Lenvatinib inhibits angiogenesis and tumor fibroblast growth factor signaling pathways in human hepatocellular carcinoma models
Matsuki, Masahiro, Hoshi, Taisuke, Yamamoto, Yuji, Ikemori‐Kawada, Megumi, Minoshima, Yukinori, Funahashi, Yasuhiro, Matsui, Junji
Published in Cancer medicine (Malden, MA) (01.06.2018)
Published in Cancer medicine (Malden, MA) (01.06.2018)
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Journal Article
Distinct Binding Mode of Multikinase Inhibitor Lenvatinib Revealed by Biochemical Characterization
Okamoto, Kiyoshi, Ikemori-Kawada, Megumi, Jestel, Anja, von König, Konstanze, Funahashi, Yasuhiro, Matsushima, Tomohiro, Tsuruoka, Akihiko, Inoue, Atsushi, Matsui, Junji
Published in ACS medicinal chemistry letters (08.01.2015)
Published in ACS medicinal chemistry letters (08.01.2015)
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Journal Article
Discovery of anti-inflammatory clinical candidate E6201, inspired from resorcylic lactone LL-Z1640-2, III
Shen, Yongchun, Boivin, Roch, Yoneda, Naoki, Du, Hong, Schiller, Shawn, Matsushima, Tomohiro, Goto, Masaki, Shirota, Hiroshi, Gusovsky, Fabian, Lemelin, Charles, Jiang, Yimin, Zhang, Zhiyi, Pelletier, Robert, Ikemori-Kawada, Megumi, Kawakami, Yoshiyuki, Inoue, Atsushi, Schnaderbeck, Matthew, Wang, Yuan
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
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Journal Article
Antitumor Activity of Tasurgratinib as an Orally Available FGFR1-3 Inhibitor in Cholangiocarcinoma Models With FGFR2-fusion
Kawano, Satoshi, Kawada, Megumi Ikemori, Fukushima, Sayo, Arai, Yasuhito, Shibata, Tatsuhiro, Miyano, Saori Watanabe
Published in Anticancer research (01.06.2024)
Published in Anticancer research (01.06.2024)
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Journal Article
Discovery of an in vitro and in vivo potent resorcylic lactone analog of LL-Z1640-2 as anti-inflammatory lead, II
Shen, Yongchun, Du, Hong, Kotake, Makoto, Matsushima, Tomohiro, Goto, Masaki, Shirota, Hiroshi, Gusovsky, Fabian, Li, Xiangyi, Jiang, Yimin, Schiller, Shawn, Spyvee, Mark, Davis, Heather, Zhang, Zhiyi, Pelletier, Robert, Ikemori-Kawada, Megumi, Kawakami, Yoshiyuki, Inoue, Atsushi, Wang, Yuan
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
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Journal Article
Novel ATP-competitive MEK inhibitor E6201 is effective against vemurafenib-resistant melanoma harboring the MEK1-C121S mutation in a preclinical model
Narita, Yusuke, Okamoto, Kiyoshi, Kawada, Megumi Ikemori, Takase, Kazuma, Minoshima, Yukinori, Kodama, Kotaro, Iwata, Masao, Miyamoto, Norimasa, Sawada, Kohei
Published in Molecular cancer therapeutics (01.04.2014)
Published in Molecular cancer therapeutics (01.04.2014)
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Journal Article
Abstract 1362: Distinct binding mode of lenvatinib to VEGFR2 revealed by biochemical characterization
Okamoto, Kiyoshi, Kawada, Megumi Ikemori, Jestel, Anja, von König, Konstanze, Funahashi, Yasuhiro, Matsushima, Tomohiro, Tsuruoka, Akihiko, Inoue, Atsushi, Matsui, Junji
