Imaging synaptic density in the living human brain
Finnema, Sjoerd J, Nabulsi, Nabeel B, Eid, Tore, Detyniecki, Kamil, Lin, Shu-Fei, Chen, Ming-Kai, Dhaher, Roni, Matuskey, David, Baum, Evan, Holden, Daniel, Spencer, Dennis D, Mercier, Joël, Hannestad, Jonas, Huang, Yiyun, Carson, Richard E
Published in Science translational medicine (20.07.2016)
Published in Science translational medicine (20.07.2016)
Get more information
Journal Article
Late-Stage (18) F-Difluoromethyl Labeling of N-Heteroaromatics with High Molar Activity for PET Imaging
Trump, Laura, Lemos, Agostinho, Lallemand, Benedicte, Pasau, Patrick, Mercier, Joel, Lemaire, Christian, Luxen, André, Genicot, Christophe
Year of Publication 09.09.2019
Year of Publication 09.09.2019
Get full text
Web Resource
The tau positron‐emission tomography tracer AV‐1451 binds with similar affinities to tau fibrils and monoamine oxidases
Vermeiren, Céline, Motte, Philippe, Viot, Delphine, Mairet‐Coello, Georges, Courade, Jean‐Philippe, Citron, Martin, Mercier, Joël, Hannestad, Jonas, Gillard, Michel
Published in Movement disorders (01.02.2018)
Published in Movement disorders (01.02.2018)
Get full text
Journal Article
Kinetic evaluation and test–retest reproducibility of [11C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans
Finnema, Sjoerd J, Nabulsi, Nabeel B, Mercier, Joël, Lin, Shu-fei, Chen, Ming-Kai, Matuskey, David, Gallezot, Jean-Dominique, Henry, Shannan, Hannestad, Jonas, Huang, Yiyun, Carson, Richard E
Published in Journal of cerebral blood flow and metabolism (01.11.2018)
Published in Journal of cerebral blood flow and metabolism (01.11.2018)
Get full text
Journal Article
Development of a General Automated Flow Photoredox 18F‑Difluoromethylation of N‑Heteroaromatics in an AllinOne Synthesizer
Trump, Laura, Lemos, Agostinho, Jacq, Jérôme, Pasau, Patrick, Lallemand, Bénédicte, Mercier, Joël, Genicot, Christophe, Luxen, André, Lemaire, Christian
Published in Organic process research & development (15.05.2020)
Published in Organic process research & development (15.05.2020)
Get full text
Journal Article
Web Resource
Brivaracetam, a selective high‐affinity synaptic vesicle protein 2A (SV2A) ligand with preclinical evidence of high brain permeability and fast onset of action
Nicolas, Jean‐Marie, Hannestad, Jonas, Holden, Daniel, Kervyn, Sophie, Nabulsi, Nabeel, Tytgat, Dominique, Huang, Yiyun, Chanteux, Hugues, Staelens, Ludovicus, Matagne, Alain, Mathy, François‐Xavier, Mercier, Joël, Stockis, Armel, Carson, Richard E., Klitgaard, Henrik
Published in Epilepsia (Copenhagen) (01.02.2016)
Published in Epilepsia (Copenhagen) (01.02.2016)
Get full text
Journal Article
Pharmacokinetic Characterization of [18F]UCB‑H PET Radiopharmaceutical in the Rat Brain
Becker, Guillaume, Warnier, Corentin, Serrano, Maria Elisa, Bahri, Mohamed Ali, Mercier, Joël, Lemaire, Christian, Salmon, Eric, Luxen, André, Plenevaux, Alain
Published in Molecular pharmaceutics (07.08.2017)
Published in Molecular pharmaceutics (07.08.2017)
Get full text
Journal Article
Web Resource
Evaluation and Application of a PET Tracer in Preclinical and Phase 1 Studies to Determine the Brain Biodistribution of Minzasolmin (UCB0599)
