N-substituted piperidinyl alkyl imidazoles: Discovery of methimepip as a potent and selective histamine H-3 receptor agonist
Kitbunnadaj, R, Hashimoto, T, Poli, E, Zuiderveld, OP, Menozzi, A, Hidaka, R, de Esch, IJP, Bakker, RA, Menge, WMPB, Yamatodani, A, Coruzzi, G, Timmerman, H, Leurs, R
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H-3 receptor agonist
Kitbunnadaj, R, Zuiderveld, OP, Christophe, B, Hulscher, S, Menge, WMPB, Gelens, E, Snip, E, Bakker, RA, Celanire, S, Gillard, M, Talaga, P, Timmerman, H, Leurs, R
Published in Journal of medicinal chemistry (06.05.2004)
Published in Journal of medicinal chemistry (06.05.2004)
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Synthesis and structure-activity relationships of conformationally constrained histamine H-3 receptor agonists
Kitbunnadaj, R, Zuiderveld, OP, De Esch, IJP, Vollinga, RC, Bakker, R, Lutz, M, Spek, AL, Cavoy, E, Deltent, MF, Menge, WMPB, Timmerman, H, Leurs, R
Published in Journal of medicinal chemistry (04.12.2003)
Published in Journal of medicinal chemistry (04.12.2003)
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Synthesis and Structure−Activity Relationship of the First Nonpeptidergic Inverse Agonists for the Human Cytomegalovirus Encoded Chemokine Receptor US28
Hulshof, Janneke W, Casarosa, Paola, Menge, Wiro M. P. B, Kuusisto, Leena M. S, van der Goot, Henk, Smit, Martine J, de Esch, Iwan J. P, Leurs, Rob
Published in Journal of medicinal chemistry (06.10.2005)
Published in Journal of medicinal chemistry (06.10.2005)
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A chemical switch for the modulation of the functional activity of higher homologues of histamine on the human histamine H-3 receptor: Effect of various substitutions at the primary amino function
Govoni, M, Lim, HD, El-Atmioui, D, Menge, WMPB, Timmerman, H, Bakker, RA, Leurs, R, De Esch, IJP
Published in Journal of medicinal chemistry (20.04.2006)
Published in Journal of medicinal chemistry (20.04.2006)
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Synthesis of Novel 3,7-Substituted-2-(3‘,4‘-dihydroxyphenyl)flavones with Improved Antioxidant Activity
van Acker, Frédérique A. A, Hageman, Jos A, Haenen, Guido R. M. M, van der Vijgh, Wim J. F, Bast, Aalt, Menge, Wiro M. P. B
Published in Journal of medicinal chemistry (05.10.2000)
Published in Journal of medicinal chemistry (05.10.2000)
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New high affinity H 3 receptor agonists without a basic side chain
Kitbunnadaj, Ruengwit, Hoffmann, Marcel, Fratantoni, Silvina A., Bongers, Gerold, Bakker, Remko A., Wieland, Kerstin, Jilali, Ahmed el, De Esch, Iwan J.P., Menge, Wiro M.P.B., Timmerman, Henk, Leurs, Rob
Published in Bioorganic & medicinal chemistry (01.12.2005)
Published in Bioorganic & medicinal chemistry (01.12.2005)
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A NEW POTENT AND SELECTIVE HISTAMINE H-3 RECEPTOR AGONIST, 4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE
VOLLINGA, RC, DEKONING, JP, JANSEN, FP, LEURS, R, MENGE, WMPB, TIMMERMAN, H
Published in Journal of medicinal chemistry (04.02.1994)
Published in Journal of medicinal chemistry (04.02.1994)
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Development of a pharmacophore model for histamine H-3 receptor antagonists, using the newly developed molecular modeling program SLATE
De Esch, IJP, Mills, JEJ, Perkins, TDJ, Romeo, G, Hoffmann, M, Wieland, K, Leurs, R, Menge, WMPB, Nederkoorn, PHJ, Dean, PM, Timmerman, H
Published in Journal of medicinal chemistry (24.05.2001)
Published in Journal of medicinal chemistry (24.05.2001)
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Synthesis of Novel Se-Substituted Selenocysteine Derivatives as Potential Kidney Selective Prodrugs of Biologically Active Selenol Compounds: Evaluation of Kinetics of β-Elimination Reactions in Rat Renal Cytosol
Andreadou, Ioanna, Menge, Wiro M. P. B, Commandeur, Jan N. M, Worthington, Eduard A, Vermeulen, Nico P. E
Published in Journal of medicinal chemistry (10.05.1996)
Published in Journal of medicinal chemistry (10.05.1996)
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Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice
Hough, L.B., Nalwalk, J.W., Chen, Y., Schuller, A., Zhu, Y., Zhang, J., Menge, W.M.P.B., Leurs, R., Timmerman, H., Pintar, J.E.
Published in Brain research (13.10.2000)
Published in Brain research (13.10.2000)
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NEW ANALOGS OF BURIMAMIDE AS POTENT AND SELECTIVE HISTAMINE H-3 RECEPTOR ANTAGONISTS - THE EFFECT OF CHAIN-LENGTH VARIATION OF THE ALKYL SPACER AND MODIFICATIONS OF THE N-THIOUREA SUBSTITUENT
VOLLINGA, RC, MENGE, WMPB, LEURS, R, TIMMERMAN, H
Published in Journal of medicinal chemistry (09.06.1995)
Published in Journal of medicinal chemistry (09.06.1995)
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Significance of gabaergic systems in the action of improgan, a non-opioid analgesic
Hough, L.B., Nalwalk, J.W., Leurs, R., Menge, W.M.P.B., Timmerman, H.
Published in Life sciences (1973) (04.05.2001)
Published in Life sciences (1973) (04.05.2001)
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