Large Clostridial Toxins: Mechanisms and Roles in Disease
Orrell, Kathleen E, Melnyk, Roman A
Published in Microbiology and molecular biology reviews (18.08.2021)
Published in Microbiology and molecular biology reviews (18.08.2021)
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Journal Article
Dual Inhibition of Vacuolar-ATPase and TMPRSS2 Is Required for Complete Blockade of SARS-CoV-2 Entry into Cells
Icho, Simoun, Rujas, Edurne, Muthuraman, Krithika, Tam, John, Liang, Huazhu, Landreth, Shelby, Liao, Mingmin, Falzarano, Darryl, Julien, Jean-Philippe, Melnyk, Roman A
Published in Antimicrobial agents and chemotherapy (19.07.2022)
Published in Antimicrobial agents and chemotherapy (19.07.2022)
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Tauroursodeoxycholic Acid Inhibits Clostridioides difficile Toxin-Induced Apoptosis
Pike, Colleen M, Tam, John, Melnyk, Roman A, Theriot, Casey M
Published in Infection and immunity (18.08.2022)
Published in Infection and immunity (18.08.2022)
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Journal Article
Translocation expands the scope of the large clostridial toxin family
Orrell, Kathleen E., Melnyk, Roman A.
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (01.12.2021)
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (01.12.2021)
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Journal Article
bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA)
Lim, Shuhui, Khoo, Regina, Peh, Khong Ming, Teo, Jinkai, Chang, Shih Chieh, Ng, Simon, Beilhartz, Greg L., Melnyk, Roman A., Johannes, Charles W., Brown, Christopher J., Lane, David P., Henry, Brian, Partridge, Anthony W.
Published in Proceedings of the National Academy of Sciences - PNAS (17.03.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (17.03.2020)
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The glucosyltransferase activity of C. difficile Toxin B is required for disease pathogenesis
Bilverstone, Terry W, Garland, Megan, Cave, Rory J, Kelly, Michelle L, Tholen, Martina, Bouley, Donna M, Kaye, Philip, Minton, Nigel P, Bogyo, Matthew, Kuehne, Sarah A, Melnyk, Roman A
Published in PLoS pathogens (22.09.2020)
Published in PLoS pathogens (22.09.2020)
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Journal Article
Repurposing bacterial toxins for intracellular delivery of therapeutic proteins
Beilhartz, Greg L., Sugiman-Marangos, Seiji N., Melnyk, Roman A.
Published in Biochemical pharmacology (15.10.2017)
Published in Biochemical pharmacology (15.10.2017)
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Journal Article
Dismantling a Toxin to Disarm a Superbug
Icho, Simoun, Melnyk, Roman A.
Published in Trends in pharmacological sciences (Regular ed.) (01.03.2019)
Published in Trends in pharmacological sciences (Regular ed.) (01.03.2019)
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Journal Article
Intestinal bile acids provide a surmountable barrier against C. difficile TcdB-induced disease pathogenesis
Icho, Simoun, Ward, Jennifer S, Tam, John, Kociolek, Larry K, Theriot, Casey M, Melnyk, Roman A
Published in Proceedings of the National Academy of Sciences - PNAS (09.05.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (09.05.2023)
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Journal Article
Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota
Tam, John, Hamza, Therwa, Ma, Bing, Chen, Kevin, Beilhartz, Greg L., Ravel, Jacques, Feng, Hanping, Melnyk, Roman A.
Published in Nature communications (07.12.2018)
Published in Nature communications (07.12.2018)
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Journal Article
Intestinal bile acids directly modulate the structure and function of C. difficile TcdB toxin
Tam, John, Icho, Simoun, Utama, Evelyn, Orrell, Kathleen E., Gómez-Biagi, Rodolfo F., Theriot, Casey M., Kroh, Heather K., Rutherford, Stacey A., Lacy, D. Borden, Melnyk, Roman A.
Published in Proceedings of the National Academy of Sciences - PNAS (24.03.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (24.03.2020)
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Journal Article
An engineered chimeric toxin that cleaves activated mutant and wild-type RAS inhibits tumor growth
Vidimar, Vania, Beilhartz, Greg L., Park, Minyoung, Biancucci, Marco, Kieffer, Matthew B., Gius, David R., Melnyk, Roman A., Satchell, Karla J. F.
Published in Proceedings of the National Academy of Sciences - PNAS (21.07.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (21.07.2020)
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Journal Article
An enhanced intracellular delivery platform based on a distant diphtheria toxin homolog that evades pre-existing antitoxin antibodies
Gill, Shivneet K, Sugiman-Marangos, Seiji N, Beilhartz, Greg L, Mei, Elizabeth, Taipale, Mikko, Melnyk, Roman A
Published in EMBO molecular medicine (14.10.2024)
Published in EMBO molecular medicine (14.10.2024)
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Journal Article
Recognition of Semaphorin Proteins by P. sordellii Lethal Toxin Reveals Principles of Receptor Specificity in Clostridial Toxins
Lee, Hunsang, Beilhartz, Greg L., Kucharska, Iga, Raman, Swetha, Cui, Hong, Lam, Mandy Hiu Yi, Liang, Huazhu, Rubinstein, John L., Schramek, Daniel, Julien, Jean-Philippe, Melnyk, Roman A., Taipale, Mikko
Published in Cell (23.07.2020)
Published in Cell (23.07.2020)
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Journal Article
Comment on "A small-molecule antivirulence agent for treating Clostridium difficile infection"
Beilhartz, Greg L, Tam, John, Zhang, Zhifen, Melnyk, Roman A
Published in Science translational medicine (21.12.2016)
Published in Science translational medicine (21.12.2016)
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Journal Article
Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms
Baker, Perrin, Hill, Preston J, Snarr, Brendan D, Alnabelseya, Noor, Pestrak, Matthew J, Lee, Mark J, Jennings, Laura K, Tam, John, Melnyk, Roman A, Parsek, Matthew R, Sheppard, Donald C, Wozniak, Daniel J, Howell, P Lynne
Published in Science advances (01.05.2016)
Published in Science advances (01.05.2016)
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Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor-binding determinants
Gupta, Pulkit, Zhang, Zhifen, Sugiman-Marangos, Seiji N., Tam, John, Raman, Swetha, Julien, Jean-Phillipe, Kroh, Heather K., Lacy, D. Borden, Murgolo, Nicholas, Bekkari, Kavitha, Therien, Alex G., Hernandez, Lorraine D., Melnyk, Roman A.
Published in The Journal of biological chemistry (20.10.2017)
Published in The Journal of biological chemistry (20.10.2017)
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