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Abstract 1377: Chemical probe-based approach clarifies binding of receptor tyrosine kinases (RTKs) to lenvatinib in preclinical models
Kimura, Takayuki, Yamamoto, Noboru, Kamiyama, Hiroshi, Kawada, Megumi Ikemori, Yamamoto, Akihiko, Kotake, Yoshihiko, Takase, Yasutaka, Funahashi, Yasuhiro, Oda, Yoshiya
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Abstract A289: Novel ATP-competitive MEK inhibitor E6201 is effective against vemurafenib-resistant melanoma harboring the MEK1-C121S mutation
Narita, Yusuke, Okamoto, Kiyoshi, Kawada, Megumi Ikemori, Takase, Kazuma, Minoshima, Yukinori, Kodama, Kotaro, Iwata, Masao
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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Journal Article
Discovery of an in vitro and in vivo potent resorcylic lactone analog of LL-Z1640-2 as anti-inflammatory lead
Shen, Yongchun, Du, Hong, Kotake, Makoto, Matsushima, Tomohiro, Goto, Masaki, Shirota, Hiroshi, Gusovsky, Fabian, Li, Xiangyi, Jiang, Yimin, Schiller, Shawn, Spyvee, Mark, Davis, Heather, Zhang, Zhiyi, Pelletier, Robert, Ikemori-Kawada, Megumi, Kawakami, Yoshiyuki, Inoue, Atsushi, Wang, Yuan
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
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Journal Article
Discovery of anti-inflammatory clinical candidate E6201, inspired from resorcylic lactone LL-Z1640-2
Shen, Yongchun, Boivin, Roch, Yoneda, Naoki, Du, Hong, Schiller, Shawn, Matsushima, Tomohiro, Goto, Masaki, Shirota, Hiroshi, Gusovsky, Fabian, Lemelin, Charles, Jiang, Yimin, Zhang, Zhiyi, Pelletier, Robert, Ikemori-Kawada, Megumi, Kawakami, Yoshiyuki, Inoue, Atsushi, Schnaderbeck, Matthew, Wang, Yuan
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
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Journal Article
MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS
Kawada, Megumi, Kotake, Makoto, Jiang, Yimin, Spyvee, Mark, Goto, Masaki, Inoue, Atsushi, Eguchi, Yoshihito, Sakurai, Hideki, Muramoto, Kenzo, Shirota, Hiroshi, Boivin, Roch, Mizui, Yoshiharu, Shen, Yong-Chun, KIMURA, Akifumi, Matsushima, Tomohiro, Kuboi, Yoshikazu, Wang, John (Yuan), Du, Hong, Lemelin, Charles-André, Chiba, Kenichi, Kawai, Takatoshi, Chow, Jesse, Gusovsky, Fabian, Tanaka, Isao, Kawakami, Yoshiyuki, Li, Xiang-Yi, Harmange, Jean-Christophe, Yamamoto, Satoshi, Yoneda, Naoki, Fujita, Masanori
Year of Publication 01.03.2017
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Year of Publication 01.03.2017
Patent
compostos macrocíclicos úteis como substâncias farmacêuticas
John Wang, Mark Spyvee, Hong Du, Masanori Fujita, Kenichi Chiba, Isao Tanaka, Satoshi Yamamoto, Yong-Chun Shen, Yoshiharu Mizui, Jesse Chow, Akifumi Kimura, Kenzo Muramoto, Fabian Gusovsky, Jean-Christophe Harmange, Hideki Sakurai, TOMOHIRO MATSUSHIMA, Xiang-Yi Li, Atsushi Inoue, Megumi Kawada, Yoshikazu Kuboi, ROCH BOIVIN, Hiroshi Shirota, Makoto Kotake, Yoshihito Eguchi, Yoshiyuki Kawakami, Naoki Yoneda, Yimin Jiang, Takatoshi Kawai, Masaki Goto, Charles-André Lemelin
