Complex dietary polysaccharide modulates gut immune function and microbiota, and promotes protection from autoimmune diabetes
Gudi, Radhika, Perez, Nicolas, Johnson, Benjamin M., Sofi, M. Hanief, Brown, Robert, Quan, Songhua, Karumuthil‐Melethil, Subha, Vasu, Chenthamarakshan
Published in Immunology (01.05.2019)
Published in Immunology (01.05.2019)
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Journal Article
Activation of T cell checkpoint pathways during β‐cell antigen presentation by engineered dendritic cells promotes protection from type 1 diabetes
Gudi, Radhika R., Perez, Nicolas, Karumuthil‐Melethil, Subha, Li, Gongbo, Vasu, Chenthamarakshan
Published in Immunology (01.07.2022)
Published in Immunology (01.07.2022)
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Journal Article
Intrathecal administration of AAV/GALC vectors in 10-11-day-old twitcher mice improves survival and is enhanced by bone marrow transplant
Karumuthil-Melethil, Subha, Marshall, Michael S., Heindel, Clifford, Jakubauskas, Benas, Bongarzone, Ernesto R., Gray, Steven J.
Published in Journal of neuroscience research (01.11.2016)
Published in Journal of neuroscience research (01.11.2016)
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Journal Article
Immunological considerations for treating globoid cell leukodystrophy
Karumuthil-Melethil, Subha, Gray, Steven J.
Published in Journal of neuroscience research (01.11.2016)
Published in Journal of neuroscience research (01.11.2016)
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Journal Article
Sexually dimorphic patterns in electroencephalography power spectrum and autism-related behaviors in a rat model of fragile X syndrome
Wong, Hayes, Hooper, Alexander W.M., Niibori, Yosuke, Lee, Shiron J., Hategan, Luca A., Zhang, Liang, Karumuthil-Melethil, Subha, Till, Sally M., Kind, Peter C., Danos, Olivier, Bruder, Joseph T., Hampson, David R.
Published in Neurobiology of disease (01.12.2020)
Published in Neurobiology of disease (01.12.2020)
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Journal Article
Sex Difference Leads to Differential Gene Expression Patterns and Therapeutic Efficacy in Mucopolysaccharidosis IVA Murine Model Receiving AAV8 Gene Therapy
Piechnik, Matthew, Amendum, Paige C, Sawamoto, Kazuki, Stapleton, Molly, Khan, Shaukat, Fnu, Nidhi, Álvarez, Victor, Pachon, Angelica Maria Herreño, Danos, Olivier, Bruder, Joseph T, Karumuthil-Melethil, Subha, Tomatsu, Shunji
Published in International journal of molecular sciences (21.10.2022)
Published in International journal of molecular sciences (21.10.2022)
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Journal Article
Investigating Immune Responses to the scAAV9-HEXM Gene Therapy Treatment in Tay–Sachs Disease and Sandhoff Disease Mouse Models
Kot, Shalini, Karumuthil-Melethil, Subha, Woodley, Evan, Zaric, Violeta, Thompson, Patrick, Chen, Zhilin, Lykken, Erik, Keimel, John G., Kaemmerer, William F., Gray, Steven J., Walia, Jagdeep S.
Published in International journal of molecular sciences (01.07.2021)
Published in International journal of molecular sciences (01.07.2021)
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Journal Article
Novel Vector Design and Hexosaminidase Variant Enabling Self-Complementary Adeno-Associated Virus for the Treatment of Tay-Sachs Disease
Karumuthil-Melethil, Subha, Nagabhushan Kalburgi, Sahana, Thompson, Patrick, Tropak, Michael, Kaytor, Michael D, Keimel, John G, Mark, Brian L, Mahuran, Don, Walia, Jagdeep S, Gray, Steven J
Published in Human gene therapy (01.07.2016)
Published in Human gene therapy (01.07.2016)
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Journal Article
Gene therapy using an ortholog of human fragile X mental retardation protein partially rescues behavioral abnormalities and EEG activity
Hooper, Alexander W.M., Wong, Hayes, Niibori, Yosuke, Abdoli, Rozita, Karumuthil-Melethil, Subha, Qiao, Chunping, Danos, Olivier, Bruder, Joseph T., Hampson, David R.
