Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents
Hirai, Hiroshi, Iwasawa, Yoshikazu, Okada, Megumu, Arai, Tsuyoshi, Nishibata, Toshihide, Kobayashi, Makiko, Kimura, Toshifumi, Kaneko, Naoki, Ohtani, Junko, Yamanaka, Kazunori, Itadani, Hiraku, Takahashi-Suzuki, Ikuko, Fukasawa, Kazuhiro, Oki, Hiroko, Nambu, Tadahiro, Jiang, Jian, Sakai, Takumi, Arakawa, Hiroharu, Sakamoto, Toshihiro, Sagara, Takeshi, Yoshizumi, Takashi, Mizuarai, Shinji, Kotani, Hidehito
Published in Molecular cancer therapeutics (01.11.2009)
Published in Molecular cancer therapeutics (01.11.2009)
Get full text
Journal Article
MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil
Hirai, Hiroshi, Arai, Tsuyoshi, Okada, Megumu, Nishibata, Toshihide, Kobayashi, Makiko, Sakai, Naoko, Imagaki, Kazuhide, Ohtani, Junko, Sakai, Takumi, Yoshizumi, Takashi, Mizuarai, Shinji, Iwasawa, Yoshikazu, Kotani, Hidehito
Published in Cancer biology & therapy (01.04.2010)
Published in Cancer biology & therapy (01.04.2010)
Get full text
Journal Article
Blockade of body weight gain and plasma corticosterone levels in Zucker fatty rats using an orally active neuropeptide Y Y1 antagonist
Ishihara, Akane, Kanatani, Akio, Okada, Megumu, Hidaka, Masayasu, Tanaka, Takeshi, Mashiko, Satoshi, Gomori, Akira, Kanno, Tetsuya, Hata, Mikiko, Kanesaka, Maki, Tominaga, Yushin, Sato, Naga‐aki, Kobayashi, Masahiko, Murai, Takashi, Watanabe, Keiko, Ishii, Yasuyuki, Fukuroda, Takahiro, Fukami, Takehiro, Ihara, Masaki
Published in British journal of pharmacology (01.06.2002)
Published in British journal of pharmacology (01.06.2002)
Get full text
Journal Article
Pathophysiological Roles of Endothelin-1 in Dahl Salt-Sensitive Hypertension
Ikeda, Takanori, Ohta, Hisashi, Okada, Megumu, Kawai, Nobuko, Nakao, Rumi, Siegl, Peter K.S, Kobayashi, Tsutomu, Maeda, Seiji, Miyauchi, Takashi, Nishikibe, Masaru
Published in Hypertension (Dallas, Tex. 1979) (01.09.1999)
Published in Hypertension (Dallas, Tex. 1979) (01.09.1999)
Get full text
Journal Article
Antihypertensive effect of a newly synthesized endothelin antagonist, BQ-123, in a genetic hypertensive model
Nishikibe, Masaru, Tsuchida, Sonoko, Okada, Megumu, Fukuroda, Takahiro, Shimamoto, Koji, Yano, Mitsuo, Ishikawa, Kiyofumi, Ikemoto, Fumihiko
Published in Life sciences (1973) (1993)
Published in Life sciences (1973) (1993)
Get full text
Journal Article
Abstract A269: A selective Aurora A inhibitor, TAS-119, enhanced the antitumor activity of taxanes in an intermittent dosing schedule without affecting neurotoxicity
Ishihara, Keiko, Sootome, Hiroshi, Suzuki, Takamasa, Masuko, Norio, Miura, Akihiro, Okada, Megumu, Oda, Nobuyuki, Hirai, Hiroshi, Utsugi, Teruhiro
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
Get full text
Journal Article
Abstract C177: TAS-117, a highly selective non-ATP competitive inhibitor of AKT demonstrated antitumor activity in combination with chemotherapeutic agents and molecular targeted drugs
Ichikawa, Koji, Abe, Tetsuya, Nagase, Hideki, Saito, Hitoshi, Fujita, Ryouto, Okada, Megumu, Yonekura, Kazuhiko, Shimomura, Toshiyasu, Utsugi, Teruhiro
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
Get full text
Journal Article
Contribution of Endogenous Endothelin-1 to the Progression of Cardiopulmonary Alterations in Rats With Monocrotaline-Induced Pulmonary Hypertension
Miyauchi, Takashi, Yorikane, Ryosuke, Sakai, Satoshi, Sakurai, Takeshi, Okada, Megumu, Nishikibe, Masaru, Yano, Mitsuo, Yamaguchi, Iwao, Sugishita, Yasuro, Goto, Katsutoshi
Published in Circulation research (01.11.1993)
Published in Circulation research (01.11.1993)
Get full text
Journal Article
Antiplatelet and Antithrombotic Effects of a Novel Selective Phosphodiesterase 3 Inhibitor, NSP-513, in Mice and Rats
Hirose, Hiroyasu, Kimura, Toshifumi, Okada, Megumu, Itoh, Yoshiki, Ishida, Fumiaki, Mochizuki, Nobuo, Nishibe, Tadayuki, Nishikibe, Masaru
Published in Japanese Journal of Pharmacology (2000)
Published in Japanese Journal of Pharmacology (2000)
Get full text
Journal Article
COMPARISON OF THE EFFECTS OF ENDOTHELIN ETA(J-112534) AND ETA/ETB(J-104132) RECEPTOR ANTAGONISTS ON ATHEROSCLEROSIS IN APOLIPOPROTEIN E-DEFICIENT MICE
Rumi Nakao, Jiang Jian, Keiko Watanabe, Megumu Okada, Masaru Nishikibe
Published in Japanese Journal of Pharmacology (2001)
Get full text
Published in Japanese Journal of Pharmacology (2001)
Journal Article