Pharmacological characterization of GLPG1972/S201086, a potent and selective small-molecule inhibitor of ADAMTS5
Clement-Lacroix, P., Little, C.B., Smith, M.M., Cottereaux, C., Merciris, D., Meurisse, S., Mollat, P., Touitou, R., Brebion, F., Gosmini, R., De Ceuninck, F., Botez, I., Lepescheux, L., van der Aar, E., Christophe, T., Vandervoort, N., Blanqué, R., Comas, D., Deprez, P., Amantini, D.
Published in Osteoarthritis and cartilage (01.02.2022)
Published in Osteoarthritis and cartilage (01.02.2022)
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OP0258 Efficacy of the highly selective adamts-5 inhibitor glpg1972 in the rat meniscectomy model
Lepescheux, L., Clement-Lacroix, P., Merciris, D., Meurisse, S., Borgonovi, M., Cottereaux, C., Mollat, P., Brebion, F., Gosmini, R., De Ceuninck, F., Botez, I., van der Aar, E., Christophe, T., Vandervoort, N., Blanqué, R., Comas, D., Deprez, P., Amantini, D.
Published in Annals of the rheumatic diseases (01.06.2018)
Published in Annals of the rheumatic diseases (01.06.2018)
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Journal Article
New cartilage quality evaluation using bio-indentation: effect of a tool dmoad compound active in the rat MNX model
Lavet, C, Clement-Lacroix, P, Merciris, D, Meurisse, S, Lepescheux, L, Gaillard, V, Pastoureau, P, Deprez, P, Amantini, D, Ammann, P
Published in Osteoarthritis and cartilage (01.04.2016)
Published in Osteoarthritis and cartilage (01.04.2016)
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Journal Article
THU0138 Glpg0634m1, A Major Metabolite of the Jak1-Selective Inhibitor Glpg0634, is Also Jak1-Selective and Efficient in the Rat CIA Model
Belleville-Da-Costa, C., Merciris, D., Vayssière, B., Houvenaghel, N., Monjardet, A., Lepescheux, L., Dupont, S., Christophe, T., Borgonovi, M., Clément-Lacroix, P., Menet, C., Van Rompaey, L., Brys, R., Galien, R.
Published in Annals of the rheumatic diseases (01.06.2014)
Published in Annals of the rheumatic diseases (01.06.2014)
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THU0116 Biological Effects of the JAK1 Selective Inhibitor GLPG0634 on Inflammation Markers in Arthritic Mice
Vayssiere, B., de Vos, S., Merciris, D., Auberval, M., Dupont, S., Vandeghinste, N., Lepescheux, L., Clement-Lacroix, P., Delerive, P., van Rompaey, L., Brys, R., Galien, R.
Published in Annals of the rheumatic diseases (01.06.2013)
Published in Annals of the rheumatic diseases (01.06.2013)
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Over-expression of TIMP-1 in osteoblasts increases the anabolic response to PTH
Merciris, D, Schiltz, C, Legoupil, N, Marty-Morieux, C, de Vernejoul, M.C, Geoffroy, V
Published in Bone (New York, N.Y.) (01.01.2007)
Published in Bone (New York, N.Y.) (01.01.2007)
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POS0442 GLPG4399: SELECTIVE SIK3 INHIBITION AS A NOVEL MODE OF ACTION FOR THE TREATMENT OF INFLAMMATORY ARTHRITIC DISEASES (PRECLINICAL)
Lavazais, S., Pereira-Fernandes, A., Delachaume, C., Jagerschmidt, C., Drennan, M., Merciris, D., Peixoto, C., Borgonovi, M., Desroy, N., Amantini, D., De Vos, S., Nys, K.
Published in Annals of the rheumatic diseases (01.06.2022)
Published in Annals of the rheumatic diseases (01.06.2022)
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Journal Article
ADAMTS-5 inhibition with the potent and highly selective inhibitor GLPG1972 results in strong disease-modifying OA drug effects in the rat meniscectomy model
Clement-Lacroix, P., Meurisse, S., Lepescheux, L., Merciris, D., Borgonovi, M., Cottereaux, C., Mollat, P., Brebion, F., Gosmini, R., De Ceuninck, F., Botez, I., Christophe, T., van der Aar, E.E., Vandervoort, N., Blanqué, R., Comas, D., Deprez, P., Amantini, D.
Published in Osteoarthritis and cartilage (01.04.2018)
Published in Osteoarthritis and cartilage (01.04.2018)
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Journal Article
OP0161 The JAK1 selective inhibitor filgotinib regulates both enthesis and colon inflammation in a mouse model of psoriatic arthritis
Robin-Jagerschmidt, C, Lavazais, S, Marsais, F, Monjardet, A, Cauvin, A, Saccomani, C, Parent, I, Merciris, D, Chanudet, E, Borgonovi, M, Lepescheux, L, Auberval, M, Dupont, S, Clement-Lacroix, P, Galien, R
Published in Annals of the rheumatic diseases (01.06.2017)
Published in Annals of the rheumatic diseases (01.06.2017)
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P072 GLPG0634, the first selective JAK1 inhibitor, shows strong activity in the mouse DSS-colitis model
Merciris, D., Delachaume, C., De Vriendt, V., Boutet, A.-L., Perret, L., Ceccotti, M.-C., De Vos, S., Monjardet, A., Brys, R., Galien, R.
Published in Journal of Crohn's and colitis (01.02.2014)
Published in Journal of Crohn's and colitis (01.02.2014)
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