Mercier, Joël, Bani, Massimo, Colson, Anny-Odile, Germani, Massimiliano, Lalla, Marianna, Plisson, Christophe, Huiban, Mickael, Searle, Graham, Mathy, François-Xavier, Nicholl, Richard, Otoul, Christian, Smit, Johan Willem, van Asch, Vanja, Wagneur, Michel, Maguire, Ralph Paul
Published in Molecular imaging and biology (01.04.2024)
Published in Molecular imaging and biology (01.04.2024)
Get full text
Journal Article
A single‐center, open‐label positron emission tomography study to evaluate brivaracetam and levetiracetam synaptic vesicle glycoprotein 2A binding in healthy volunteers
Finnema, Sjoerd J., Rossano, Samantha, Naganawa, Mika, Henry, Shannan, Gao, Hong, Pracitto, Richard, Maguire, Ralph P., Mercier, Joël, Kervyn, Sophie, Nicolas, Jean‐Marie, Klitgaard, Henrik, DeBruyn, Steven, Otoul, Christian, Martin, Paul, Muglia, Pierandrea, Matuskey, David, Nabulsi, Nabeel B., Huang, Yiyun, Kaminski, Rafal M., Hannestad, Jonas, Stockis, Armel, Carson, Richard E.
Published in Epilepsia (Copenhagen) (01.05.2019)
Published in Epilepsia (Copenhagen) (01.05.2019)
Get full text
Journal Article
Evaluating the In Vivo Specificity of [ 18 F]UCB-H for the SV2A Protein, Compared with SV2B and SV2C in Rats Using microPET
Serrano, Maria Elisa, Becker, Guillaume, Bahri, Mohamed Ali, Seret, Alain, Mestdagh, Nathalie, Mercier, Joël, Mievis, Frédéric, Giacomelli, Fabrice, Lemaire, Christian, Salmon, Eric, Luxen, André, Plenevaux, Alain
Published in Molecules (Basel, Switzerland) (01.05.2019)
Published in Molecules (Basel, Switzerland) (01.05.2019)
Get full text
Journal Article
Web Resource
Late‐Stage 18F‐Difluoromethyl Labeling of N‐Heteroaromatics with High Molar Activity for PET Imaging
Trump, Laura, Lemos, Agostinho, Lallemand, Bénédicte, Pasau, Patrick, Mercier, Joël, Lemaire, Christian, Luxen, André, Genicot, Christophe
Published in Angewandte Chemie International Edition (09.09.2019)
Published in Angewandte Chemie International Edition (09.09.2019)
Get full text
Journal Article
Radical C–H 18F-Difluoromethylation of Heteroarenes with [18F]Difluoromethyl Heteroaryl-Sulfones by Visible Light Photoredox Catalysis
Lemos, Agostinho Luís Pereira, Trump, Laura, Lallemand, Bénédicte, Pasau, Patrick, Mercier, Joël, Lemaire, Christian, Monbaliu, Jean-Christophe, Genicot, Christophe, Luxen, André
Published in Catalysts (01.03.2020)
Published in Catalysts (01.03.2020)
Get full text
Journal Article
The Aminotriazole Antagonist Cmpd‐1 Stabilises a Distinct Inactive State of the Adenosine 2A Receptor
Landin, Erik J. B., Lovera, Silvia, de Fabritiis, Gianni, Kelm, Sebastian, Mercier, Joël, McMillan, David, Sessions, Richard B., Taylor, Richard J., Sands, Zara A., Joedicke, Lisa, Crump, Matthew P.
Published in Angewandte Chemie International Edition (08.07.2019)
Published in Angewandte Chemie International Edition (08.07.2019)
Get full text
Journal Article
A Comparative Study of in vitro Assays for Predicting the Nonspecific Binding of PET Imaging Agents in vivo
Gobbi, Luca, Mercier, Joël, Bang‐Andersen, Benny, Nicolas, Jean‐Marie, Reilly, John, Wagner, Björn, Whitehead, David, Briard, Emmanuelle, Maguire, R. Paul, Borroni, Edilio, Auberson, Yves P.
