DARK Classics in Chemical Neuroscience: Heroin and Desomorphine
Mella-Raipán, Jaime, Romero-Parra, Javier, Recabarren-Gajardo, Gonzalo
Published in ACS chemical neuroscience (02.12.2020)
Published in ACS chemical neuroscience (02.12.2020)
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Journal Article
Arylamines QSAR-Based Design and Molecular Dynamics of New Phenylthiophene and Benzimidazole Derivatives with Affinity for the C111, Y268, and H73 Sites of SARS-CoV-2 PLpro Enzyme
Sabadini, Gianfranco, Mellado, Marco, Morales, César, Mella, Jaime
Published in Pharmaceuticals (Basel, Switzerland) (01.05.2024)
Published in Pharmaceuticals (Basel, Switzerland) (01.05.2024)
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Journal Article
Coumarin-Resveratrol-Inspired Hybrids as Monoamine Oxidase B Inhibitors: 3-Phenylcoumarin versus trans -6-Styrylcoumarin
Mellado, Marco, González, César, Mella, Jaime, Aguilar, Luis F, Celik, Ismail, Borges, Fernanda, Uriarte, Eugenio, Delogu, Giovanna, Viña, Dolores, Matos, Maria J
Published in Molecules (Basel, Switzerland) (29.01.2022)
Published in Molecules (Basel, Switzerland) (29.01.2022)
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Journal Article
Insights into the Structural Requirements of Potent Brassinosteroids as Vegetable Growth Promoters Using Second-Internode Elongation as Biological Activity: CoMFA and CoMSIA Studies
Ferrer-Pertuz, Karoll, Espinoza, Luis, Mella, Jaime
Published in International journal of molecular sciences (17.12.2017)
Published in International journal of molecular sciences (17.12.2017)
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Journal Article
Cytotoxic Activity, Topoisomerase I Inhibition and In Silico Studies of New Sesquiterpene-aryl Ester Derivatives of (-) Drimenol
Araque, Ileana, Ramírez, Javiera, Vergara, Rut, Mella, Jaime, Aránguiz, Pablo, Espinoza, Luis, Vera, Waleska, Montenegro, Iván, Salas, Cristian O, Villena, Joan, Cuellar, Mauricio A
Published in Molecules (Basel, Switzerland) (08.05.2023)
Published in Molecules (Basel, Switzerland) (08.05.2023)
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Journal Article
QSAR Studies, Synthesis, and Biological Evaluation of New Pyrimido-Isoquinolin-Quinone Derivatives against Methicillin-Resistant Staphylococcus aureus
Andrades-Lagos, Juan, Campanini-Salinas, Javier, Sabadini, Gianfranco, Andrade, Victor, Mella, Jaime, Vásquez-Velásquez, David
Published in Pharmaceuticals (Basel, Switzerland) (01.11.2023)
Published in Pharmaceuticals (Basel, Switzerland) (01.11.2023)
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Journal Article
Structure-Activity Relationships Based on 3D-QSAR CoMFA/CoMSIA and Design of Aryloxypropanol-Amine Agonists with Selectivity for the Human β3-Adrenergic Receptor and Anti-Obesity and Anti-Diabetic Profiles
Lorca, Marcos, Morales-Verdejo, Cesar, Vásquez-Velásquez, David, Andrades-Lagos, Juan, Campanini-Salinas, Javier, Soto-Delgado, Jorge, Recabarren-Gajardo, Gonzalo, Mella, Jaime
Published in Molecules (Basel, Switzerland) (16.05.2018)
Published in Molecules (Basel, Switzerland) (16.05.2018)
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Journal Article
