Multimodal single-cell and whole-genome sequencing of small, frozen clinical specimens
Wang, Yiping, Fan, Joy Linyue, Melms, Johannes C., Amin, Amit Dipak, Georgis, Yohanna, Barrera, Irving, Ho, Patricia, Tagore, Somnath, Abril-Rodríguez, Gabriel, He, Siyu, Jin, Yinuo, Biermann, Jana, Hofree, Matan, Caprio, Lindsay, Berhe, Simon, Khan, Shaheer A., Henick, Brian S., Ribas, Antoni, Macosko, Evan Z., Chen, Fei, Taylor, Alison M., Schwartz, Gary K., Carvajal, Richard D., Azizi, Elham, Izar, Benjamin
Published in Nature genetics (01.01.2023)
Published in Nature genetics (01.01.2023)
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Journal Article
Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I–III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial
Altorki, Nasser K., Walsh, Zachary H., Melms, Johannes C., Port, Jeffery L., Lee, Benjamin E., Nasar, Abu, Spinelli, Cathy, Caprio, Lindsay, Rogava, Meri, Ho, Patricia, Christos, Paul J., Saxena, Ashish, Elemento, Olivier, Bhinder, Bhavneet, Ager, Casey, Amin, Amit Dipak, Sanfilippo, Nicholas J., Mittal, Vivek, Borczuk, Alain C., Formenti, Silvia C., Izar, Benjamin, McGraw, Timothy E.
Published in Nature communications (19.12.2023)
Published in Nature communications (19.12.2023)
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Journal Article
Inhibition of Haspin Kinase Promotes Cell-Intrinsic and Extrinsic Antitumor Activity
Melms, Johannes C, Vallabhaneni, Sreeram, Mills, Caitlin E, Yapp, Clarence, Chen, Jia-Yun, Morelli, Eugenio, Waszyk, Patricia, Kumar, Sushil, Deming, Derrick, Moret, Nienke, Rodriguez, Steven, Subramanian, Kartik, Rogava, Meri, Cartwright, Adam N R, Luoma, Adrienne, Mei, Shaolin, Brinker, Titus J, Miller, David M, Spektor, Alexander, Schadendorf, Dirk, Riggi, Nicolo, Wucherpfennig, Kai W, Sorger, Peter K, Izar, Benjamin
Published in Cancer research (Chicago, Ill.) (15.02.2020)
Published in Cancer research (Chicago, Ill.) (15.02.2020)
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Journal Article
Author Correction: Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I–III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial
Altorki, Nasser K., Walsh, Zachary H., Melms, Johannes C., Port, Jeffery L., Lee, Benjamin E., Nasar, Abu, Spinelli, Cathy, Caprio, Lindsay, Rogava, Meri, Ho, Patricia, Christos, Paul J., Saxena, Ashish, Elemento, Olivier, Bhinder, Bhavneet, Ager, Casey, Amin, Amit Dipak, Sanfilippo, Nicholas J., Mittal, Vivek, Borczuk, Alain C., Formenti, Silvia C., Izar, Benjamin, McGraw, Timothy E.
