Impact of a five-dimensional framework on R&D productivity at AstraZeneca
Morgan, Paul, Brown, Dean G, Lennard, Simon, Anderton, Mark J, Barrett, J Carl, Eriksson, Ulf, Fidock, Mark, Hamrén, Bengt, Johnson, Anthony, March, Ruth E, Matcham, James, Mettetal, Jerome, Nicholls, David J, Platz, Stefan, Rees, Steve, Snowden, Michael A, Pangalos, Menelas N
Published in Nature reviews. Drug discovery (01.03.2018)
Published in Nature reviews. Drug discovery (01.03.2018)
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Implementation of digital health technology in clinical trials: the 6R framework
Durán, Cristina Ortega, Bonam, Matthew, Björk, Elisabeth, Hughes, Rod, Ghiorghiu, Serban, Massacesi, Cristian, Campbell, Alicyn, Hutchison, Emmette, Pangalos, Menelas N, Galbraith, Susan
Published in Nature medicine (01.11.2023)
Published in Nature medicine (01.11.2023)
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Loss of Retrograde Endocannabinoid Signaling and Reduced Adult Neurogenesis in Diacylglycerol Lipase Knock-out Mice
Gao, Ying, Vasilyev, Dmitry V, Goncalves, Maria Beatriz, Howell, Fiona V, Hobbs, Carl, Reisenberg, Melina, Shen, Ru, Zhang, Mei-Yi, Strassle, Brian W, Lu, Peimin, Mark, Lilly, Piesla, Michael J, Deng, Kangwen, Kouranova, Evguenia V, Ring, Robert H, Whiteside, Garth T, Bates, Brian, Walsh, Frank S, Williams, Gareth, Pangalos, Menelas N, Samad, Tarek A, Doherty, Patrick
Published in The Journal of neuroscience (10.02.2010)
Published in The Journal of neuroscience (10.02.2010)
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Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels
Riddell, David R, Zhou, Hua, Atchison, Kevin, Warwick, Helen K, Atkinson, Peter J, Jefferson, Julius, Xu, Lin, Aschmies, Suzan, Kirksey, Yolanda, Hu, Yun, Wagner, Erik, Parratt, Adrienne, Xu, Jane, Li, Zhuting, Zaleska, Margaret M, Jacobsen, J. Steve, Pangalos, Menelas N, Reinhart, Peter H
Published in The Journal of neuroscience (05.11.2008)
Published in The Journal of neuroscience (05.11.2008)
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Rapamycin alleviates toxicity of different aggregate-prone proteins
Berger, Zdenek, Ravikumar, Brinda, Menzies, Fiona M., Oroz, Lourdes Garcia, Underwood, Benjamin R., Pangalos, Menelas N., Schmitt, Ina, Wullner, Ullrich, Evert, Bernd O., O'Kane, Cahir J., Rubinsztein, David C.
Published in Human molecular genetics (01.02.2006)
Published in Human molecular genetics (01.02.2006)
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Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system
Chanda, Pranab K, Gao, Ying, Mark, Lilly, Btesh, Joan, Strassle, Brian W, Lu, Peimin, Piesla, Michael J, Zhang, Mei-Yi, Bingham, Brendan, Uveges, Albert, Kowal, Dianne, Garbe, David, Kouranova, Evguenia V, Ring, Robert H, Bates, Brian, Pangalos, Menelas N, Kennedy, Jeffrey D, Whiteside, Garth T, Samad, Tarek A
Published in Molecular pharmacology (01.12.2010)
Published in Molecular pharmacology (01.12.2010)
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Early-Onset Behavioral and Synaptic Deficits in a Mouse Model of Alzheimer's Disease
Jacobsen, J. Steven, Wu, Chi-Cheng, Redwine, Jeffrey M., Comery, Thomas A., Arias, Robert, Bowlby, Mark, Martone, Robert, Morrison, John H., Pangalos, Menelas N., Reinhart, Peter H., Bloom, Floyd E.
Published in Proceedings of the National Academy of Sciences - PNAS (28.03.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (28.03.2006)
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Prolonged activation of NMDA receptors promotes dephosphorylation and alters postendocytic sorting of GABAB receptors
Terunuma, Miho, Vargas, Karina J., Wilkins, Megan E., Ramírez, Omar A., Jaureguiberry-Bravo, Matías, Pangalos, Menelas N., Smart, Trevor G., Moss, Stephen J., Couve, Andrés
Published in Proceedings of the National Academy of Sciences - PNAS (03.08.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (03.08.2010)
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Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility
Douthwaite, Julie A, Brown, Christopher A, Ferdinand, John R, Sharma, Rahul, Elliott, Jane, Taylor, Molly A, Malintan, Nancy T, Duvoisin, Hannah, Hill, Thomas, Delpuech, Oona, Orton, Alexandra L, Pitt, Haidee, Kuenzi, Fred, Fish, Simon, Nicholls, David J, Cuthbert, Anna, Richards, Ian, Ratcliffe, Giles, Upadhyay, Abhishek, Marklew, Abigail, Hewitt, Craig, Ross-Thriepland, Douglas, Brankin, Christopher, Chodorge, Matthieu, Browne, Gareth, Mander, Palwinder K, DeWildt, Ruud M, Weaver, Shane, Smee, Penny A, van Kempen, Joost, Bartlett, Jon G, Allen, Paula M, Koppe, Emma L, Ashby, Charlotte A, Phipps, Julian D, Mehta, Nalini, Brierley, David J, Tew, David G, Leveridge, Melanie V, Baddeley, Stuart M, Goodfellow, Ian G, Green, Clive, Abell, Chris, Neely, Andy, Waddell, Ian, Rees, Steve, Maxwell, Patrick H, Pangalos, Menelas N, Howes, Rob, Clark, Roger
Published in Scientific reports (24.02.2022)
Published in Scientific reports (24.02.2022)
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Clusterin Is Required for β-Amyloid Toxicity in Human iPSC-Derived Neurons
Robbins, Jacqueline P, Perfect, Leo, Ribe, Elena M, Maresca, Marcello, Dangla-Valls, Adrià, Foster, Evangeline M, Killick, Richard, Nowosiad, Paulina, Reid, Matthew J, Polit, Lucia Dutan, Nevado, Alejo J, Ebner, Daniel, Bohlooly-Y, Mohammad, Buckley, Noel, Pangalos, Menelas N, Price, Jack, Lovestone, Simon
Published in Frontiers in neuroscience (25.07.2018)
Published in Frontiers in neuroscience (25.07.2018)
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Phospho-Dependent Functional Modulation of GABAB Receptors by the Metabolic Sensor AMP-Dependent Protein Kinase
Kuramoto, Nobuyuki, Wilkins, Megan E., Fairfax, Benjamin P., Revilla-Sanchez, Raquel, Terunuma, Miho, Tamaki, Keisuke, Iemata, Mika, Warren, Noel, Couve, Andrés, Calver, Andrew, Horvath, Zsolt, Freeman, Katie, Carling, David, Huang, Lan, Gonzales, Cathleen, Cooper, Edward, Smart, Trevor G., Pangalos, Menelas N., Moss, Stephen J.