Synthesis, Docking, 3-D-Qsar, and Biological Assays of Novel Indole Derivatives Targeting Serotonin Transporter, Dopamine D2 Receptor, and Mao-A Enzyme: In the Pursuit for Potential Multitarget Directed Ligands
Cerda-Cavieres, Christopher, Quiroz, Gabriel, Iturriaga-Vásquez, Patricio, Rodríguez-Lavado, Julio, Alarcón-Espósito, Jazmín, Saitz, Claudio, Pessoa-Mahana, Carlos D, Chung, Hery, Araya-Maturana, Ramiro, Mella-Raipán, Jaime, Cabezas, David, Ojeda-Gómez, Claudia, Reyes-Parada, Miguel, Pessoa-Mahana, Hernán
Published in Molecules (Basel, Switzerland) (10.10.2020)
Published in Molecules (Basel, Switzerland) (10.10.2020)
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Journal Article
2D/3D-QSAR Model Development Based on a Quinoline Pharmacophoric Core for the Inhibition of Plasmodium falciparum : An In Silico Approach with Experimental Validation
Lorca, Marcos, Muscia, Gisela C, Pérez-Benavente, Susana, Bautista, José M, Acosta, Alison, González, Cesar, Sabadini, Gianfranco, Mella, Jaime, Asís, Silvia E, Mellado, Marco
Published in Pharmaceuticals (Basel, Switzerland) (04.07.2024)
Published in Pharmaceuticals (Basel, Switzerland) (04.07.2024)
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Journal Article
Promising 2,6,9-Trisubstituted Purine Derivatives for Anticancer Compounds: Synthesis, 3D-QSAR, and Preliminary Biological Assays
O Salas, Cristian, Zarate, Ana Maria, Kryštof, Vladimir, Mella, Jaime, Faundez, Mario, Brea, Jose, Loza, María Isabel, Brito, Ivan, Hendrychová, Denisa, Jorda, Radek, Cabrera, Alan R, Tapia, Ricardo A, Espinosa-Bustos, Christian
Published in International journal of molecular sciences (25.12.2019)
Published in International journal of molecular sciences (25.12.2019)
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Journal Article
Three-Dimensional Quantitative Structure-Activity Relationships (3D-QSAR) on a Series of Piperazine-Carboxamides Fatty Acid Amide Hydrolase (FAAH) Inhibitors as a Useful Tool for the Design of New Cannabinoid Ligands
Lorca, Marcos, Valdes, Yudisladys, Chung, Hery, Romero-Parra, Javier, Pessoa-Mahana, C David, Mella, Jaime
Published in International journal of molecular sciences (21.05.2019)
Published in International journal of molecular sciences (21.05.2019)
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Journal Article
Design of benzimidazoles, benzoxazoles, benzothiazoles and thiazolopyridines as leukotriene A4 hydrolase inhibitors through 3D-QSAR, docking and molecular dynamics
Lorca, Marcos, Faúndez, Mario, Pessoa-Mahana, David, Recabarren-Gajardo, Gonzalo, Diethelm-Varela, Benjamin, Millán, Daniela, Celik, Ismail, Mellado, Marco, Araque, Ileana, Mella, Jaime, Romero-Parra, Javier
Published in Journal of the Serbian Chemical Society (01.01.2023)
Published in Journal of the Serbian Chemical Society (01.01.2023)
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Journal Article
Design, Synthesis, In Silico Studies and Inhibitory Activity towards Bcr-Abl, BTK and FLT3-ITD of New 2,6,9-Trisubstituted Purine Derivatives as Potential Agents for the Treatment of Leukaemia
Bertrand, Jeanluc, Dostálová, Hana, Kryštof, Vladimír, Jorda, Radek, Delgado, Thalía, Castro-Alvarez, Alejandro, Mella, Jaime, Cabezas, David, Faúndez, Mario, Espinosa-Bustos, Christian, Salas, Cristian O.