Published in Nature communications (03.01.2024)
Published in Nature communications (03.01.2024)
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Journal Article
Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cells
Huang, Huachao, Fang, Yinshan, Jiang, Ming, Zhang, Yihan, Biermann, Jana, Melms, Johannes C, Danielsson, Jennifer A, Yang, Ying, Qiang, Li, Liu, Jia, Zhou, Yiwu, Wang, Manli, Hu, Zhihong, Wang, Timothy C, Saqi, Anjali, Sun, Jie, Matsumoto, Ichiro, Cardoso, Wellington V, Emala, Charles W, Zhu, Jian, Izar, Benjamin, Mou, Hongmei, Que, Jianwen
Published in eLife (21.09.2022)
Published in eLife (21.09.2022)
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Journal Article
KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response
Ager, Casey R, Zhang, Mingxuan, Chaimowitz, Matthew, Bansal, Shruti, Tagore, Somnath, Obradovic, Aleksandar, Jugler, Collin, Rogava, Meri, Melms, Johannes C, McCann, Patrick, Spina, Catherine, Drake, Charles G, Dallos, Matthew C, Izar, Benjamin
Published in Journal for immunotherapy of cancer (01.09.2023)
Published in Journal for immunotherapy of cancer (01.09.2023)
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Journal Article
Alpha-fetoprotein (AFP) as tumor marker in a patient with urothelial cancer with exceptional response to anti-PD-1 therapy and an escape lesion mimic
Melms, Johannes C, Thummalapalli, Rohit, Shaw, Kristin, Ye, Huihui, Tsai, Leo, Bhatt, Rupal S, Izar, Benjamin
Published in Journal for immunotherapy of cancer (12.09.2018)
Published in Journal for immunotherapy of cancer (12.09.2018)
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Journal Article
A molecular single-cell lung atlas of lethal COVID-19
Melms, Johannes C., Biermann, Jana, Huang, Huachao, Wang, Yiping, Nair, Ajay, Tagore, Somnath, Katsyv, Igor, Rendeiro, André F., Amin, Amit Dipak, Schapiro, Denis, Frangieh, Chris J., Luoma, Adrienne M., Filliol, Aveline, Fang, Yinshan, Ravichandran, Hiranmayi, Clausi, Mariano G., Alba, George A., Rogava, Meri, Chen, Sean W., Ho, Patricia, Montoro, Daniel T., Kornberg, Adam E., Han, Arnold S., Bakhoum, Mathieu F., Anandasabapathy, Niroshana, Suárez-Fariñas, Mayte, Bakhoum, Samuel F., Bram, Yaron, Borczuk, Alain, Guo, Xinzheng V., Lefkowitch, Jay H., Marboe, Charles, Lagana, Stephen M., Del Portillo, Armando, Tsai, Emily J., Zorn, Emmanuel, Markowitz, Glen S., Schwabe, Robert F., Schwartz, Robert E., Elemento, Olivier, Saqi, Anjali, Hibshoosh, Hanina, Que, Jianwen, Izar, Benjamin
Published in Nature (London) (01.07.2021)
Published in Nature (London) (01.07.2021)
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Journal Article
A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade
Jerby-Arnon, Livnat, Shah, Parin, Cuoco, Michael S., Rodman, Christopher, Su, Mei-Ju, Melms, Johannes C., Leeson, Rachel, Kanodia, Abhay, Mei, Shaolin, Lin, Jia-Ren, Wang, Shu, Rabasha, Bokang, Liu, David, Zhang, Gao, Margolais, Claire, Ashenberg, Orr, Ott, Patrick A., Buchbinder, Elizabeth I., Haq, Rizwan, Hodi, F. Stephen, Boland, Genevieve M., Sullivan, Ryan J., Frederick, Dennie T., Miao, Benchun, Moll, Tabea, Flaherty, Keith T., Herlyn, Meenhard, Jenkins, Russell W., Thummalapalli, Rohit, Kowalczyk, Monika S., Cañadas, Israel, Schilling, Bastian, Cartwright, Adam N.R., Luoma, Adrienne M., Malu, Shruti, Hwu, Patrick, Bernatchez, Chantale, Forget, Marie-Andrée, Barbie, David A., Shalek, Alex K., Tirosh, Itay, Sorger, Peter K., Wucherpfennig, Kai, Van Allen, Eliezer M., Schadendorf, Dirk, Johnson, Bruce E., Rotem, Asaf, Rozenblatt-Rosen, Orit, Garraway, Levi A., Yoon, Charles H., Izar, Benjamin, Regev, Aviv
