A Phase 3 Trial of Difelikefalin in Hemodialysis Patients with Pruritus
Fishbane, Steven, Jamal, Aamir, Munera, Catherine, Wen, Warren, Menzaghi, Frédérique
Published in The New England journal of medicine (16.01.2020)
Published in The New England journal of medicine (16.01.2020)
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Journal Article
A phase 2 study of oral difelikefalin in subjects with chronic kidney disease and moderate-to-severe pruritus
Yosipovitch, Gil, Awad, Ahmed, Spencer, Robert H., Munera, Catherine, Menzaghi, Frédérique
Published in Journal of the American Academy of Dermatology (01.08.2023)
Published in Journal of the American Academy of Dermatology (01.08.2023)
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Journal Article
Clinically meaningful change in itch intensity scores: An evaluation in patients with chronic kidney disease–associated pruritus
Vernon, Margaret, Ständer, Sonja, Munera, Catherine, Spencer, Robert H., Menzaghi, Frédérique
Published in Journal of the American Academy of Dermatology (01.04.2021)
Published in Journal of the American Academy of Dermatology (01.04.2021)
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Journal Article
Difelikefalin improves itch-related sleep disruption in patients undergoing haemodialysis
Weiner, Daniel E, Schaufler, Thilo, McCafferty, Kieran, Kalantar-Zadeh, Kamyar, Germain, Michael, Ruessmann, Despina, Morin, Isabelle, Menzaghi, Frédérique, Wen, Warren, Ständer, Sonja
Published in Nephrology, dialysis, transplantation (28.06.2024)
Published in Nephrology, dialysis, transplantation (28.06.2024)
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Journal Article
Difelikefalin in Black/African American Hemodialysis Patients with Moderate-to-Severe Pruritus: Post hoc Analysis of KALM-1 and KALM-2
Fishbane, Steven, Clegg, Deborah J., Lerma, Edgar V., Rastogi, Anjay, Budden, Jeffrey, Morin, Isabelle, Wen, Warren, Menzaghi, Frédérique, Topf, Joel
Published in American journal of nephrology (01.06.2024)
Published in American journal of nephrology (01.06.2024)
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Journal Article
Psychometric validation and meaningful change thresholds of the Worst Itching Intensity Numerical Rating Scale for assessing itch in patients with chronic kidney disease-associated pruritus
Vernon, Margaret K., Swett, Laura L., Speck, Rebecca M., Munera, Catherine, Spencer, Robert H., Wen, Warren, Menzaghi, Frédérique
Published in Journal of patient-reported outcomes (24.12.2021)
Published in Journal of patient-reported outcomes (24.12.2021)
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Journal Article
Pharmacokinetics, Metabolism, and Excretion of Intravenous [14C]Difelikefalin in Healthy Subjects and Subjects on Hemodialysis
Stark, Jeffrey G., Noonan, Patrick K., Spencer, Robert H., Bhaduri, Sarbani, O’Connor, Stephen J., Menzaghi, Frédérique
Published in Clinical pharmacokinetics (01.09.2023)
Published in Clinical pharmacokinetics (01.09.2023)
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Journal Article
Assessment of the physical dependence potential of difelikefalin: Randomized placebo-controlled study in patients receiving hemodialysis
Spencer, Robert H, Munera, Catherine, Shram, Megan J, Menzaghi, Frédérique
Published in Clinical and translational science (01.09.2023)
Published in Clinical and translational science (01.09.2023)
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Journal Article
Safety and Tolerability of Difelikefalin for the Treatment of Moderate to Severe Pruritus in Hemodialysis Patients: Pooled Analysis From the Phase 3 Clinical Trial Program
Fishbane, Steven, Wen, Warren, Munera, Catherine, Lin, Rong, Bagal, Sukirti, McCafferty, Kieran, Menzaghi, Frédérique, Goncalves, Joana
Published in Kidney medicine (01.08.2022)
Published in Kidney medicine (01.08.2022)
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Journal Article
Self-reported Pruritus and Clinical, Dialysis-Related, and Patient-Reported Outcomes in Hemodialysis Patients
Sukul, Nidhi, Karaboyas, Angelo, Csomor, Philipp A., Schaufler, Thilo, Wen, Warren, Menzaghi, Frédérique, Rayner, Hugh C., Hasegawa, Takeshi, Al Salmi, Issa, Al-Ghamdi, Saeed M.G., Guebre-Egziabher, Fitsum, Ureña-Torres, Pablo-Antonio, Pisoni, Ronald L.
