Comparative analysis of PD‐1 target engagement of dostarlimab and pembrolizumab in advanced solid tumors using ex vivo IL‐2 stimulation data
Austin, Daren, Melhem, Murad, Gandhi, Yash, Lu, Sharon, Visser, Sandra
Published in CPT: pharmacometrics and systems pharmacology (01.01.2023)
Published in CPT: pharmacometrics and systems pharmacology (01.01.2023)
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Journal Article
Quantification of Radiation Injury on Neutropenia and the Link between Absolute Neutrophil Count Time Course and Overall Survival in Nonhuman Primates Treated with G-CSF
Harrold, John, Gisleskog, Per Olsson, Delor, Isabelle, Jacqmin, Philippe, Perez-Ruixo, Juan Jose, Narayanan, Adimoolam, Doshi, Sameer, Chow, Andrew, Yang, Bing-Bing, Melhem, Murad
Published in Pharmaceutical research (01.06.2020)
Published in Pharmaceutical research (01.06.2020)
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Journal Article
A bridging assay for detection and characterization of anti-drug antibodies to dostarlimab, a new anti-PD-1 therapeutic monoclonal antibody
Patterson, Marilyn, Beausang, Lee Anne, Rup, Bonita, Bowsher, Ronald R., Krug, Kim, Melhem, Murad, Lu, Sharon
Published in AAPS open (20.12.2021)
Published in AAPS open (20.12.2021)
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Journal Article
A competitive ligand-binding assay for the detection of neutralizing antibodies against dostarlimab (TSR-042)
Zhang, Xiaolong Tom, Chen, Hong, Shao, Weiping, Lin, Zhongping John, Melhem, Murad, Lu, Sharon
Published in AAPS open (11.11.2021)
Published in AAPS open (11.11.2021)
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Journal Article
Mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes
Schiffer, Joshua T, Swan, David A, Magaret, Amalia, Corey, Lawrence, Wald, Anna, Ossig, Joachim, Ruebsamen-Schaeff, Helga, Stoelben, Susanne, Timmler, Burkhard, Zimmermann, Holger, Melhem, Murad R, Van Wart, Scott A, Rubino, Christopher M, Birkmann, Alexander
Published in Science translational medicine (03.02.2016)
Published in Science translational medicine (03.02.2016)
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Journal Article
Prediction of Survival Benefit of Filgrastim in Adult and Pediatric Patients With Acute Radiation Syndrome
Harrold, John, Gisleskog, Per Olsson, Perez‐Ruixo, Juan Jose, Delor, Isabelle, Chow, Andrew, Jacqmin, Philippe, Melhem, Murad
Published in Clinical and translational science (01.07.2020)
Published in Clinical and translational science (01.07.2020)
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Journal Article
Hemodialysis Vascular Access Dysfunction: From Pathophysiology to Novel Therapies
Roy-Chaudhury, Prabir, Kelly, Burnett S., Zhang, Jianhua, Narayana, Ashwath, Desai, Pankaj, Melhem, Murad, Duncan, Heather, Heffelfinger, Sue C.