Year of Publication 25.05.2021
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Year of Publication 25.05.2021
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MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS
FUJITA MASANORI, WANG JOHN (YUAN), KAWAI TAKATOSHI, GOTO MASAKI, MIZUI YOSHIHARU, LI XIANG-YI, SHIROTA HIROSHI, EGUCHI YOSHIHITO, GUSOVSKY FABIAN, YONEDA NAOKI, MURAMOTO KENZO, CHIBA KENICHI, DU HONG, KAWAKAMI YOSHIYUKI, BOIVIN ROCH, TANAKA ISAO, KUBOI YOSHIKAZU, YAMAMOTO SATOSHI, KOTAKE MAKOTO, LEMELIN CHARLES ANDRE, JIANG YIMIN, CHOW JESSE, KIMURA AKIFUMI, SPYVEE MARK, INOUE ATSUSHI, SHEN YONGUN, SAKURAI HIDEKI, MATSUSHIMA TOMOHIRO, KAWADA MEGUMI, HARMANGE JEAN CHRISTOPHE
Year of Publication 29.04.2016
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Year of Publication 29.04.2016
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MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS
KUBOI, YOSHIKAZU, KAWAKAMI, YOSHIYUKI, LI, XIANG-YI, EGUCHI, YOSHIHITO, SPYVEE, MARK, YAMAMOTO, SATOSHI, SAKURAI, HIDEKI, CHIBA, KENICHI, FUJITA, MASANORI, WANG, JOHN (YUAN), HARMANGE, JEANRISTOPHE, KOTAKE, MAKOTO, YONEDA, NAOKI, KAWADA, MEGUMI, BOIVIN, ROCH, JIANG, YIMIN, KOBAYASHI, SEIICHI, DU, HONG, INOUE, ATSUSHI, MIZUI, YOSHIHARU, SHEN, YONGUN, MATSUSHIMA, TOMOHIRO, CHOW, JESSE, LEMELIN, CHARLES-ANDRÉ, TANAKA, ISAO, GUSOVSKY, FABIAN, GOTO, MASAKI, KIMURA, AKIFUMI, MURAMOTO, KENZO, SHIROTA, HIROSHI, KAWAI, TAKATOSHI
Year of Publication 16.09.2015
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Year of Publication 16.09.2015
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Macrocyclic Compounds Useful As Pharmaceuticals
FUJITA MASANORI, CHIBA KENICH, KAWAI TAKATOSHI, GOTO MASAKI, LEMELIN CHARLES-ANDRE, MIZUI YOSHIHARU, SHIROTA HIROSHI, LI XIANG-YI, EGUCHI YOSHIHITO, HARMANGE JEANRISTOPHE, GUSOVSKY FABIAN, YONEDA NAOKI, MURAMOTO KENZO, DU HONG, KAWAKAMI YOSHIYUKI, TANAKA ISAO, BOIVIN ROCH, KUBOI YOSHIKAZU, YAMAMOTO SATOSHI, KOTAKE MAKOTO, WANG JOHN YUAN, JIANG YIMIN, CHOW JESSE, SUKURAI HIDEKI, KIMURA AKIFUMI, SPYVEE MARK, INOUE ATSUSHI, SHEN YONGUN, MATSUSHIMA TOMOHIRO, KAWADA MEGUMI
Year of Publication 02.09.2015
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Year of Publication 02.09.2015
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Macrocyclic compounds useful as pharmaceuticals
Boivin, Roch, Chiba, Kenichi, Chow, Jesse, Du, Hong, Eguchi, Yoshihito, Fujita, Masanori, Goto, Masaki, Gusovsky, Fabian, Harmange, Jean-Christophe, Inoue, Atsushi, Jiang, Yimin, Kawada, Megumi, Kawai, Takatoshi, Kawakami, Yoshiyuki, Kimura, Akifumi, Kotake, Makoto, Kuboi, Yoshikazu, Lemelin, Charles-André, Li, Xiang-Yi, Matsushima, Tomohiro, Mizui, Yoshiharu, Muramoto, Kenzo, Sakurai, Hideki, Shen, Yong-Chun, Shirota, Hiroshi, Spyvee, Mark, Tanaka, Isao, Wang, John (Yuan), Yamamoto, Satoshi, Yoneda, Naoki
Year of Publication 11.12.2012
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Year of Publication 11.12.2012
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