Published in Neuron (Cambridge, Mass.) (18.01.2007)
Published in Neuron (Cambridge, Mass.) (18.01.2007)
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Highly Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitors
Malamas, Michael S, Ni, Yike, Erdei, James, Stange, Hans, Schindler, Rudolf, Lankau, Hans-Joachim, Grunwald, Christian, Fan, Kristi Yi, Parris, Kevin, Langen, Barbara, Egerland, Ute, Hage, Thorsten, Marquis, Karen L, Grauer, Steve, Brennan, Julie, Navarra, Rachel, Graf, Radka, Harrison, Boyd L, Robichaud, Albert, Kronbach, Thomas, Pangalos, Menelas N, Hoefgen, Norbert, Brandon, Nicholas J
Published in Journal of medicinal chemistry (10.11.2011)
Published in Journal of medicinal chemistry (10.11.2011)
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Enhanced clearance of Aβ in brain by sustaining the plasmin proteolysis cascade
Jacobsen, J. Steven, Comery, Thomas A, Martone, Robert L, Elokdah, Hassan, Crandall, David L, Oganesian, Aram, Aschmies, Suzan, Kirksey, Yolanda, Gonzales, Cathleen, Xu, Jane, Zhou, Hua, Atchison, Kevin, Wagner, Erik, Zaleska, Margaret M, Das, Indranil, Arias, Robert L, Bard, Jonathan, Riddell, David, Gardell, Stephen J, Abou-Gharbia, Magid, Robichaud, Albert, Magolda, Ronald, Vlasuk, George P, Bjornsson, Thorir, Reinhart, Peter H, Pangalos, Menelas N
Published in Proceedings of the National Academy of Sciences - PNAS (24.06.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (24.06.2008)
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Characterization of vabicaserin (SCA-136), a selective 5-hydroxytryptamine 2C receptor agonist
Dunlop, John, Watts, Stephanie W, Barrett, James E, Coupet, Joseph, Harrison, Boyd, Mazandarani, Hossein, Nawoschik, Stanley, Pangalos, Menelas N, Ramamoorthy, Siva, Schechter, Lee, Smith, Deborah, Stack, Gary, Zhang, Jean, Zhang, Guoming, Rosenzweig-Lipson, Sharon
Published in The Journal of pharmacology and experimental therapeutics (01.06.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2011)
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Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities
Ruan, Benfang, Pong, Kevin, Jow, Flora, Bowlby, Mark, Crozier, Robert A, Liu, Danni, Liang, Shi, Chen, Yi, Mercado, Mary Lynn, Feng, Xidong, Bennett, Frann, von Schack, David, McDonald, Leonard, Zaleska, Margaret M, Wood, Andrew, Reinhart, Peter H, Magolda, Ronald L, Skotnicki, Jerauld, Pangalos, Menelas N, Koehn, Frank E, Carter, Guy T, Abou-Gharbia, Magid, Graziani, Edmund I
Published in Proceedings of the National Academy of Sciences - PNAS (08.01.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (08.01.2008)
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Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke
Feuerstein, Giora Z, Zaleska, Margaret M, Krams, Michael, Wang, Xinkang, Day, Mark, Rutkowski, Julia L, Finklestein, Seth P, Pangalos, Menelas N, Poole, Michael, Stiles, Gary L, Ruffolo, Robert R, Walsh, Frank L
Published in Journal of cerebral blood flow and metabolism (01.01.2008)
Published in Journal of cerebral blood flow and metabolism (01.01.2008)
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Intramuscular AZD7442 (Tixagevimab–Cilgavimab) for Prevention of Covid-19
Levin, Myron J., Ustianowski, Andrew, De Wit, Stéphane, Launay, Odile, Avila, Miles, Templeton, Alison, Yuan, Yuan, Seegobin, Seth, Ellery, Adam, Levinson, Dennis J., Ambery, Philip, Arends, Rosalinda H., Beavon, Rohini, Dey, Kanika, Garbes, Pedro, Kelly, Elizabeth J., Koh, Gavin C.K.W., Near, Karen A., Padilla, Kelly W., Psachoulia, Konstantina, Sharbaugh, Audrey, Streicher, Katie, Pangalos, Menelas N., Esser, Mark T.
Published in New England Journal of Medicine (09.06.2022)
Published in New England Journal of Medicine (09.06.2022)
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