The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials
Mercer, Amy E., Copple, Ian M., Maggs, James L., O'Neill, Paul M., Park, B. Kevin
Published in The Journal of biological chemistry (14.01.2011)
Published in The Journal of biological chemistry (14.01.2011)
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Journal Article
Evidence for the Involvement of Carbon-centered Radicals in the Induction of Apoptotic Cell Death by Artemisinin Compounds
Mercer, Amy E., Maggs, James L., Sun, Xiao-Ming, Cohen, Gerald M., Chadwick, James, O'Neill, Paul M., Park, B. Kevin
Published in The Journal of biological chemistry (30.03.2007)
Published in The Journal of biological chemistry (30.03.2007)
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Journal Article
Evidence for a Common Non‐Heme Chelatable‐Iron‐Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs
Stocks, Paul A., Bray, Patrick G., Barton, Victoria E., Al‐Helal, Mohammed, Jones, Michael, Araujo, Nuna C., Gibbons, Peter, Ward, Stephen A., Hughes, Ruth H., Biagini, Giancarlo A., Davies, Jill, Amewu, Richard, Mercer, Amy E., Ellis, Gemma, O'Neill, Paul M.
Published in Angewandte Chemie International Edition (01.01.2007)
Published in Angewandte Chemie International Edition (01.01.2007)
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Journal Article
Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines
Chadwick, James, Jones, Michael, Mercer, Amy E., Stocks, Paul A., Ward, Stephen A., Park, B. Kevin, O’Neill, Paul M.
Published in Bioorganic & medicinal chemistry (01.04.2010)
Published in Bioorganic & medicinal chemistry (01.04.2010)
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Journal Article
Antitumour and antimalarial activity of artemisinin-acridine hybrids
JONES, Michael, MERCER, Amy E, BRAY, Patrick G, RAWE, Sarah L, BAIRD, Jonathan, CHARIDZA, Tafadzwa, JANNEH, Omar, O'NEILL, Paul M, STOCKS, Paul A, LA PENSEE, Louise J. I, COSSTICK, Rick, PARK, B. Kevin, KENNEDY, Miriam E, PIANTANIDA, Ivo, WARD, Stephen A, DAVIES, Jill
Published in Bioorganic & medicinal chemistry letters (01.04.2009)
Published in Bioorganic & medicinal chemistry letters (01.04.2009)
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Journal Article
Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells
Chadwick, James, Mercer, Amy E., Park, B. Kevin, Cosstick, Richard, O’Neill, Paul M.
Published in Bioorganic & medicinal chemistry (01.02.2009)
Published in Bioorganic & medicinal chemistry (01.02.2009)
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Journal Article
Antimalarial and Antitumor Evaluation of Novel C-10 Non-Acetal Dimers of 10β-(2-Hydroxyethyl)deoxoartemisinin
Jeyadevan, J. Prince, Bray, Patrick G, Chadwick, James, Mercer, Amy E, Byrne, Aoife, Ward, Stephen A, Park, B. Kevin, Williams, Dominic P, Cosstick, Rick, Davies, Jill, Higson, Adrian P, Irving, Ed, Posner, Gary H, O'Neill, Paul M
Published in Journal of medicinal chemistry (26.02.2004)
Published in Journal of medicinal chemistry (26.02.2004)
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Journal Article
Assessing the cytotoxic profile of novel endoperoxide derivatives
Firman, James W, MacFarlane, Marion, Park, B. Kevin, Mercer, Amy E
Published in Toxicology (Amsterdam) (2011)
Published in Toxicology (Amsterdam) (2011)
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Journal Article
Examination of the cytotoxic and embryotoxic potential and underlying mechanisms of next-generation synthetic trioxolane and tetraoxane antimalarials
Copple, Ian M, Mercer, Amy E, Firman, James, Donegan, Gail, Herpers, Bram, Wong, Michael Hl, Chadwick, James, Bringela, Andreia D, Cristiano, Maria L S, van de Water, Bob, Ward, Stephen A, O'Neill, Paul M, Park, B Kevin
Published in Molecular medicine (Cambridge, Mass.) (01.07.2012)
Published in Molecular medicine (Cambridge, Mass.) (01.07.2012)
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Journal Article
Evidence for a Common Non-Heme Chelatable-Iron-Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs
Stocks, Paul A, Bray, Patrick G, Barton, Victoria E, Al-Helal, Mohammed, Jones, Michael, Araujo, Nuna C, Gibbons, Peter, Ward, Stephen A, Hughes, Ruth H, Biagini, Giancarlo A, Davies, Jill, Amewu, Richard, Mercer, Amy E, Ellis, Gemma, O'Neill, Paul M
Published in Angewandte Chemie (International ed.) (20.08.2007)
Published in Angewandte Chemie (International ed.) (20.08.2007)
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Journal Article
Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols
Amewu, Richard, Gibbons, Peter, Mukhtar, Amira, Stachulski, Andrew V., Ward, Stephen A., Hall, Charlotte, Rimmer, Karen, Davies, Jill, Vivas, Livia, Bacsa, John, Mercer, Amy E., Nixon, Gemma, Stocks, Paul A., O'Neill, Paul M.
