Screening of the Pathogen Box for inhibitors with dual efficacy against Giardia lamblia and Cryptosporidium parvum
Hennessey, Kelly M, Rogiers, Ilse C, Shih, Han-Wei, Hulverson, Matthew A, Choi, Ryan, McCloskey, Molly C, Whitman, Grant R, Barrett, Lynn K, Merritt, Ethan A, Paredez, Alexander R, Ojo, Kayode K
Published in PLoS neglected tropical diseases (01.08.2018)
Published in PLoS neglected tropical diseases (01.08.2018)
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Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors
Ojo, Kayode K, Pfander, Claudia, Mueller, Natascha R, Burstroem, Charlotte, Larson, Eric T, Bryan, Cassie M, Fox, Anna M W, Reid, Molly C, Johnson, Steven M, Murphy, Ryan C, Kennedy, Mark, Mann, Henning, Leibly, David J, Hewitt, Stephen N, Verlinde, Christophe L M J, Kappe, Stefan, Merritt, Ethan A, Maly, Dustin J, Billker, Oliver, Van Voorhis, Wesley C
Published in The Journal of clinical investigation (01.06.2012)
Published in The Journal of clinical investigation (01.06.2012)
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Active site profiling reveals coupling between domains in SRC-family kinases
Krishnamurty, Ratika, Brigham, Jennifer L, Leonard, Stephen E, Ranjitkar, Pratistha, Larson, Eric T, Dale, Edward J, Merritt, Ethan A, Maly, Dustin J
Published in Nature chemical biology (01.01.2013)
Published in Nature chemical biology (01.01.2013)
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Selective Inhibitors of Methionyl-tRNA Synthetase Have Potent Activity against Trypanosoma brucei Infection in Mice
SHIBATA, Sayaka, GILLESPIE, J. Robert, MERRITT, Ethan A, HOL, Wim G. J, VERLINDE, Christophe L. M. J, ERKANG FAN, BUCKNER, Frederick S, KELLEY, Angela M, NAPULI, Alberto J, ZHONGSHENG ZHANG, KOVZUN, Kuzma V, PEFLEY, Ranae M, LAM, Jocelyn, ZUCKER, Frank H, VAN VOORHIS, Wesley C
Published in Antimicrobial Agents and Chemotherapy (01.05.2011)
Published in Antimicrobial Agents and Chemotherapy (01.05.2011)
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Journal Article
Identification and Validation of Small-Gatekeeper Kinases as Drug Targets in Giardia lamblia
Hennessey, Kelly M, Smith, Tess R, Xu, Jennifer W, Alas, Germain C M, Ojo, Kayode K, Merritt, Ethan A, Paredez, Alexander R
Published in PLoS neglected tropical diseases (02.11.2016)
Published in PLoS neglected tropical diseases (02.11.2016)
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Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1
Larson, Eric T, Ojo, Kayode K, Murphy, Ryan C, Johnson, Steven M, Zhang, Zhongsheng, Kim, Jessica E, Leibly, David J, Fox, Anna M. W, Reid, Molly C, Dale, Edward J, Perera, B. Gayani K, Kim, Jae, Hewitt, Stephen N, Hol, Wim G. J, Verlinde, Christophe L. M. J, Fan, Erkang, Van Voorhis, Wesley C, Maly, Dustin J, Merritt, Ethan A
Published in Journal of medicinal chemistry (22.03.2012)
Published in Journal of medicinal chemistry (22.03.2012)
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Journal Article
Toxoplasma gondii Cathepsin L Is the Primary Target of the Invasion-inhibitory Compound Morpholinurea-leucyl-homophenyl-vinyl Sulfone Phenyl
Larson, Eric T., Parussini, Fabiola, Huynh, My-Hang, Giebel, Jonathan D., Kelley, Angela M., Zhang, Li, Bogyo, Matthew, Merritt, Ethan A., Carruthers, Vern B.
Published in The Journal of biological chemistry (25.09.2009)
Published in The Journal of biological chemistry (25.09.2009)
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Journal Article
Cooperative hydrogen bond interactions in the streptavidin–biotin system
Hyre, David E., Le Trong, Isolde, Merritt, Ethan A., Eccleston, John F., Green, N. Michael, Stenkamp, Ronald E., Stayton, Patrick S.