Published in ChemMedChem (03.04.2020)
Published in ChemMedChem (03.04.2020)
Get full text
Journal Article
Discovery of Heterocyclic Nonacetamide Synaptic Vesicle Protein 2A (SV2A) Ligands with Single-Digit Nanomolar Potency: Opening Avenues towards the First SV2A Positron Emission Tomography (PET) Ligands
Mercier, Joël, Archen, Laurence, Bollu, Véronique, Carré, Stéphane, Evrard, Yves, Jnoff, Eric, Kenda, Benoît, Lallemand, Bénédicte, Michel, Philippe, Montel, Florian, Moureau, Florence, Price, Nathalie, Quesnel, Yannick, Sauvage, Xavier, Valade, Anne, Provins, Laurent
Published in ChemMedChem (01.04.2014)
Published in ChemMedChem (01.04.2014)
Get full text
Journal Article
Enabling Efficient Positron Emission Tomography (PET) Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) with a Robust and One-Step Radiosynthesis of a Highly Potent 18F‑Labeled Ligand ([18F]UCB-H)
Warnier, Corentin, Lemaire, Christian, Becker, Guillaume, Zaragoza, Guillermo, Giacomelli, Fabrice, Aerts, Joël, Otabashi, Muhammad, Bahri, Mohamed Ali, Mercier, Joël, Plenevaux, Alain, Luxen, André
Published in Journal of medicinal chemistry (13.10.2016)
Published in Journal of medicinal chemistry (13.10.2016)
Get full text
Journal Article
Drug characteristics derived from kinetic modeling: combined 11C-UCB-J human PET imaging with levetiracetam and brivaracetam occupancy of SV2A
Naganawa, Mika, Gallezot, Jean-Dominique, Finnema, Sjoerd J., Maguire, Ralph Paul, Mercier, Joël, Nabulsi, Nabeel B., Kervyn, Sophie, Henry, Shannan, Nicolas, Jean-Marie, Huang, Yiyun, Chen, Ming-Kai, Hannestad, Jonas, Klitgaard, Henrik, Stockis, Armel, Carson, Richard E.
Published in EJNMMI research (08.11.2022)
Published in EJNMMI research (08.11.2022)
Get full text
Journal Article
A General Copper-Mediated Nucleophilic 18F Fluorination of Arenes
Tredwell, Matthew, Preshlock, Sean M., Taylor, Nicholas J., Gruber, Stefan, Huiban, Mickael, Passchier, Jan, Mercier, Joël, Génicot, Christophe, Gouverneur, Véronique
Published in Angewandte Chemie International Edition (21.07.2014)
Published in Angewandte Chemie International Edition (21.07.2014)
Get full text
Journal Article
Discovery of Indolone Acetamides as Novel SV2A Ligands with Improved Potency Toward Seizure Suppression
Frycia, Anne, Starck, Jean-Philippe, Jadot, Sophie, Lallemand, Bénédicte, Leclercq, Karine, Lo Brutto, Patrick, Matagne, Alain, Verbois, Valérie, Mercier, Joël, Kenda, Benoit
Published in ChemMedChem (01.02.2010)
Published in ChemMedChem (01.02.2010)
Get full text
Journal Article
Derisking the Cu-Mediated 18F‑Fluorination of Heterocyclic Positron Emission Tomography Radioligands
Taylor, Nicholas J, Emer, Enrico, Preshlock, Sean, Schedler, Michael, Tredwell, Matthew, Verhoog, Stefan, Mercier, Joel, Genicot, Christophe, Gouverneur, Véronique
Published in Journal of the American Chemical Society (21.06.2017)
Published in Journal of the American Chemical Society (21.06.2017)
Get full text
Journal Article