The H274Y mutation in the influenza A/H1N1 neuraminidase active site following oseltamivir phosphate treatment leave virus severely compromised both in vitro and in vivo
Ives, J.A.L., Carr, J.A., Mendel, D.B., Tai, C.Y., Lambkin, R., Kelly, L., Oxford, J.S., Hayden, F.G., Roberts, N.A.
Published in Antiviral research (01.08.2002)
Published in Antiviral research (01.08.2002)
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Structure−Activity Relationship Studies of Novel Carbocyclic Influenza Neuraminidase Inhibitors
Kim, Choung U, Lew, Willard, Williams, Matthew A, Wu, Huiwei, Zhang, Lijun, Chen, Xiaowu, Escarpe, Paul A, Mendel, Dirk B, Laver, W. Graeme, Stevens, Raymond C
Published in Journal of medicinal chemistry (02.07.1998)
Published in Journal of medicinal chemistry (02.07.1998)
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Oral Administration of a Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071 Protects Mice and Ferrets against Influenza Infection
MENDEL, D. B, TAI, C. Y, LEW, W, WILLIAMS, M. A, ZHANG, L, CHEN, M. S, BISCHOFBERGER, N, KIM, C. U, ESCARPE, P. A, LI, W, SIDWELL, R. W, HUFFMAN, J. H, SWEET, C, JAKEMAN, K. J, MERSON, J, LACY, S. A
Published in Antimicrobial Agents and Chemotherapy (01.03.1998)
Published in Antimicrobial Agents and Chemotherapy (01.03.1998)
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Identification of GS 4104 as an Orally Bioavailable Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071
WEIXING LI, ESCARPE, P. A, KIM, C. U, BISCHOFBERGER, N, CHEN, M. S, MENDEL, D. B, EISENBERG, E. J, CUNDY, K. C, SWEET, C, JAKEMAN, K. J, MERSON, J, LEW, W, WILLIAMS, M, LIJUN ZHANG
Published in Antimicrobial Agents and Chemotherapy (01.03.1998)
Published in Antimicrobial Agents and Chemotherapy (01.03.1998)
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Characterization of Human Influenza Virus Variants Selected In Vitro in the Presence of the Neuraminidase Inhibitor GS 4071
TAI, C. Y, ESCARPE, P. A, SIDWELL, R. W, WILLIAMS, M. A, LEW, W, HUIWEI WU, KIM, C. U, MENDEL, D. B
Published in Antimicrobial Agents and Chemotherapy (01.12.1998)
Published in Antimicrobial Agents and Chemotherapy (01.12.1998)
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1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo
Bischofberger, N, Hitchcock, M J, Chen, M S, Barkhimer, D B, Cundy, K C, Kent, K M, Lacy, S A, Lee, W A, Li, Z H, Mendel, D B
Published in Antimicrobial Agents and Chemotherapy (01.10.1994)
Published in Antimicrobial Agents and Chemotherapy (01.10.1994)
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Identity of 4a-Carbinolamine Dehydratase, a Component of the Phenylalanine Hydroxylation System, and DCoH, a Transregulator of Homeodomain Proteins
Citron, Bruce A., Davis, Michael D., Milstien, Sheldon, Gutierrez, Joanne, Mendel, Dirk B., Crabtree, Gerald R., Kaufman, Seymour
Published in Proceedings of the National Academy of Sciences - PNAS (15.12.1992)
Published in Proceedings of the National Academy of Sciences - PNAS (15.12.1992)
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Molybdate-stabilized nonactivated glucocorticoid-receptor complexes contain a 90-kDa non-steroid-binding phosphoprotein that is lost on activation
Mendel, D B, Bodwell, J E, Gametchu, B, Harrison, R W, Munck, A
Published in The Journal of biological chemistry (15.03.1986)
Published in The Journal of biological chemistry (15.03.1986)
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Agonist-dependent phosphorylation and nuclear dephosphorylation of glucocorticoid receptors in intact cells
Ortí, E, Mendel, D B, Smith, L I, Munck, A
Published in The Journal of biological chemistry (15.06.1989)
Published in The Journal of biological chemistry (15.06.1989)
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Neuraminidase Inhibitors as Anti-Influenza Virus Agents
Kim, Choung U, Chen, Xiaowu, Mendel, Dirk B
Published in Antiviral Chemistry and Chemotherapy (01.08.1999)
Published in Antiviral Chemistry and Chemotherapy (01.08.1999)
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Book Review
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Influenza Neuraminidase Inhibitors Possessing a Novel Hydrophobic Interaction in the Enzyme Active Site: Design, Synthesis, and Structural Analysis of Carbocyclic Sialic Acid Analogues with Potent Anti-Influenza Activity
Kim, Choung U, Lew, Willard, Williams, Matthew A, Liu, Hongtao, Zhang, Lijun, Swaminathan, S, Bischofberger, Norbert, Chen, Ming S, Mendel, Dirk B, Tai, Chun Y, Laver, W. Graeme, Stevens, Raymond C
Published in Journal of the American Chemical Society (29.01.1997)
Published in Journal of the American Chemical Society (29.01.1997)
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