Published in Protein science (01.03.2006)
Published in Protein science (01.03.2006)
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Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies
Arakaki, Tracy L, Buckner, Frederick S, Gillespie, J. Robert, Malmquist, Nicholas A, Phillips, Margaret A, Kalyuzhniy, Oleksandr, Luft, Joseph R, DeTitta, George T, Verlinde, Christophe L.M.J, Van Voorhis, Wesley C, Hol, Wim G.J, Merritt, Ethan A
Published in Molecular microbiology (01.04.2008)
Published in Molecular microbiology (01.04.2008)
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Journal Article
HingeMaster: Normal mode hinge prediction approach and integration of complementary predictors
Flores, Samuel C., Keating, Kevin S., Painter, Jay, Morcos, Faruck, Nguyen, Khang, Merritt, Ethan A., Kuhn, Leslie A., Gerstein, Mark B.
Published in Proteins, structure, function, and bioinformatics (01.11.2008)
Published in Proteins, structure, function, and bioinformatics (01.11.2008)
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Journal Article
Neospora caninum calcium-dependent protein kinase 1 is an effective drug target for neosporosis therapy
Ojo, Kayode K, Reid, Molly C, Kallur Siddaramaiah, Latha, Müller, Joachim, Winzer, Pablo, Zhang, Zhongsheng, Keyloun, Katelyn R, Vidadala, Rama Subba Rao, Merritt, Ethan A, Hol, Wim G J, Maly, Dustin J, Fan, Erkang, Van Voorhis, Wesley C, Hemphill, Andrew
Published in PloS one (28.03.2014)
Published in PloS one (28.03.2014)
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AB5 toxins: structures and inhibitor design
Fan, Erkang, Merritt, Ethan A, Verlinde, Christophe LMJ, Hol, Wim GJ
Published in Current opinion in structural biology (01.12.2000)
Published in Current opinion in structural biology (01.12.2000)
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Journal Article
The 1.25 Å resolution refinement of the cholera toxin B-pentamer: evidence of peptide backbone strain at the receptor-binding site
Merritt, Ethan A, Kuhn, Peter, Sarfaty, Steve, Erbe, Jarrod L, Holmes, Randall K, Hol, Wim G.J
Published in Journal of molecular biology (09.10.1998)
Published in Journal of molecular biology (09.10.1998)
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Prediction of protein crystallization outcome using a hybrid method
Zucker, Frank H., Stewart, Christine, Rosa, Jaclyn dela, Kim, Jessica, Zhang, Li, Xiao, Liren, Ross, Jenni, Napuli, Alberto J., Mueller, Natascha, Castaneda, Lisa J., Nakazawa Hewitt, Stephen R., Arakaki, Tracy L., Larson, Eric T., Subramanian, Easwara, Verlinde, Christophe L.M.J., Fan, Erkang, Buckner, Frederick S., Van Voorhis, Wesley C., Merritt, Ethan A., Hol, Wim G.J.
Published in Journal of structural biology (01.07.2010)
Published in Journal of structural biology (01.07.2010)
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A Combined Approach Reveals a Regulatory Mechanism Coupling Src’s Kinase Activity, Localization, and Phosphotransferase-Independent Functions
Ahler, Ethan, Register, Ames C., Chakraborty, Sujata, Fang, Linglan, Dieter, Emily M., Sitko, Katherine A., Vidadala, Rama Subba Rao, Trevillian, Bridget M., Golkowski, Martin, Gelman, Hannah, Stephany, Jason J., Rubin, Alan F., Merritt, Ethan A., Fowler, Douglas M., Maly, Dustin J.
Published in Molecular cell (18.04.2019)
Published in Molecular cell (18.04.2019)
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Journal Article
To B or not to B: a question of resolution?
Merritt, Ethan A.
Published in Acta crystallographica. Section D, Biological crystallography. (01.04.2012)
Published in Acta crystallographica. Section D, Biological crystallography. (01.04.2012)
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Journal Article
Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis
Vidadala, Rama Subba Rao, Rivas, Kasey L, Ojo, Kayode K, Hulverson, Matthew A, Zambriski, Jennifer A, Bruzual, Igor, Schultz, Tracey L, Huang, Wenlin, Zhang, Zhongsheng, Scheele, Suzanne, DeRocher, Amy E, Choi, Ryan, Barrett, Lynn K, Siddaramaiah, Latha Kallur, Hol, Wim G. J, Fan, Erkang, Merritt, Ethan A, Parsons, Marilyn, Freiberg, Gail, Marsh, Kennan, Kempf, Dale J, Carruthers, Vern B, Isoherranen, Nina, Doggett, J. Stone, Van Voorhis, Wesley C, Maly, Dustin J
Published in Journal of medicinal chemistry (14.07.2016)
Published in Journal of medicinal chemistry (14.07.2016)
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