Published in Cell (01.11.2018)
Published in Cell (01.11.2018)
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Journal Article
Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion
Frangieh, Chris J., Melms, Johannes C., Thakore, Pratiksha I., Geiger-Schuller, Kathryn R., Ho, Patricia, Luoma, Adrienne M., Cleary, Brian, Jerby-Arnon, Livnat, Malu, Shruti, Cuoco, Michael S., Zhao, Maryann, Ager, Casey R., Rogava, Meri, Hovey, Lila, Rotem, Asaf, Bernatchez, Chantale, Wucherpfennig, Kai W., Johnson, Bruce E., Rozenblatt-Rosen, Orit, Schadendorf, Dirk, Regev, Aviv, Izar, Benjamin
Published in Nature genetics (01.03.2021)
Published in Nature genetics (01.03.2021)
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Journal Article
A single-cell landscape of high-grade serous ovarian cancer
Izar, Benjamin, Tirosh, Itay, Stover, Elizabeth H., Wakiro, Isaac, Cuoco, Michael S., Alter, Idan, Rodman, Christopher, Leeson, Rachel, Su, Mei-Ju, Shah, Parin, Iwanicki, Marcin, Walker, Sarah R., Kanodia, Abhay, Melms, Johannes C., Mei, Shaolin, Lin, Jia-Ren, Porter, Caroline B. M., Slyper, Michal, Waldman, Julia, Jerby-Arnon, Livnat, Ashenberg, Orr, Brinker, Titus J., Mills, Caitlin, Rogava, Meri, Vigneau, Sébastien, Sorger, Peter K., Garraway, Levi A., Konstantinopoulos, Panagiotis A., Liu, Joyce F., Matulonis, Ursula, Johnson, Bruce E., Rozenblatt-Rosen, Orit, Rotem, Asaf, Regev, Aviv
Published in Nature medicine (01.08.2020)
Published in Nature medicine (01.08.2020)
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Journal Article
Metastasis and Immune Evasion from Extracellular cGAMP Hydrolysis
Li, Jun, Duran, Mercedes A, Dhanota, Ninjit, Chatila, Walid K, Bettigole, Sarah E, Kwon, John, Sriram, Roshan K, Humphries, Matthew P, Salto-Tellez, Manuel, James, Jacqueline A, Hanna, Matthew G, Melms, Johannes C, Vallabhaneni, Sreeram, Litchfield, Kevin, Usaite, Ieva, Biswas, Dhruva, Bareja, Rohan, Li, Hao Wei, Martin, Maria Laura, Dorsaint, Princesca, Cavallo, Julie-Ann, Li, Peng, Pauli, Chantal, Gottesdiener, Lee, DiPardo, Benjamin J, Hollmann, Travis J, Merghoub, Taha, Wen, Hannah Y, Reis-Filho, Jorge S, Riaz, Nadeem, Su, Shin-San Michael, Kalbasi, Anusha, Vasan, Neil, Powell, Simon N, Wolchok, Jedd D, Elemento, Olivier, Swanton, Charles, Shoushtari, Alexander N, Parkes, Eileen E, Izar, Benjamin, Bakhoum, Samuel F
Published in Cancer discovery (01.05.2021)
Published in Cancer discovery (01.05.2021)
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Journal Article
Dissecting the treatment-naive ecosystem of human melanoma brain metastasis
Biermann, Jana, Melms, Johannes C, Amin, Amit Dipak, Wang, Yiping, Caprio, Lindsay A, Karz, Alcida, Tagore, Somnath, Barrera, Irving, Ibarra-Arellano, Miguel A, Andreatta, Massimo, Fullerton, Benjamin T, Gretarsson, Kristjan H, Sahu, Varun, Mangipudy, Vaibhav S, Nguyen, Trang T T, Nair, Ajay, Rogava, Meri, Ho, Patricia, Koch, Peter D, Banu, Matei, Humala, Nelson, Mahajan, Aayushi, Walsh, Zachary H, Shah, Shivem B, Vaccaro, Daniel H, Caldwell, Blake, Mu, Michael, Wünnemann, Florian, Chazotte, Margot, Berhe, Simon, Luoma, Adrienne M, Driver, Joseph, Ingham, Matthew, Khan, Shaheer A, Rapisuwon, Suthee, Slingluff, Jr, Craig L, Eigentler, Thomas, Röcken, Martin, Carvajal, Richard, Atkins, Michael B, Davies, Michael A, Agustinus, Albert, Bakhoum, Samuel F, Azizi, Elham, Siegelin, Markus, Lu, Chao, Carmona, Santiago J, Hibshoosh, Hanina, Ribas, Antoni, Canoll, Peter, Bruce, Jeffrey N, Bi, Wenya Linda, Agrawal, Praveen, Schapiro, Denis, Hernando, Eva, Macosko, Evan Z, Chen, Fei, Schwartz, Gary K, Izar, Benjamin
Published in Cell (07.07.2022)
