Burns, David J, Zhong, Ping, Cao, Zhensheng, Saiki, Anne Y C, Lerner, Claude G, Chovan, Linda E, Soni, Niru B, Nilius, Angela M, Wagenaar, Frank L, Merta, Philip J, Traphagen, Linda M, Beutel, Bruce A
Published in Journal of biomolecular screening (01.02.2004)
Published in Journal of biomolecular screening (01.02.2004)
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JAK2.sup.V617F Drives Mcl-1 Expression and Sensitizes Hematologic Cell Lines to Dual Inhibition of JAK2 and Bcl-xL
Guo, Jun, Roberts, Lisa, Chen, Zhui, Merta, Philip J, Glaser, Keith B, Shah, O. Jameel
Published in PloS one (17.03.2015)
Published in PloS one (17.03.2015)
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Abstract 12: JAK2 V617F drives Mcl-1 expression and sensitizes acute myeloid leukemia cells to dual inhibition of JAK2 and Bcl-XL
Guo, Jun, Roberts, Lisa, Kraft, Jeffrey B., Merta, Philip J., Glaser, Keith B., Shah, Omar J.
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo-[b,e][1,4]diazepin-11-ones as potent Chkl inhibitors
HASVOLD, Lisa A, LE WANG, PARK, Chang, SOWIN, Thomas J, ROSENBERG, Saul H, LIN, Nan-Horng, PRZYTULINSKA, Magdalena, ZHAN XIAO, ZEHAN CHEN, GU, Wen-Zhen, MERTA, Philip J, XUE, John, KOVAR, Peter, HAIYING ZHANG
Published in Bioorganic & medicinal chemistry letters (2008)
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Published in Bioorganic & medicinal chemistry letters (2008)
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