Published in Molecular therapy. Methods & clinical development (10.09.2021)
Published in Molecular therapy. Methods & clinical development (10.09.2021)
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Journal Article
Construction of a hybrid β-hexosaminidase subunit capable of forming stable homodimers that hydrolyze GM2 ganglioside in vivo
Tropak, Michael B, Yonekawa, Sayuri, Karumuthil-Melethil, Subha, Thompson, Patrick, Wakarchuk, Warren, Gray, Steven J, Walia, Jagdeep S, Mark, Brian L, Mahuran, Don
Published in Molecular therapy. Methods & clinical development (01.01.2016)
Published in Molecular therapy. Methods & clinical development (01.01.2016)
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Journal Article
Bone Marrow Is a Preferential Homing Site for Autoreactive T-Cells in Type 1 Diabetes
RUOBING LI, PEREZ, Nicolas, KARUMUTHIL-MELETHIL, Subha, VASU, Chenthamarakshan
Published in Diabetes (New York, N.Y.) (01.09.2007)
Published in Diabetes (New York, N.Y.) (01.09.2007)
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Journal Article
Liver-Targeted AAV8 Gene Therapy Ameliorates Skeletal and Cardiovascular Pathology in a Mucopolysaccharidosis IVA Murine Model
Sawamoto, Kazuki, Karumuthil-Melethil, Subha, Khan, Shaukat, Stapleton, Molly, Bruder, Joseph T., Danos, Olivier, Tomatsu, Shunji
Published in Molecular therapy. Methods & clinical development (11.09.2020)
Published in Molecular therapy. Methods & clinical development (11.09.2020)
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Journal Article
점액다당류증 IVA의 치료
SAWAMOTO KAZUKI, MELETHIL SUBHA KARUMUTHIL, DANOS OLIVIER, TOMATSU SHUNJI
Year of Publication 14.04.2021
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Year of Publication 14.04.2021
Patent
신경원성 세로이드 리포푸신증에 대한 유전자 요법
KONDRAGUNTA BHARGAVI, GUIBERT MATTHIEU PIERRE, BEE JARED, DEPAZ ROBERTO, BUSS NICHOLAS ALEXANDER PIERS SASCHA, MERCER ANDREW CHRISTOPHER, MELETHIL SUBHA KARUMUTHIL, CARRELL MICHAEL JAMES, STADELMAN ROBERT THOMAS, MARSHALL TRISTAN JAMES, GERNER FRANZ MICHAEL
Year of Publication 26.07.2021
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Year of Publication 26.07.2021
Patent
Fungal β-glucan, a Dectin-1 ligand, promotes protection from type 1 diabetes by inducing regulatory innate immune response
Karumuthil-Melethil, Subha, Gudi, Radhika, Johnson, Benjamin M, Perez, Nicolas, Vasu, Chenthamarakshan
Published in The Journal of immunology (1950) (01.10.2014)
Published in The Journal of immunology (1950) (01.10.2014)
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Journal Article
The presence of CpGs in AAV gene therapy vectors induces a plasmacytoid dendritic cell-like population very early after administration
Glenn, Justin D., Negash, Henos, Henry, William, Qian, Randolph, Liu, Ye, Danos, Olivier, Bruder, Joseph T., Karumuthil-Melethil, Subha
Published in Cellular immunology (01.05.2024)
Published in Cellular immunology (01.05.2024)
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Journal Article
Intracisternal administration of AAV9 gene therapies to target the central nervous system
Pukenas, Bryan, Papisov, Mikhail, Buss, Nicholas, Karumuthil-Melethil, Subha, O'Berry, Anthony, Cowley, Kirsten, Nevoret, Marie-Laure, Falabella, Paulo
Published in Molecular genetics and metabolism (01.02.2021)
Published in Molecular genetics and metabolism (01.02.2021)
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Journal Article