Published in Organic & biomolecular chemistry (01.01.2010)
Published in Organic & biomolecular chemistry (01.01.2010)
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Journal Article
Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis
Mercer, Amy E., Regan, Sophie L., Hirst, Charlotte M., Graham, Emma E., Antoine, Daniel J., Benson, Craig A., Williams, Dominic P., Foster, John, Kenna, J. Gerry, Park, B. Kevin
Published in Toxicology and applied pharmacology (15.09.2009)
Published in Toxicology and applied pharmacology (15.09.2009)
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Journal Article
A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance
O’Neill, Paul M., Amewu, Richard K., Charman, Susan A., Sabbani, Sunil, Gnädig, Nina F., Straimer, Judith, Fidock, David A., Shore, Emma R., Roberts, Natalie L., Wong, Michael H.-L., Hong, W. David, Pidathala, Chandrakala, Riley, Chris, Murphy, Ben, Aljayyoussi, Ghaith, Gamo, Francisco Javier, Sanz, Laura, Rodrigues, Janneth, Cortes, Carolina Gonzalez, Herreros, Esperanza, Angulo-Barturén, Iñigo, Jiménez-Díaz, María Belén, Bazaga, Santiago Ferrer, Martínez-Martínez, María Santos, Campo, Brice, Sharma, Raman, Ryan, Eileen, Shackleford, David M., Campbell, Simon, Smith, Dennis A., Wirjanata, Grennady, Noviyanti, Rintis, Price, Ric N., Marfurt, Jutta, Palmer, Michael J., Copple, Ian M., Mercer, Amy E., Ruecker, Andrea, Delves, Michael J., Sinden, Robert E., Siegl, Peter, Davies, Jill, Rochford, Rosemary, Kocken, Clemens H. M., Zeeman, Anne-Marie, Nixon, Gemma L., Biagini, Giancarlo A., Ward, Stephen A.
Published in Nature communications (24.05.2017)
Published in Nature communications (24.05.2017)
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Journal Article
Evidence for a Common Non-Heme Chelatable-Iron-Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs
Stocks, Paul A., Bray, Patrick G., Barton, Victoria E., Al-Helal, Mohammed, Jones, Michael, Araujo, Nuna C., Gibbons, Peter, Ward, Stephen A., Hughes, Ruth H., Biagini, Giancarlo A., Davies, Jill, Amewu, Richard, Mercer, Amy E., Ellis, Gemma, O'Neill, Paul M.
Published in Angewandte Chemie (20.08.2007)
Published in Angewandte Chemie (20.08.2007)
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Journal Article
Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10beta-(2-hydroxyethyl)deoxoartemisinin
Jeyadevan, J Prince, Bray, Patrick G, Chadwick, James, Mercer, Amy E, Byrne, Aoife, Ward, Stephen A, Park, B Kevin, Williams, Dominic P, Cosstick, Rick, Davies, Jill, Higson, Adrian P, Irving, Ed, Posner, Gary H, O'Neill, Paul M
Published in Journal of medicinal chemistry (26.02.2004)
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Published in Journal of medicinal chemistry (26.02.2004)
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