Published in Blood purification (01.01.2003)
Published in Blood purification (01.01.2003)
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Journal Article
Conference Proceeding
Dostarlimab, an anti‐programmed death‐1 monoclonal antibody, does not cause QT prolongation in patients with solid tumours: A concentration‐QT analysis
Kuchimanchi, Mita, Dabrowski, Christine, Lu, Sharon, Melhem, Murad
Published in British journal of clinical pharmacology (01.07.2023)
Published in British journal of clinical pharmacology (01.07.2023)
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Journal Article
Population pharmacokinetics and exposure–response of anti‐programmed cell death protein‐1 monoclonal antibody dostarlimab in advanced solid tumours
Melhem, Murad, Hanze, Eva, Lu, Sharon, Alskär, Oskar, Visser, Sandra, Gandhi, Yash
Published in British journal of clinical pharmacology (01.09.2022)
Published in British journal of clinical pharmacology (01.09.2022)
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Journal Article
Bridging adults and paediatrics with secondary hyperparathyroidism receiving haemodialysis: a pharmacokinetic‐pharmacodynamic analysis of cinacalcet
Chen, Ping, Sohn, Winnie, Narayanan, Adimoolam, Gisleskog, Per Olsson, Melhem, Murad
Published in British journal of clinical pharmacology (01.06.2019)
Published in British journal of clinical pharmacology (01.06.2019)
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Journal Article
Dose Optimization in Oncology Drug Development: An International Consortium for Innovation and Quality in Pharmaceutical Development White Paper
Samineni, Divya, Venkatakrishnan, Karthik, Othman, Ahmed A., Pithavala, Yazdi K., Poondru, Srinivasu, Patel, Chirag, Vaddady, Pavan, Ankrom, Wendy, Ramanujan, Saroja, Budha, Nageshwar, Wu, Michael, Haddish‐Berhane, Nahor, Fritsch, Holger, Hussain, Azher, Kanodia, Jitendra, Li, Meng, Li, Mengyao, Melhem, Murad, Parikh, Apurvasena, Upreti, Vijay V., Gupta, Neeraj
Published in Clinical pharmacology and therapeutics (01.09.2024)
Published in Clinical pharmacology and therapeutics (01.09.2024)
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Journal Article
Pharmacokinetic–pharmacodynamic modelling of neutrophil response to G‐CSF in healthy subjects and patients with chemotherapy‐induced neutropenia
Melhem, Murad, Delor, Isabelle, Pérez‐Ruixo, Juan Jose, Harrold, John, Chow, Andrew, Wu, Liviawati, Jacqmin, Philippe
Published in British journal of clinical pharmacology (01.05.2018)
Published in British journal of clinical pharmacology (01.05.2018)
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Journal Article
Population pharmacokinetics analysis of AMG 416, an allosteric activator of the calcium-sensing receptor, in subjects with secondary hyperparathyroidism receiving hemodialysis
Chen, Ping, Melhem, Murad, Xiao, Jim, Kuchimanchi, Mita, Perez Ruixo, Juan Jose
Published in Journal of clinical pharmacology (01.06.2015)
Published in Journal of clinical pharmacology (01.06.2015)
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Journal Article
Drug disposition model of radiolabeled etelcalcetide in patients with chronic kidney disease and secondary hyperparathyroidism on hemodialysis
Wu, Liviawati, Melhem, Murad, Subramanian, Raju, Wu, Benjamin
Published in Journal of pharmacokinetics and pharmacodynamics (01.02.2017)
Published in Journal of pharmacokinetics and pharmacodynamics (01.02.2017)
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Journal Article
Population Pharmacokinetic and Pharmacodynamic Modeling of Etelcalcetide in Patients with Chronic Kidney Disease and Secondary Hyperparathyroidism Receiving Hemodialysis
Chen, Ping, Narayanan, Adimoolam, Wu, Benjamin, Gisleskog, Per Olsson, Gibbs, John P., Chow, Andrew T., Melhem, Murad
Published in Clinical pharmacokinetics (2018)
Published in Clinical pharmacokinetics (2018)
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Journal Article
Clinical Pharmacokinetics and Pharmacodynamics of Etelcalcetide, a Novel Calcimimetic for Treatment of Secondary Hyperparathyroidism in Patients With Chronic Kidney Disease on Hemodialysis
Wu, Benjamin, Melhem, Murad, Subramanian, Raju, Chen, Ping, Jaramilla Sloey, Bethlyn, Fouqueray, Bruno, Hock, M Benjamin, Skiles, Gary L, Chow, Andrew T, Lee, Edward
Published in Journal of clinical pharmacology (01.06.2018)
Published in Journal of clinical pharmacology (01.06.2018)
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Journal Article
Bendamustine pharmacokinetic profile and exposure-response relationships in patients with indolent non-Hodgkin's lymphoma
Owen, Joel S, Melhem, Murad, Passarell, Julie A, D'Andrea, Denise, Darwish, Mona, Kahl, Bradley
Published in Cancer chemotherapy and pharmacology (01.11.2010)
Published in Cancer chemotherapy and pharmacology (01.11.2010)
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Journal Article
Abstract 6647: Dostarlimab shows dose-dependent immune activation of the tumor microenvironment in a patient-derived NSCLC explant model similar to pembrolizumab
Perrin, Jessica, Wippich, Frank, Sherina, Valeriia, Dvornikov, Dmytro, Lupar, Katharina, Melhem, Murad M., Hanafin, Patrick, Waight, Jeremy, Yu, Jong, Yadavilli, Sapna, Poeckel, Daniel, Bergamini, Giovanna
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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