Published in Cell (07.07.2022)
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Journal Article
Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma
Jerby-Arnon, Livnat, Neftel, Cyril, Shore, Marni E., Weisman, Hannah R., Mathewson, Nathan D., McBride, Matthew J., Haas, Brian, Izar, Benjamin, Volorio, Angela, Boulay, Gaylor, Cironi, Luisa, Richman, Alyssa R., Broye, Liliane C., Gurski, Joseph M., Luo, Christina C., Mylvaganam, Ravindra, Nguyen, Lan, Mei, Shaolin, Melms, Johannes C., Georgescu, Christophe, Cohen, Ofir, Buendia-Buendia, Jorge E., Segerstolpe, Asa, Sud, Malika, Cuoco, Michael S., Labes, Danny, Gritsch, Simon, Zollinger, Daniel R., Ortogero, Nicole, Beechem, Joseph M., Petur Nielsen, G., Chebib, Ivan, Nguyen-Ngoc, Tu, Montemurro, Michael, Cote, Gregory M., Choy, Edwin, Letovanec, Igor, Cherix, Stéphane, Wagle, Nikhil, Sorger, Peter K., Haynes, Alex B., Mullen, John T., Stamenkovic, Ivan, Rivera, Miguel N., Kadoch, Cigall, Wucherpfennig, Kai W., Rozenblatt-Rosen, Orit, Suvà, Mario L., Riggi, Nicolò, Regev, Aviv
Published in Nature medicine (01.02.2021)
Published in Nature medicine (01.02.2021)
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Journal Article
Mapping variant effects on anti-tumor hallmarks of primary human T cells with base-editing screens
Walsh, Zachary H, Shah, Parin, Kothapalli, Neeharika, Shah, Shivem B, Nikolenyi, Gergo, Brodtman, D Zack, Leuzzi, Giuseppe, Rogava, Meri, Mu, Michael, Ho, Patricia, Abuzaid, Sinan, Vasan, Neil, AlQuraishi, Mohammed, Milner, Joshua D, Ciccia, Alberto, Melms, Johannes C, Izar, Benjamin
Published in Nature biotechnology (23.05.2024)
Published in Nature biotechnology (23.05.2024)
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Journal Article
Histone acetylation of bile acid transporter genes plays a critical role in cirrhosis
Garrido, Amanda, Kim, Eunjeong, Teijeiro, Ana, Sánchez Sánchez, Paula, Gallo, Rosa, Nair, Ajay, Matamala Montoya, María, Perna, Cristian, Vicent, Guillermo P., Muñoz, Javier, Campos-Olivas, Ramón, Melms, Johannes C., Izar, Benjamin, Schwabe, Robert F., Djouder, Nabil
Published in Journal of hepatology (01.04.2022)
Published in Journal of hepatology (01.04.2022)
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Journal Article
Single-cell profiling of sarcomas from archival tissue reveals programs associated with resistance to immune checkpoint blockade
Luthria, Karan, Shah, Parin, Caldwell, Blake, Melms, Johannes C, Abuzaid, Sinan, Jakubikova, Viktoria, Brodtman, D Zack, Bose, Sminu, Amin, Amit Dipak, Ho, Patricia, Biermann, Jana, Tagore, Somnath, Ingham, Matthew, Schwartz, Gary K, Izar, Benjamin
Published in Clinical cancer research (01.10.2024)
Published in Clinical cancer research (01.10.2024)
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Journal Article
The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity
Ho, Patricia, Melms, Johannes C., Rogava, Meri, Frangieh, Chris J., Poźniak, Joanna, Shah, Shivem B., Walsh, Zachary, Kyrysyuk, Oleksandr, Amin, Amit Dipak, Caprio, Lindsay, Fullerton, Benjamin T., Soni, Rajesh Kumar, Ager, Casey R., Biermann, Jana, Wang, Yiping, Khosravi-Maharlooei, Mohsen, Zanetti, Giorgia, Mu, Michael, Fatima, Hijab, Moore, Emily K., Vasan, Neil, Bakhoum, Samuel F., Reiner, Steven L., Bernatchez, Chantale, Sykes, Megan, Mace, Emily M., Wucherpfennig, Kai W., Schadendorf, Dirk, Bechter, Oliver, Shah, Parin, Schwartz, Gary K., Marine, Jean-Christophe, Izar, Benjamin
Published in Cancer cell (10.07.2023)
Published in Cancer cell (10.07.2023)
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Journal Article