RadH: A Versatile Halogenase for Integration into Synthetic Pathways
Menon, Binuraj R. K., Brandenburger, Eileen, Sharif, Humera H., Klemstein, Ulrike, Shepherd, Sarah A., Greaney, Michael F., Micklefield, Jason
Published in Angewandte Chemie International Edition (18.09.2017)
Published in Angewandte Chemie International Edition (18.09.2017)
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Journal Article
A Structure-Guided Switch in the Regioselectivity of a Tryptophan Halogenase
Shepherd, Sarah A., Menon, Binuraj R. K., Fisk, Heidi, Struck, Anna-Winona, Levy, Colin, Leys, David, Micklefield, Jason
Published in Chembiochem : a European journal of chemical biology (03.05.2016)
Published in Chembiochem : a European journal of chemical biology (03.05.2016)
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Journal Article
Structure and Biocatalytic Scope of Coclaurine N‐Methyltransferase
Bennett, Matthew R., Thompson, Mark L., Shepherd, Sarah A., Dunstan, Mark S., Herbert, Abigail J., Smith, Duncan R. M., Cronin, Victoria A., Menon, Binuraj R. K., Levy, Colin, Micklefield, Jason
Published in Angewandte Chemie International Edition (13.08.2018)
Published in Angewandte Chemie International Edition (13.08.2018)
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Journal Article
Cryogenic and Laser Photoexcitation Studies Identify Multiple Roles for Active Site Residues in the Light-driven Enzyme Protochlorophyllide Oxidoreductase
Menon, Binuraj R.K., Waltho, Jonathan P., Scrutton, Nigel S., Heyes, Derren J.
Published in The Journal of biological chemistry (03.07.2009)
Published in The Journal of biological chemistry (03.07.2009)
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Journal Article
Development of Halogenase Enzymes for Use in Synthesis
Latham, Jonathan, Brandenburger, Eileen, Shepherd, Sarah A, Menon, Binuraj R. K, Micklefield, Jason
Published in Chemical reviews (10.01.2018)
Published in Chemical reviews (10.01.2018)
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Journal Article
Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C–H activation
Latham, Jonathan, Henry, Jean-Marc, Sharif, Humera H., Menon, Binuraj R. K., Shepherd, Sarah A., Greaney, Michael F., Micklefield, Jason
Published in Nature communications (10.06.2016)
Published in Nature communications (10.06.2016)
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Journal Article
Assembling a plug-and-play production line for combinatorial biosynthesis of aromatic polyketides in Escherichia coli
Cummings, Matthew, Peters, Anna D, Whitehead, George F S, Menon, Binuraj R K, Micklefield, Jason, Webb, Simon J, Takano, Eriko
Published in PLoS biology (18.07.2019)
Published in PLoS biology (18.07.2019)
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Journal Article
Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes
Shepherd, Sarah A, Karthikeyan, Chinnan, Latham, Jonathan, Struck, Anna-Winona, Thompson, Mark L, Menon, Binuraj R K, Styles, Matthew Q, Levy, Colin, Leys, David, Micklefield, Jason
Published in Chemical science (Cambridge) (01.06.2015)
Published in Chemical science (Cambridge) (01.06.2015)
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Journal Article
Structure and biocatalytic scope of thermophilic flavin-dependent halogenase and flavin reductase enzymes
Menon, Binuraj R. K., Latham, Jonathan, Dunstan, Mark S., Brandenburger, Eileen, Klemstein, Ulrike, Leys, David, Karthikeyan, Chinnan, Greaney, Michael F., Shepherd, Sarah A., Micklefield, Jason
Published in Organic & biomolecular chemistry (01.01.2016)
Published in Organic & biomolecular chemistry (01.01.2016)
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Journal Article
An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme
Ortmayer, Mary, Lafite, Pierre, Menon, Binuraj R. K., Tralau, Tewes, Fisher, Karl, Denkhaus, Lukas, Scrutton, Nigel S., Rigby, Stephen E. J., Munro, Andrew W., Hay, Sam, Leys, David
Published in Nature (London) (24.11.2016)
Published in Nature (London) (24.11.2016)
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Journal Article
Multiple active site residues are important for photochemical efficiency in the light-activated enzyme protochlorophyllide oxidoreductase (POR)
Menon, Binuraj R.K., Hardman, Samantha J.O., Scrutton, Nigel S., Heyes, Derren J.
Published in Journal of photochemistry and photobiology. B, Biology (01.08.2016)
Published in Journal of photochemistry and photobiology. B, Biology (01.08.2016)
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Journal Article
Glutamate 338 is an electrostatic facilitator of C–Co bond breakage in a dynamic/electrostatic model of catalysis by ornithine aminomutase
Menon, Binuraj R. K, Menon, Navya, Fisher, Karl, Rigby, Stephen E. J, Leys, David, Scrutton, Nigel S
Published in The FEBS journal (01.04.2015)
Published in The FEBS journal (01.04.2015)
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Journal Article
Conformational Events during Ternary Enzyme−Substrate Complex Formation Are Rate Limiting in the Catalytic Cycle of the Light-Driven Enzyme Protochlorophyllide Oxidoreductase
Heyes, Derren J, Menon, Binuraj R. K, Sakuma, Michiyo, Scrutton, Nigel S
Published in Biochemistry (Easton) (14.10.2008)
Published in Biochemistry (Easton) (14.10.2008)
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Journal Article