Published in Pharmaceutics (17.06.2022)
Published in Pharmaceutics (17.06.2022)
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Journal Article
Novel N-Arylsulfonylindoles Targeted as Ligands of the 5-HT6 Receptor. Insights on the Influence of C-5 Substitution on Ligand Affinity
Arrieta-Rodríguez, Loreto, Espinoza-Rosales, Daniela, Vera, Gonzalo, Cho, Young Hwa, Cabezas, David, Vásquez-Velásquez, David, Mella-Raipán, Jaime, Lagos, Carlos F., Recabarren-Gajardo, Gonzalo
Published in Pharmaceuticals (Basel, Switzerland) (01.06.2021)
Published in Pharmaceuticals (Basel, Switzerland) (01.06.2021)
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Journal Article
Design, synthesis, binding and docking-based 3D-QSAR studies of 2-pyridylbenzimidazoles--a new family of high affinity CB1 cannabinoid ligands
Mella-Raipán, Jaime A, Lagos, Carlos F, Recabarren-Gajardo, Gonzalo, Espinosa-Bustos, Christian, Romero-Parra, Javier, Pessoa-Mahana, Hernán, Iturriaga-Vásquez, Patricio, Pessoa-Mahana, Carlos David
Published in Molecules (Basel, Switzerland) (04.04.2013)
Published in Molecules (Basel, Switzerland) (04.04.2013)
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Journal Article
2D-QSAR and 3D-QSAR/CoMSIA Studies on a Series of (R)-2-((2-(1H-Indol-2-yl)ethyl)amino)-1-Phenylethan-1-ol with Human β₃-Adrenergic Activity
Apablaza, Gastón, Montoya, Luisa, Morales-Verdejo, Cesar, Mellado, Marco, Cuellar, Mauricio, Lagos, Carlos F, Soto-Delgado, Jorge, Chung, Hery, Pessoa-Mahana, Carlos David, Mella, Jaime
Published in Molecules (Basel, Switzerland) (05.03.2017)
Published in Molecules (Basel, Switzerland) (05.03.2017)
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Journal Article
A New Kind of Quinonic-Antibiotic Useful Against Multidrug-Resistant S. aureus and E. faecium Infections
Campanini-Salinas, Javier, Andrades-Lagos, Juan, Gonzalez Rocha, Gerardo, Choquesillo-Lazarte, Duane, Bollo Dragnic, Soledad, Faúndez, Mario, Alarcón, Pedro, Silva, Francisco, Vidal, Roberto, Salas-Huenuleo, Edison, Kogan, Marcelo, Mella, Jaime, Recabarren Gajardo, Gonzalo, Vásquez-Velásquez, David
Published in Molecules (Basel, Switzerland) (19.07.2018)
Published in Molecules (Basel, Switzerland) (19.07.2018)
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Journal Article
Extended N-Arylsulfonylindoles as 5-HT₆ Receptor Antagonists: Design, Synthesis & Biological Evaluation
Vera, Gonzalo, Lagos, Carlos F, Almendras, Sebastián, Hebel, Dan, Flores, Francisco, Valle-Corvalán, Gissella, Pessoa-Mahana, C David, Mella-Raipán, Jaime, Montecinos, Rodrigo, Recabarren-Gajardo, Gonzalo
Published in Molecules (Basel, Switzerland) (16.08.2016)
Published in Molecules (Basel, Switzerland) (16.08.2016)
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Journal Article
3D-QSAR/CoMFA-based structure-affinity/selectivity relationships of aminoalkylindoles in the cannabinoid CB1 and CB2 receptors
Mella-Raipán, Jaime, Hernández-Pino, Santiago, Morales-Verdejo, César, Pessoa-Mahana, David
Published in Molecules (Basel, Switzerland) (05.03.2014)
Published in Molecules (Basel, Switzerland) (05.03.2014)
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Journal Article
Design, Synthesis, and Structure-Activity Relationship Studies of New Quinone Derivatives as Antibacterial Agents
Andrades-Lagos, Juan, Campanini-Salinas, Javier, Pedreros-Riquelme, América, Mella, Jaime, Choquesillo-Lazarte, Duane, Zamora, P P, Pessoa-Mahana, Hernán, Burbulis, Ian, Vásquez-Velásquez, David
Published in Antibiotics (Basel) (01.06.2023)
Published in Antibiotics (Basel) (01.06.2023)
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