Published in Kidney medicine (01.01.2021)
Published in Kidney medicine (01.01.2021)
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Journal Article
Evaluation of the abuse potential of difelikefalin, a selective kappa‐opioid receptor agonist, in recreational polydrug users
Shram, Megan J., Spencer, Robert H., Qian, Jenny, Munera, Catherine L., Lewis, Michael E., Henningfield, Jack E., Webster, Lynn, Menzaghi, Frédérique
Published in Clinical and translational science (01.02.2022)
Published in Clinical and translational science (01.02.2022)
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Journal Article
Chronic kidney disease-associated pruritus and quality of life with difelikefalin treatment: a post hoc analysis of phase 3 data using the Skindex-10 questionnaire
Ständer, Sonja, Fishbane, Steven, Schaufler, Thilo, Ruessmann, Despina, Morin, Isabelle, Menzaghi, Frédérique, Wen, Warren, Kalantar-Zadeh, Kamyar
Published in Clinical kidney journal (01.10.2024)
Published in Clinical kidney journal (01.10.2024)
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Journal Article
Efficacy of Difelikefalin for the Treatment of Moderate to Severe Pruritus in Hemodialysis Patients: Pooled Analysis of KALM-1 and KALM-2 Phase 3 Studies
Topf, Joel, Wooldridge, Thomas, McCafferty, Kieran, Schömig, Michael, Csiky, Botond, Zwiech, Rafal, Wen, Warren, Bhaduri, Sarbani, Munera, Catherine, Lin, Rong, Jebara, Alia, Cirulli, Joshua, Menzaghi, Frédérique
Published in Kidney medicine (01.08.2022)
Published in Kidney medicine (01.08.2022)
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Journal Article
The Burden of Pruritus Associated With CKD: A Mixed Methods Analysis Among Patients Undergoing Dialysis
Menzaghi, Frédérique, Vernon, Margaret K., Mattera, Maria, Cirulli, Joshua, Wen, Warren, Spencer, Robert H., Munera, Catherine
Published in Kidney medicine (01.09.2023)
Published in Kidney medicine (01.09.2023)
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Journal Article
Analgesic Efficacy of Peripheral κ-Opioid Receptor Agonist CR665 Compared to Oxycodone in a Multi-modal, Multi-tissue Experimental Human Pain Model: Selective Effect on Visceral Pain
ARENDT-NIELSEN, Lars, OLESEN, Anne E, STAAHL, Camilla, MENZAGHI, Frédérique, KELL, Sherron, WONG, Gilbert Y, DREWES, Asbjørn M
Published in Anesthesiology (Philadelphia) (01.09.2009)
Published in Anesthesiology (Philadelphia) (01.09.2009)
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Journal Article
Pruritus Severity and Serum Phosphate in CKD: A Post Hoc Analysis of Difelikefalin Studies
Fishbane, Steven N, Block, Geoff A, Evenepoel, Pieter, Budden, Jeffrey, Morin, Isabelle, Menzaghi, Frédérique, Wen, Warren, Lerma, Edgar V
Published in Kidney360 (01.09.2024)
Published in Kidney360 (01.09.2024)
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Journal Article
Randomized Controlled Trial of Difelikefalin for Chronic Pruritus in Hemodialysis Patients
Fishbane, Steven, Mathur, Vandana, Germain, Michael J., Shirazian, Shayan, Bhaduri, Sarbani, Munera, Catherine, Spencer, Robert H., Menzaghi, Frédérique, Aaronson, Michael, Alford, Kelly, Awad, Ahmed, Bhat, Premila, Broumand, Varshab, Calhoun, Wesley, Darwish, Riad, Dua, Sohan, Dukes, Carl, Erinle, Ayodele, Hadley, Alexander, Hsieh, John, Kashif, Mohammad, Kopyt, Nelson, Kumar, Jayant, Kusnir, Jorge, Lee, Jean, Maasarani, Essam, Miller, Richard, Mizani, M. Reza, Navarro, Jesus, Podoll, Amber, Pohlman, Thomas, Rivers, Denise, Robinson, Derrick, Rich, Lisa, Shirazian, Shayan, Silva, Arnold, Smith, Mark, Topf, Joel, Tumlin, James, Ungar, Scott, Zeig, Steven
Published in Kidney international reports (01.05.2020)
Published in Kidney international reports (01.05.2020)
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Journal Article
Safety and Effectiveness of Difelikefalin in Patients With Moderate-to-Severe Pruritus Undergoing Hemodialysis: An Open-Label, Multicenter Study
Weiner, Daniel E., Vervloet, Marc G., Walpen, Sebastian, Schaufler, Thilo, Munera, Catherine, Menzaghi, Frédérique, Wen, Warren, Bhaduri, Sarbani, Germain, Michael J.
Published in Kidney medicine (01.10.2022)
Published in Kidney medicine (01.10.2022)
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Journal Article